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RIEDLISSVPTGLWIGGEEREAASTFNVLDPSDDQVITAVADATAEDAIAALDAACAVQDEWAATPARTR GEILRSVFEKITERADDIAALMTLEMGKVLPESKGEVAYGAEFFRWFSEEAVRIDGRYTHAPAGTGRILV TKQAVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMDEAGLPKGVLSVLPTS NPRGVTGALIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFIVFDDADVDAAVDGAILAK MRNGGEACTAANRFHVANSVREEFTEKLVKRMSEFTLGKGLDPSSTLGPLINSKQVATVTELVSDAVSRG ATVAVGGVAPGGPGNFYPATVLADVPADARILKEEVFGPVAPITGFDTEEEGIAAANDTEYGLAAYIYTQ SLDRALRVAETIQSGMVGINRGVISDPAAPFGGIKESGFGREGGIEGIEEYLDTKYIALTK*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5538 | - | - | 100% (482) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155] |
M. smegmatis MC2 155 | MSMEG_2488 | - | e-161 | 58.49% (477) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
M. smegmatis MC2 155 | MSMEG_0582 | - | e-135 | 49.59% (482) | succinic semialdehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0239c | gabD1 | 4e-70 | 34.15% (451) | succinic semialdehyde dehydrogenase |
M. gilvum PYR-GCK | Mflv_1858 | - | 0.0 | 90.42% (480) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
M. tuberculosis H37Rv | Rv0223c | - | 5e-73 | 34.73% (478) | aldehyde dehydrogenase |
M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-70 | 34.81% (451) | succinic semialdehyde dehydrogenase |
M. abscessus ATCC 19977 | MAB_4208 | - | 0.0 | 69.60% (477) | putative succinate-semialdehyde dehydrogenase |
M. marinum M | MMAR_3556 | - | 7e-83 | 37.18% (468) | aldehyde dehydrogenase NAD dependent |
M. avium 104 | MAV_2101 | - | 8e-82 | 37.29% (472) | aldehyde dehydrogenase |
M. thermoresistible (build 8) | TH_3381 | - | 1e-176 | 87.15% (358) | PUTATIVE Succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
M. ulcerans Agy99 | MUL_2789 | - | 7e-82 | 36.75% (468) | gamma-aminobutyraldehyde dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_4876 | - | 0.0 | 90.99% (477) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
CLUSTAL 2.0.9 multiple sequence alignment Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA MLBr_02573|M.leprae_Br4923 -------------------------------------------------- Mflv_1858|M.gilvum_PYR-GCK --------------------------MDNSAVEALLASVPTGLWIGGEER Mvan_4876|M.vanbaalenii_PYR-1 --------------------------MDTS---ALLKSVPTGLWIGGEER MSMEG_5538|M.smegmatis_MC2_155 --------------------------MRIE---DLISSVPTGLWIGGEER TH_3381|M.thermoresistible__bu -------------------------------------------------- MAB_4208|M.abscessus_ATCC_1997 --------------------------MTDHS--TLIDAIPTDLWIGGKQV Rv0223c|M.tuberculosis_H37Rv --------------------------------MSDSATEYDKLFIGGKWT MAV_2101|M.avium_104 -------------------------------------------------- MMAR_3556|M.marinum_M --------------------------------MTTTVSVAGSWING--AA MUL_2789|M.ulcerans_Agy99 --------------------------------MTTTVSVAGSWING--AA Mb0239c|M.bovis_AF2122/97 KDVS-VPIATINPATGETVKTFTAATDDEVDAAIARAHRRFA--DYRQTS MLBr_02573|M.leprae_Br4923 -----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFD--NYRHTT Mflv_1858|M.gilvum_PYR-GCK EGTS--TFDVLDPSDDTVLTSVADATADDARAALDAACAVQA--EWAGTA Mvan_4876|M.vanbaalenii_PYR-1 QGTS--TFSVLDPSDDEVLATVADATADDARDALDAACAVQG--EWAATP MSMEG_5538|M.smegmatis_MC2_155 EAAS--TFNVLDPSDDQVITAVADATAEDAIAALDAACAVQD--EWAATP TH_3381|M.thermoresistible__bu -------------------------------------------------V MAB_4208|M.abscessus_ATCC_1997 PSSTGTRFPVHNPATGAVLTTVADAAASDGAIALDEATAVQR--SWAATA Rv0223c|M.tuberculosis_H37Rv KPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTP MAV_2101|M.avium_104 ---MSTTIPVFNPSTEEQIAEVPDSDQAAVDAAVARARETFESGVWRKAP MMAR_3556|M.marinum_M HSTGGRQHAVINPATQETIAELALATPADVDRAVVAARRALP--QWAGVT MUL_2789|M.ulcerans_Agy99 HSTGGRQHAVINPATQETIAELALATPADVDHAVVAARRALP--QWAGVT Mb0239c|M.bovis_AF2122/97 FAQRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRY MLBr_02573|M.leprae_Br4923 FTQRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRY Mflv_1858|M.gilvum_PYR-GCK PRKRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRW Mvan_4876|M.vanbaalenii_PYR-1 ARKRGEILRSVFETITARADDIAALMTLEMGKVFAESKGEVTYGAEFFRW MSMEG_5538|M.smegmatis_MC2_155 ARTRGEILRSVFEKITERADDIAALMTLEMGKVLPESKGEVAYGAEFFRW TH_3381|M.thermoresistible__bu VRRRG--------------------------------------------- MAB_4208|M.abscessus_ATCC_1997 PRERAEILRRAWELVIARRDDFALAMTLEMGKPLAESQGEVAYGGEFLRW Rv0223c|M.tuberculosis_H37Rv PHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMN MAV_2101|M.avium_104 ASHRANVLFRAARIIEERKDELAALESQDNGMNLTAAGHIIPV-SVDMLK MMAR_3556|M.marinum_M PAERSAVLAKLADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIR MUL_2789|M.ulcerans_Agy99 TAERSAVLAELADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIR *. Mb0239c|M.bovis_AF2122/97 YAENAEALLADEPADAAKVG------ASAAYGRYQPLGVILAVMPWNFPL MLBr_02573|M.leprae_Br4923 YAEKAETLLADEPAEAAAVG------ASKALARYQPLGVVLAVMPWNFPL Mflv_1858|M.gilvum_PYR-GCK FAE--EAVRIDGRYTAAPAG------TGRILVTKQAVGPCYAITPWNFPL Mvan_4876|M.vanbaalenii_PYR-1 FAE--EAVRIEGRYTPAPAG------TGRILVTKQAVGPCYAITPWNFPL MSMEG_5538|M.smegmatis_MC2_155 FSE--EAVRIDGRYTHAPAG------TGRILVTKQAVGPCYAITPWNFPL TH_3381|M.thermoresistible__bu -----------GPPPRAPAG------NGRILVTKQAVGPCYAITPWNFPL MAB_4208|M.abscessus_ATCC_1997 FSE--EAVRINGRYTSSPTG------AGRILVAKQPIGPTLAITPWNFPL Rv0223c|M.tuberculosis_H37Rv YFAGAADKVTWTETRTGSYG--------QSIVSREPVGVVGAIVAWNVPL MAV_2101|M.avium_104 YYAGWVGKIHGESANLVSDGLLGTWETYHTFTQLEPVGVVGLIIPWNGPF MMAR_3556|M.marinum_M FFAGAARRLPGQATAEYSAD-------HTSSIRREAIGVVATITPWNYPL MUL_2789|M.ulcerans_Agy99 FFAGAARRLPGQATAEYSAD-------HTSSIRREAIGVVATITPWNYPL . :.:* : .** *: Mb0239c|M.bovis_AF2122/97 WQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLL MLBr_02573|M.leprae_Br4923 WQTVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLL Mflv_1858|M.gilvum_PYR-GCK AMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLP Mvan_4876|M.vanbaalenii_PYR-1 AMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMAEAGLPKGVLSVLP MSMEG_5538|M.smegmatis_MC2_155 AMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMDEAGLPKGVLSVLP TH_3381|M.thermoresistible__bu AMGTRKIGPALAAGCTMIVKPAQETPLTMLLLAKLIDEAGLPKGVLSVLP MAB_4208|M.abscessus_ATCC_1997 AMGTRKIGPALAAGCTMIVKPAAETPLTMLLLGQVFADAGLPAGVLSILP Rv0223c|M.tuberculosis_H37Rv FLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLS-VV MAV_2101|M.avium_104 FVAMLKVAPALAAGCSAVLKPAEETPLTALKLEEIFREAGLPDGVLN-VI MMAR_3556|M.marinum_M QMAVWKVMPALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLN-VV MUL_2789|M.ulcerans_Agy99 QMAVWKVMPALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLN-VV **: ** ::* : .* * : *:* . :. : Mb0239c|M.bovis_AF2122/97 VSSG--AVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGS MLBr_02573|M.leprae_Br4923 ISAN--GVEAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGS Mflv_1858|M.gilvum_PYR-GCK TTSPGPVTETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGN Mvan_4876|M.vanbaalenii_PYR-1 TSNPGAVTEALINDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGN MSMEG_5538|M.smegmatis_MC2_155 TSNPRGVTGALIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGN TH_3381|M.thermoresistible__bu TSNPRPLTEALIGDGRLRKLTFTGSTGVGKALAQQASAKLLRTSMELGGN MAB_4208|M.abscessus_ATCC_1997 TTNASALTGPLIDDPRLRKLTFTGSTGVGKILLSQCATRVLRSSMELGGN Rv0223c|M.tuberculosis_H37Rv PG-GIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGK MAV_2101|M.avium_104 TGYGETTGAALTAHPDVDKISFTGSTEVGRLIVKAAAGNLKRLTLELGGK MMAR_3556|M.marinum_M TGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGK MUL_2789|M.ulcerans_Agy99 TGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGK .: . : ::*** .*: : .. :****. Mb0239c|M.bovis_AF2122/97 DPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKF MLBr_02573|M.leprae_Br4923 DPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKF Mflv_1858|M.gilvum_PYR-GCK APFVVFDDADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTDKF Mvan_4876|M.vanbaalenii_PYR-1 APFIVFDDADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTEKF MSMEG_5538|M.smegmatis_MC2_155 APFIVFDDADVDAAVDGAILAKMRNGGEACTAANRFHVANSVREEFTEKL TH_3381|M.thermoresistible__bu APFIVFDDADIDAAVDGAMLAKMRNGGEACTAANRFHVANAVREEFTEKL MAB_4208|M.abscessus_ATCC_1997 APFVVFDDADVDAAVDGAMAAKMRNIGEACTAANRFHVDNAVRAEFTEKL Rv0223c|M.tuberculosis_H37Rv SAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAV MAV_2101|M.avium_104 SPLIMFDDANLDKAIMGAGMGLLAGSGQNCSCTSRIYVQRGIYDQVVEGL MMAR_3556|M.marinum_M APFVVFDDADLDAAIQGAVAGALINSGQDCTAATRAIVARELYHDFVAGV MUL_2789|M.ulcerans_Agy99 APFVVFDDADLDAAIQGAVAGAVINSGQDCTAATRAIVARELCHDFVAGV . ::: ..:: *: . : . *: * .* . :.. . Mb0239c|M.bovis_AF2122/97 VARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGG- MLBr_02573|M.leprae_Br4923 VARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGG- Mflv_1858|M.gilvum_PYR-GCK VKRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGG- Mvan_4876|M.vanbaalenii_PYR-1 VKRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGG- MSMEG_5538|M.smegmatis_MC2_155 VKRMSEFTLGKGLDPSSTLGPLINSKQVATVTELVSDAVSRGATVAVGG- TH_3381|M.thermoresistible__bu VKRMSEVTLGNGLDGSSTLGPLINAQQRDTVVELVTDAVERGATVAVGG- MAB_4208|M.abscessus_ATCC_1997 TARMGALTIGPGDENGVQVGPLITAKQRASVDELVQDAVSKGAVVTTGG- Rv0223c|M.tuberculosis_H37Rv TNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGG MAV_2101|M.avium_104 AEFAMMLPMGGSDDPNSVLGPLISEKQRQRVEGIVNDGVAAGAKVITGG- MMAR_3556|M.marinum_M ADVMSTVVIGDPMDPDTDIGPLISLAHRDRVADIVAKAPAQGARIVVGG- MUL_2789|M.ulcerans_Agy99 ADVMSTVVIGDPMDPDTDIGPLISLAHRDRVADILAKAPAQGARIVVGG- . . :* : :*** . * : . ** : ** Mb0239c|M.bovis_AF2122/97 -KRLDRPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIA MLBr_02573|M.leprae_Br4923 -KRPDRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIA Mflv_1858|M.gilvum_PYR-GCK -VAPGGPGNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAA Mvan_4876|M.vanbaalenii_PYR-1 -VAPGGPGNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAA MSMEG_5538|M.smegmatis_MC2_155 -VAPGGPGNFYPATVLADVPADARILKEEVFGPVAPITGFDTEEEGIAAA TH_3381|M.thermoresistible__bu -TVPDGPGWFYPATVLTDVSADARILKEEVFGPVAPIVGFDTEEEGIAAA MAB_4208|M.abscessus_ATCC_1997 -VVADGEGYFYPPTVLTDVPADARILREEVFGPVAAITGFDGEEAGIAAA Rv0223c|M.tuberculosis_H37Rv RPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIA MAV_2101|M.avium_104 KPMDRK-GYFYEATIITNTTPDMRLIREEIFGPVGCVIPFDDEDEVIAAA MMAR_3556|M.marinum_M RIPDLA-GAFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQA MUL_2789|M.ulcerans_Agy99 RIPDLA-GAFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQA * * .*:::: . :*:**** : : : * Mb0239c|M.bovis_AF2122/97 NATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKR MLBr_02573|M.leprae_Br4923 NATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKR Mflv_1858|M.gilvum_PYR-GCK NDTEYGLAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKE Mvan_4876|M.vanbaalenii_PYR-1 NDTEYGLAAYVYTQSLDRALRVAENIESGMVGVNRGVISDAAAPFGGIKE MSMEG_5538|M.smegmatis_MC2_155 NDTEYGLAAYIYTQSLDRALRVAETIQSGMVGINRGVISDPAAPFGGIKE TH_3381|M.thermoresistible__bu NDTEYGLAAYIYTRSLDRALRVAEAIESGMVGVNRGVISDAAAPFGGIKE MAB_4208|M.abscessus_ATCC_1997 NDTEFGLAAYVYTANLDRALRVSQAVESGMVGVNRGVISDVAAPFGGIKE Rv0223c|M.tuberculosis_H37Rv NDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGIN-WYAFDPGSPFGGYKN MAV_2101|M.avium_104 NDTHYGLAGAIWTENLSRAHRVVNELRAGQIWVNSALAADPSMPISGHKQ MMAR_3556|M.marinum_M NDTDYGLAASAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVAA MUL_2789|M.ulcerans_Agy99 NDTDYGLAASAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVAA * : :**.. :* . . : : :* :* * .* Mb0239c|M.bovis_AF2122/97 SGYGRELSAHGIREFCNIKTVWIA------------------ MLBr_02573|M.leprae_Br4923 SGYGRELSTHGIREFCNIKTVWIA------------------ Mflv_1858|M.gilvum_PYR-GCK SGFGREGGTEGIEEYLDTKYIALTK----------------- Mvan_4876|M.vanbaalenii_PYR-1 SGFGREGGTEGIEEYLDTKYIALTR----------------- MSMEG_5538|M.smegmatis_MC2_155 SGFGREGGIEGIEEYLDTKYIALTK----------------- TH_3381|M.thermoresistible__bu SGFGREGGTEGIEEYLETKYIALT------------------ MAB_4208|M.abscessus_ATCC_1997 SGIGREAGSEGIEEYLETKYIALP------------------ Rv0223c|M.tuberculosis_H37Rv SGIGRENGPEGVEHFTQQKSVLLPMGYTVA------------ MAV_2101|M.avium_104 SGWGGERGRKGIEAYFNTKAVYIGL----------------- MMAR_3556|M.marinum_M SGFGKDMSEYSFEEYLTIKHVMSDITGVAEKPWHRTIFSTRI MUL_2789|M.ulcerans_Agy99 SGFGNDMSEYSFDEYLTIKHVMSDITGVAEKPWHRTIFSTRI ** * : . .. : * :