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STLPALDGVEHRFVDLDGGITIHVADAGPADGPAVMLVHGFPENWWEWHELIGPLAADGYRVLCPDLRGA GWSSAPRSRYTKKEMADDLAGVLDRLGIASVRLVAHDWGGPVAFIMMLRYPAKVTGFFGMNTAAPWFPRD LGMVRDIWRFWYQIPILLPVIGPRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAGSR WYRTFQSSEALPWMRGEYADARVDVPVRWLHGTDDPVLTPQLLRGYEDHISDFEVEFVDGVGHWIVEQRP DLVLDRLRAFLRIET*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4778 | ephF | - | 100% (296) | epoxide hydrolase EphF |
| M. ulcerans Agy99 | MUL_4193 | ephA | 2e-26 | 28.97% (321) | epoxide hydrolase EphA |
| M. ulcerans Agy99 | MUL_2888 | ephB | 2e-20 | 41.74% (115) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 5e-21 | 41.94% (124) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1960 | - | 7e-39 | 33.46% (272) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 1e-144 | 78.38% (296) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-20 | 28.36% (275) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 4e-53 | 38.62% (290) | epoxide hydrolase EphF |
| M. marinum M | MMAR_0342 | ephF | 1e-180 | 99.32% (296) | epoxide hydrolase EphF |
| M. avium 104 | MAV_5163 | - | 1e-139 | 76.35% (296) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3287 | - | 9e-32 | 30.80% (276) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2421 | - | 5e-44 | 37.13% (272) | PUTATIVE alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 1e-40 | 32.78% (302) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4778|M.ulcerans_Agy99 --MSTLPALDGVEHRFVDLDGGITIHVADAGP-ADGPAVMLVHGFPENWW
MMAR_0342|M.marinum_M --MSTLPALDGVEHRFVDLDGGITIHVADAGP-ADGPAVMLVHGFPENWW
Rv0134|M.tuberculosis_H37Rv --MIALPALEGVEHRHVDVAEGVRIHVADAGP-ADGPAVMLVHGFPQNWW
MAV_5163|M.avium_104 --MVTMPELDGVEHRYVDLGDDVTIHVADAGP-ASGPAVMLVHGFPQNWW
Mflv_1960|M.gilvum_PYR-GCK ----------------MTVRG-VDFHITEAGP-EDGRPVLALHGWPQHHW
Mvan_4764|M.vanbaalenii_PYR-1 -MTDQPPPIDGVRRHFVTARG-VNFHVTEAGP-EDGRPVLALHGWPQHHW
TH_2421|M.thermoresistible__bu -----------VRRSFVEARG-VRFHVTESGP-ADGRPVLALHGWPQHHW
MAB_4522c|M.abscessus_ATCC_199 MTQRSMPVLDGVEHQYVQAGD-VKIHVAVAGP-QDGRAVVLLHGWPENWW
Mb1973|M.bovis_AF2122/97 ---------MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWY
MSMEG_3287|M.smegmatis_MC2_155 --------------MDSYRRGNLEFEVSEAGP-SDGATVILLHGFPQRNS
MLBr_00862|M.leprae_Br4923 --MPATQSIHKVPHQFVESPDGVRLAIYQSGQ-PEGPAIVLVHGFPDSHV
: : .* :: :**:*:
MUL_4778|M.ulcerans_Agy99 EWHELIGPLAAD----------GYRVLCPDLRGAGWSS--APRSRYTKKE
MMAR_0342|M.marinum_M EWHELIGPLAAD----------GYRVLCPDLRGAGWSS--APRSRYTKKE
Rv0134|M.tuberculosis_H37Rv EWRDLIGPLAAD----------GNRVLCPDLRGAGWSS--APRSRYTKTE
MAV_5163|M.avium_104 EWRALIGPLAAD----------GYRVLCPDLRGAGWSS--APRSSYRKDE
Mflv_1960|M.gilvum_PYR-GCK AYRDLLGDPP-----------PGLRIIAPDLPGYGWSG--PPPHRWAKED
Mvan_4764|M.vanbaalenii_PYR-1 VYRSLLADPPTSAGASSRLPEPGLRIIAPDLPGYGWSG--PAPHKWAKED
TH_2421|M.thermoresistible__bu AYRDLLADPP-----------AGLRIIAPDLPGYGWSG--PAPHRWAKED
MAB_4522c|M.abscessus_ATCC_199 MWHKVIPALAA----------AGYRVHAMDLRGAGWSE--VAPAGYEKEQ
Mb1973|M.bovis_AF2122/97 SWRHQIPALAG----------AGYRVVAIDQRGYGRSSKYRVQKAYRIKE
MSMEG_3287|M.smegmatis_MC2_155 SWEPIVGRLTAH----------GFRCLAPNQRGYSPGARPPRRRDYRVGE
MLBr_00862|M.leprae_Br4923 LWDGVVPLLAKR-----------FRIVRYDNRGVGQSSVPKPVSAYTMTR
: : . * : * . . :
MUL_4778|M.ulcerans_Agy99 MADDLAGVLDRLGIAS-VRLVAHDWG--GPVAFIMMLRYPAKVTGFFGMN
MMAR_0342|M.marinum_M MADDLAGVLDRLGIAS-VRLVAHDWG--GPVAFIMMLRYPAKVTGFFGMN
Rv0134|M.tuberculosis_H37Rv MADDLAAVLDGLGVAK-VKLVAHDWG--GPVAFIMMLRHPEKVTGFFGVN
MAV_5163|M.avium_104 MADDLAGVLDRLGVRS-VDLVAHDWG--GPVAFIMMLRHPEKVTGFFGVN
Mflv_1960|M.gilvum_PYR-GCK VVTDLVALVDALGLDR-FLLVGHDWG--GYIGHLLALRIPERIDAYLALN
Mvan_4764|M.vanbaalenii_PYR-1 VVSDLVALMDAMGLDR-VLLIGHDWG--GYIGHLLAMRVPERIDGYLALN
TH_2421|M.thermoresistible__bu VASDLLALMDELGLGR-TLLIGHDWG--GYIGFLMILRAPERFDGYIPLN
MAB_4522c|M.abscessus_ATCC_199 FASDVLAAADALGLES-FDLVGHDWG--GWTAQLVALKAQSRIRRLVVLN
Mb1973|M.bovis_AF2122/97 LVGDVVGVLDSYGAEQ-AFVVGHDWG--APVAWTFAWLHPDRCAGVVGIS
MSMEG_3287|M.smegmatis_MC2_155 LVEDVVALIDASGADR-VHLVGHDWG--AAVAWGVASYVPARLATLSALS
MLBr_00862|M.leprae_Br4923 FADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVS
.. *. . * . ::.**** . : :.
MUL_4778|M.ulcerans_Agy99 TAAPWF------------------PRDLGMVRDIWRFW-YQIPILLPVIG
MMAR_0342|M.marinum_M TAAPWF------------------PRDLGMVRDIWRFW-YQIPIMLPVIG
Rv0134|M.tuberculosis_H37Rv TVAPWV------------------KRDLGMLRNMWRFW-YQIPMSLPVIG
MAV_5163|M.avium_104 TSAPFV------------------KRSLSTIRNVWRFW-YQIPISLPVIG
Mflv_1960|M.gilvum_PYR-GCK IAHPWV------------------PPKV-MAPHLWRFLLYQPVVASAGVP
Mvan_4764|M.vanbaalenii_PYR-1 IAHPWV------------------PPKV-MAPHLWRFLQYQPLVAFAGVP
TH_2421|M.thermoresistible__bu IAHPWV------------------STGT-VLKHIWRFS-YQPPMAAFGVP
MAB_4522c|M.abscessus_ATCC_199 IPPVWQ------------------QPGR-VARYAHKLA-YQLVVGAPVVG
Mb1973|M.bovis_AF2122/97 VPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEI
MSMEG_3287|M.smegmatis_MC2_155 VPHPQA------------------FLRAMTTSRQGLASWYMYLNQLPRLP
MLBr_00862|M.leprae_Br4923 GPSQDQLVDYILSG----LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLV
:
MUL_4778|M.ulcerans_Agy99 PRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAG----
MMAR_0342|M.marinum_M PRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAG----
Rv0134|M.tuberculosis_H37Rv PRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAG----
MAV_5163|M.avium_104 PRVISTPDSRFVRLLGSWVGGGYTLPEEDVRLYLECMRQPGHAEAG----
Mflv_1960|M.gilvum_PYR-GCK LQTRTRYLEKVVFRAAAPK-----LDAATVGTYAERFRDPVVARTA----
Mvan_4764|M.vanbaalenii_PYR-1 LQRHTSFLKR-AYKLAAPK-----LDPQTVRVYSERFRDPVVARTA----
TH_2421|M.thermoresistible__bu LQQRTRVLERVVFGKGS-A-----LDAETAKVYADRFRDPVCARAG----
MAB_4522c|M.abscessus_ATCC_199 PLSHLSPTLWWFIRRSG-------MPKESVDFFRSCFRDRDRRVAG----
Mb1973|M.bovis_AF2122/97 EEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAGPLCM
MSMEG_3287|M.smegmatis_MC2_155 ERLMLGRDGGAARMVRTLQRSG--QTREIAERDARAMAEPGALTAA----
MLBr_00862|M.leprae_Br4923 PMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRA
. :
MUL_4778|M.ulcerans_Agy99 ------------SRWYRTFQSSEALPWMRGEYADARV-DVPVRWLHGTD-
MMAR_0342|M.marinum_M ------------SRWYRTFQSSEALPWMRGEYADARV-DVPVRWLHGTE-
Rv0134|M.tuberculosis_H37Rv ------------SRWYRTFQTREMLRWLRGEYNDARV-DVPVRWLHGTG-
MAV_5163|M.avium_104 ------------SRWYRSFQTREMLSWMRGEYDGARV-HVPVRWLSGTE-
Mflv_1960|M.gilvum_PYR-GCK ------------RDTYRTFLTREIPKGVRDG-ERRWS-TVPTRVLFGRS-
Mvan_4764|M.vanbaalenii_PYR-1 ------------RDTYRTFLLREAPAAIRNG-ERRRS-KVPTRALFGRD-
TH_2421|M.thermoresistible__bu ------------RDTYRTFLVREMPAAARNP-EKRRA-TVPIRALFGTR-
MAB_4522c|M.abscessus_ATCC_199 ------------SKIYRSMVGKEFANLARGPYDDQKL-TMPVRVLFGLD-
Mb1973|M.bovis_AF2122/97 AEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGF-GGPLSFYHNIDN
MSMEG_3287|M.smegmatis_MC2_155 ------------LNWYRAMFLSTSDPRAKHKVAKRKI-TVPTLYVWSDR-
MLBr_00862|M.leprae_Br4923 FSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKA
* .
MUL_4778|M.ulcerans_Agy99 ----------DPVLTPQLLRG------------------------YEDHI
MMAR_0342|M.marinum_M ----------DPVLTPQLLRG------------------------YEDHI
Rv0134|M.tuberculosis_H37Rv ----------DPVITPDLLDG------------------------YAERA
MAV_5163|M.avium_104 ----------DPVLTPDLLDG------------------------YAERI
Mflv_1960|M.gilvum_PYR-GCK ----------DTAIHPDLAAA------------------------ETARA
Mvan_4764|M.vanbaalenii_PYR-1 ----------DAAIHPSLAAA------------------------ETARA
TH_2421|M.thermoresistible__bu ----------DLAIHPSLAAP------------------------ETALA
MAB_4522c|M.abscessus_ATCC_199 ----------DVAVHPSLLDG------------------------FKDHA
Mb1973|M.bovis_AF2122/97 DWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQA-------IERAHEVMP
MSMEG_3287|M.smegmatis_MC2_155 ----------DIAITEKPARET-----------------------ANYVA
MLBr_00862|M.leprae_Br4923 G-------HFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDT
.
MUL_4778|M.ulcerans_Agy99 SDFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET---------------
MMAR_0342|M.marinum_M SDFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET---------------
Rv0134|M.tuberculosis_H37Rv SDFEVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD-----------
MAV_5163|M.avium_104 DDFQLELVDGVGHWIVDQRPDLVLDRVRAFLRRET---------------
Mflv_1960|M.gilvum_PYR-GCK DDYTI-DVVDGGHFILDEQPDLVRAKLIAVADEFPERPVR----------
Mvan_4764|M.vanbaalenii_PYR-1 DDYTI-DVVDGGHFILDEQPELVRAKLIALAEEFPAR-------------
TH_2421|M.thermoresistible__bu DDYTL-ETVDCSHFIVDERPDLVRARLVALAEETA---------------
MAB_4522c|M.abscessus_ATCC_199 DDLNITEVPNCGHFIVDEQPELVVKWLSEVLAEPAP--------------
Mb1973|M.bovis_AF2122/97 NYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP--------------
MSMEG_3287|M.smegmatis_MC2_155 GPYRFETLHGVSHWIPEERPDEVADLLLEWFAAHPV--------------
MLBr_00862|M.leprae_Br4923 FGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVAS
. . * : .
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTP
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSL
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPT
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYA
MUL_4778|M.ulcerans_Agy99 ---------------------
MMAR_0342|M.marinum_M ---------------------
Rv0134|M.tuberculosis_H37Rv ---------------------
MAV_5163|M.avium_104 ---------------------
Mflv_1960|M.gilvum_PYR-GCK ---------------------
Mvan_4764|M.vanbaalenii_PYR-1 ---------------------
TH_2421|M.thermoresistible__bu ---------------------
MAB_4522c|M.abscessus_ATCC_199 ---------------------
Mb1973|M.bovis_AF2122/97 ---------------------
MSMEG_3287|M.smegmatis_MC2_155 ---------------------
MLBr_00862|M.leprae_Br4923 LYGISRVLPQVLRSTARIRVI