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SDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHE RAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYGQSI VSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPG GIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGV MNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGA RLVCGGGRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWT TDVPKGIKISQQIRTGTYGINWYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0223c | - | - | 100% (487) | PROBABLE ALDEHYDE DEHYDROGENASE |
| M. tuberculosis H37Rv | Rv0768 | aldA | 2e-95 | 41.48% (458) | aldehyde dehydrogenase NAD dependent AldA |
| M. tuberculosis H37Rv | Rv2858c | aldC | 2e-76 | 37.23% (470) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0228c | - | 0.0 | 95.83% (360) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | 0.0 | 69.38% (480) | betaine-aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-59 | 33.19% (452) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 0.0 | 70.89% (481) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 0.0 | 85.48% (482) | aldehyde dehydrogenase |
| M. avium 104 | MAV_4946 | - | 0.0 | 84.16% (486) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 0.0 | 69.09% (482) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4171 | - | 1e-134 | 79.04% (291) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 0.0 | 84.23% (482) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 0.0 | 69.29% (482) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
Mb0228c|M.bovis_AF2122/97 ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
MMAR_0472|M.marinum_M -----------MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKV
MUL_1122|M.ulcerans_Agy99 -----------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKV
MAV_4946|M.avium_104 ------MSDIQTQAKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKV
Mflv_0428|M.gilvum_PYR-GCK ---MTQS----TAFRTEWDKLFIGGKWVEPASSEVIEVRSPATGDVVGKV
Mvan_0240|M.vanbaalenii_PYR-1 ---MTQS----TTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKV
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATGEKVGQA
TH_4171|M.thermoresistible__bu --------------------------------------------------
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQC
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
Rv0223c|M.tuberculosis_H37Rv PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
Mb0228c|M.bovis_AF2122/97 PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
MMAR_0472|M.marinum_M PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MUL_1122|M.ulcerans_Agy99 PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MAV_4946|M.avium_104 PLAAAADVDAAVAAARAAFDNGPWPTTPPKERAAVIANALKVMEERKDLF
Mflv_0428|M.gilvum_PYR-GCK PLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEERADEL
Mvan_0240|M.vanbaalenii_PYR-1 PLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADEL
MSMEG_0309|M.smegmatis_MC2_155 PLATKADVDAACAAARKAFDEGPWPRMTPQEREAVLAKATALIEESADEF
TH_4171|M.thermoresistible__bu --------------------------------------------------
MAB_4484|M.abscessus_ATCC_1997 PLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEI
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQS
Rv0223c|M.tuberculosis_H37Rv TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYG-
Mb0228c|M.bovis_AF2122/97 TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYG-
MMAR_0472|M.marinum_M AKLLADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYG-
MUL_1122|M.ulcerans_Agy99 AKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYG-
MAV_4946|M.avium_104 TGLLAAETGQPPTSVETMHWMSSIGALNFFAGPAVDQVKWKEVRTGGYG-
Mflv_0428|M.gilvum_PYR-GCK KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
Mvan_0240|M.vanbaalenii_PYR-1 KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYG-
MSMEG_0309|M.smegmatis_MC2_155 KTLLKLETGQPQTIVDMMQYGAAMSTLQFYAS-AADKFAWKDIRDGIYG-
TH_4171|M.thermoresistible__bu --------------------------------------------------
MAB_4484|M.abscessus_ATCC_1997 CKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYG-
MLBr_02573|M.leprae_Br4923 AALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAVGA
Rv0223c|M.tuberculosis_H37Rv -QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPL
Mb0228c|M.bovis_AF2122/97 -QSIVSRESVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPL
MMAR_0472|M.marinum_M -QTIVHREPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPL
MUL_1122|M.ulcerans_Agy99 -QTIVHREPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAETPL
MAV_4946|M.avium_104 -QSIVHREPIGVVGAIVAWNVPLFLAVNKLGPALLAGCTVVLKPAAETPL
Mflv_0428|M.gilvum_PYR-GCK -QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPL
Mvan_0240|M.vanbaalenii_PYR-1 -QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPL
MSMEG_0309|M.smegmatis_MC2_155 -QTLVLKEPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAAETPL
TH_4171|M.thermoresistible__bu --------------------------------------------------
MAB_4484|M.abscessus_ATCC_1997 -QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPL
MLBr_02573|M.leprae_Br4923 SKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQ
Rv0223c|M.tuberculosis_H37Rv TANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVG
Mb0228c|M.bovis_AF2122/97 TANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVG
MMAR_0472|M.marinum_M TANALAEVFAEAGLPEGVLSVVPGGVETGQALTSNPGVDLFTFTGSSAVG
MUL_1122|M.ulcerans_Agy99 TANALAEVFAEAGLPEGVLSVVPGGVETGQALTSNPGVDLFTFTGSSAVG
MAV_4946|M.avium_104 SANALAEAFAEAGLPEGVLSVVPGGIETGQALTSNTDVDIFSFTGSSAVG
Mflv_0428|M.gilvum_PYR-GCK SVFAMAEMFVEAGLPEGVLSIVPGGPETGQALTANPNLDKYTFTGSSGVG
Mvan_0240|M.vanbaalenii_PYR-1 SVFAMAEMFVEAGLPEGVLSIVPGGPETGQALTANPNLDKYTFTGSSGVG
MSMEG_0309|M.smegmatis_MC2_155 TTNLMAQKFLEAGLPEGVLSVVPGGPETGRALTDNPALDKFTFTGSSAVG
TH_4171|M.thermoresistible__bu -------VFAEAGLPEGVLSVVPGGAETGRALTSNKDLDKYTFTGSSAVG
MAB_4484|M.abscessus_ATCC_1997 SSFILAEVFAEAGVPEGVLSVVPGGAETGRALTNNPDVDVFSFTGSTAVG
MLBr_02573|M.leprae_Br4923 CALYLADVIARGGFPEDCFQTLLISANGVEAILRDPRVAAATLTGSEPAG
: . *.**. :. : . : .*: : : ::*** .*
Rv0223c|M.tuberculosis_H37Rv REVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQG
Mb0228c|M.bovis_AF2122/97 REVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQG
MMAR_0472|M.marinum_M KEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQA
MUL_1122|M.ulcerans_Agy99 KEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQA
MAV_4946|M.avium_104 REIGRRAADMLKPCTLELGGKSAAIVLDDVDLPSALPMLVFSGIMNSGQA
Mflv_0428|M.gilvum_PYR-GCK KEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLMNSGQA
Mvan_0240|M.vanbaalenii_PYR-1 KEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLMNSGQA
MSMEG_0309|M.smegmatis_MC2_155 KEIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLLFSGLMNSGQA
TH_4171|M.thermoresistible__bu REIGKIAAENLKPCTLELGGKSAAIILEDADLDATLPMLVFSGVMNSGQA
MAB_4484|M.abscessus_ATCC_1997 KEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQG
MLBr_02573|M.leprae_Br4923 QAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQS
: :. *.. :* .*****... *:: ..** :::. : . : * **.
Rv0223c|M.tuberculosis_H37Rv CVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRT
Mb0228c|M.bovis_AF2122/97 CVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRT
MMAR_0472|M.marinum_M CVGQTRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLISEKQRA
MUL_1122|M.ulcerans_Agy99 CVGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLISEKQRA
MAV_4946|M.avium_104 CVAQTRILAPRSRYDEIVDAVSTFVQSLPVGLPSDPAAQIGSLISEKQRA
Mflv_0428|M.gilvum_PYR-GCK CVGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPLISEKQRD
Mvan_0240|M.vanbaalenii_PYR-1 CVGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLISEKQRD
MSMEG_0309|M.smegmatis_MC2_155 CVGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPLISEKQRE
TH_4171|M.thermoresistible__bu CVGQTRILAPRSRYDEVVEKVANFVAAMPVGLPDDPNTAIGPLISEKQRE
MAB_4484|M.abscessus_ATCC_1997 CVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRT
MLBr_02573|M.leprae_Br4923 CIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRA
*: .*.:* . *:*.: . : * * :* : :*.* :*. *
Rv0223c|M.tuberculosis_H37Rv RVEGYIAKGIEEGARLVCGGGRPEGLDNGFFIQPTVFADVDNKMTIAQEE
Mb0228c|M.bovis_AF2122/97 RVEALHRQG-HRGGRSVGVRRRP---------------------------
MMAR_0472|M.marinum_M RVEGYIAKGIEEGARLVSGGGRPEGLDNGFFVQPTVFADVDNKMTIAQEE
MUL_1122|M.ulcerans_Agy99 RVEGYIAKGIEEGARLVSGGGRPESLDNGFFVQPTVFADVDNKMTIAQEE
MAV_4946|M.avium_104 RVEGYIAKGIEEGARLVCGGGRPEGLDSGFFVQPTVFADVDNKMTIAQEE
Mflv_0428|M.gilvum_PYR-GCK RVEGYIKKGIEEGARVITGGGRPEGLDSGWFVEPTVFADVDNSMTIAQEE
Mvan_0240|M.vanbaalenii_PYR-1 RVEGYIKKGIEEGARVVTGGGRPEGLDSGWYVQPTVFADVDNSMTIAQEE
MSMEG_0309|M.smegmatis_MC2_155 RVEGYIKKGIEEGARLVTGGGRPEGLDSGWFVQPTVFADVDNSMTIAQEE
TH_4171|M.thermoresistible__bu RVEGYIKKGIEEGARLVTGGGRPEGLDSGWFVQPTVFADVDNSMTIAQEE
MAB_4484|M.abscessus_ATCC_1997 RVEGYIAKGIAEGARLAYGGKRPEGLDGGYFVQPTIFADVDNSMTIAQEE
MLBr_02573|M.leprae_Br4923 QVEQQVDAAAAAGAVIRCGGKRPD--RPGWFYPPTVITDITKDMALYTDE
:** . *. **
Rv0223c|M.tuberculosis_H37Rv IFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTG
Mb0228c|M.bovis_AF2122/97 ----------------SRGLGQRLLYPIHERRWR----------------
MMAR_0472|M.marinum_M IFGPVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTG
MUL_1122|M.ulcerans_Agy99 IFGPVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTG
MAV_4946|M.avium_104 IFGPVLSIIPYDTEEDAIKIANDSVYGLAGSVWTADVQRGIAVSEKIRTG
Mflv_0428|M.gilvum_PYR-GCK IFGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIARRIRTG
Mvan_0240|M.vanbaalenii_PYR-1 IFGPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIARRIRTG
MSMEG_0309|M.smegmatis_MC2_155 IFGPVLVVIPFEDEDDAVRIANDSVYGLAGSVYTTDHAKGVEIASKVRTG
TH_4171|M.thermoresistible__bu IFGPVLCIIPYEDEDDAVRIANDSVYGLAGSVYTQDYPKALEIASKIRTG
MAB_4484|M.abscessus_ATCC_1997 IFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTG
MLBr_02573|M.leprae_Br4923 VFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAG
: :.: : : :
Rv0223c|M.tuberculosis_H37Rv TYGIN-WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTV
Mb0228c|M.bovis_AF2122/97 ------------------------GKWHGQCG------------------
MMAR_0472|M.marinum_M TYAIN-WYAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTL
MUL_1122|M.ulcerans_Agy99 TYAIN-WYAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTL
MAV_4946|M.avium_104 TYAIN-WYAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTL
Mflv_0428|M.gilvum_PYR-GCK TYAVN-MYAFDPCAPFGGYKNSGIGRENGWEGIEAYCEQKSILLPFGYTP
Mvan_0240|M.vanbaalenii_PYR-1 TYAVN-MYAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKSILLPFGYTP
MSMEG_0309|M.smegmatis_MC2_155 TYGIN-MYAFDPGAPFGGYKNSGIGRECGPEGIAGYCESKSVLLPFGYTP
TH_4171|M.thermoresistible__bu TYAVN-MYAFDPGAPFGGYKNSGIGRENGPEGIEAYCQQKSVLLPFGYTP
MAB_4484|M.abscessus_ATCC_1997 TYGIN-WYAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTL
MLBr_02573|M.leprae_Br4923 QVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA-----
*: . *
Rv0223c|M.tuberculosis_H37Rv A--
Mb0228c|M.bovis_AF2122/97 ---
MMAR_0472|M.marinum_M ES-
MUL_1122|M.ulcerans_Agy99 ES-
MAV_4946|M.avium_104 EG-
Mflv_0428|M.gilvum_PYR-GCK PAS
Mvan_0240|M.vanbaalenii_PYR-1 AT-
MSMEG_0309|M.smegmatis_MC2_155 E--
TH_4171|M.thermoresistible__bu ED-
MAB_4484|M.abscessus_ATCC_1997 ESI
MLBr_02573|M.leprae_Br4923 ---