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STTIPVFNPSTEEQIAEVPDSDQAAVDAAVARARETFESGVWRKAPASHRANVLFRAARIIEERKDELAA LESQDNGMNLTAAGHIIPVSVDMLKYYAGWVGKIHGESANLVSDGLLGTWETYHTFTQLEPVGVVGLIIP WNGPFFVAMLKVAPALAAGCSAVLKPAEETPLTALKLEEIFREAGLPDGVLNVITGYGETTGAALTAHPD VDKISFTGSTEVGRLIVKAAAGNLKRLTLELGGKSPLIMFDDANLDKAIMGAGMGLLAGSGQNCSCTSRI YVQRGIYDQVVEGLAEFAMMLPMGGSDDPNSVLGPLISEKQRQRVEGIVNDGVAAGAKVITGGKPMDRKG YFYEATIITNTTPDMRLIREEIFGPVGCVIPFDDEDEVIAAANDTHYGLAGAIWTENLSRAHRVVNELRA GQIWVNSALAADPSMPISGHKQSGWGGERGRKGIEAYFNTKAVYIGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2101 | - | - | 100% (468) | aldehyde dehydrogenase |
| M. avium 104 | MAV_2765 | - | e-147 | 53.76% (465) | P-cumic aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 9e-97 | 41.20% (466) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 3e-84 | 39.79% (470) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | 1e-100 | 43.91% (476) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 3e-95 | 41.45% (468) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-63 | 32.54% (464) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 9e-96 | 41.29% (465) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 6e-95 | 41.24% (468) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | 1e-105 | 41.86% (473) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2957 | - | 1e-89 | 38.33% (467) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 6e-94 | 40.94% (469) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-99 | 43.70% (476) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0428|M.gilvum_PYR-GCK MTQSTAFRTEWD------------------KLFIGGKWVEPASSEVIEVR
Mvan_0240|M.vanbaalenii_PYR-1 MTQSTTFRTEWD------------------KLFIGGKWVEPATSDVIEVH
MMAR_0472|M.marinum_M ----MGEKTEYD------------------KLFIGGKWTEPSTSEVIEVH
MUL_1122|M.ulcerans_Agy99 ----MGEKTEYD------------------KLFIGGRWTEPSTSEVIEVH
Rv0223c|M.tuberculosis_H37Rv ---MSDSATEYD------------------KLFIGGKWTKPSTSDVIEVR
MAB_4484|M.abscessus_ATCC_1997 -------MTNYD------------------KLFIGGVWTEPATDQVIEVI
MAV_2101|M.avium_104 ------------------------------------------MSTTIPVF
MSMEG_6297|M.smegmatis_MC2_155 ----MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSY
TH_2957|M.thermoresistible__bu ----MTSTLERP----------------EVTLRIGGEKRRTASGGTFDHI
Mb2883c|M.bovis_AF2122/97 -------------------------------------------MSTTQLI
MLBr_02573|M.leprae_Br4923 --------------------------------------------MSIATI
Mflv_0428|M.gilvum_PYR-GCK SPATGDVVGKVPLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRA
Mvan_0240|M.vanbaalenii_PYR-1 SPATGELVGKVPLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRA
MMAR_0472|M.marinum_M CPATGEYVGKVPLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANA
MUL_1122|M.ulcerans_Agy99 CPATGEYVGKVPLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANA
Rv0223c|M.tuberculosis_H37Rv CPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAA
MAB_4484|M.abscessus_ATCC_1997 SPATGQKVGQCPLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKA
MAV_2101|M.avium_104 NPSTEEQIAEVPDSDQAAVDAAVARARETFESGVWRKAPASHRANVLFRA
MSMEG_6297|M.smegmatis_MC2_155 EPRSGRVWARLPRANSTDIDRAVRAARAAFEGP-WGAVSPADRGRFLMKI
TH_2957|M.thermoresistible__bu NPCTGAPDAAIPLAGPAEIDDAVKAAHDAFHS--WRQTNPAERRRLLFRL
Mb2883c|M.bovis_AF2122/97 NPATEEVLASVDHTDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAF
MLBr_02573|M.leprae_Br4923 NPATGETVKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANAT
* : : :: * * : .*
Mflv_0428|M.gilvum_PYR-GCK VKLMEERADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFT
Mvan_0240|M.vanbaalenii_PYR-1 VKIMEERADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFT
MMAR_0472|M.marinum_M LKLLEERKDHFAKLLADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVR
MUL_1122|M.ulcerans_Agy99 LKLLEERKDHFAKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVR
Rv0223c|M.tuberculosis_H37Rv VKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVT
MAB_4484|M.abscessus_ATCC_1997 VSLLESRKDEICKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVK
MAV_2101|M.avium_104 ARIIEERKDELAALESQDNGMNLTAAGHIIPVS-VDMLKYYAG-WVGKIH
MSMEG_6297|M.smegmatis_MC2_155 AAVVDRHRDQLTVIESRDNGKPVREVRAEIDAV-VRYFEYFAG-VCQTTV
TH_2957|M.thermoresistible__bu AELIEQHTDDFVRLGTFDNGTPVGLVAGLVAMS-AEWTRYYAG-WADKIT
Mb2883c|M.bovis_AF2122/97 AAAVQAHLDELAALEVANSGHP-IVSAEWEAGHVRDVLAFYAA-SPERLS
MLBr_02573|M.leprae_Br4923 ADLLEAEANQSAALMTLEMGKTLQSAK-DEAMKCAKGFRYYAEKAETLLA
: . : : * ::*
Mflv_0428|M.gilvum_PYR-GCK ---WQDIRDGVYG-----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPA
Mvan_0240|M.vanbaalenii_PYR-1 ---WQDIRDGVYG-----QTLVVREPVGVVGAVTAWNVPFFLAANKLGPA
MMAR_0472|M.marinum_M ---WKEIRNGSYG-----QTIVHREPIGVVGAIVAWNVPLFLAINKLGPA
MUL_1122|M.ulcerans_Agy99 ---WKEIRNGSYG-----QTIVHREPIGVVGAIVAWNVPLFLAINKLGPA
Rv0223c|M.tuberculosis_H37Rv ---WTETRTGSYG-----QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPA
MAB_4484|M.abscessus_ATCC_1997 ---WKELRNGAYG-----QTLVTREPAGVVAAIAAWNVPLFLALNKIGPA
MAV_2101|M.avium_104 GESANLVSDGLLGTWETYHTFTQLEPVGVVGLIIPWNGPFFVAMLKVAPA
MSMEG_6297|M.smegmatis_MC2_155 G--ETHPQAATA------FSYTRREPVGVVGAIVPWNSPLLMLAWKLSPA
TH_2957|M.thermoresistible__bu S--EVSGTYGTTGE----FSYTLSQPYGVIGVIITWNGPLISLAMKVPAA
Mb2883c|M.bovis_AF2122/97 G--RQIPVAGGVD-------VTFNEPMGVVGVITPWNFPMVIASWAIAPA
MLBr_02573|M.leprae_Br4923 DEPAEAAAVGASK------ALARYQPLGVVLAVMPWNFPLWQTVRFAAPA
. . :* **: : .** *: .*
Mflv_0428|M.gilvum_PYR-GCK LLAGCTVVLKPAAETPLSVFAMAEMFVEAGLPEGVLSIVPG-GPETGQAL
Mvan_0240|M.vanbaalenii_PYR-1 LLAGCTVVLKPAAETPLSVFAMAEMFVEAGLPEGVLSIVPG-GPETGQAL
MMAR_0472|M.marinum_M LLAGCTVVLKPAAETPLTANALAEVFAEAGLPEGVLSVVPG-GVETGQAL
MUL_1122|M.ulcerans_Agy99 PLAGCTVVLKPAAETPLTANALAEVFAEAGLPEGVLSVVPG-GVETGQAL
Rv0223c|M.tuberculosis_H37Rv LLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPG-GIETGQAL
MAB_4484|M.abscessus_ATCC_1997 FLAGCAVVLKPAAETPLSSFILAEVFAEAGVPEGVLSVVPG-GAETGRAL
MAV_2101|M.avium_104 LAAGCSAVLKPAEETPLTALKLEEIFREAGLPDGVLNVITGYGETTGAAL
MSMEG_6297|M.smegmatis_MC2_155 LAGGNTIILKPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAAL
TH_2957|M.thermoresistible__bu LAAGNTVVVKPSELTPFSATLFADLAAEAGIPDGVINVVPGTG-DAGAAL
Mb2883c|M.bovis_AF2122/97 LAAGNAVLVKPAELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERF
MLBr_02573|M.leprae_Br4923 LMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAIL
.* ::* : .. : :: . *. :. :. : . . :
Mflv_0428|M.gilvum_PYR-GCK TANPNLDKYTFTGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADL
Mvan_0240|M.vanbaalenii_PYR-1 TANPNLDKYTFTGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADL
MMAR_0472|M.marinum_M TSNPGVDLFTFTGSSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDL
MUL_1122|M.ulcerans_Agy99 TSNPGVDLFTFTGSSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDL
Rv0223c|M.tuberculosis_H37Rv TSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDL
MAB_4484|M.abscessus_ATCC_1997 TNNPDVDVFSFTGSTAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADL
MAV_2101|M.avium_104 TAHPDVDKISFTGSTEVGRLIVKAAAGNLKRLTLELGGKSPLIMFDDANL
MSMEG_6297|M.smegmatis_MC2_155 VAHPDVDKIAFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIFDDADL
TH_2957|M.thermoresistible__bu VAHPLVKKVTFTGGPDTARKILQSCAEHIKPSVMELGGKSGNIIFEDANL
Mb2883c|M.bovis_AF2122/97 VTHPDIRKIVFTGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDL
MLBr_02573|M.leprae_Br4923 R-DPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADL
.* : :**. ..: : .. :* .:****.. ::: . :*
Mflv_0428|M.gilvum_PYR-GCK DSTLPM-LVFSGLMNSGQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPG
Mvan_0240|M.vanbaalenii_PYR-1 DSTLPM-LVFSGLMNSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPG
MMAR_0472|M.marinum_M STAVPM-MVFSGIMNTGQACVGQTRILAPRSRYEEIVEAVSAFVQALPVG
MUL_1122|M.ulcerans_Agy99 STAVPM-MVFSGIMNTGQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVG
Rv0223c|M.tuberculosis_H37Rv AAAIPM-MVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVG
MAB_4484|M.abscessus_ATCC_1997 AAALPM-LVFSGLMNAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVG
MAV_2101|M.avium_104 DKAIMG-AGMGLLAGSGQNCSCTSRIYVQRGIYDQVVEGLAEFAMMLPMG
MSMEG_6297|M.smegmatis_MC2_155 DAAVHR-TAYGIFSAAGQTCQAASRIFVQDTIHDEFLDRFAALARRIRVG
TH_2957|M.thermoresistible__bu DTACSVGTLMSVGMMSGQGCAFPTRMIVARPLYDEVLTRVSALAPMVKVG
Mb2883c|M.bovis_AF2122/97 ERAATT-APAGVFDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVG
MLBr_02573|M.leprae_Br4923 DAAVAT-AVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVG
: . ** * .*. . ::..: . : *
Mflv_0428|M.gilvum_PYR-GCK LPDNPAAMIGPLISEKQRDRVEGYIKKGIEEGARVITGGGR--PEGLDSG
Mvan_0240|M.vanbaalenii_PYR-1 LPDNPAAMIGPLISEKQRDRVEGYIKKGIEEGARVVTGGGR--PEGLDSG
MMAR_0472|M.marinum_M PPSDPAAQIGSLISEKQRARVEGYIAKGIEEGARLVSGGGR--PEGLDNG
MUL_1122|M.ulcerans_Agy99 PPSDPAAQIGSLISEKQRARVEGYIAKGIEEGARLVSGGGR--PESLDNG
Rv0223c|M.tuberculosis_H37Rv PPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR--PEGLDNG
MAB_4484|M.abscessus_ATCC_1997 LPDDPATQVGPLITEKQRTRVEGYIAKGIAEGARLAYGGKR--PEGLDGG
MAV_2101|M.avium_104 GSDDPNSVLGPLISEKQRQRVEGIVNDGVAAGAKVITGGKP--MD--RKG
MSMEG_6297|M.smegmatis_MC2_155 DPLSERTQMGAQISAQHRERIAGYVASGIQEGANLVCGGTQPTEAPLAQG
TH_2957|M.thermoresistible__bu DPLEPDTVAGPVVNEAALQRILGMIERAKQDGARLLTGGER-LGGDLADE
Mb2883c|M.bovis_AF2122/97 DPGSRATEMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGR--------G
MLBr_02573|M.leprae_Br4923 DPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKR----PDRPG
. . : *. . :: : . .
Mflv_0428|M.gilvum_PYR-GCK WFVEPTVFADVDNSMTIAQEEIFGPVLSVIPYEDEDDAVRIANDSVYGLA
Mvan_0240|M.vanbaalenii_PYR-1 WYVQPTVFADVDNSMTIAQEEIFGPVLAVIPYEDEDDAVRIANDSVYGLA
MMAR_0472|M.marinum_M FFVQPTVFADVDNKMTIAQEEIFGPVLVVIPYDTEEDAIKIANDSVYGLA
MUL_1122|M.ulcerans_Agy99 FFVQPTVFADVDNKMTIAQEEIFGPVLVVIPYDTKEDAIKIANDSVYGLA
Rv0223c|M.tuberculosis_H37Rv FFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLA
MAB_4484|M.abscessus_ATCC_1997 YFVQPTIFADVDNSMTIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGLA
MAV_2101|M.avium_104 YFYEATIITNTTPDMRLIREEIFGPVGCVIPFDDEDEVIAAANDTHYGLA
MSMEG_6297|M.smegmatis_MC2_155 YYYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDTEYGLA
TH_2957|M.thermoresistible__bu YFVAPTVFADVDPYSELAQKEVFGPVLSIIPFDTEEQAVEIANSTPYGLS
Mb2883c|M.bovis_AF2122/97 FWFPPTVLTPKRGDRTVT-DEIFGPVVVVLTFDDEADAISLANDTAYGLS
MLBr_02573|M.leprae_Br4923 WFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLG
:: .*:: : .*:**** : :.: ** : :**.
Mflv_0428|M.gilvum_PYR-GCK GSVYTTDNDRALKIARRIRTGTYAVN-MYAFDPCAPFGGYKNSGIGRENG
Mvan_0240|M.vanbaalenii_PYR-1 GSVYTTDNDRALKIARRIRTGTYAVN-MYAFDPCAPFGGFKNSGIGRENG
MMAR_0472|M.marinum_M GSVWTSNVPKGIEISEKIRTGTYAIN-WYAFDPCCPFGGYKNSGIGRENG
MUL_1122|M.ulcerans_Agy99 GSVWTSNVPKGIEISEKIRTGTYAIN-WYAFDPCCPFGGYKNSGIGRENG
Rv0223c|M.tuberculosis_H37Rv GSVWTTDVPKGIKISQQIRTGTYGIN-WYAFDPGSPFGGYKNSGIGRENG
MAB_4484|M.abscessus_ATCC_1997 GSVWTTDVQKGLEVAAQIRTGTYGIN-WYAFDPSCPFGGYKQSGIGRENG
MAV_2101|M.avium_104 GAIWTENLSRAHRVVNELRAGQIWVNSALAADPSMPISGHKQSGWGGERG
MSMEG_6297|M.smegmatis_MC2_155 GSVWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGREGG
TH_2957|M.thermoresistible__bu GYVFTNDLKRAHRVAEQLETGEVLINGAAPLTVHRPFGGFGISGIGKEGG
Mb2883c|M.bovis_AF2122/97 GSIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELG
MLBr_02573|M.leprae_Br4923 SNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELS
. :* : . .. : :* :* *:.* ** * * .
Mflv_0428|M.gilvum_PYR-GCK WEGIEAYCEQKSILLPFGYTPPAS---
Mvan_0240|M.vanbaalenii_PYR-1 WEGIEAYCEPKSILLPFGYTPAT----
MMAR_0472|M.marinum_M PEGVEHFTQQKSVLMPMGYTLES----
MUL_1122|M.ulcerans_Agy99 PEGVEHFTQQKSVLMPMGYTLES----
Rv0223c|M.tuberculosis_H37Rv PEGVEHFTQQKSVLLPMGYTVA-----
MAB_4484|M.abscessus_ATCC_1997 PEGIEEYCELKSVLLPMGYTLESI---
MAV_2101|M.avium_104 RKGIEAYFNTKAVYIGL----------
MSMEG_6297|M.smegmatis_MC2_155 QAVMEHYTRIKSVWVDMQDDLPNWYAD
TH_2957|M.thermoresistible__bu REGLAEFLRTKSVSIA-----------
Mb2883c|M.bovis_AF2122/97 PDAPLQFTETKNVFIAVGEEM------
MLBr_02573|M.leprae_Br4923 THGIREFCNIKTVWIA-----------
: . * : :