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MAHIQPFRIAIPDADLADLTARLQRTRWPEAECVDDWSQGIPLSYTRELAAYWADEYDWRAREASLNRFE QFTTEIDGLPIHFIHARSTRPDAFPLIITHGWPGSVVEFHKVIEPLTDAGFHVVCPSLPGYGFSGKPRST GWGVERIAAAWDELMVRLGYRRYGAQGGDWGGAVTTQIGRNIGHCVAIHTNMPIGRAPKDLSDPTPDEQA ALERLGYYQRWDSGYSKQQSTRPQTLGYGLVDSPVGQLAWIVEKFWSWTDCDGHPENALTRDELLDNVML YWATGTGASSARLYWESFGSFAGGGAVTLPTGVAAFPLEILRSPRHWCEPHYNITRWTTMPRGGHFAAFE QPGPFVEEVGSFFADFR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4998 | - | - | 100% (367) | epocide hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0521 | - | e-160 | 68.45% (374) | epocide hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 4e-09 | 31.30% (131) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 2e-07 | 30.61% (98) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_1749 | - | 0.0 | 84.20% (367) | epocide hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv3617 | ephA | 6e-08 | 29.92% (127) | epoxide hydrolase EphA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0679c | - | 9e-08 | 29.06% (117) | hydrolase |
| M. marinum M | MMAR_3314 | - | 1e-164 | 71.93% (374) | hydrolase |
| M. avium 104 | MAV_2202 | - | 1e-169 | 74.19% (372) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_5658 | - | 1e-172 | 74.79% (365) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_4567 | - | 2e-68 | 76.67% (150) | PUTATIVE epoxide hydrolase |
| M. ulcerans Agy99 | MUL_4778 | ephF | 1e-08 | 32.43% (111) | epoxide hydrolase EphF |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4998|M.vanbaalenii_PYR-1 --MAHIQPFRIAIPDADLADLTARLQRTRWPEAECVDDWSQGIPLSYTRE
Mflv_1749|M.gilvum_PYR-GCK --MAHIQPFRIDVPDSVLTDLAERLQRTRWPEPECVDDWSQGIPLAYTRE
MSMEG_5658|M.smegmatis_MC2_155 MTDSLIRPFRIAVPDADLDDLKSRLSRTRWPEPETVDDWGQGIPLDYTRE
MMAR_3314|M.marinum_M -----MRPFRIDVPDDVIDDLKARLTRTRWPEAECVDDWSQGIPLSYTRD
MAV_2202|M.avium_104 -----MKPFRIDVPDDVLDDLRARLARTRWPEAECVDDWSQGMPLAYTRE
TH_4567|M.thermoresistible__bu --------------------------------------------------
Mb1864c|M.bovis_AF2122/97 ------------------------------------------MSIDFT--
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Rv3617|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0679c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4998|M.vanbaalenii_PYR-1 LAAYWADEYDWRAREASLNRFEQFTTEIDGLPIHFIHARSTRPDAFPLII
Mflv_1749|M.gilvum_PYR-GCK LADYWANEYDWRSRESMLNRFDQFTTEIDGLDIHFVHQRSPRPDAFPLII
MSMEG_5658|M.smegmatis_MC2_155 LAEYWANGYDWRAREQALNRFDHYVTELDGLDIHFIHQRCARPDAFPLLL
MMAR_3314|M.marinum_M LAAYWANEYDWRAREAALNRFDQFITEIDGLDLHFIHQRSPHQDAFPLLI
MAV_2202|M.avium_104 LADYWANDYDWRAREAALNRFDQFVTEIDGLDIHFIHQRSPHADAFPLLI
TH_4567|M.thermoresistible__bu --------------------------------VVIVSATAWRIVGYAGLI
Mb1864c|M.bovis_AF2122/97 -------------PDPQLYPFESRWFDSSRGRIHYVDEG----TGPPILL
MUL_4778|M.ulcerans_Agy99 -----------MSTLPALDGVEHRFVDLDGG-ITIHVADAGPADGPAVML
Rv3617|M.tuberculosis_H37Rv -----------------MGAPTERLVDTNGVRLRVVEAG--EPGAPVVIL
MAB_0679c|M.abscessus_ATCC_199 ---------------------MSRLSTFTNDGLTFDVIDEGALDGPVIVA
: . :
Mvan_4998|M.vanbaalenii_PYR-1 THGWPGSVVEFHKVIEPLT---------DAGFHVVCPSLPGYGFSGKP-R
Mflv_1749|M.gilvum_PYR-GCK THGWPGSIVEFQKVIAPLT---------EAGFHVVCPSLPGYGFSGKP-T
MSMEG_5658|M.smegmatis_MC2_155 THGWPGSIVEFHKVIEPLT---------EAGFDVVCPSLPGYGFSGKP-T
MMAR_3314|M.marinum_M THGWPGSVVEFHKVIEPLTNPTAHGGRAEDAFHVVCPSLPGYGFSGKP-S
MAV_2202|M.avium_104 THGWPGSIVEFHKVIEPLTNPAS--GRGEDAFHVVCPSLPGYGFSGKP-T
TH_4567|M.thermoresistible__bu AGG-----VWLAQATAPVAG-----------------AQPGDDDSGD--S
Mb1864c|M.bovis_AF2122/97 CHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFGLSERP-S
MUL_4778|M.ulcerans_Agy99 VHGFPENWWEWHELIGPLAA---------DGYRVLCPDLRGAGWSSAP-R
Rv3617|M.tuberculosis_H37Rv AHGFPELAYSWRHQIPALAD---------AGYHVLAPDQRGYGGSSRPEA
MAB_0679c|M.abscessus_ATCC_199 LHGFPERATMWEEVIPQLTG---------AGFRVLAPNQRGYSPGARPVG
* . : * . .
Mvan_4998|M.vanbaalenii_PYR-1 STGWGVERIAAAWDELMVRLGYRRYGAQGGDWGGAVTTQIGRNIGHCVAI
Mflv_1749|M.gilvum_PYR-GCK ATGWGVERIAAAWDELMVRLGYDRYGAQGGDWGAAVTTQIGRNVGHCVAI
MSMEG_5658|M.smegmatis_MC2_155 TTGWGIGRIAQAWDTLMTRLGYDRYGAQGGDWGAAVTTQIGRNVGNCVGI
MMAR_3314|M.marinum_M STGWGVDRIARAWETLMQNLGYQRYGAQGGDWGAAVTTQIGRNGGRCVAI
MAV_2202|M.avium_104 RAGWGVERIARAWETLMLRLGYQRYGAQGGDWGAAVTTQIGRNRGHCVAI
TH_4567|M.thermoresistible__bu GAGRSSQ---SATPAASAQAGSARAGSS--QAGSPRTADARRN-----GS
Mb1864c|M.bovis_AF2122/97 GFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRG
MUL_4778|M.ulcerans_Agy99 SR-YTKKEMADDLAGVLDRLGIASVRLVAHDWGGPVAFIMMLRYPAKVTG
Rv3617|M.tuberculosis_H37Rv IEAYDIHRLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADRVAA
MAB_0679c|M.abscessus_ATCC_199 VRNYAVDKLEGDIIALVDQAGVRKFHVLAHDWGAAVAWQLAGNHADRVQT
* : *.
Mvan_4998|M.vanbaalenii_PYR-1 HTNMPIGRAPKD-LSDPTPDEQAALERLGYYQRWDSG--YSKQQSTRPQT
Mflv_1749|M.gilvum_PYR-GCK HTNMPFGRPPKS-LSDPDADEVAALERLGYYQKWDSG--YSKQQATRPQT
MSMEG_5658|M.smegmatis_MC2_155 HVNMPIARPPAEGVGEMTEEVRQALERMQYYRKWDSG--YMKQQSTRPQT
MMAR_3314|M.marinum_M HLNMPIAMPTRTALTNPTAAEQEVLAALAYHRKWGTG--YFKQQSTRPQT
MAV_2202|M.avium_104 HLNMPIGRPGQEALTNPTEQERAALAALANHRKRGTG--YSKQQSTRPQT
TH_4567|M.thermoresistible__bu PVRFGAGRGPIX----------------XXYRRWDSG--YAKQQSTRPQT
Mb1864c|M.bovis_AF2122/97 VVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNF--FVER--LIPAG
MUL_4778|M.ulcerans_Agy99 FFGMNTAAPWFPRDLGMVRDIWRFWYQIPILLPVIG-----PRVIADPKA
Rv3617|M.tuberculosis_H37Rv VAALSVPALPRAQVPPTQAFRSRFGENFFYILYFQEPGIADAELNGDPAR
MAB_0679c|M.abscessus_ATCC_199 LSILSVPHPRAFQDAMLRGQLLHSWYMLLFQIPRLPEWLFGFNETEAFKK
.
Mvan_4998|M.vanbaalenii_PYR-1 LGYGLVDSPVG------QLAWIVEKFWSWTDCDGHPENALT---------
Mflv_1749|M.gilvum_PYR-GCK LGYGLVDSPVA------QMAWIVEKFWSWMDCDGHPENVLT---------
MSMEG_5658|M.smegmatis_MC2_155 VGYGLVDSPVG------QLAWIVEKFWSWMDCDGHPENVLS---------
MMAR_3314|M.marinum_M VGYGLTDSPVG------QLAWIVEKFWAWMDCAGNPENVLT---------
MAV_2202|M.avium_104 LGYGLADSPVG------QLAWIVEKFWDWADCDGHPENALS---------
TH_4567|M.thermoresistible__bu LGYGLVDSPVG------QLAWIVEKFWAWTDCDGHPENVLS---------
Mb1864c|M.bovis_AF2122/97 TEHRPSSAVMA------HYRAVQPNAAARRGVAEMPKQILA---------
MUL_4778|M.ulcerans_Agy99 RYFRVLTSWVGG-----GFTIADEDVRMYVERMRQPGHAVAGSRW-----
Rv3617|M.tuberculosis_H37Rv TMRRMIGGLRPPGDQSAAMRMLAPGPDGFIDRLPEPAGLPAWISQEELDH
MAB_0679c|M.abscessus_ATCC_199 FGKS-------------WMKVSDRLAERIRELFSEPGATTA---------
* :
Mvan_4998|M.vanbaalenii_PYR-1 ------------RDELLDNVMLYWATGTGASSARLYWESFGSFAGGGAVT
Mflv_1749|M.gilvum_PYR-GCK ------------KDELLDNVMLYWATATGASSARLYWESFGAFGGGDPVT
MSMEG_5658|M.smegmatis_MC2_155 ------------RDELLDNVMLYWVTASAASSARLYWESYDTFAGGDFVT
MMAR_3314|M.marinum_M ------------RDELLDNVMMYWVNAAAASSARLYWESFKVWGQTERVE
MAV_2202|M.avium_104 ------------RDELLDNVMVYWVTNTAASSARLYWESFSAWGGGDRVE
TH_4567|M.thermoresistible__bu ------------RDELLDNVMLYWVTGSAASSARLYWESFAVFGSTDRVR
Mb1864c|M.bovis_AF2122/97 ------------ARPLLARLAREVPATLGTKPTLLIWG-MKDVAFRPKTI
MUL_4778|M.ulcerans_Agy99 ------------YRTFQSSEALPWMRG-EYADARVDVPVRWLHGTDDPVL
Rv3617|M.tuberculosis_H37Rv YIGEFTRTGFTGGLNWYRNFDRNWETTADLAGKTISVPSLFIAGTADPVL
MAB_0679c|M.abscessus_ATCC_199 ----------------TVNWYRAMRYSLRSPARPSRVPTLFIWSDGDSAV
. .
Mvan_4998|M.vanbaalenii_PYR-1 LPTGVAAFPLEILRSPRHWCEPHYNITRWTTMPRGGHFAAFEQPGPFVEE
Mflv_1749|M.gilvum_PYR-GCK LPTGVASFPKEILRSPRHWCEGNYTITRWTTMPRGGHFAAFEQPSSFVDD
MSMEG_5658|M.smegmatis_MC2_155 LPTGVASFPKEILRAPRAWCEKAYNVTHFTMMPRGGHFAAFEQPELFVED
MMAR_3314|M.marinum_M LPTGVASFPKEVLRAPRAWCEPNYNITHWTTMPRGGHFAAFEQPELFVGD
MAV_2202|M.avium_104 LPTGVAAFPGELLKAPRSWCEPAYNITHWTDMPRGGHFAAFEQPELFVED
TH_4567|M.thermoresistible__bu VPTGVARFPREINQAPRHWCEAIYPITHWTDMPRGGHFAAFEQPELFVED
Mb1864c|M.bovis_AF2122/97 IPRLSATFPDHVL----------------VELPNAKHFIQEDAPDRIAAA
MUL_4778|M.ulcerans_Agy99 TPQLLRGYEDHIS------------DFEVEFVDGVGHWIVEQRPDLVLDR
Rv3617|M.tuberculosis_H37Rv TFTRTDRAAEVISG-----------PYREVLIDGAGHWLQQERPGEVTAA
MAB_0679c|M.abscessus_ATCC_199 TRAAADATPKYVEAP-----------YRFEVFEGVSHWIAEERPLETAAL
: . *: : *
Mvan_4998|M.vanbaalenii_PYR-1 VGSFFADFR--
Mflv_1749|M.gilvum_PYR-GCK VAAFFDDFR--
MSMEG_5658|M.smegmatis_MC2_155 VAKFFDSVR--
MMAR_3314|M.marinum_M VRAFFATVR--
MAV_2202|M.avium_104 LRVFFATVR--
TH_4567|M.thermoresistible__bu VRTFFRTIR--
Mb1864c|M.bovis_AF2122/97 IIERFG-----
MUL_4778|M.ulcerans_Agy99 LRAFLRIET--
Rv3617|M.tuberculosis_H37Rv LLEFLTGLELR
MAB_0679c|M.abscessus_ATCC_199 VLEHIAEYSA-
: :