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MAAPRRIGAPDAKNRVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAVFHRRAE EGLAVLSTALRSAQPLWALWRFSTAPEATRLTMEFMGLANHRKALRAEIVYYAERFRQEQNRAISDALQR YGMVSDDVPPVVWTVFATSVSQALVMERALGMDTGHAETFAFCEQWIRRFEGEPSPELADGHEMAPAQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2518 | - | - | 100% (209) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1588 | - | 5e-34 | 40.21% (194) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1270 | - | 3e-30 | 36.98% (192) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 5e-07 | 24.73% (186) | TetR/ACRR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 3e-07 | 22.99% (187) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 8e-06 | 31.43% (70) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0476c | - | 2e-07 | 29.41% (170) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4693 | - | 2e-74 | 69.59% (194) | transcriptional regulator |
| M. avium 104 | MAV_0966 | - | 3e-77 | 70.83% (192) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4779 | - | 1e-81 | 73.13% (201) | regulatory protein |
| M. thermoresistible (build 8) | TH_3070 | - | 5e-77 | 69.39% (196) | PUTATIVE probable regulatory protein |
| M. ulcerans Agy99 | MUL_0675 | - | 3e-09 | 43.94% (66) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4140 | - | 1e-103 | 92.93% (198) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0310|M.bovis_AF2122/97 ---MGVP----------------------AKKKQQQGERSRESILDATER
Rv0302|M.tuberculosis_H37Rv ---MGVP----------------------AKKKQQQGERSRESILDATER
Mflv_2518|M.gilvum_PYR-GCK ---MAAP-----------------------RRIGAPDAKNRVVLLDAAEQ
Mvan_4140|M.vanbaalenii_PYR-1 ---MTSP-----------------------RRIGAPDAKNRVVLLDAAEQ
MSMEG_4779|M.smegmatis_MC2_155 ---MASA-----------------------RRIGAPDAKNRIVLLDAAEA
TH_3070|M.thermoresistible__bu ---MASG-----------------------RRIGTPDAKNRGVLLDAAER
MMAR_4693|M.marinum_M ---MTSA-----------------------RRIGAPDAKNRGVLLDTAEE
MAV_0966|M.avium_104 ---MTSASSGASSGASS-----------GARRIGAPDAKNRGLLLDAAER
MUL_0675|M.ulcerans_Agy99 ---MPTA--------------------------AERGAQTRAALMAAAVA
MAB_0476c|M.abscessus_ATCC_199 ---MQKGPTSG-------------------AASRRPWAERHAHLLDAAEQ
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
: . : :: .:
Mb0310|M.bovis_AF2122/97 LMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA
Rv0302|M.tuberculosis_H37Rv LMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA
Mflv_2518|M.gilvum_PYR-GCK LLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAVFHRRAEEGLA
Mvan_4140|M.vanbaalenii_PYR-1 LLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAVFHRRAEEGLA
MSMEG_4779|M.smegmatis_MC2_155 LMIDEGYAAVTSRRVAERAGLKPQLVHYYFRTMDDLFLAVFRRRAEEGLA
TH_3070|M.thermoresistible__bu LMLEEGYVAVTSRRVAEKAGLKPQLVHYYFRTMDDLFLEVFRRRAEEGLR
MMAR_4693|M.marinum_M LMIEEGYAAVTSRRVASEAGLKPQLVHYYFRTMEELFLELFRRRAEEGLR
MAV_0966|M.avium_104 LMLEEGYAAVTSRRLASRAGLKPQLVHYYFRTMEELFLEVFRRRAEEGLA
MUL_0675|M.ulcerans_Agy99 VIAERGWGAATTRMVAERAGLPPGLVHYHFASLNDLLIDAALQAAREEAA
MAB_0476c|M.abscessus_ATCC_199 LFFERGFAAVSLSDIAQAAGVTKPIAYRHFKTKDGAYLACARRAQADFAQ
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
:: .*: *. : . .*: : :* : :
Mb0310|M.bovis_AF2122/97 AIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPVV
Rv0302|M.tuberculosis_H37Rv AIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPAV
Mflv_2518|M.gilvum_PYR-GCK VLSTALRSAQPL--WALWRFSTAPEATRLTMEFMGLANHRKALRAEIVYY
Mvan_4140|M.vanbaalenii_PYR-1 VLSTALASPQPL--WALWRFSTAPEATRLTMEFMGLANHRKALRAEIVYY
MSMEG_4779|M.smegmatis_MC2_155 AQARALDSPQPL--WALWRFGIDPSATRLTMEIMGVANHRKALRTEIGRY
TH_3070|M.thermoresistible__bu AQEEAFASPQPL--WALWRFGTDPAGTRLTMELMGLANHRPALRAEMARY
MMAR_4693|M.marinum_M AQAQALQSPKPL--WALWRLGSDPAFARISMEFMALANHRKALRAEIAHY
MAV_0966|M.avium_104 VQAQALQSDQPL--WAVWRFGTDPAFTQISMEFMALANHRKDMRAEIAYY
MUL_0675|M.ulcerans_Agy99 QVLDGLAGDSSS--QGIDRLIDAVSSYDVDDRNQNPAILVFGEMLLAATR
MAB_0476c|M.abscessus_ATCC_199 ALVQRADPTQAV--REQFAAAADLFYELLETHPERWELIYGSAAVLPAES
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNN--RQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPRV
Mb0310|M.bovis_AF2122/97 AAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELTAFAVALSDGV
Rv0302|M.tuberculosis_H37Rv AAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELTAFAVALSDGV
Mflv_2518|M.gilvum_PYR-GCK AERFRQEQNRAISDALQRYG-MVSDDVPPVVWTVFATSVSQALVMERALG
Mvan_4140|M.vanbaalenii_PYR-1 AERFRQEQNRAIADALQRYG-TDFTDVPPVVWTVFATSVSQALVMERALG
MSMEG_4779|M.smegmatis_MC2_155 AERFRDEQTKAMTAALDRYG-VNAADVPPIVWTFLATSVSRVMVMEQALG
TH_3070|M.thermoresistible__bu AERFREKERDAIAAILERYG-IDASDVPPVVWAVFAAAVSRMLVMEKAIG
MMAR_4693|M.marinum_M AERFRDEQRRVITAALQRYG-VDSQDVPPVVWTVLMASLSRFLVLEKALG
MAV_0966|M.avium_104 AERFRDEQQRAVAAALERYG-VQNKDVPPVVWTVLMTSLSRFLVLEQAIG
MUL_0675|M.ulcerans_Agy99 YERLRMGLAEILGDYRSTLR-QWLADQGGAIDPEATAALMFAAIDGLVLH
MAB_0476c|M.abscessus_ATCC_199 RDELSALRLGNIETTYALIT-KDHPDIPKLFAEGLSHAMSGAAERLGHWW
MLBr_00815|M.leprae_Br4923 AAQVRVATESCIDAVFALIS--ADSRLDPHRARMVAVGLVGISVDCARYW
. : :
Mb0310|M.bovis_AF2122/97 YFAG-HLEPDTTDVERMYRRLRQALEALIPVLLEET--------------
Rv0302|M.tuberculosis_H37Rv YFAG-HLEPDTTDVERMYRRLRQALEALIPVLLEET--------------
Mflv_2518|M.gilvum_PYR-GCK MDTG-HAETFAFCEQWIRRFEGEPSPELADGHEMAPAQP-----------
Mvan_4140|M.vanbaalenii_PYR-1 MDTG-HAETFAFCEEWIRRLEGDPLPPLDQRA------------------
MSMEG_4779|M.smegmatis_MC2_155 MSAG-HAEVLEFCEGWLRRIEGEPLPIEAAG-------------------
TH_3070|M.thermoresistible__bu MSVG-HKEILEFCEDWLRRLEGEPLPASDPDSVASA--------------
MMAR_4693|M.marinum_M MSGG-HAETIELVESYLRRLEGEP--------------------------
MAV_0966|M.avium_104 MSSG-HAETVQLVESYLRRLEGEPKPIAGAPSSWTVHQGRIEQSTPLGPS
MUL_0675|M.ulcerans_Agy99 RVID-PRLRTLAIRPTLRRLAGLPTAQTDERTPS----------------
MAB_0476c|M.abscessus_ATCC_199 RSRP-DLDRQHMVDIHVEIFYAAVAPYLDSR-------------------
MLBr_00815|M.leprae_Br4923 LDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL------------------
:
Mb0310|M.bovis_AF2122/97 -------------
Rv0302|M.tuberculosis_H37Rv -------------
Mflv_2518|M.gilvum_PYR-GCK -------------
Mvan_4140|M.vanbaalenii_PYR-1 -------------
MSMEG_4779|M.smegmatis_MC2_155 -------------
TH_3070|M.thermoresistible__bu -------------
MMAR_4693|M.marinum_M -------------
MAV_0966|M.avium_104 LDTTTAPSTVRSQ
MUL_0675|M.ulcerans_Agy99 -------------
MAB_0476c|M.abscessus_ATCC_199 -------------
MLBr_00815|M.leprae_Br4923 -------------