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MDNSAVEALLASVPTGLWIGGEEREGTSTFDVLDPSDDTVLTSVADATADDARAALDAACAVQAEWAGTA PRKRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRWFAEEAVRIDGRYTAAPAGTG RILVTKQAVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSV LPTTSPGPVTETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFVVFDDADVDAAVDGA ILAKMRNGGEACTAANRIHVANAVREEFTDKFVKRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDA VSRGATVAVGGVAPGGPGNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYGLAAY VYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKESGFGREGGTEGIEEYLDTKYIALTK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1858 | - | - | 100% (485) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. gilvum PYR-GCK | Mflv_4860 | - | 6e-83 | 37.34% (466) | gamma-aminobutyraldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | 8e-78 | 36.83% (486) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0239c | gabD1 | 6e-73 | 35.25% (451) | succinic semialdehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0234c | gabD1 | 6e-73 | 35.25% (451) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-72 | 34.81% (451) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4208 | - | 0.0 | 70.65% (477) | putative succinate-semialdehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 9e-84 | 37.39% (468) | aldehyde dehydrogenase NAD dependent |
| M. avium 104 | MAV_1897 | - | 4e-79 | 37.87% (470) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5538 | - | 0.0 | 90.42% (480) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
| M. thermoresistible (build 8) | TH_3381 | - | 1e-174 | 87.43% (350) | PUTATIVE Succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. ulcerans Agy99 | MUL_2789 | - | 9e-82 | 36.75% (468) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4876 | - | 0.0 | 94.02% (485) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1858|M.gilvum_PYR-GCK -----------------------MDNSAVEALLAS--VPTGLWIGGEERE
Mvan_4876|M.vanbaalenii_PYR-1 -----------------------MDTS---ALLKS--VPTGLWIGGEERQ
MSMEG_5538|M.smegmatis_MC2_155 -----------------------MRIE---DLISS--VPTGLWIGGEERE
TH_3381|M.thermoresistible__bu --------------------------------------------------
MAB_4208|M.abscessus_ATCC_1997 -----------------------MTDHS--TLIDA--IPTDLWIGGKQVP
MMAR_3556|M.marinum_M -----------------------MTTTVSVAGS---------WING-AAH
MUL_2789|M.ulcerans_Agy99 -----------------------MTTTVSVAGS---------WING-AAH
MAV_1897|M.avium_104 -----------------------MTDTTISNGVTEQLVHFDLVIGGESVA
Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
Rv0234c|M.tuberculosis_H37Rv MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mflv_1858|M.gilvum_PYR-GCK GTS--TFDVLDPSDDTVLTSVADATADDARAALDAACAVQA-EWAGTAPR
Mvan_4876|M.vanbaalenii_PYR-1 GTS--TFSVLDPSDDEVLATVADATADDARDALDAACAVQG-EWAATPAR
MSMEG_5538|M.smegmatis_MC2_155 AAS--TFNVLDPSDDQVITAVADATAEDAIAALDAACAVQD-EWAATPAR
TH_3381|M.thermoresistible__bu -----------------------------------------------VVR
MAB_4208|M.abscessus_ATCC_1997 SSTGTRFPVHNPATGAVLTTVADAAASDGAIALDEATAVQR-SWAATAPR
MMAR_3556|M.marinum_M STGGRQHAVINPATQETIAELALATPADVDRAVVAARRALP-QWAGVTPA
MUL_2789|M.ulcerans_Agy99 STGGRQHAVINPATQETIAELALATPADVDHAVVAARRALP-QWAGVTTA
MAV_1897|M.avium_104 AESGRTYDSIDPYTALPWARVPDCGPADVDRAVAAARAALRGPWGQLTGT
Mb0239c|M.bovis_AF2122/97 KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFA-DYRQTSFA
Rv0234c|M.tuberculosis_H37Rv KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFA-DYRQTSFA
MLBr_02573|M.leprae_Br4923 ----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFD-NYRHTTFT
Mflv_1858|M.gilvum_PYR-GCK KRGEILRSVFETITARADDIAALMTLEMGKVLAESKG-EVTYGAEFFRWF
Mvan_4876|M.vanbaalenii_PYR-1 KRGEILRSVFETITARADDIAALMTLEMGKVFAESKG-EVTYGAEFFRWF
MSMEG_5538|M.smegmatis_MC2_155 TRGEILRSVFEKITERADDIAALMTLEMGKVLPESKG-EVAYGAEFFRWF
TH_3381|M.thermoresistible__bu RRG-----------------------------------------------
MAB_4208|M.abscessus_ATCC_1997 ERAEILRRAWELVIARRDDFALAMTLEMGKPLAESQG-EVAYGGEFLRWF
MMAR_3556|M.marinum_M ERSAVLAKLADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFF
MUL_2789|M.ulcerans_Agy99 ERSAVLAELADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFF
MAV_1897|M.avium_104 ARGKLLWRLGELIAREAESLAELEVRDGGKLVREMIG-QMKALPDYYIYY
Mb0239c|M.bovis_AF2122/97 QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
Rv0234c|M.tuberculosis_H37Rv QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
MLBr_02573|M.leprae_Br4923 QRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYA
*.
Mflv_1858|M.gilvum_PYR-GCK AEEAVRIDGRYTAAPAG-TGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
Mvan_4876|M.vanbaalenii_PYR-1 AEEAVRIEGRYTPAPAG-TGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
MSMEG_5538|M.smegmatis_MC2_155 SEEAVRIDGRYTHAPAG-TGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
TH_3381|M.thermoresistible__bu --------GPPPRAPAG-NGRILVTKQAVGPCYAITPWNFPLAMGTRKIG
MAB_4208|M.abscessus_ATCC_1997 SEEAVRINGRYTSSPTG-AGRILVAKQPIGPTLAITPWNFPLAMGTRKIG
MMAR_3556|M.marinum_M AGAARRLPGQATAEYSA-DHTSSIRREAIGVVATITPWNYPLQMAVWKVM
MUL_2789|M.ulcerans_Agy99 AGAARRLPGQATAEYSA-DHTSSIRREAIGVVATITPWNYPLQMAVWKVM
MAV_1897|M.avium_104 AGLADKLQGEVVPVDKP-NFFVYTRHEPVGVVGAITPWNSPLLLLTWKLA
Mb0239c|M.bovis_AF2122/97 ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
Rv0234c|M.tuberculosis_H37Rv ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
MLBr_02573|M.leprae_Br4923 EKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAA
. :.:* :: *** ** .
Mflv_1858|M.gilvum_PYR-GCK PAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLPTTSPGPVT
Mvan_4876|M.vanbaalenii_PYR-1 PAFAAGCTMIVKPAQETPLTMLLLAKLMAEAGLPKGVLSVLPTSNPGAVT
MSMEG_5538|M.smegmatis_MC2_155 PAFAAGCTMIVKPAQETPLTMLLLAKLMDEAGLPKGVLSVLPTSNPRGVT
TH_3381|M.thermoresistible__bu PALAAGCTMIVKPAQETPLTMLLLAKLIDEAGLPKGVLSVLPTSNPRPLT
MAB_4208|M.abscessus_ATCC_1997 PALAAGCTMIVKPAAETPLTMLLLGQVFADAGLPAGVLSILPTTNASALT
MMAR_3556|M.marinum_M PALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLNVVTGLGAD-VG
MUL_2789|M.ulcerans_Agy99 PALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLNVVTGLGAD-VG
MAV_1897|M.avium_104 AGLAAGCTFVVKPSDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQ-TG
Mb0239c|M.bovis_AF2122/97 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSGA--V
Rv0234c|M.tuberculosis_H37Rv PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSGA--V
MLBr_02573|M.leprae_Br4923 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANG--V
..: ** . ::* : .* * :. : .*:* . :. :
Mflv_1858|M.gilvum_PYR-GCK ETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFVVFDD
Mvan_4876|M.vanbaalenii_PYR-1 EALINDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFIVFDD
MSMEG_5538|M.smegmatis_MC2_155 GALIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFIVFDD
TH_3381|M.thermoresistible__bu EALIGDGRLRKLTFTGSTGVGKALAQQASAKLLRTSMELGGNAPFIVFDD
MAB_4208|M.abscessus_ATCC_1997 GPLIDDPRLRKLTFTGSTGVGKILLSQCATRVLRSSMELGGNAPFVVFDD
MMAR_3556|M.marinum_M AALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGKAPFVVFDD
MUL_2789|M.ulcerans_Agy99 AALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGKAPFVVFDD
MAV_1897|M.avium_104 AALAAHPDVDKIAFTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDD
Mb0239c|M.bovis_AF2122/97 EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
Rv0234c|M.tuberculosis_H37Rv EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
MLBr_02573|M.leprae_Br4923 EAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS
.: . : ::*** .* : . . :****. . :*: .
Mflv_1858|M.gilvum_PYR-GCK ADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTDKFVKRMSEFT
Mvan_4876|M.vanbaalenii_PYR-1 ADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTEKFVKRMSEFT
MSMEG_5538|M.smegmatis_MC2_155 ADVDAAVDGAILAKMRNGGEACTAANRFHVANSVREEFTEKLVKRMSEFT
TH_3381|M.thermoresistible__bu ADIDAAVDGAMLAKMRNGGEACTAANRFHVANAVREEFTEKLVKRMSEVT
MAB_4208|M.abscessus_ATCC_1997 ADVDAAVDGAMAAKMRNIGEACTAANRFHVDNAVRAEFTEKLTARMGALT
MMAR_3556|M.marinum_M ADLDAAIQGAVAGALINSGQDCTAATRAIVARELYHDFVAGVADVMSTVV
MUL_2789|M.ulcerans_Agy99 ADLDAAIQGAVAGAVINSGQDCTAATRAIVARELCHDFVAGVADVMSTVV
MAV_1897|M.avium_104 ADLDAAANGVIAGVFAATGQTCLAGSRLLVHESVADALVERIVARASTIK
Mb0239c|M.bovis_AF2122/97 ADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALR
Rv0234c|M.tuberculosis_H37Rv ADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALR
MLBr_02573|M.leprae_Br4923 ADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLR
**:*** .: . . *: * *..* . : :. .. .
Mflv_1858|M.gilvum_PYR-GCK LGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGGVAP-GGPGN
Mvan_4876|M.vanbaalenii_PYR-1 LGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGGVAP-GGPGN
MSMEG_5538|M.smegmatis_MC2_155 LGKGLDPSSTLGPLINSKQVATVTELVSDAVSRGATVAVGGVAP-GGPGN
TH_3381|M.thermoresistible__bu LGNGLDGSSTLGPLINAQQRDTVVELVTDAVERGATVAVGGTVP-DGPGW
MAB_4208|M.abscessus_ATCC_1997 IGPGDENGVQVGPLITAKQRASVDELVQDAVSKGAVVTTGGVVA-DGEGY
MMAR_3556|M.marinum_M IGDPMDPDTDIGPLISLAHRDRVADIVAKAPAQGARIVVGGRIP-DLAGA
MUL_2789|M.ulcerans_Agy99 IGDPMDPDTDIGPLISLAHRDRVADILAKAPAQGARIVVGGRIP-DLAGA
MAV_1897|M.avium_104 LGDPKDPATEMGPVSNQPQYEKVLSHFASAREQGATVAYGGEPAGELGGF
Mb0239c|M.bovis_AF2122/97 VGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRL-DRPGW
Rv0234c|M.tuberculosis_H37Rv VGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRL-DRPGW
MLBr_02573|M.leprae_Br4923 VGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRP-DRPGW
:* : :**: . * . . * ** : ** *
Mflv_1858|M.gilvum_PYR-GCK FYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYGLAA
Mvan_4876|M.vanbaalenii_PYR-1 FYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYGLAA
MSMEG_5538|M.smegmatis_MC2_155 FYPATVLADVPADARILKEEVFGPVAPITGFDTEEEGIAAANDTEYGLAA
TH_3381|M.thermoresistible__bu FYPATVLTDVSADARILKEEVFGPVAPIVGFDTEEEGIAAANDTEYGLAA
MAB_4208|M.abscessus_ATCC_1997 FYPPTVLTDVPADARILREEVFGPVAAITGFDGEEAGIAAANDTEFGLAA
MMAR_3556|M.marinum_M FYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAA
MUL_2789|M.ulcerans_Agy99 FYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAA
MAV_1897|M.avium_104 FVKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAA
Mb0239c|M.bovis_AF2122/97 FYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGS
Rv0234c|M.tuberculosis_H37Rv FYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGS
MLBr_02573|M.leprae_Br4923 FYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGS
* .*:::.: . :*:**** .: : .: ** * :**.:
Mflv_1858|M.gilvum_PYR-GCK YVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKESGFGREGGT
Mvan_4876|M.vanbaalenii_PYR-1 YVYTQSLDRALRVAENIESGMVGVNRGVISDAAAPFGGIKESGFGREGGT
MSMEG_5538|M.smegmatis_MC2_155 YIYTQSLDRALRVAETIQSGMVGINRGVISDPAAPFGGIKESGFGREGGI
TH_3381|M.thermoresistible__bu YIYTRSLDRALRVAEAIESGMVGVNRGVISDAAAPFGGIKESGFGREGGT
MAB_4208|M.abscessus_ATCC_1997 YVYTANLDRALRVSQAVESGMVGVNRGVISDVAAPFGGIKESGIGREAGS
MMAR_3556|M.marinum_M SAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVAASGFGKDMSE
MUL_2789|M.ulcerans_Agy99 SAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVAASGFGNDMSE
MAV_1897|M.avium_104 GVWTKDVHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGI
Mb0239c|M.bovis_AF2122/97 NAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSA
Rv0234c|M.tuberculosis_H37Rv NAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSA
MLBr_02573|M.leprae_Br4923 NAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELST
:* . . : : :* * :* *.**: ** *.: .
Mflv_1858|M.gilvum_PYR-GCK EGIEEYLDTKYIALTK-----------------
Mvan_4876|M.vanbaalenii_PYR-1 EGIEEYLDTKYIALTR-----------------
MSMEG_5538|M.smegmatis_MC2_155 EGIEEYLDTKYIALTK-----------------
TH_3381|M.thermoresistible__bu EGIEEYLETKYIALT------------------
MAB_4208|M.abscessus_ATCC_1997 EGIEEYLETKYIALP------------------
MMAR_3556|M.marinum_M YSFEEYLTIKHVMSDITGVAEKPWHRTIFSTRI
MUL_2789|M.ulcerans_Agy99 YSFDEYLTIKHVMSDITGVAEKPWHRTIFSTRI
MAV_1897|M.avium_104 DAVKDFTETKAVWVELSGATRDPFTLG------
Mb0239c|M.bovis_AF2122/97 HGIREFCNIKTVWIA------------------
Rv0234c|M.tuberculosis_H37Rv HGIREFCNIKTVWIA------------------
MLBr_02573|M.leprae_Br4923 HGIREFCNIKTVWIA------------------
.. :: * :