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MTEHENRVVSGVQKRLFIDGKWVDATDGATFDVLDPATGEVLCAVADASPQDGRAALDAAVAAQPEFAAL PPRERADMLTGAFELLHERIDDLALLMTLEMGKPLAEARGEITYAAEFFRHFAAEAVRIDGGYQTAPAGG SRFLIARQPVGPCLLITPWNFPMAMGTRKLGPAIAAGCTSVIKPAHQTPLSMLALMDILSEVGVPAGAVN CVTAMDAGGVMEPLIRSGLARKLSFTGSTKVGRMLLEQCAEKILRTSLELGGNAPLIVFEDADLDEAVEG AILAKMRNMGEACTAANRLFVHSSVIDEFGRRLAERMAEMPVGRGTEDGVRVGPLIDEAALQKVTSLVDD AVKRGATVLTGGSAPSGPGFFYPPTVLSGVPRDAEMVGQEIFGPVAPLTPFDTEEEAVAAANDTEYGLVS YVFTNDLRRALRVAEALETGMVGLNQGIVSNPAAPFGGIKESGLGREGGAVGIDEFLETKYVGIKM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2488 | - | - | 100% (486) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155] |
| M. smegmatis MC2 155 | MSMEG_5538 | - | e-161 | 58.49% (477) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
| M. smegmatis MC2 155 | MSMEG_0582 | - | e-132 | 51.39% (469) | succinic semialdehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0239c | gabD1 | 4e-74 | 36.42% (453) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1858 | - | 1e-162 | 58.49% (477) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. tuberculosis H37Rv | Rv0223c | - | 2e-75 | 34.10% (478) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-70 | 35.10% (453) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4418 | - | 1e-160 | 60.35% (454) | succinate-semialdehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 6e-79 | 35.96% (470) | aldehyde dehydrogenase NAD dependent |
| M. avium 104 | MAV_2101 | - | 5e-81 | 36.31% (471) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4137 | - | 1e-127 | 48.63% (475) | PUTATIVE putative [NADP+] succinate-semialdehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 8e-78 | 35.74% (470) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4876 | - | 1e-160 | 58.28% (477) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1858|M.gilvum_PYR-GCK -------------------------MDNSAVEALLASVPTGLWIGGEERE
Mvan_4876|M.vanbaalenii_PYR-1 -------------------------MDTS---ALLKSVPTGLWIGGEERQ
MSMEG_2488|M.smegmatis_MC2_155 -------------------------MTEHEN-RVVSGVQKRLFIDGKWVD
MAB_4418|M.abscessus_ATCC_1997 -------------------------MHPGTVSTPLSSSSSVVDSALTHQD
TH_4137|M.thermoresistible__bu -----------------------------------------MYIDGEWQS
Rv0223c|M.tuberculosis_H37Rv -------------------------------MSDSATEYDKLFIGGKWTK
MAV_2101|M.avium_104 --------------------------------------------------
MMAR_3556|M.marinum_M -------------------------------MTTTVSVAGSWING--AAH
MUL_2789|M.ulcerans_Agy99 -------------------------------MTTTVSVAGSWING--AAH
Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mflv_1858|M.gilvum_PYR-GCK GTS--TFDVLDPSDDTVLTSVADATADDARAALDAACAVQA--EWAGTAP
Mvan_4876|M.vanbaalenii_PYR-1 GTS--TFSVLDPSDDEVLATVADATADDARDALDAACAVQG--EWAATPA
MSMEG_2488|M.smegmatis_MC2_155 ATDGATFDVLDPATGEVLCAVADASPQDGRAALDAAVAAQP--EFAALPP
MAB_4418|M.abscessus_ATCC_1997 RHET-TFPVVNPATEEVLADVADLDGAAAVAALDNAVAAQR--SWAATTP
TH_4137|M.thermoresistible__bu AASGKTFASINPANGAVLDSVPDGEREDARRAIDAAAAALP--DWRSRTA
Rv0223c|M.tuberculosis_H37Rv PSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPP
MAV_2101|M.avium_104 --MSTTIPVFNPSTEEQIAEVPDSDQAAVDAAVARARETFESGVWRKAPA
MMAR_3556|M.marinum_M STGGRQHAVINPATQETIAELALATPADVDRAVVAARRALP--QWAGVTP
MUL_2789|M.ulcerans_Agy99 STGGRQHAVINPATQETIAELALATPADVDHAVVAARRALP--QWAGVTT
Mb0239c|M.bovis_AF2122/97 KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFA--DYRQTSF
MLBr_02573|M.leprae_Br4923 ----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFD--NYRHTTF
*: : .. *: * : .
Mflv_1858|M.gilvum_PYR-GCK RKRGEILRSVFETITARADDIAALMTLEMGKV-LAESKGEVTYGAEFFRW
Mvan_4876|M.vanbaalenii_PYR-1 RKRGEILRSVFETITARADDIAALMTLEMGKV-FAESKGEVTYGAEFFRW
MSMEG_2488|M.smegmatis_MC2_155 RERADMLTGAFELLHERIDDLALLMTLEMGKP-LAEARGEITYAAEFFRH
MAB_4418|M.abscessus_ATCC_1997 QQRSDVLMRAYTLMIQRTEDLALLMTLEMGKP-LPESRGEVAYAAEFFRW
TH_4137|M.thermoresistible__bu YERAEVLVEAHRIMLERRDDLAELMTREQGKP-LRMARTEVGYAADFLLW
Rv0223c|M.tuberculosis_H37Rv HERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNY
MAV_2101|M.avium_104 SHRANVLFRAARIIEERKDELAALESQDNGMNLTAAGHIIPV-SVDMLKY
MMAR_3556|M.marinum_M AERSAVLAKLADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRF
MUL_2789|M.ulcerans_Agy99 AERSAVLAELADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRF
Mb0239c|M.bovis_AF2122/97 AQRARWANATADLLEAEADQAAAMMTLEMGKT-LAAAKAEALKCAKGFRY
MLBr_02573|M.leprae_Br4923 TQRAKWANATADLLEAEANQSAALMTLEMGKT-LQSAKDEAMKCAKGFRY
.*. : . : * :
Mflv_1858|M.gilvum_PYR-GCK FAEEAVRIDGRYTAAPAGT-------GRILVTKQAVGPCYAITPWNFPLA
Mvan_4876|M.vanbaalenii_PYR-1 FAEEAVRIEGRYTPAPAGT-------GRILVTKQAVGPCYAITPWNFPLA
MSMEG_2488|M.smegmatis_MC2_155 FAAEAVRIDGGYQTAPAGG-------SRFLIARQPVGPCLLITPWNFPMA
MAB_4418|M.abscessus_ATCC_1997 FAGEAVRLDGSVMLAPDGQ-------SRLIVTHRPVGPCLLITPWNFPLA
TH_4137|M.thermoresistible__bu FAEEAKRVYGEVIPSARAD-------QRFIVLAQPVGVCAAITPWNYPIS
Rv0223c|M.tuberculosis_H37Rv FAGAADKVTWTETRTGSYG--------QSIVSREPVGVVGAIVAWNVPLF
MAV_2101|M.avium_104 YAGWVGKIHGESANLVSDGLLGTWETYHTFTQLEPVGVVGLIIPWNGPFF
MMAR_3556|M.marinum_M FAGAARRLPGQATAEYSAD-------HTSSIRREAIGVVATITPWNYPLQ
MUL_2789|M.ulcerans_Agy99 FAGAARRLPGQATAEYSAD-------HTSSIRREAIGVVATITPWNYPLQ
Mb0239c|M.bovis_AF2122/97 YAENAEALLADEPADAAKVG-----ASAAYGRYQPLGVILAVMPWNFPLW
MLBr_02573|M.leprae_Br4923 YAEKAETLLADEPAEAAAVG-----ASKALARYQPLGVVLAVMPWNFPLW
:* . : ..:* : .** *:
Mflv_1858|M.gilvum_PYR-GCK MGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLPT
Mvan_4876|M.vanbaalenii_PYR-1 MGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMAEAGLPKGVLSVLPT
MSMEG_2488|M.smegmatis_MC2_155 MGTRKLGPAIAAGCTSVIKPAHQTPLSMLALMDILSEVGVPAGAVNCVTA
MAB_4418|M.abscessus_ATCC_1997 MGTRKIGPALAAGCTCLVKPAEQTPLSMLALLGILREAGVPDGVVSVITT
TH_4137|M.thermoresistible__bu MLTRKLAPALAAGCTSVLKPAEQTPLCAVETFKVFADAGVPAGVVNLVTC
Rv0223c|M.tuberculosis_H37Rv LAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPG
MAV_2101|M.avium_104 VAMLKVAPALAAGCSAVLKPAEETPLTALKLEEIFREAGLPDGVLNVITG
MMAR_3556|M.marinum_M MAVWKVMPALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLNVVTG
MUL_2789|M.ulcerans_Agy99 MAVWKVMPALAAGCTVVIKPSELTPLTTLTLARLAAEAGLPDGVLNVVTG
Mb0239c|M.bovis_AF2122/97 QAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLV
MLBr_02573|M.leprae_Br4923 QTVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLI
**: ** ::* : .* : *.* . .. :
Mflv_1858|M.gilvum_PYR-GCK TSPGPVTETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNA
Mvan_4876|M.vanbaalenii_PYR-1 SNPGAVTEALINDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNA
MSMEG_2488|M.smegmatis_MC2_155 MDAGGVMEPLIRSGLARKLSFTGSTKVGRMLLEQCAEKILRTSLELGGNA
MAB_4418|M.abscessus_ATCC_1997 ADPGATMAPLLADPRVRKLSFTGSTEVGRYLLAQCAPTVKRTSMELGGNA
TH_4137|M.thermoresistible__bu SDPEPVADELLGDPRVRKISFTGSTEVGRMIASRAGATMKRVSMELGGHA
Rv0223c|M.tuberculosis_H37Rv --GIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKS
MAV_2101|M.avium_104 Y-GETTGAALTAHPDVDKISFTGSTEVGRLIVKAAAGNLKRLTLELGGKS
MMAR_3556|M.marinum_M L-GADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGKA
MUL_2789|M.ulcerans_Agy99 L-GADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGKA
Mb0239c|M.bovis_AF2122/97 S--SGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSD
MLBr_02573|M.leprae_Br4923 S--ANGVEAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSD
: ::*** .*: : .. :****
Mflv_1858|M.gilvum_PYR-GCK PFVVFDDADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTDKFV
Mvan_4876|M.vanbaalenii_PYR-1 PFIVFDDADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTEKFV
MSMEG_2488|M.smegmatis_MC2_155 PLIVFEDADLDEAVEGAILAKMRNMGEACTAANRLFVHSSVIDEFGRRLA
MAB_4418|M.abscessus_ATCC_1997 PFIVFDDADPEEAAAGALIAKMRNIGQACTAANRIYVQRGIADAFTEALT
TH_4137|M.thermoresistible__bu PFLVFPDADPEHAAKGGAAVKFLNTGQACICPNRFIVHRSIAEPFIATLR
Rv0223c|M.tuberculosis_H37Rv AAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVT
MAV_2101|M.avium_104 PLIMFDDANLDKAIMGAGMGLLAGSGQNCSCTSRIYVQRGIYDQVVEGLA
MMAR_3556|M.marinum_M PFVVFDDADLDAAIQGAVAGALINSGQDCTAATRAIVARELYHDFVAGVA
MUL_2789|M.ulcerans_Agy99 PFVVFDDADLDAAIQGAVAGAVINSGQDCTAATRAIVARELCHDFVAGVA
Mb0239c|M.bovis_AF2122/97 PFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFV
MLBr_02573|M.leprae_Br4923 PFIVMPSADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFV
. ::: ..: * . . *: * .* . . . .
Mflv_1858|M.gilvum_PYR-GCK KRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGGVA
Mvan_4876|M.vanbaalenii_PYR-1 KRMSEFTLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGGVA
MSMEG_2488|M.smegmatis_MC2_155 ERMAEMPVGRGTEDGVRVGPLIDEAALQKVTSLVDDAVKRGATVLTGGSA
MAB_4418|M.abscessus_ATCC_1997 TKLTALRMGPGVEPGVDVGPLIDPDAVAKADRLVTDARKRGATVRLGGEV
TH_4137|M.thermoresistible__bu ARIEKLVPGDGLAAGTTVGPLIDEVALKKMQRQVDDAVDKGAKLELGGSR
Rv0223c|M.tuberculosis_H37Rv NFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR
MAV_2101|M.avium_104 EFAMMLPMGGSDDPNSVLGPLISEKQRQRVEGIVNDGVAAGAKVITGG-K
MMAR_3556|M.marinum_M DVMSTVVIGDPMDPDTDIGPLISLAHRDRVADIVAKAPAQGARIVVGG-R
MUL_2789|M.ulcerans_Agy99 DVMSTVVIGDPMDPDTDIGPLISLAHRDRVADILAKAPAQGARIVVGG-R
Mb0239c|M.bovis_AF2122/97 ARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKR
MLBr_02573|M.leprae_Br4923 ARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKR
. * :*** : . ** : **
Mflv_1858|M.gilvum_PYR-GCK PGGP----GNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAA
Mvan_4876|M.vanbaalenii_PYR-1 PGGP----GNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAA
MSMEG_2488|M.smegmatis_MC2_155 PSGP----GFFYPPTVLSGVPRDAEMVGQEIFGPVAPLTPFDTEEEAVAA
MAB_4418|M.abscessus_ATCC_1997 PDGT----GYFYPPSVLTDVPDESDMMRTEIFAPVAAIATFETEQEVITR
TH_4137|M.thermoresistible__bu LQGPAFDNGHFYAPTILTGVTPDMLICSEETFGPIAPVMVFDDEDEAIAM
Rv0223c|M.tuberculosis_H37Rv PEGLDN--GFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAI
MAV_2101|M.avium_104 PMDRK---GYFYEATIITNTTPDMRLIREEIFGPVGCVIPFDDEDEVIAA
MMAR_3556|M.marinum_M IPDLA---GAFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQ
MUL_2789|M.ulcerans_Agy99 IPDLA---GAFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQ
Mb0239c|M.bovis_AF2122/97 LDRP----GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEI
MLBr_02573|M.leprae_Br4923 PDRP----GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEI
* * .::::. . * *.*: : :: :
Mflv_1858|M.gilvum_PYR-GCK ANDTEYGLAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIK
Mvan_4876|M.vanbaalenii_PYR-1 ANDTEYGLAAYVYTQSLDRALRVAENIESGMVGVNRGVISDAAAPFGGIK
MSMEG_2488|M.smegmatis_MC2_155 ANDTEYGLVSYVFTNDLRRALRVAEALETGMVGLNQGIVSNPAAPFGGIK
MAB_4418|M.abscessus_ATCC_1997 ANDSEFGLVAYLYTNDTRRGWRVSEQLETGMVGLNRPVVSTPAAPFGGVK
TH_4137|M.thermoresistible__bu ANSTEYGLAGYIYTRDISRAIRVGEALDFGMIGINDINPTSAAVPFGGIK
Rv0223c|M.tuberculosis_H37Rv ANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGIN-WYAFDPGSPFGGYK
MAV_2101|M.avium_104 ANDTHYGLAGAIWTENLSRAHRVVNELRAGQIWVNSALAADPSMPISGHK
MMAR_3556|M.marinum_M ANDTDYGLAASAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVA
MUL_2789|M.ulcerans_Agy99 ANDTDYGLAASAWTRDVYRAQRASREISAGCVWINDHIPIVSEMPHGGVA
Mb0239c|M.bovis_AF2122/97 ANATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVK
MLBr_02573|M.leprae_Br4923 ANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIK
** : :** . :* . . : : * :* . * .*
Mflv_1858|M.gilvum_PYR-GCK ESGFGREGGTEGIEEYLDTKYIALTK-----------------
Mvan_4876|M.vanbaalenii_PYR-1 ESGFGREGGTEGIEEYLDTKYIALTR-----------------
MSMEG_2488|M.smegmatis_MC2_155 ESGLGREGGAVGIDEFLETKYVGIKM-----------------
MAB_4418|M.abscessus_ATCC_1997 QSGIGREGGFAGIEEFMETKYIGAAV-----------------
TH_4137|M.thermoresistible__bu QSGLGREGARAGIEEYLDTKVLGIAL-----------------
Rv0223c|M.tuberculosis_H37Rv NSGIGRENGPEGVEHFTQQKSVLLPMGYTVA------------
MAV_2101|M.avium_104 QSGWGGERGRKGIEAYFNTKAVYIGL-----------------
MMAR_3556|M.marinum_M ASGFGKDMSEYSFEEYLTIKHVMSDITGVAEKPWHRTIFSTRI
MUL_2789|M.ulcerans_Agy99 ASGFGNDMSEYSFDEYLTIKHVMSDITGVAEKPWHRTIFSTRI
Mb0239c|M.bovis_AF2122/97 RSGYGRELSAHGIREFCNIKTVWIA------------------
MLBr_02573|M.leprae_Br4923 RSGYGRELSTHGIREFCNIKTVWIA------------------
** * : . .. : * :