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M. smegmatis MC2 155 MSMEG_5538 (-)

annotation: [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155]
coordinates: 5628893 - 5630341
length: 482

RIEDLISSVPTGLWIGGEEREAASTFNVLDPSDDQVITAVADATAEDAIAALDAACAVQDEWAATPARTR
GEILRSVFEKITERADDIAALMTLEMGKVLPESKGEVAYGAEFFRWFSEEAVRIDGRYTHAPAGTGRILV
TKQAVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMDEAGLPKGVLSVLPTS
NPRGVTGALIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFIVFDDADVDAAVDGAILAK
MRNGGEACTAANRFHVANSVREEFTEKLVKRMSEFTLGKGLDPSSTLGPLINSKQVATVTELVSDAVSRG
ATVAVGGVAPGGPGNFYPATVLADVPADARILKEEVFGPVAPITGFDTEEEGIAAANDTEYGLAAYIYTQ
SLDRALRVAETIQSGMVGINRGVISDPAAPFGGIKESGFGREGGIEGIEEYLDTKYIALTK*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_5538--100% (482)[NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155]
M. smegmatis MC2 155MSMEG_2488-e-16158.49% (477) [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium
M. smegmatis MC2 155MSMEG_0582-e-13549.59% (482) succinic semialdehyde dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0239cgabD14e-7034.15% (451) succinic semialdehyde dehydrogenase
M. gilvum PYR-GCKMflv_1858-0.090.42% (480) succinate-semialdehyde dehydrogenase (NAD(P)(+))
M. tuberculosis H37RvRv0223c-5e-7334.73% (478) aldehyde dehydrogenase
M. leprae Br4923MLBr_02573gabD12e-7034.81% (451) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_4208-0.069.60% (477) putative succinate-semialdehyde dehydrogenase
M. marinum MMMAR_3556-7e-8337.18% (468) aldehyde dehydrogenase NAD dependent
M. avium 104MAV_2101-8e-8237.29% (472) aldehyde dehydrogenase
M. thermoresistible (build 8)TH_3381-1e-17687.15% (358) PUTATIVE Succinate-semialdehyde dehydrogenase (NAD(P)(+))
M. ulcerans Agy99MUL_2789-7e-8236.75% (468) gamma-aminobutyraldehyde dehydrogenase
M. vanbaalenii PYR-1Mvan_4876-0.090.99% (477) succinate-semialdehyde dehydrogenase (NAD(P)(+))

CLUSTAL 2.0.9 multiple sequence alignment


Mb0239c|M.bovis_AF2122/97           MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
Mflv_1858|M.gilvum_PYR-GCK          --------------------------MDNSAVEALLASVPTGLWIGGEER
Mvan_4876|M.vanbaalenii_PYR-1       --------------------------MDTS---ALLKSVPTGLWIGGEER
MSMEG_5538|M.smegmatis_MC2_155      --------------------------MRIE---DLISSVPTGLWIGGEER
TH_3381|M.thermoresistible__bu      --------------------------------------------------
MAB_4208|M.abscessus_ATCC_1997      --------------------------MTDHS--TLIDAIPTDLWIGGKQV
Rv0223c|M.tuberculosis_H37Rv        --------------------------------MSDSATEYDKLFIGGKWT
MAV_2101|M.avium_104                --------------------------------------------------
MMAR_3556|M.marinum_M               --------------------------------MTTTVSVAGSWING--AA
MUL_2789|M.ulcerans_Agy99           --------------------------------MTTTVSVAGSWING--AA
                                                                                      

Mb0239c|M.bovis_AF2122/97           KDVS-VPIATINPATGETVKTFTAATDDEVDAAIARAHRRFA--DYRQTS
MLBr_02573|M.leprae_Br4923          -----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFD--NYRHTT
Mflv_1858|M.gilvum_PYR-GCK          EGTS--TFDVLDPSDDTVLTSVADATADDARAALDAACAVQA--EWAGTA
Mvan_4876|M.vanbaalenii_PYR-1       QGTS--TFSVLDPSDDEVLATVADATADDARDALDAACAVQG--EWAATP
MSMEG_5538|M.smegmatis_MC2_155      EAAS--TFNVLDPSDDQVITAVADATAEDAIAALDAACAVQD--EWAATP
TH_3381|M.thermoresistible__bu      -------------------------------------------------V
MAB_4208|M.abscessus_ATCC_1997      PSSTGTRFPVHNPATGAVLTTVADAAASDGAIALDEATAVQR--SWAATA
Rv0223c|M.tuberculosis_H37Rv        KPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTP
MAV_2101|M.avium_104                ---MSTTIPVFNPSTEEQIAEVPDSDQAAVDAAVARARETFESGVWRKAP
MMAR_3556|M.marinum_M               HSTGGRQHAVINPATQETIAELALATPADVDRAVVAARRALP--QWAGVT
MUL_2789|M.ulcerans_Agy99           HSTGGRQHAVINPATQETIAELALATPADVDHAVVAARRALP--QWAGVT
                                                                                      

Mb0239c|M.bovis_AF2122/97           FAQRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRY
MLBr_02573|M.leprae_Br4923          FTQRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRY
Mflv_1858|M.gilvum_PYR-GCK          PRKRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRW
Mvan_4876|M.vanbaalenii_PYR-1       ARKRGEILRSVFETITARADDIAALMTLEMGKVFAESKGEVTYGAEFFRW
MSMEG_5538|M.smegmatis_MC2_155      ARTRGEILRSVFEKITERADDIAALMTLEMGKVLPESKGEVAYGAEFFRW
TH_3381|M.thermoresistible__bu      VRRRG---------------------------------------------
MAB_4208|M.abscessus_ATCC_1997      PRERAEILRRAWELVIARRDDFALAMTLEMGKPLAESQGEVAYGGEFLRW
Rv0223c|M.tuberculosis_H37Rv        PHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMN
MAV_2101|M.avium_104                ASHRANVLFRAARIIEERKDELAALESQDNGMNLTAAGHIIPV-SVDMLK
MMAR_3556|M.marinum_M               PAERSAVLAKLADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIR
MUL_2789|M.ulcerans_Agy99           TAERSAVLAELADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIR
                                       *.                                             

Mb0239c|M.bovis_AF2122/97           YAENAEALLADEPADAAKVG------ASAAYGRYQPLGVILAVMPWNFPL
MLBr_02573|M.leprae_Br4923          YAEKAETLLADEPAEAAAVG------ASKALARYQPLGVVLAVMPWNFPL
Mflv_1858|M.gilvum_PYR-GCK          FAE--EAVRIDGRYTAAPAG------TGRILVTKQAVGPCYAITPWNFPL
Mvan_4876|M.vanbaalenii_PYR-1       FAE--EAVRIEGRYTPAPAG------TGRILVTKQAVGPCYAITPWNFPL
MSMEG_5538|M.smegmatis_MC2_155      FSE--EAVRIDGRYTHAPAG------TGRILVTKQAVGPCYAITPWNFPL
TH_3381|M.thermoresistible__bu      -----------GPPPRAPAG------NGRILVTKQAVGPCYAITPWNFPL
MAB_4208|M.abscessus_ATCC_1997      FSE--EAVRINGRYTSSPTG------AGRILVAKQPIGPTLAITPWNFPL
Rv0223c|M.tuberculosis_H37Rv        YFAGAADKVTWTETRTGSYG--------QSIVSREPVGVVGAIVAWNVPL
MAV_2101|M.avium_104                YYAGWVGKIHGESANLVSDGLLGTWETYHTFTQLEPVGVVGLIIPWNGPF
MMAR_3556|M.marinum_M               FFAGAARRLPGQATAEYSAD-------HTSSIRREAIGVVATITPWNYPL
MUL_2789|M.ulcerans_Agy99           FFAGAARRLPGQATAEYSAD-------HTSSIRREAIGVVATITPWNYPL
                                                       .              :.:*    : .** *:

Mb0239c|M.bovis_AF2122/97           WQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLL
MLBr_02573|M.leprae_Br4923          WQTVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLL
Mflv_1858|M.gilvum_PYR-GCK          AMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLP
Mvan_4876|M.vanbaalenii_PYR-1       AMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMAEAGLPKGVLSVLP
MSMEG_5538|M.smegmatis_MC2_155      AMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMDEAGLPKGVLSVLP
TH_3381|M.thermoresistible__bu      AMGTRKIGPALAAGCTMIVKPAQETPLTMLLLAKLIDEAGLPKGVLSVLP
MAB_4208|M.abscessus_ATCC_1997      AMGTRKIGPALAAGCTMIVKPAAETPLTMLLLGQVFADAGLPAGVLSILP
Rv0223c|M.tuberculosis_H37Rv        FLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLS-VV
MAV_2101|M.avium_104                FVAMLKVAPALAAGCSAVLKPAEETPLTALKLEEIFREAGLPDGVLN-VI
MMAR_3556|M.marinum_M               QMAVWKVMPALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLN-VV
MUL_2789|M.ulcerans_Agy99           QMAVWKVMPALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLN-VV
                                            **: **   ::* :  .*     *  :    *:* . :. : 

Mb0239c|M.bovis_AF2122/97           VSSG--AVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGS
MLBr_02573|M.leprae_Br4923          ISAN--GVEAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGS
Mflv_1858|M.gilvum_PYR-GCK          TTSPGPVTETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGN
Mvan_4876|M.vanbaalenii_PYR-1       TSNPGAVTEALINDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGN
MSMEG_5538|M.smegmatis_MC2_155      TSNPRGVTGALIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGN
TH_3381|M.thermoresistible__bu      TSNPRPLTEALIGDGRLRKLTFTGSTGVGKALAQQASAKLLRTSMELGGN
MAB_4208|M.abscessus_ATCC_1997      TTNASALTGPLIDDPRLRKLTFTGSTGVGKILLSQCATRVLRSSMELGGN
Rv0223c|M.tuberculosis_H37Rv        PG-GIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGK
MAV_2101|M.avium_104                TGYGETTGAALTAHPDVDKISFTGSTEVGRLIVKAAAGNLKRLTLELGGK
MMAR_3556|M.marinum_M               TGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGK
MUL_2789|M.ulcerans_Agy99           TGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGK
                                             .:  .  :   ::***  .*: :   ..       :****.

Mb0239c|M.bovis_AF2122/97           DPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKF
MLBr_02573|M.leprae_Br4923          DPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKF
Mflv_1858|M.gilvum_PYR-GCK          APFVVFDDADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTDKF
Mvan_4876|M.vanbaalenii_PYR-1       APFIVFDDADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTEKF
MSMEG_5538|M.smegmatis_MC2_155      APFIVFDDADVDAAVDGAILAKMRNGGEACTAANRFHVANSVREEFTEKL
TH_3381|M.thermoresistible__bu      APFIVFDDADIDAAVDGAMLAKMRNGGEACTAANRFHVANAVREEFTEKL
MAB_4208|M.abscessus_ATCC_1997      APFVVFDDADVDAAVDGAMAAKMRNIGEACTAANRFHVDNAVRAEFTEKL
Rv0223c|M.tuberculosis_H37Rv        SAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAV
MAV_2101|M.avium_104                SPLIMFDDANLDKAIMGAGMGLLAGSGQNCSCTSRIYVQRGIYDQVVEGL
MMAR_3556|M.marinum_M               APFVVFDDADLDAAIQGAVAGALINSGQDCTAATRAIVARELYHDFVAGV
MUL_2789|M.ulcerans_Agy99           APFVVFDDADLDAAIQGAVAGAVINSGQDCTAATRAIVARELCHDFVAGV
                                     . ::: ..::  *:     . : . *: *   .*  .      :..  .

Mb0239c|M.bovis_AF2122/97           VARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGG-
MLBr_02573|M.leprae_Br4923          VARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGG-
Mflv_1858|M.gilvum_PYR-GCK          VKRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGG-
Mvan_4876|M.vanbaalenii_PYR-1       VKRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGG-
MSMEG_5538|M.smegmatis_MC2_155      VKRMSEFTLGKGLDPSSTLGPLINSKQVATVTELVSDAVSRGATVAVGG-
TH_3381|M.thermoresistible__bu      VKRMSEVTLGNGLDGSSTLGPLINAQQRDTVVELVTDAVERGATVAVGG-
MAB_4208|M.abscessus_ATCC_1997      TARMGALTIGPGDENGVQVGPLITAKQRASVDELVQDAVSKGAVVTTGG-
Rv0223c|M.tuberculosis_H37Rv        TNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGG
MAV_2101|M.avium_104                AEFAMMLPMGGSDDPNSVLGPLISEKQRQRVEGIVNDGVAAGAKVITGG-
MMAR_3556|M.marinum_M               ADVMSTVVIGDPMDPDTDIGPLISLAHRDRVADIVAKAPAQGARIVVGG-
MUL_2789|M.ulcerans_Agy99           ADVMSTVVIGDPMDPDTDIGPLISLAHRDRVADILAKAPAQGARIVVGG-
                                    .     . :*   :    :*** .      *   :  .   ** :  ** 

Mb0239c|M.bovis_AF2122/97           -KRLDRPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIA
MLBr_02573|M.leprae_Br4923          -KRPDRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIA
Mflv_1858|M.gilvum_PYR-GCK          -VAPGGPGNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAA
Mvan_4876|M.vanbaalenii_PYR-1       -VAPGGPGNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAA
MSMEG_5538|M.smegmatis_MC2_155      -VAPGGPGNFYPATVLADVPADARILKEEVFGPVAPITGFDTEEEGIAAA
TH_3381|M.thermoresistible__bu      -TVPDGPGWFYPATVLTDVSADARILKEEVFGPVAPIVGFDTEEEGIAAA
MAB_4208|M.abscessus_ATCC_1997      -VVADGEGYFYPPTVLTDVPADARILREEVFGPVAAITGFDGEEAGIAAA
Rv0223c|M.tuberculosis_H37Rv        RPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIA
MAV_2101|M.avium_104                KPMDRK-GYFYEATIITNTTPDMRLIREEIFGPVGCVIPFDDEDEVIAAA
MMAR_3556|M.marinum_M               RIPDLA-GAFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQA
MUL_2789|M.ulcerans_Agy99           RIPDLA-GAFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQA
                                           * *  .*::::   .     :*:****  :      :  :  *

Mb0239c|M.bovis_AF2122/97           NATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKR
MLBr_02573|M.leprae_Br4923          NATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKR
Mflv_1858|M.gilvum_PYR-GCK          NDTEYGLAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKE
Mvan_4876|M.vanbaalenii_PYR-1       NDTEYGLAAYVYTQSLDRALRVAENIESGMVGVNRGVISDAAAPFGGIKE
MSMEG_5538|M.smegmatis_MC2_155      NDTEYGLAAYIYTQSLDRALRVAETIQSGMVGINRGVISDPAAPFGGIKE
TH_3381|M.thermoresistible__bu      NDTEYGLAAYIYTRSLDRALRVAEAIESGMVGVNRGVISDAAAPFGGIKE
MAB_4208|M.abscessus_ATCC_1997      NDTEFGLAAYVYTANLDRALRVSQAVESGMVGVNRGVISDVAAPFGGIKE
Rv0223c|M.tuberculosis_H37Rv        NDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGIN-WYAFDPGSPFGGYKN
MAV_2101|M.avium_104                NDTHYGLAGAIWTENLSRAHRVVNELRAGQIWVNSALAADPSMPISGHKQ
MMAR_3556|M.marinum_M               NDTDYGLAASAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVAA
MUL_2789|M.ulcerans_Agy99           NDTDYGLAASAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVAA
                                    * : :**..  :* .  .  :    : :*   :*         * .*   

Mb0239c|M.bovis_AF2122/97           SGYGRELSAHGIREFCNIKTVWIA------------------
MLBr_02573|M.leprae_Br4923          SGYGRELSTHGIREFCNIKTVWIA------------------
Mflv_1858|M.gilvum_PYR-GCK          SGFGREGGTEGIEEYLDTKYIALTK-----------------
Mvan_4876|M.vanbaalenii_PYR-1       SGFGREGGTEGIEEYLDTKYIALTR-----------------
MSMEG_5538|M.smegmatis_MC2_155      SGFGREGGIEGIEEYLDTKYIALTK-----------------
TH_3381|M.thermoresistible__bu      SGFGREGGTEGIEEYLETKYIALT------------------
MAB_4208|M.abscessus_ATCC_1997      SGIGREAGSEGIEEYLETKYIALP------------------
Rv0223c|M.tuberculosis_H37Rv        SGIGRENGPEGVEHFTQQKSVLLPMGYTVA------------
MAV_2101|M.avium_104                SGWGGERGRKGIEAYFNTKAVYIGL-----------------
MMAR_3556|M.marinum_M               SGFGKDMSEYSFEEYLTIKHVMSDITGVAEKPWHRTIFSTRI
MUL_2789|M.ulcerans_Agy99           SGFGNDMSEYSFDEYLTIKHVMSDITGVAEKPWHRTIFSTRI
                                    ** * : .  ..  :   * :