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MGNTLTVQTALLDVEVRRHGNPENTDKLPVVLLHGWPDSVATWTHVIPALASAGHQVYAPSVRGTGQTKF RYADTPRTGRLGDLLRDLFAVCDQLKLERFHLVGHDWGARTAFACGIVAPHRIASLSAISAGWHPAGHGP ALSSLQAQRFWYQWLLNTPAGADLLRRERRELVELIWRDWSPNWKFSDQEFDDTFTSLQSSDWLEVTLSY YRARWGWGPVIDDPFEKQIAQATAISVPSLVLHGDSDNCVLPIASEGMNQHFPHGFSRLTTPGVGHFPQR EDPLWVSGALLQWFKEWGNAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3556 | - | - | 100% (301) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_2499c | - | 7e-32 | 30.15% (272) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_4522c | - | 6e-20 | 29.93% (274) | epoxide hydrolase EphF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1155 | ephC | 5e-18 | 29.00% (269) | epoxide hydrolase EphC |
| M. gilvum PYR-GCK | Mflv_0191 | - | 3e-15 | 27.88% (312) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1124 | ephC | 5e-18 | 29.00% (269) | epoxide hydrolase EphC |
| M. leprae Br4923 | MLBr_02297 | - | 8e-08 | 23.16% (285) | putative hydrolase |
| M. marinum M | MMAR_5114 | ephA | 3e-18 | 27.15% (291) | epoxide hydrolase EphA |
| M. avium 104 | MAV_0539 | - | 3e-16 | 26.07% (303) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3287 | - | 3e-21 | 29.02% (286) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2114 | ephC | 5e-19 | 27.46% (284) | PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4193 | ephA | 7e-18 | 26.80% (291) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_0326 | - | 3e-31 | 30.30% (297) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5114|M.marinum_M --------------------------------------MVATSTERLVDT
MUL_4193|M.ulcerans_Agy99 --------------------------------------MVATSTERLVDT
MAV_0539|M.avium_104 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------MDSYRR
Mb1155|M.bovis_AF2122/97 ------------------------MRAGRGERESTWRTTMAEPHWIDVKG
Rv1124|M.tuberculosis_H37Rv ------------------------MRAGRGERESTWRTTMAEPHWIDVKG
TH_2114|M.thermoresistible__bu -------------------------------------VTMTEPRWIDVRT
Mflv_0191|M.gilvum_PYR-GCK ---------------------------------------MTDPQTLTLTL
MAB_3556|M.abscessus_ATCC_1997 -----------------------------------------MGNTLTVQT
MLBr_02297|M.leprae_Br4923 ----------------------------MAMSNPSVTRIAGPWHHLDVHA
Mvan_0326|M.vanbaalenii_PYR-1 MNGFSRRDFGLLATAAAGAVTLTACTSTPATAGPPPAPRNQLGPIKQIDA
MMAR_5114|M.marinum_M NGVRLRVTEAGERG------------APVVILAHGFPELAYSWRHQIPVL
MUL_4193|M.ulcerans_Agy99 NGVRLRVTEAGERG------------APVVILAHGFPELAYSWRHQIPVL
MAV_0539|M.avium_104 --MRLRVTEAGDRG------------APVVILAHGFPELAYSWRHQIDVL
MSMEG_3287|M.smegmatis_MC2_155 GNLEFEVSEAGPSD------------GATVILLHGFPQRNSSWEPIVGRL
Mb1155|M.bovis_AF2122/97 PNGDLKALTWGPAG------------APVALCLHGFPDTAYGWRKVAPRL
Rv1124|M.tuberculosis_H37Rv PNGDLKALTWGPAG------------APVALCLHGFPDTAYGWRKVAPRL
TH_2114|M.thermoresistible__bu PGADLRALVWEPAESD---------NAPIALCLHGFPDTAHGWRKLAPLL
Mflv_0191|M.gilvum_PYR-GCK PHLTVTALSWGPPD------------GRLVLCLHGFPDSAWGWRKFAPIL
MAB_3556|M.abscessus_ATCC_1997 ALLDVEVRRHGNPENT---------DKLPVVLLHGWPDSVATWTHVIPAL
MLBr_02297|M.leprae_Br4923 NGIRFHVVEAVPTQPAGQDCAPSATARPLVMLLHGFGSFWWSWRHQLRGL
Mvan_0326|M.vanbaalenii_PYR-1 GDLNVGYAEAGPPD------------GQPVILLHGWPYDIHSYADVTAIL
. .: **: : *
MMAR_5114|M.marinum_M AEAGYHVLAPDQRGYGGSSR--PEAIEDYDIHQLTADLVGLLDDVG-AER
MUL_4193|M.ulcerans_Agy99 AEAGYHVLAPDQRGYGGSSR--PEAIEDYDIHQLTADLVGLLDDVG-AER
MAV_0539|M.avium_104 ADAGYHVLAPDQRGYGGSDR--PDAVEAYDIHQLTADLVGLLDDVG-AQR
MSMEG_3287|M.smegmatis_MC2_155 TAHGFRCLAPNQRGYSPGAR--PPRRRDYRVGELVEDVVALIDASG-ADR
Mb1155|M.bovis_AF2122/97 AESGWHVVAPFMRGYAPSS---IPADGSYHVGALMHDALRVRSAAGGTER
Rv1124|M.tuberculosis_H37Rv AESGWHVVAPFMRGYAPSS---IPADGSYHVGALMHDALRVRSAAGGTER
TH_2114|M.thermoresistible__bu ADAGWRVVAPFNRGYAPSS---PAHDGSYHVGALMDDALRVLDAAGRTGR
Mflv_0191|M.gilvum_PYR-GCK AEHGFRVVAPFSRGYAPTG---PAPDGDYHIGALMYDALAVHRELGAPDD
MAB_3556|M.abscessus_ATCC_1997 ASAGHQVYAPSVRGTGQTKFRYADTPRTGRLGDLLRDLFAVCDQLK-LER
MLBr_02297|M.leprae_Br4923 TEA--RLVAVDLRGYGGSDK----PPRGYDGWTLAGDTAGLIRALG-HSS
Mvan_0326|M.vanbaalenii_PYR-1 AAQGFRVIVPHLRGFGTTRFRSANTVRNGQQAALAHDAISLMDALN-IPD
: : . ** . * * :
MMAR_5114|M.marinum_M AAWVGHDWGAVVVWNAPLLHPDRVAAVAGLSVPVLPRAQVPP--------
MUL_4193|M.ulcerans_Agy99 AAWVGHDWGAVVVWNAPLLHPDRVAAVAGLSVPVLPRAQVPP--------
MAV_0539|M.avium_104 AVWVGHDWGAAVVWNAPLLHPDRVAAVAAMSVPVTPRPRLAP--------
MSMEG_3287|M.smegmatis_MC2_155 VHLVGHDWGAAVAWGVASYVPARLATLSALSVP-HPQAFLRA--------
Mb1155|M.bovis_AF2122/97 DVIIGHDWGAIAATGLAAMPDSPFAKAVIMSVPPS-AAFRPLGRVPERGR
Rv1124|M.tuberculosis_H37Rv DVIIGHDWGAIAATGLAAMPDSPFAKAVIMSVPPS-AAFRPLGRVPERGR
TH_2114|M.thermoresistible__bu DLLIGHDWGAIAGAGLAAMPDSPFTRAVIMSVPPA-ASFRPLGRVADPAR
Mflv_0191|M.gilvum_PYR-GCK AVLIGHDWGGFTAAGIAAYPDSPFAEHITMAVAPIGAVNRTRGPLT---R
MAB_3556|M.abscessus_ATCC_1997 FHLVGHDWGARTAFACGIVAPHRIASLSAISAGWHPAGHGPA--------
MLBr_02297|M.leprae_Br4923 ATLVGHAEGGLACWATALLHP-RLVRAIALINSPHPAALRRS--------
Mvan_0326|M.vanbaalenii_PYR-1 AILGGYDWGGRTANAVAALWPQRCTGLVAVSGYIVVNLATNLEP------
*: *. . . :
MMAR_5114|M.marinum_M IQAFRQRFGEHFFYILYFQQPGVADAELNGDPARTMRRMIGGQRSPTDQG
MUL_4193|M.ulcerans_Agy99 IQAFRQRFGEHFFYILYFQQPGVADAELNGDPARTMRRMIGGQRSPTDQG
MAV_0539|M.avium_104 TQAWRKMFGENFFYILYFQEPGVADAELNADPAQVMRRMMGSLRTDGDKA
MSMEG_3287|M.smegmatis_MC2_155 MTTSRQGLASWYMYLN--QLPRLPERLMLGRDGGAARMVRTLQRSGQTRE
Mb1155|M.bovis_AF2122/97 LLRELPHQLLRSWYILYFQLPWLPERSASWVVPLLWRRWSP-GYHAEEDL
Rv1124|M.tuberculosis_H37Rv LLRELPHQLLRSWYILYFQLPWLPERSASWVVPLLWRRWSP-GYHAEEDL
TH_2114|M.thermoresistible__bu LAARLPRQLLRSWYIMYFQLPWLPDRSSKWVVPALWRHWSP-DYPADEDI
Mflv_0191|M.gilvum_PYR-GCK QLALLPKQLRNSWYIMFFQLPELPERLLPRVIPRLWRDWGPQGYDTGAEL
MAB_3556|M.abscessus_ATCC_1997 LSSLQAQRFWYQWLLNTPAGADLLRRERRELVELIWRDWSPNWKFSDQEF
MLBr_02297|M.leprae_Br4923 MLTHRNQGYALLPTLLRYQLPIWPERLLTRNNAAEIERLVRSRSSAKWQA
Mvan_0326|M.vanbaalenii_PYR-1 LAPQSEYGWWYQYYFATPRGELGYRRNTKDFNRLIWTNASPLWHFDDAAY
:
MMAR_5114|M.marinum_M AALRMVAPGPEGFIDRLPEPDTPPSWISRDELDHYISEFTRTGFTGGLNW
MUL_4193|M.ulcerans_Agy99 AALRMVAPGPEGFIDRLPEPDAPPSWISRDELDHYISEFTRTGFTGGLNW
MAV_0539|M.avium_104 AGLRMVAPGPEGFLERLPEPDGLPEWISQDELDHYIAEFSRTGFTGGLNW
MSMEG_3287|M.smegmatis_MC2_155 IAERDAR--------AMAEPG---------------------ALTAALNW
Mb1155|M.bovis_AF2122/97 RHVDAAIGTPE-------------------------------GRRAALGP
Rv1124|M.tuberculosis_H37Rv RHVDAAIGTPE-------------------------------GRRAALGP
TH_2114|M.thermoresistible__bu ELVRDAIGAPE-------------------------------RWRAALGY
Mflv_0191|M.gilvum_PYR-GCK ADALAALPSPA-------------------------------HRRAAVAY
MAB_3556|M.abscessus_ATCC_1997 DDTFTSLQSSD-------------------------------WLEVTLSY
MLBr_02297|M.leprae_Br4923 CEDFAVTIDHLRIAIQIP-----------------------AAAHCALEY
Mvan_0326|M.vanbaalenii_PYR-1 DMAARAFDNPD-------------------------------HADIVIHN
:
MMAR_5114|M.marinum_M YRNFDR---NWETTADLEGATITVP---SLFMAGTKDPVLSFARSDRASE
MUL_4193|M.ulcerans_Agy99 YRNFDR---NWETTADLEGATITVP---SLFMAGTKDPVLSFARSDRASE
MAV_0539|M.avium_104 YRNFDR---NWETTPELDGAKIAVP---CLFIGGTADPVLSFTRADRAAE
MSMEG_3287|M.smegmatis_MC2_155 YRAMFLSTSDPRAKHKVAKRKITVP---TLYVWSDRDIAITEKPARETAN
Mb1155|M.bovis_AF2122/97 YRATMRNTRAPADYADLNRLWTEAPKLPVLYLHGHDDGCATSAFTHWTAR
Rv1124|M.tuberculosis_H37Rv YRATMRNTRAPADYADLNRLWTEAPKLPVLYLHGHDDGCATSAFTHWTAR
TH_2114|M.thermoresistible__bu YRATIRNTRPPHRYAELHQHWLSAPRIPTLYLHGADDGCATPDYARWVEP
Mflv_0191|M.gilvum_PYR-GCK YRAMVRPSEPSGRYADLHRWCFDVPRVPILHLQGELDGAMEAEYAAPIAT
MAB_3556|M.abscessus_ATCC_1997 YRARWGWGPVIDDPFEKQIAQATAISVPSLVLHGDSDNCVLPIASEGMNQ
MLBr_02297|M.leprae_Br4923 QRWAVRSQLRNEGRKFMKSMSRPFS-VPLLHVRGDADPYLLADSVDRTRR
Mvan_0326|M.vanbaalenii_PYR-1 YRWRLSLAPGESRYDADEQRLAAKPPIEVPTITIGSDFDGPAKDGSTYRA
* : *
MMAR_5114|M.marinum_M VITGPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW----
MUL_4193|M.ulcerans_Agy99 VITGPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW----
MAV_0539|M.avium_104 VISGPYRHVMIDGAGHWLQQERPAEVNAALLDFLNGLELR---
MSMEG_3287|M.smegmatis_MC2_155 YVAGPYRFETLHGVSHWIPEERPDEVADLLLEWFAAHPV----
Mb1155|M.bovis_AF2122/97 VLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG-----
Rv1124|M.tuberculosis_H37Rv VLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG-----
TH_2114|M.thermoresistible__bu VLPVGSAVAILDRAGHFLQLDRPDAVADHILRFAG--------
Mflv_0191|M.gilvum_PYR-GCK ALPAGSRVRIIDEAGHFLQIERPQVTADTVLDYLGDRRGPR--
MAB_3556|M.abscessus_ATCC_1997 HFPHGFSRLTTPGVGHFPQREDPLWVSGALLQWFKEWGNAR--
MLBr_02297|M.leprae_Br4923 YAPHG-RYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
Mvan_0326|M.vanbaalenii_PYR-1 LYTGPYQHRVLDGIGHNVPQEAPQEFASAITDVTRQ-------
. .* : * :