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MTSASSGASSGASSGARRIGAPDAKNRGLLLDAAERLMLEEGYAAVTSRRLASRAGLKPQLVHYYFRTME ELFLEVFRRRAEEGLAVQAQALQSDQPLWAVWRFGTDPAFTQISMEFMALANHRKDMRAEIAYYAERFRD EQQRAVAAALERYGVQNKDVPPVVWTVLMTSLSRFLVLEQAIGMSSGHAETVQLVESYLRRLEGEPKPIA GAPSSWTVHQGRIEQSTPLGPSLDTTTAPSTVRSQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0966 | - | - | 100% (245) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_0367 | - | 2e-41 | 44.92% (187) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_0847 | - | 3e-38 | 46.24% (173) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 1e-05 | 23.68% (190) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2518 | - | 5e-77 | 70.83% (192) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 6e-06 | 24.74% (194) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 5e-05 | 31.43% (70) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0377 | - | 1e-06 | 29.31% (116) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4693 | - | 3e-90 | 81.87% (193) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4779 | - | 7e-80 | 70.35% (199) | regulatory protein |
| M. thermoresistible (build 8) | TH_3070 | - | 3e-77 | 67.66% (201) | PUTATIVE probable regulatory protein |
| M. ulcerans Agy99 | MUL_0675 | - | 1e-08 | 27.69% (195) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4140 | - | 9e-77 | 71.35% (192) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0310|M.bovis_AF2122/97 ------------------------MGVP-----------AKKKQQQGERS
Rv0302|M.tuberculosis_H37Rv ------------------------MGVP-----------AKKKQQQGERS
MAV_0966|M.avium_104 ------------------------MTSASSGASSGASSGARRIGAPDAKN
MMAR_4693|M.marinum_M ------------------------MTS------------ARRIGAPDAKN
MSMEG_4779|M.smegmatis_MC2_155 ------------------------MAS------------ARRIGAPDAKN
TH_3070|M.thermoresistible__bu ------------------------MAS------------GRRIGTPDAKN
Mflv_2518|M.gilvum_PYR-GCK ------------------------MAA------------PRRIGAPDAKN
Mvan_4140|M.vanbaalenii_PYR-1 ------------------------MTS------------PRRIGAPDAKN
MUL_0675|M.ulcerans_Agy99 ---------------------------------------MPTAAERGAQT
MAB_0377|M.abscessus_ATCC_1997 ------------------------MPTP-----------RRTQEERSAAM
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPN----------QRSNRLSRDKR
Mb0310|M.bovis_AF2122/97 RESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAM
Rv0302|M.tuberculosis_H37Rv RESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAM
MAV_0966|M.avium_104 RGLLLDAAERLMLEEGYAAVTSRRLASRAGLKPQLVHYYFRTMEELFLEV
MMAR_4693|M.marinum_M RGVLLDTAEELMIEEGYAAVTSRRVASEAGLKPQLVHYYFRTMEELFLEL
MSMEG_4779|M.smegmatis_MC2_155 RIVLLDAAEALMIDEGYAAVTSRRVAERAGLKPQLVHYYFRTMDDLFLAV
TH_3070|M.thermoresistible__bu RGVLLDAAERLMLEEGYVAVTSRRVAEKAGLKPQLVHYYFRTMDDLFLEV
Mflv_2518|M.gilvum_PYR-GCK RVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAV
Mvan_4140|M.vanbaalenii_PYR-1 RVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAV
MUL_0675|M.ulcerans_Agy99 RAALMAAAVAVIAERGWGAATTRMVAERAGLPPGLVHYHFASLNDLLIDA
MAB_0377|M.abscessus_ATCC_1997 RARLLEATIDCLVEFGYSGTTTSRIASRAGATRGALIHHFQSKSELMAES
MLBr_00815|M.leprae_Br4923 RGQLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAV
* :: .: : *: .. : . .* : :* : :
Mb0310|M.bovis_AF2122/97 MERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLL
Rv0302|M.tuberculosis_H37Rv MERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLL
MAV_0966|M.avium_104 FRRRAEEGLAVQAQALQSDQPL--WAVWRFGTDPAFTQISMEFMALANHR
MMAR_4693|M.marinum_M FRRRAEEGLRAQAQALQSPKPL--WALWRLGSDPAFARISMEFMALANHR
MSMEG_4779|M.smegmatis_MC2_155 FRRRAEEGLAAQARALDSPQPL--WALWRFGIDPSATRLTMEIMGVANHR
TH_3070|M.thermoresistible__bu FRRRAEEGLRAQEEAFASPQPL--WALWRFGTDPAGTRLTMELMGLANHR
Mflv_2518|M.gilvum_PYR-GCK FHRRAEEGLAVLSTALRSAQPL--WALWRFSTAPEATRLTMEFMGLANHR
Mvan_4140|M.vanbaalenii_PYR-1 FHRRAEEGLAVLSTALASPQPL--WALWRFSTAPEATRLTMEFMGLANHR
MUL_0675|M.ulcerans_Agy99 ALQAAREEAAQVLDGLAGDSSS--QGIDRLIDAVSSYDVDDRNQNPAILV
MAB_0377|M.abscessus_ATCC_1997 VRHLAFKRTQAVLEELMAMDQS-ADPIERYLDVLWRIHQGPLFIAVVELL
MLBr_00815|M.leprae_Br4923 LERHMNNLVSSVQQALRTTTNN--RQRLHAAVQAFFDFIEHDGQGYRLIF
: . :
Mb0310|M.bovis_AF2122/97 SMERSQDPVVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELT
Rv0302|M.tuberculosis_H37Rv SMERSQDPAVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELT
MAV_0966|M.avium_104 KDMRAEIAYYAERFRDEQQRAVAAALERYG-VQNKDVPPVVWTVLMTSLS
MMAR_4693|M.marinum_M KALRAEIAHYAERFRDEQRRVITAALQRYG-VDSQDVPPVVWTVLMASLS
MSMEG_4779|M.smegmatis_MC2_155 KALRTEIGRYAERFRDEQTKAMTAALDRYG-VNAADVPPIVWTFLATSVS
TH_3070|M.thermoresistible__bu PALRAEMARYAERFREKERDAIAAILERYG-IDASDVPPVVWAVFAAAVS
Mflv_2518|M.gilvum_PYR-GCK KALRAEIVYYAERFRQEQNRAISDALQRYG-MVSDDVPPVVWTVFATSVS
Mvan_4140|M.vanbaalenii_PYR-1 KALRAEIVYYAERFRQEQNRAIADALQRYG-TDFTDVPPVVWTVFATSVS
MUL_0675|M.ulcerans_Agy99 FGEMLLAATRYERLRMGLAEILGDYRSTLR-QWLADQGGAIDPEATAALM
MAB_0377|M.abscessus_ATCC_1997 IAARTEP--DLRVHLDQFEKIVLHNLSALNVLGDDDVGSPKERRDLGLLA
MLBr_00815|M.leprae_Br4923 ENDNITEPRVAAQVRVATESCIDAVFALIS--ADSRLDPHRARMVAVGLV
: :
Mb0310|M.bovis_AF2122/97 AFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET-----
Rv0302|M.tuberculosis_H37Rv AFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET-----
MAV_0966|M.avium_104 RFLVLEQAIGMSSGHAETVQLVESYLRRLEGEPKPIAGAPSSWTVHQGRI
MMAR_4693|M.marinum_M RFLVLEKALGMSGGHAETIELVESYLRRLEGEP-----------------
MSMEG_4779|M.smegmatis_MC2_155 RVMVMEQALGMSAGHAEVLEFCEGWLRRIEGEPLPIEAAG----------
TH_3070|M.thermoresistible__bu RMLVMEKAIGMSVGHKEILEFCEDWLRRLEGEPLPASDPDSVASA-----
Mflv_2518|M.gilvum_PYR-GCK QALVMERALGMDTGHAETFAFCEQWIRRFEGEPSPELADGHEMAPAQP--
Mvan_4140|M.vanbaalenii_PYR-1 QALVMERALGMDTGHAETFAFCEEWIRRLEGDPLPPLDQRA---------
MUL_0675|M.ulcerans_Agy99 FAAIDGLVLHRVIDPRLRTLAIRPTLRRLAGLPTAQTDERTPS-------
MAB_0377|M.abscessus_ATCC_1997 MDIIRGLLVSSLTASQETRDRRWSRAKHMLELRLRAPSPEA---------
MLBr_00815|M.leprae_Br4923 GISVDCARYWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL--------
: :
Mb0310|M.bovis_AF2122/97 ----------------------
Rv0302|M.tuberculosis_H37Rv ----------------------
MAV_0966|M.avium_104 EQSTPLGPSLDTTTAPSTVRSQ
MMAR_4693|M.marinum_M ----------------------
MSMEG_4779|M.smegmatis_MC2_155 ----------------------
TH_3070|M.thermoresistible__bu ----------------------
Mflv_2518|M.gilvum_PYR-GCK ----------------------
Mvan_4140|M.vanbaalenii_PYR-1 ----------------------
MUL_0675|M.ulcerans_Agy99 ----------------------
MAB_0377|M.abscessus_ATCC_1997 ----------------------
MLBr_00815|M.leprae_Br4923 ----------------------