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VTWLGALRRLSASATAEEDLSHVLAEIAETARSLLGFDFCGVLLPDEQSRHLRVRGASGLSSDYVDRVNS DRPLVLHGGSPSSRAFHTAEAVAIRDVTAEPGFELWAGIANEQGYRSMIAVPLVARGEVLGTLNGYYGAV HTYTRFEVERMTLLANHAAIAVSSARRLDELRALTASLRRQRDALTRSEQIHDRLLAVTLRSGGLDGIAA VLQGLIGRPILIDDIQHEVLACSVVTTDFPDTTWRAAAEAGTGSSPVPVGQFDGTTYLASAVHLGDEVAA RIWFPETSIDLDPIMVRAVEHASIVTALELLRCQTAAEVEQRLRGELLSDVLSSGAALSDRLLDRAHRLG HDLTVPHIAIVGAFTGLDPVAERRAYERSLVLLAKESAAHRPKPVVAMHAGTIVMLWPAQDAADAAGAGE VVRQAMRAASADRQATVAVGPGDVASHRESYQTAKGALQVAIMSGRTAAVVGLDDLGIAGLLLRINDPAA LSTFARRTLAPILDYDHAHRTELLVTLRAYLECRQERSATATRLVIHPNTVAQRLRRIESLCSVTLTDPA VILQFSAALTVYDIAALD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6492 | - | - | 100% (578) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4044 | - | 3e-61 | 31.09% (595) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 7e-17 | 27.25% (400) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 4e-09 | 27.20% (239) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_0356 | - | 4e-13 | 23.08% (416) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv2242 | - | 4e-09 | 27.20% (239) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 4e-08 | 25.97% (231) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0291 | - | 1e-19 | 23.67% (469) | hypothetical protein MAB_0291 |
| M. marinum M | MMAR_2601 | - | 5e-09 | 26.18% (275) | hypothetical protein MMAR_2601 |
| M. avium 104 | MAV_1987 | - | 1e-13 | 27.63% (304) | putative DNA-binding protein |
| M. thermoresistible (build 8) | TH_2137 | - | 2e-13 | 24.30% (395) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_1307 | - | 8e-08 | 24.46% (233) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 1e-103 | 41.03% (580) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2266|M.bovis_AF2122/97 -----------------------------------MNDNQLAPVAR---P
Rv2242|M.tuberculosis_H37Rv -----------------------------------MNDNQLAPVAR---P
MLBr_01652|M.leprae_Br4923 -----------------------------------MNHNHFVPAP---PR
MUL_1307|M.ulcerans_Agy99 -----------------------------------MNNNQFSAIARLGSA
MSMEG_6492|M.smegmatis_MC2_155 ------------MTWLGALRRLSASATAEEDLSHVLAEIAETARSLLGFD
Mvan_5765|M.vanbaalenii_PYR-1 MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVLDRVARTACTLLGYD
MAV_1987|M.avium_104 ---------------MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIH
TH_2137|M.thermoresistible__bu ---------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALH
Mflv_0356|M.gilvum_PYR-GCK -----MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADLSTL
MAB_0291|M.abscessus_ATCC_1997 MTDIQVGGAREGVPSAGPSALSVLRLLASGTAPDVFEARLKEMARESSPP
MMAR_2601|M.marinum_M -------------------------------------------MELQWPP
Mb2266|M.bovis_AF2122/97 RSPLELLDTVPDSLLRR---------------------------------
Rv2242|M.tuberculosis_H37Rv RSPLELLDTVPDSLLRR---------------------------------
MLBr_01652|M.leprae_Br4923 RLPLELLDTVPDSLLRR---------------------------------
MUL_1307|M.ulcerans_Agy99 RSPLELLETVPDSLLRR---------------------------------
MSMEG_6492|M.smegmatis_MC2_155 FCGVLLPDEQSRHLRVRGASGLSSDYVDRVNSDRPLVLHGG----SPSSR
Mvan_5765|M.vanbaalenii_PYR-1 FCAVFLPDEQGRALTIEGSYGLSADYIAQVNANRPILLDVRGDHEAPTSL
MAV_1987|M.avium_104 ETPEDRP-VVGDVLLAVGAGSLDEAVRWAASARAAVVVLRDDE---TPMT
TH_2137|M.thermoresistible__bu ENAGGLR-VTGDVLLAVGAESVAEAVRWAETAQAVVVLTRAG----PDAS
Mflv_0356|M.gilvum_PYR-GCK LQGGELVLTTGAAMARSPRTYLRGLAEAGAVGVVVEVG------------
MAB_0291|M.abscessus_ATCC_1997 WSAADLHRARGYAERIYGLIEGQNQREARLSNLVGIGIDLLGCHGLDEAS
MMAR_2601|M.marinum_M ACDAEAQRVWQRVLVPL---------------------------------
Mb2266|M.bovis_AF2122/97 ---------LKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVVQT-
Rv2242|M.tuberculosis_H37Rv ---------LKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVVQT-
MLBr_01652|M.leprae_Br4923 ---------LKQYSGRLATEAVTAMQERLPFFADLEASQRASVTLVVQT-
MUL_1307|M.ulcerans_Agy99 ---------LKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVVQT-
MSMEG_6492|M.smegmatis_MC2_155 AFHTAEAVAIRDVTAEPGFELWAGIANEQGYRSMIAVPLVARGEVLGTLN
Mvan_5765|M.vanbaalenii_PYR-1 AYRTGDVVTLEDIELVPDFT-WGGVAQEQGYRALISAPLRRPGTVVGALN
MAV_1987|M.avium_104 FDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETESGRGPTDLFALAD
TH_2137|M.thermoresistible__bu RSCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETESGRGPTDLFALAD
Mflv_0356|M.gilvum_PYR-GCK AVVPEVPPGVGGIAEQLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVE
MAB_0291|M.abscessus_ATCC_1997 TTLVKRARIMLDADFSFISVRDDSEPETRHHVRYVDGPTTAINHGLYFPI
MMAR_2601|M.marinum_M ---------AAEMGTQAADLAQRAVARMQAEVPQLFPDEQTVKENLVSTE
Mb2266|M.bovis_AF2122/97 ----AVVNFVEWMHDPHSDVGYTAQAFELVP----QDLTRRIALRQTVDM
Rv2242|M.tuberculosis_H37Rv ----AVVNFVEWMHDPHSDVGYTAQAFELVP----QDLTRRIALRQTVDM
MLBr_01652|M.leprae_Br4923 ----AVVNFVQWMQNPHSDVSYTAQAFELVP----QDLARRIALRHTVDM
MUL_1307|M.ulcerans_Agy99 ----AVVNFAEWMQNPRSDVSYTAQAFELVP----QDLTRRIALRHTVDM
MSMEG_6492|M.smegmatis_MC2_155 GYYGAVHTYTRFEVERMTLLANHAAIAVSSARRLDELRALTASLRRQRDA
Mvan_5765|M.vanbaalenii_PYR-1 GYRTAPHRFDRAEVSLVTTLATQVAIALGTA----QLRAKEQATIR---E
MAV_1987|M.avium_104 SLADGIGNPVVIQDRHLGVLAYS-RLAQADP-----ALVETVLQRQTPEP
TH_2137|M.thermoresistible__bu NLADAVGGPVTIEDRMSRVLAYSQRQQHADP-----ARAQTILARQAPEP
Mflv_0356|M.gilvum_PYR-GCK FDRRVHETFTDLSMKRASLSGIVDAAAKLLG---EHVVLEDLSHQALVAS
MAB_0291|M.abscessus_ATCC_1997 GDDVGLVSLYRPGQGPVWTADYPSDTRFSRASDGDAAMRSEGVHSLMVMP
MMAR_2601|M.marinum_M ASLRQLAQVIEAGADPRQVELPPSTQAIARA-----AVPRQVALADLLRF
Mb2266|M.bovis_AF2122/97 VRVTMEFFEEVVPLLARSE-------------------------------
Rv2242|M.tuberculosis_H37Rv VRVTMEFFEEVVPLLARSE-------------------------------
MLBr_01652|M.leprae_Br4923 VRVTMEFFEEVVPLLARSE-------------------------------
MUL_1307|M.ulcerans_Agy99 VRVTMEFFEEVVPLLARSE-------------------------------
MSMEG_6492|M.smegmatis_MC2_155 LTRSEQIHDRLLAVTLRSGGLDGIAAVLQGLIGRPILIDDIQHEVLACSV
Mvan_5765|M.vanbaalenii_PYR-1 LRRAEEVHTLLTATALRGEGVSGVAAALSELLGRGVLIEDVYDEPLT---
MAV_1987|M.avium_104 LRALLEARGVFAHLQVADEPLFVAEDAERGLSGR----------------
TH_2137|M.thermoresistible__bu LRRLFEQLGVSEHLAAGDDPLFIAARPGHDLTGR----------------
Mflv_0356|M.gilvum_PYR-GCK TGIPADLLTDWARRSRRSPGGGAGAEPWSATDVG----------------
MAB_0291|M.abscessus_ATCC_1997 MEHEDQHFGNLYVGSRTVRSFSAAERSLFASLCSFAGIALARASEFSSN-
MMAR_2601|M.marinum_M YRLAQELVWQWMFGRITADS------------------------------
:
Mb2266|M.bovis_AF2122/97 --------------------------------------------------
Rv2242|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01652|M.leprae_Br4923 --------------------------------------------------
MUL_1307|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6492|M.smegmatis_MC2_155 VTTDFPDTTWRAAAEAGTGSSPVPVGQFDGTTYLASAVHLGDEVAARIWF
Mvan_5765|M.vanbaalenii_PYR-1 ------DANWTAPDPR-------------AQDHVVATVTLDGSPVARIHV
MAV_1987|M.avium_104 ---------------------------------MVVAVRAGAELIGSVWV
TH_2137|M.thermoresistible__bu ---------------------------------TVIAVRAGRELLGSVWV
Mflv_0356|M.gilvum_PYR-GCK ----------------------------------------PRFEQWGRLV
MAB_0291|M.abscessus_ATCC_1997 --------------------TEQISALERRLELRSILLDTGAGPGGMDGF
MMAR_2601|M.marinum_M --------------------------------------------------
Mb2266|M.bovis_AF2122/97 ----EQLTALTVGILKYSRDLAFTAATAYADA------AEARGTWDSRME
Rv2242|M.tuberculosis_H37Rv ----EQLTALTVGILKYSRDLAFTAATAYADA------AEARGTWDSRME
MLBr_01652|M.leprae_Br4923 ----EQLTALTVGILKYSRDLAFTAATAYADA------AEARGTWDSRME
MUL_1307|M.ulcerans_Agy99 ----EQLTALTVGILKYSRDLAFTAASAYADA------AEARGTWDSRME
MSMEG_6492|M.smegmatis_MC2_155 PETSIDLDPIMVRAVEHASIVTALELLRCQTA------AEVEQRLRGELL
Mvan_5765|M.vanbaalenii_PYR-1 AASDSELSRLDVRAVEHATVVTALELLRARTA------AEVEQRIRGSLV
MAV_1987|M.avium_104 ACEAP-LQPAALRALADGARTVALHLLRSRAS------ADLERQVESELV
TH_2137|M.thermoresistible__bu VTPEP-LDDGRRRALADGARTVALHLLRSRAS------ADLERQVESDLV
Mflv_0356|M.gilvum_PYR-GCK VPYAPADATRAATVLERAAAALAMHRMVEQNR------TGLQHQAQSGLI
MAB_0291|M.abscessus_ATCC_1997 VLTAGEQLGVAMRVTGHDGSEIASYKWEPDTQNILTTALTVGDDYHGELS
MMAR_2601|M.marinum_M -RDAAEQAKAVELATGWIFGYVDAALMRAERAYD----VEREAWLRGATV
.
Mb2266|M.bovis_AF2122/97 ASVVDAVVRGDT---GPELLSRAAALN-WDTTAPATVLVGTPAPGPNGSN
Rv2242|M.tuberculosis_H37Rv ASVVDAVVRGDT---GPELLSRAAALN-WDTTAPATVLVGTPAPGPNGSN
MLBr_01652|M.leprae_Br4923 ASVVDAVVRGDT---GPELLSRAAALN-WDTTAPATVVVGTPTPNHDGPN
MUL_1307|M.ulcerans_Agy99 ASVVDAVVRGDT---GPELLSRAAALN-WDTTAPATVVVGTPASARDGSD
MSMEG_6492|M.smegmatis_MC2_155 SDVLS--SGAAL---SDRLLDRAHRLG-HDLTVPHIAIVGAFTGLDPVAE
Mvan_5765|M.vanbaalenii_PYR-1 ADLLS--SDDAG---IPALLDRARRLG-WDLSG-----VQSLIALRPADE
MAV_1987|M.avium_104 IRLLEGTADAAT---VASRLDLAHNGL-RVVAVQAFVGADRDAPLLLAFE
TH_2137|M.thermoresistible__bu LRLLEGTSDAAG---AAARLGLPQEAL-RIIAVRARSGVDRQGPLLLAFE
Mflv_0356|M.gilvum_PYR-GCK DDVLRGRVVDDR---DAAARAQALGLRSNAQYLPVVVRVARPAEIDDPVA
MAB_0291|M.abscessus_ATCC_1997 VASLDDQPVSVYPLKIEDLATTAAVVMCGDNRMSLSVSQLRNDLLHDVLD
MMAR_2601|M.marinum_M ARASAIDDIVAE---RERDPQRASKRLRYDVSTQHLAVIAWIDRLPEDGD
.
Mb2266|M.bovis_AF2122/97 SDGDSERASQDVRDTAARHGRAALTDVHG--------------TWLVAIV
Rv2242|M.tuberculosis_H37Rv SDGDSERASQDVRDTAARHGRAALTDVHG--------------TWLVAIV
MLBr_01652|M.leprae_Br4923 GQVSSERASQEVREIAARHGRAALTDVHG--------------TWLVAII
MUL_1307|M.ulcerans_Agy99 G---SERAIQDVRDAAAQHGRAALTDVHG--------------TWLVAIV
MSMEG_6492|M.smegmatis_MC2_155 RRAYERSLVLLAK-ESAAHRPKPVVAMHAGTIV---------MLWPAQDA
Mvan_5765|M.vanbaalenii_PYR-1 R-----TLAAADR-FTAGVTPHPLVALHRGDLV---------FVWPA-DT
MAV_1987|M.avium_104 RATTGFGWSRPGRSALAGNSVYAVLPADEASTA---------RRWVG-AL
TH_2137|M.thermoresistible__bu HATTGFGWSRAGRSALAGDTVYTVLPADHAATA---------RRWVE-GL
Mflv_0356|M.gilvum_PYR-GCK GHRRNVAVLDAVAHTVNACGHTGLFSLRGDGEVGAVLSLKDSRTRSVDQA
MAB_0291|M.abscessus_ATCC_1997 YRQRDSRLVQIYARRLALDLNQPHVVVIVRPERGGLDRASLWSASFASRV
MMAR_2601|M.marinum_M AQPLLGRVVADLARATAAQSTLVHTLG---------------SLAVAGWV
Mb2266|M.bovis_AF2122/97 SGQLSPTEKFLKDLLAAFADA--------------PVVIGPTAPMLTAAH
Rv2242|M.tuberculosis_H37Rv SGQLSPTEKFLKDLLAAFADA--------------PVVIGPTAPMLTAAH
MLBr_01652|M.leprae_Br4923 SGQLAPTDKFFSDLLHAFSDG--------------PVVIGPTAPMLTAAY
MUL_1307|M.ulcerans_Agy99 SGHLSPTDKVFKDLLEAFSDG--------------PVVIGPTAPMLTAAY
MSMEG_6492|M.smegmatis_MC2_155 ADAAGAGEVVRQAMRAASADR--------------QATVAVGPGDVASHR
Mvan_5765|M.vanbaalenii_PYR-1 GPAVPVAHRLLEFLNAATIPE--------------APTAAVSRQAAAREL
MAV_1987|M.avium_104 RAALPERLTMIAGISGVAEVG--------------DLAAARQEADECLAL
TH_2137|M.thermoresistible__bu QAALPSEVTVSAGISGIADHT--------------ELPDARREADECLAL
Mflv_0356|M.gilvum_PYR-GCK LGALARRIHTEIRRVDGSDRV--------------VVTLGPSARNVTDAI
MAB_0291|M.abscessus_ATCC_1997 GGLRATQDEVVVLLIPGSDAGRIAQTVWDETTAHLRMPVTVSSAGPSERI
MMAR_2601|M.marinum_M SGRGSLSVRDAQDGVAGAPAG-----------------VRLAVGDPARGL
Mb2266|M.bovis_AF2122/97 RSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALH-----
Rv2242|M.tuberculosis_H37Rv RSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALH-----
MLBr_01652|M.leprae_Br4923 HSASEAVSGMNAVAGWSGAPRPVQARELLPERALMGDASAIVALH-----
MUL_1307|M.ulcerans_Agy99 HSASEAISGMNAVAGWRGASRPVLARELLPERALMGDASAIVALH-----
MSMEG_6492|M.smegmatis_MC2_155 -ESYQTAKGALQVAIMSGRTAAVVGLDDLGIAGLLLRINDPAALSTFARR
Mvan_5765|M.vanbaalenii_PYR-1 PGIFRTVRGALDLAGDR-DTATVIDLDEPTIDHLLLQLDDPARLRDFASA
MAV_1987|M.avium_104 HEMSPAAPPP--------------AYDESWDDILLQRLRAAARSGRAPTR
TH_2137|M.thermoresistible__bu HDALHDARPDTGSPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPSR
Mflv_0356|M.gilvum_PYR-GCK AGLAEAIDTAEVALSLRGDVRDFYRTSDIRLRGLISLLRDDPRIRRFAET
MAB_0291|M.abscessus_ATCC_1997 ESIEDTYQDAMRCLDAMSALGALGTAAAAHELGFLGVLLSRHQDVEGFVR
MMAR_2601|M.marinum_M KGFRRSYLEATYAHRVASLMGRRADAVTLYRGVAVAALASADRDHAVFFA
:
Mb2266|M.bovis_AF2122/97 ---TDVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLK
Rv2242|M.tuberculosis_H37Rv ---TDVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLK
MLBr_01652|M.leprae_Br4923 ---TDVMLPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLK
MUL_1307|M.ulcerans_Agy99 ---TDVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLK
MSMEG_6492|M.smegmatis_MC2_155 -TLAPILDYDHAHRTELLVTLRAYLECRQERSATATRLVIHPNTVAQRLR
Mvan_5765|M.vanbaalenii_PYR-1 -VLGPAVDYDRTRSTELLHTVRVLLEHGLDRRAAAQALHLHPNTVAQRVR
MAV_1987|M.avium_104 GPVADLGRHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLR
TH_2137|M.thermoresistible__bu GPIAALHEHDLRHATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRLR
Mflv_0356|M.gilvum_PYR-GCK -ELRALLAHDAGAEPSNISVLREYLRLAGNKSALAERLHMSRPALYKRLR
MAB_0291|M.abscessus_ATCC_1997 SMVGPVIDYDEDRDTDLLQTLDVYFSVGASPTRAAKILHTHPNTVVRRLD
MMAR_2601|M.marinum_M TRVLGGLAAADEDTYRIATTLAVFLAENRSRTRAAKRLNVHPNTVSYRVN
.: : . * :: *:
Mb2266|M.bovis_AF2122/97 RITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH----------------
Rv2242|M.tuberculosis_H37Rv RITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH----------------
MLBr_01652|M.leprae_Br4923 RITDFTGHDPTLPRDAYVLRVAATVGKLNYPTHH----------------
MUL_1307|M.ulcerans_Agy99 RITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVR
MSMEG_6492|M.smegmatis_MC2_155 RIESLCSVTLTDPAVILQFSAALTVYDIAALD------------------
Mvan_5765|M.vanbaalenii_PYR-1 RLEELTGLSLARPADLLRLTAALTVSRIASLS------------------
MAV_1987|M.avium_104 KMAEITNLSLDDSKKRLAMMIELAAIHTD---------------------
TH_2137|M.thermoresistible__bu KMTAVTQLDLQDPDKRLAMMIELAAIEGPPILSG----------------
Mflv_0356|M.gilvum_PYR-GCK GIEDALGVDLDDGESMTSLHVAVMVLDSLTGSG-----------------
MAB_0291|M.abscessus_ATCC_1997 RVNELLGDGWQDAERLLDTQLAIKLWKVRGSLLTRQTG------------
MMAR_2601|M.marinum_M QAEAILGRAVD--ADVLELSVALALLPVLPGLAQGRSGEL----------
Mb2266|M.bovis_AF2122/97 ------
Rv2242|M.tuberculosis_H37Rv ------
MLBr_01652|M.leprae_Br4923 ------
MUL_1307|M.ulcerans_Agy99 RGTEGP
MSMEG_6492|M.smegmatis_MC2_155 ------
Mvan_5765|M.vanbaalenii_PYR-1 ------
MAV_1987|M.avium_104 ------
TH_2137|M.thermoresistible__bu ------
Mflv_0356|M.gilvum_PYR-GCK ------
MAB_0291|M.abscessus_ATCC_1997 ------
MMAR_2601|M.marinum_M ------