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TSPRRIGAPDAKNRVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAVFHRRAEE GLAVLSTALASPQPLWALWRFSTAPEATRLTMEFMGLANHRKALRAEIVYYAERFRQEQNRAIADALQRY GTDFTDVPPVVWTVFATSVSQALVMERALGMDTGHAETFAFCEEWIRRLEGDPLPPLDQRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4140 | - | - | 100% (202) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5169 | - | 1e-35 | 42.86% (189) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4193 | - | 2e-07 | 30.94% (139) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 5e-07 | 24.06% (187) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2518 | - | 1e-103 | 92.93% (198) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 2e-07 | 24.60% (187) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 4e-05 | 30.88% (68) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3397 | - | 2e-07 | 27.22% (180) | hypothetical protein MAB_3397 |
| M. marinum M | MMAR_4693 | - | 4e-76 | 71.13% (194) | transcriptional regulator |
| M. avium 104 | MAV_0966 | - | 6e-77 | 71.35% (192) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4779 | - | 7e-83 | 74.49% (196) | regulatory protein |
| M. thermoresistible (build 8) | TH_3070 | - | 9e-81 | 71.36% (199) | PUTATIVE probable regulatory protein |
| M. ulcerans Agy99 | MUL_0675 | - | 2e-09 | 41.43% (70) | transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0310|M.bovis_AF2122/97 ------------------------MGVP-----------AKKKQQQGERS
Rv0302|M.tuberculosis_H37Rv ------------------------MGVP-----------AKKKQQQGERS
Mvan_4140|M.vanbaalenii_PYR-1 ------------------------MTSP------------RRIGAPDAKN
Mflv_2518|M.gilvum_PYR-GCK ------------------------MAAP------------RRIGAPDAKN
MSMEG_4779|M.smegmatis_MC2_155 ------------------------MASA------------RRIGAPDAKN
TH_3070|M.thermoresistible__bu ------------------------MASG------------RRIGTPDAKN
MMAR_4693|M.marinum_M ------------------------MTSA------------RRIGAPDAKN
MAV_0966|M.avium_104 ------------------------MTSASSGASSGASSGARRIGAPDAKN
MAB_3397|M.abscessus_ATCC_1997 ------------------------MTNLAD----------RPNSARGDRR
MUL_0675|M.ulcerans_Agy99 ------------------------MPTA---------------AERGAQT
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQ----------RSNRLSRDKR
: :
Mb0310|M.bovis_AF2122/97 RESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAM
Rv0302|M.tuberculosis_H37Rv RESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAM
Mvan_4140|M.vanbaalenii_PYR-1 RVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAV
Mflv_2518|M.gilvum_PYR-GCK RVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAV
MSMEG_4779|M.smegmatis_MC2_155 RIVLLDAAEALMIDEGYAAVTSRRVAERAGLKPQLVHYYFRTMDDLFLAV
TH_3070|M.thermoresistible__bu RGVLLDAAERLMLEEGYVAVTSRRVAEKAGLKPQLVHYYFRTMDDLFLEV
MMAR_4693|M.marinum_M RGVLLDTAEELMIEEGYAAVTSRRVASEAGLKPQLVHYYFRTMEELFLEL
MAV_0966|M.avium_104 RGLLLDAAERLMLEEGYAAVTSRRLASRAGLKPQLVHYYFRTMEELFLEV
MAB_3397|M.abscessus_ATCC_1997 RTQLVRAGVELLSEGGWPAVTTRAVAARAGTNPGLIHYHFGGLPGLHCAV
MUL_0675|M.ulcerans_Agy99 RAALMAAAVAVIAERGWGAATTRMVAERAGLPPGLVHYHFASLNDLLIDA
MLBr_00815|M.leprae_Br4923 RGQLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAV
* :: . :: *: *. : .* :: :* :
Mb0310|M.bovis_AF2122/97 MERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLL
Rv0302|M.tuberculosis_H37Rv MERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLL
Mvan_4140|M.vanbaalenii_PYR-1 FHRRAEEGLAVLSTALASPQPL--WALWRFSTAPEATRLTMEFMGLANHR
Mflv_2518|M.gilvum_PYR-GCK FHRRAEEGLAVLSTALRSAQPL--WALWRFSTAPEATRLTMEFMGLANHR
MSMEG_4779|M.smegmatis_MC2_155 FRRRAEEGLAAQARALDSPQPL--WALWRFGIDPSATRLTMEIMGVANHR
TH_3070|M.thermoresistible__bu FRRRAEEGLRAQEEAFASPQPL--WALWRFGTDPAGTRLTMELMGLANHR
MMAR_4693|M.marinum_M FRRRAEEGLRAQAQALQSPKPL--WALWRLGSDPAFARISMEFMALANHR
MAV_0966|M.avium_104 FRRRAEEGLAVQAQALQSDQPL--WAVWRFGTDPAFTQISMEFMALANHR
MAB_3397|M.abscessus_ATCC_1997 ARETCELVISPLVATFLDAPDTR-AALHAMRDALPQAASDDNAMHLAVEL
MUL_0675|M.ulcerans_Agy99 ALQAAREEAAQVLDGLAGDSSS--QGIDRLIDAVSSYDVDDRNQNPAILV
MLBr_00815|M.leprae_Br4923 LERHMNNLVSSVQQALRTTTNN--RQRLHAAVQAFFDFIEHDGQGYRLIF
. .
Mb0310|M.bovis_AF2122/97 SMERSQDPVVAAVVRRVRNTAIARFRDSITHLLPSDIP---PGKADLVVA
Rv0302|M.tuberculosis_H37Rv SMERSQDPAVAAVVRRVRNTAIARFRDSITHLLPSDIP---PGKADLVVA
Mvan_4140|M.vanbaalenii_PYR-1 KALRAEIVYYAERFRQEQNRAIADALQRYG-TDFTDVP---PVVWTVFAT
Mflv_2518|M.gilvum_PYR-GCK KALRAEIVYYAERFRQEQNRAISDALQRYG-MVSDDVP---PVVWTVFAT
MSMEG_4779|M.smegmatis_MC2_155 KALRTEIGRYAERFRDEQTKAMTAALDRYG-VNAADVP---PIVWTFLAT
TH_3070|M.thermoresistible__bu PALRAEMARYAERFREKERDAIAAILERYG-IDASDVP---PVVWAVFAA
MMAR_4693|M.marinum_M KALRAEIAHYAERFRDEQRRVITAALQRYG-VDSQDVP---PVVWTVLMA
MAV_0966|M.avium_104 KDMRAEIAYYAERFRDEQQRAVAAALERYG-VQNKDVP---PVVWTVLMT
MAB_3397|M.abscessus_ATCC_1997 IAGATRDADLGAALGTKLKEVRAEIADHVR-LRHPDWPRRRAAGMATLIV
MUL_0675|M.ulcerans_Agy99 FGEMLLAATRYERLRMGLAEILGDYRSTLRQWLADQGGAIDPEATAALMF
MLBr_00815|M.leprae_Br4923 ENDNITEPRVAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGI
. : .
Mb0310|M.bovis_AF2122/97 ELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET--
Rv0302|M.tuberculosis_H37Rv ELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET--
Mvan_4140|M.vanbaalenii_PYR-1 SVSQALVMERALGMDTGHAETFAFCEEWIRRLEGDPLPPLDQRA------
Mflv_2518|M.gilvum_PYR-GCK SVSQALVMERALGMDTGHAETFAFCEQWIRRFEGEPSPELADGHEMAPAQ
MSMEG_4779|M.smegmatis_MC2_155 SVSRVMVMEQALGMSAGHAEVLEFCEGWLRRIEGEPLPIEAAG-------
TH_3070|M.thermoresistible__bu AVSRMLVMEKAIGMSVGHKEILEFCEDWLRRLEGEPLPASDPDSVASA--
MMAR_4693|M.marinum_M SLSRFLVLEKALGMSGGHAETIELVESYLRRLEGEP--------------
MAV_0966|M.avium_104 SLSRFLVLEQAIGMSSGHAETVQLVESYLRRLEGEPKPIAGAPSSWTVHQ
MAB_3397|M.abscessus_ATCC_1997 AFMDGLVLHHTVDPNIETAEAFSLLESLLDEE------------------
MUL_0675|M.ulcerans_Agy99 AAIDGLVLHRVIDPRLRTLAIRPTLRRLAGLPTAQTDERTPS--------
MLBr_00815|M.leprae_Br4923 SVDCARYWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL----------
Mb0310|M.bovis_AF2122/97 -------------------------
Rv0302|M.tuberculosis_H37Rv -------------------------
Mvan_4140|M.vanbaalenii_PYR-1 -------------------------
Mflv_2518|M.gilvum_PYR-GCK P------------------------
MSMEG_4779|M.smegmatis_MC2_155 -------------------------
TH_3070|M.thermoresistible__bu -------------------------
MMAR_4693|M.marinum_M -------------------------
MAV_0966|M.avium_104 GRIEQSTPLGPSLDTTTAPSTVRSQ
MAB_3397|M.abscessus_ATCC_1997 -------------------------
MUL_0675|M.ulcerans_Agy99 -------------------------
MLBr_00815|M.leprae_Br4923 -------------------------