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NGIEEDVMAPKRPQAAAEKRAEIVAAARRLFIDAGYDATPMSRLAKEAGVAPNTIYWYFPDKDEVLIAVL EAVMADVWPQYEEIASQPIAARLLWIVGKLTEMSRLVTTVHARVEHSAAVAEWHQNFHTITGSLLQFELQ AAGVPAPDAEVMIGVFTVEGLLMHDHDEAQQRAIIDALASRWTTNLPRPSDLGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4449 | - | - | 100% (195) | putative transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1500 | - | 3e-08 | 39.74% (78) | TetR family protein transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_6032 | - | 1e-07 | 22.40% (192) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 1e-08 | 41.54% (65) | transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4672 | - | 2e-07 | 40.74% (54) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 1e-08 | 41.54% (65) | transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 1e-06 | 30.67% (75) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4360c | - | 4e-08 | 28.97% (107) | transcriptional regulator TetR |
| M. marinum M | MMAR_1504 | - | 3e-08 | 37.50% (64) | transcriptional regulatory protein |
| M. avium 104 | MAV_0586 | - | 5e-09 | 31.91% (141) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2602 | - | 2e-11 | 31.41% (156) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0910 | - | 5e-08 | 27.73% (119) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5169 | - | 5e-08 | 26.79% (112) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1561|M.bovis_AF2122/97 ---MSRASARRRRAVSD-----------------EDKSQRRDEILAAAKI
Rv1534|M.tuberculosis_H37Rv ---MSRASARRRRAVSD-----------------EDKSQRRDEILAAAKI
Mflv_4672|M.gilvum_PYR-GCK MSELAKTAPRRGGQPAN-GTGSSGAAR---RGNRLPRDERRGQLLAAASE
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MAB_4360c|M.abscessus_ATCC_199 ---MPRNRQQ------------------------IPRAERESAILEQAVE
TH_2602|M.thermoresistible__bu ---VPRNNQT------------------------VPKAEREAAVLMRAVE
MMAR_1504|M.marinum_M ---MAKETESRPRKRAP-------------RRGRADGELSRARILDAATE
MAV_0586|M.avium_104 ---MAR-----------------------------WEPDARARLVAAALD
MSMEG_4449|M.smegmatis_MC2_155 MNGIEEDVMAPKRP--------------------QAAAEKRAEIVAAARR
Mvan_5169|M.vanbaalenii_PYR-1 ---MAASPKGR-----------------------GSDPNARQRLIEATAR
MUL_0910|M.ulcerans_Agy99 ---MAATRTTAR-----------------------AGGDRRAAIIEAALN
: . :: :
Mb1561|M.bovis_AF2122/97 VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
Rv1534|M.tuberculosis_H37Rv VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
Mflv_4672|M.gilvum_PYR-GCK VFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKVELYLAVLQRHVDNLVS
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
MAB_4360c|M.abscessus_ATCC_199 LFAANGYRGTSVAAVGRAAGVAPAAVHWYYPTKDDLFAAAVTSIFDSVRE
TH_2602|M.thermoresistible__bu LFKAYGYRATSIAAVAKAAGLAPAAVHWYFPTKDDLFAAVLRHMIGETQR
MMAR_1504|M.marinum_M IAAERGYEGTSIALVSAKCGLPASSIYWHFKDKDDLIAAVIERSFGGWLT
MAV_0586|M.avium_104 LFNERGYDQTTVAEIAERAGLTKSTFFRHFPDKRDVLAAGQDAIAQLLRE
MSMEG_4449|M.smegmatis_MC2_155 LFIDAGYDATPMSRLAKEAGVAPNTIYWYFPDKDEVLIAVLEAVMADVWP
Mvan_5169|M.vanbaalenii_PYR-1 VMRDEGYAAATSRRVAAEAGVKQALVYYYFPTMDDLFVEVLRAGGESALE
MUL_0910|M.ulcerans_Agy99 RFLSQGIDATALRQIQRDAGVSNGSFFHHFPSKEVLTAAVYVDCVTRYQQ
* : : .*: .. :: :
Mb1561|M.bovis_AF2122/97 HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLF-RDAYAL
Rv1534|M.tuberculosis_H37Rv HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLF-RDAYAL
Mflv_4672|M.gilvum_PYR-GCK GVRQALR-----TTTDNRQRVRAAVQAFFDFIEHDSQGYRLIF-ENDYVT
MLBr_00815|M.leprae_Br4923 SVQQALR-----TTTNNRQRLHAAVQAFFDFIEHDGQGYRLIF-ENDNIT
MAB_4360c|M.abscessus_ATCC_199 RVEADPS-----INGEPYGELVALLSESQSYRNLHREAYERME-GSE---
TH_2602|M.thermoresistible__bu RIESDPD-----VAGDPYLELTTFLDLLAPYRSLHREAYERMD-DSA---
MMAR_1504|M.marinum_M AWQIPEGQ----SGDETIQGAEQFVGLATQTAKALLDSPDFIR-LGLMLA
MAV_0586|M.avium_104 GIAAAPA------DATPLALVCSGLKSAAAAFTPFNKELAPRL-RAAIAA
MSMEG_4449|M.smegmatis_MC2_155 QYEEIAS-------QPIAARLLWIVGKLTEMSRLVTTVHARVE-HSA---
Mvan_5169|M.vanbaalenii_PYR-1 HMRAALT------NDDPLHALWLINNDAS--RTGLNTEFMALA-NHRKAI
MUL_0910|M.ulcerans_Agy99 ALLKDLVR-----YPDAESAVRGIVGMHLSWCTEHPEMARFLITMTEPAV
Mb1561|M.bovis_AF2122/97 GGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQ
Rv1534|M.tuberculosis_H37Rv GGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQ
Mflv_4672|M.gilvum_PYR-GCK EPQVAAQVKVATESCTDAVFDLISHDSG---LEPHRARMIAVGLVSISVD
MLBr_00815|M.leprae_Br4923 EPRVAAQVRVATESCIDAVFALISADSR---LDPHRARMVAVGLVGISVD
MAB_4360c|M.abscessus_ATCC_199 --AVRAAYEHVQSWLDERLLAAIAQRNR--------GGVNSELVADAAHV
TH_2602|M.thermoresistible__bu --ALHAVYTETHDWLQERLMAVVSPELP--------ADVDPAHVVDVANF
MMAR_1504|M.marinum_M LERRPAEPRARTMFLEVRAQAFGQLIGNFGRFMPGLTEAQIYQLATYAMA
MAV_0586|M.avium_104 SAELQERNALKQIGLALAVSEALQARGVP--------EPAAALAAELGAL
MSMEG_4449|M.smegmatis_MC2_155 --AVAEWHQNFHTITGSLLQFELQAAGVP----------APDAEVMIGVF
Mvan_5169|M.vanbaalenii_PYR-1 RVELRAYAERVRDIETAAVTVALRANGVD-------LDEHPPVVISMLIA
MUL_0910|M.ulcerans_Agy99 HRAAADELRSHNERFATAVQTWWRPHAHYGALRPLSPAHSQALWLGPAQE
Mb1561|M.bovis_AF2122/97 LAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Rv1534|M.tuberculosis_H37Rv LAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Mflv_4672|M.gilvum_PYR-GCK SARYWLNNERPIDKDDAVEGTVQFIWGGLSHVPLTRS---------
MLBr_00815|M.leprae_Br4923 CARYWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL---------
MAB_4360c|M.abscessus_ATCC_199 LFEGILISSRRLDRS--AGELIGLVVDALVAVAVTKRGS-------
TH_2602|M.thermoresistible__bu FFEGLLVSVRRVDKP--AAHYIDLVTSAVVGAAAARPRSGQQHPA-
MMAR_1504|M.marinum_M GADGLFIAKEIDGDAVNLIEMFELHGRALYDAARRFIEDGATR---
MAV_0586|M.avium_104 AFKTAYARWAEPDESGDLGDMACQALRELHAAAADLG---------
MSMEG_4449|M.smegmatis_MC2_155 TVEGLLMHDHDEAQQRAIIDALASRWTTNLPRPSDLGR--------
Mvan_5169|M.vanbaalenii_PYR-1 QVARSLCNEVAVGVTLGHDEMRAYVERQLKLLAPVTGG--------
MUL_0910|M.ulcerans_Agy99 LVRAWLLG--NLAAPPNAADAAILADAAWLCLRAGPAG--------