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MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVLDRVARTACTLLGYDFCAVFLPDEQGRALTIEGSY GLSADYIAQVNANRPILLDVRGDHEAPTSLAYRTGDVVTLEDIELVPDFTWGGVAQEQGYRALISAPLRR PGTVVGALNGYRTAPHRFDRAEVSLVTTLATQVAIALGTAQLRAKEQATIRELRRAEEVHTLLTATALRG EGVSGVAAALSELLGRGVLIEDVYDEPLTDANWTAPDPRAQDHVVATVTLDGSPVARIHVAASDSELSRL DVRAVEHATVVTALELLRARTAAEVEQRIRGSLVADLLSSDDAGIPALLDRARRLGWDLSGVQSLIALRP ADERTLAAADRFTAGVTPHPLVALHRGDLVFVWPADTGPAVPVAHRLLEFLNAATIPEAPTAAVSRQAAA RELPGIFRTVRGALDLAGDRDTATVIDLDEPTIDHLLLQLDDPARLRDFASAVLGPAVDYDRTRSTELLH TVRVLLEHGLDRRAAAQALHLHPNTVAQRVRRLEELTGLSLARPADLLRLTAALTVSRIASLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | - | 100% (553) | transcriptional regulator, CdaR |
| M. vanbaalenii PYR-1 | Mvan_1604 | - | 8e-20 | 24.71% (603) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_4407 | - | 7e-16 | 24.63% (471) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 5e-09 | 24.83% (298) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_1946 | - | 2e-10 | 27.50% (280) | putative DNA-binding protein |
| M. tuberculosis H37Rv | Rv2242 | - | 5e-09 | 24.83% (298) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 3e-08 | 23.73% (295) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0291 | - | 4e-17 | 23.10% (407) | hypothetical protein MAB_0291 |
| M. marinum M | MMAR_3335 | - | 7e-10 | 25.00% (292) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_1987 | - | 3e-15 | 28.42% (373) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 1e-103 | 41.03% (580) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_2137 | - | 6e-10 | 29.51% (288) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_1307 | - | 3e-10 | 25.00% (292) | hypothetical protein MUL_1307 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5765|M.vanbaalenii_PYR-1 ------------------------MSSRTLSTALPFEHWLSALAEIGEAV
MSMEG_6492|M.smegmatis_MC2_155 ------------------------------------MTWLGALRRLSASA
MMAR_3335|M.marinum_M -------------------------------------------------M
MUL_1307|M.ulcerans_Agy99 -------------------------------------------------M
Mb2266|M.bovis_AF2122/97 -------------------------------------------------M
Rv2242|M.tuberculosis_H37Rv -------------------------------------------------M
MLBr_01652|M.leprae_Br4923 -------------------------------------------------M
MAV_1987|M.avium_104 ------------------------------------MITLDRLVNVLGGY
TH_2137|M.thermoresistible__bu ------------------------------------VVTLDRLVNVLGSY
Mflv_1946|M.gilvum_PYR-GCK ------------------------MHTAGPGVASTFVITLDRLINVLGGY
MAB_0291|M.abscessus_ATCC_1997 MTDIQVGGAREGVPSAGPSALSVLRLLASGTAPDVFEARLKEMARESSPP
Mvan_5765|M.vanbaalenii_PYR-1 GGDEPVAEVLDRVARTACTLLGYDFCAVFLPDEQGRALTIEGSYGLSADY
MSMEG_6492|M.smegmatis_MC2_155 TAEEDLSHVLAEIAETARSLLGFDFCGVLLPDEQSRHLRVRGASGLSSDY
MMAR_3335|M.marinum_M NDNQFSAIARLGSARSPLELLET------VPDSLLRRLKQYSGR-LATEA
MUL_1307|M.ulcerans_Agy99 NNNQFSAIARLGSARSPLELLET------VPDSLLRRLKQYSGR-LATEA
Mb2266|M.bovis_AF2122/97 NDNQLAPVARP---RSPLELLDT------VPDSLLRRLKQYSGR-LATEA
Rv2242|M.tuberculosis_H37Rv NDNQLAPVARP---RSPLELLDT------VPDSLLRRLKQYSGR-LATEA
MLBr_01652|M.leprae_Br4923 NHNHFVPAPPR---RLPLELLDT------VPDSLLRRLKQYSGR-LATEA
MAV_1987|M.avium_104 GVRLRWSSVPRSTELRSVVIHETP-----EDRPVVGDVLLAVGAGSLDEA
TH_2137|M.thermoresistible__bu GVRLQFCPVPRSTEVRSVALHENA-----GGLRVTGDVLLAVGAESVAEA
Mflv_1946|M.gilvum_PYR-GCK GARWQGGSADRQTELRSVVLPEVV-----DGRTVSGDVLLAIGATTTAEA
MAB_0291|M.abscessus_ATCC_1997 WSAADLHRARGYAERIYGLIEGQNQREARLSNLVGIGIDLLGCHGLDEAS
: :
Mvan_5765|M.vanbaalenii_PYR-1 IAQVNANRPILLDVRGDHEAPTSLAYRTGDVVTLEDIELVPD-----FT-
MSMEG_6492|M.smegmatis_MC2_155 VDRVNSDRPLVLHGG----SPSSRAFHTAEAVAIRDVTAEPG-----FEL
MMAR_3335|M.marinum_M VSAMQERLPFFADLEASQRASVALVVQTAVVN------------------
MUL_1307|M.ulcerans_Agy99 VSAMQERLPFFADLEASQRASVALVVQTAVVN------------------
Mb2266|M.bovis_AF2122/97 VSAMQERLPFFADLEASQRASVALVVQTAVVN------------------
Rv2242|M.tuberculosis_H37Rv VSAMQERLPFFADLEASQRASVALVVQTAVVN------------------
MLBr_01652|M.leprae_Br4923 VTAMQERLPFFADLEASQRASVTLVVQTAVVN------------------
MAV_1987|M.avium_104 VRWAASARAAVVVLRDDETPMTFDGVTDVGAVLVIDPTVS----------
TH_2137|M.thermoresistible__bu VRWAETAQAVVVLTRAG-PDASRSCSDGAVAVLTVEPEVS----------
Mflv_1946|M.gilvum_PYR-GCK VRWARAARAVVVLTRGGGDPEP---DTAGVAVLVVDSAMP----------
MAB_0291|M.abscessus_ATCC_1997 TTLVKRARIMLDADFSFISVRDDSEPETRHHVRYVDGPTTAINHGLYFPI
.
Mvan_5765|M.vanbaalenii_PYR-1 WGGVAQEQGYRALISAPLRRPGTVVGALNGYRTAPHRFDRAEVSLVTTLA
MSMEG_6492|M.smegmatis_MC2_155 WAGIANEQGYRSMIAVPLVARGEVLGTLNGYYGAVHTYTRFEVERMTLLA
MMAR_3335|M.marinum_M ---------------------------FAEWMQNPRSDVSYTAQAFELVP
MUL_1307|M.ulcerans_Agy99 ---------------------------FAEWMQNPRSDVSYTAQAFELVP
Mb2266|M.bovis_AF2122/97 ---------------------------FVEWMHDPHSDVGYTAQAFELVP
Rv2242|M.tuberculosis_H37Rv ---------------------------FVEWMHDPHSDVGYTAQAFELVP
MLBr_01652|M.leprae_Br4923 ---------------------------FVQWMQNPHSDVSYTAQAFELVP
MAV_1987|M.avium_104 -------------------WSAVAAVVYGLVLEGRETESGRGPTDLFALA
TH_2137|M.thermoresistible__bu -------------------WSELAAVVYGLVLEGRETESGRGPTDLFALA
Mflv_1946|M.gilvum_PYR-GCK -------------------WSEFAAIVYGLVMEGRETESGRGPTDLFALA
MAB_0291|M.abscessus_ATCC_1997 GDDVGLVSLYRPGQGPVWTADYPSDTRFSRASDGDAAMRSEGVHSLMVMP
. :.
Mvan_5765|M.vanbaalenii_PYR-1 TQVAIALGTA------QLRAKEQATIR---ELRRAEEVHTLLTATALRGE
MSMEG_6492|M.smegmatis_MC2_155 NHAAIAVSSARRLD--ELRALTASLRRQRDALTRSEQIHDRLLAVTLRSG
MMAR_3335|M.marinum_M QDLTRRIALRHTVD--MVRVTMEFFEEVVPLLARSEEQLTALTVGILKYS
MUL_1307|M.ulcerans_Agy99 QDLTRRIALRHTVD--MVRVTMEFFEEVVPLLARSEEQLTALTVGILKYS
Mb2266|M.bovis_AF2122/97 QDLTRRIALRQTVD--MVRVTMEFFEEVVPLLARSEEQLTALTVGILKYS
Rv2242|M.tuberculosis_H37Rv QDLTRRIALRQTVD--MVRVTMEFFEEVVPLLARSEEQLTALTVGILKYS
MLBr_01652|M.leprae_Br4923 QDLARRIALRHTVD--MVRVTMEFFEEVVPLLARSEEQLTALTVGILKYS
MAV_1987|M.avium_104 DSLADGIGNPVVIQDRHLGVLAYS-RLAQADPALVETVLQRQTPEPLRAL
TH_2137|M.thermoresistible__bu DNLADAVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLRRL
Mflv_1946|M.gilvum_PYR-GCK DNLSNAVGGAVVIEDRASQVLAFSRGQLDADPARAKTILARQAPPSLRAV
MAB_0291|M.abscessus_ATCC_1997 MEHEDQHFGNLYVGSRTVRSFSAAERSLFASLCSFAG-IALARASEFSSN
:
Mvan_5765|M.vanbaalenii_PYR-1 GVSGVAAALSELLGRGVLIEDVYDEPLT---------DANWTAPDPR---
MSMEG_6492|M.smegmatis_MC2_155 GLDGIAAVLQGLIGRPILIDDIQHEVLACSVVTTDFPDTTWRAAAEAGTG
MMAR_3335|M.marinum_M --------------------------------------------------
MUL_1307|M.ulcerans_Agy99 --------------------------------------------------
Mb2266|M.bovis_AF2122/97 --------------------------------------------------
Rv2242|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01652|M.leprae_Br4923 --------------------------------------------------
MAV_1987|M.avium_104 LEARGVFAHLQVADEPLFVAEDAERGLSG---------------------
TH_2137|M.thermoresistible__bu FEQLGVSEHLAAGDDPLFIAARPGHDLTG---------------------
Mflv_1946|M.gilvum_PYR-GCK FDAHGVFAHLAVSDEPLFVPGDDAVGLTG---------------------
MAB_0291|M.abscessus_ATCC_1997 TEQISALERRLELRSILLDTGAGPGGMDGFVLTAGEQLGVAMRVTGHDGS
Mvan_5765|M.vanbaalenii_PYR-1 ----------AQDHVVATVTLDGSPVARIHVAASDSELSRLDVRAVEHAT
MSMEG_6492|M.smegmatis_MC2_155 SSPVPVGQFDGTTYLASAVHLGDEVAARIWFPETSIDLDPIMVRAVEHAS
MMAR_3335|M.marinum_M -------------------------------------------RDLAFTA
MUL_1307|M.ulcerans_Agy99 -------------------------------------------RDLAFTA
Mb2266|M.bovis_AF2122/97 -------------------------------------------RDLAFTA
Rv2242|M.tuberculosis_H37Rv -------------------------------------------RDLAFTA
MLBr_01652|M.leprae_Br4923 -------------------------------------------RDLAFTA
MAV_1987|M.avium_104 --------------RMVVAVRAGAELIGSVWVACEAPLQPAALRALADGA
TH_2137|M.thermoresistible__bu --------------RTVIAVRAGRELLGSVWVVTPEPLDDGRRRALADGA
Mflv_1946|M.gilvum_PYR-GCK --------------RMVVAARAGRELLGSVWVAVPKPLAGQQRQALADGA
MAB_0291|M.abscessus_ATCC_1997 EIASYKWEPDTQNILTTALTVGDDYHGELSVASLDDQPVSVYPLKIEDLA
: :
Mvan_5765|M.vanbaalenii_PYR-1 VVTALELLRARTAAEVEQRIRGSLVADLLSSDDAGIPALLDRARRLGWDL
MSMEG_6492|M.smegmatis_MC2_155 IVTALELLRCQTAAEVEQRLRGELLSDVLSSGAALSDRLLDRAHRLGHDL
MMAR_3335|M.marinum_M ASAYADAAEAR--GTWDSRMEASVVDAVVRGDTG--PELLSRAAALNWDT
MUL_1307|M.ulcerans_Agy99 ASAYADAAEAR--GTWDSRMEASVVDAVVRGDTG--PELLSRAAALNWDT
Mb2266|M.bovis_AF2122/97 ATAYADAAEAR--GTWDSRMEASVVDAVVRGDTG--PELLSRAAALNWDT
Rv2242|M.tuberculosis_H37Rv ATAYADAAEAR--GTWDSRMEASVVDAVVRGDTG--PELLSRAAALNWDT
MLBr_01652|M.leprae_Br4923 ATAYADAAEAR--GTWDSRMEASVVDAVVRGDTG--PELLSRAAALNWDT
MAV_1987|M.avium_104 RTVALHLLRSRASADLERQVESELVIRLLEGTAD----AATVASRLDLAH
TH_2137|M.thermoresistible__bu RTVALHLLRSRASADLERQVESDLVLRLLEGTSD----AAGAAARLGLPQ
Mflv_1946|M.gilvum_PYR-GCK RTVALHLLRSRASADLERQVESEMVIRLLESPAD----AETVASRLGLPP
MAB_0291|M.abscessus_ATCC_1997 TTAAVVMCGDNRMSLSVSQLRNDLLHDVLDYRQRDSRLVQIYARRLALDL
. . . ::. .:: :: * *
Mvan_5765|M.vanbaalenii_PYR-1 SG-----VQSLIALRPADER-----TLAAADRFTAGVTPHPLVALHRGDL
MSMEG_6492|M.smegmatis_MC2_155 TVPHIAIVGAFTGLDPVAERRAYERSLVLLAKESAAHRPKPVVAMHAGTI
MMAR_3335|M.marinum_M TAPATVVVGTPASARDGS--DG-SERAIQDVRDAAAQHGRAALTDVHGTW
MUL_1307|M.ulcerans_Agy99 TAPATVVVGTPASARDGS--DG-SERAIQDVRDAAAQHGRAALTDVHGTW
Mb2266|M.bovis_AF2122/97 TAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDVHGTW
Rv2242|M.tuberculosis_H37Rv TAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDVHGTW
MLBr_01652|M.leprae_Br4923 TAPATVVVGTPTPNHDGPNGQVSSERASQEVREIAARHGRAALTDVHGTW
MAV_1987|M.avium_104 NGLRVVAVQAFVGADRDAP----LLLAFERATTGFGWSRPGRSALAGNSV
TH_2137|M.thermoresistible__bu EALRIIAVRARSGVDRQGP----LLLAFEHATTGFGWSRAGRSALAGDTV
Mflv_1946|M.gilvum_PYR-GCK SALRVIALRALDTTGRHSA----LLQMFERATAGFGWSRPSRSALADATV
MAB_0291|M.abscessus_ATCC_1997 NQPHVVVIVRPERG---------GLDRASLWSASFASRVGGLRATQDEVV
: . :
Mvan_5765|M.vanbaalenii_PYR-1 VFVWPA-DTGPAVPVAHRLLEFLNAATIPEAPTAAVSRQAAARELPGIFR
MSMEG_6492|M.smegmatis_MC2_155 VMLWPAQDAADAAGAGEVVRQAMRAASADRQATVAVGPGDVASHR-ESYQ
MMAR_3335|M.marinum_M LVAIVSGHLSPTDKVFKDLLEAFSDGPVVIGPTAPMLTAAYHSAS----E
MUL_1307|M.ulcerans_Agy99 LVAIVSGHLSPTDKVFKDLLEAFSDGPVVIGPTAPMLTAAYHSAS----E
Mb2266|M.bovis_AF2122/97 LVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSAS----E
Rv2242|M.tuberculosis_H37Rv LVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSAS----E
MLBr_01652|M.leprae_Br4923 LVAIISGQLAPTDKFFSDLLHAFSDGPVVIGPTAPMLTAAYHSAS----E
MAV_1987|M.avium_104 YAVLPADEASTARRWVGALRAALPERLTMIAGISGVAEVGDLAAAR---Q
TH_2137|M.thermoresistible__bu YTVLPADHAATARRWVEGLQAALPSEVTVSAGISGIADHTELPDAR---R
Mflv_1946|M.gilvum_PYR-GCK YTVLAAEPAAVARDWVSALISTLPDQVTVKAGISAPAAATDLAVAR---T
MAB_0291|M.abscessus_ATCC_1997 VLLIPGSDAGRIAQTVWDETTAHLRMPVTVSSAGPSERIESIEDTY---Q
. .
Mvan_5765|M.vanbaalenii_PYR-1 TVRGALDLAGDR-DTATV-------------IDLDEPTIDHLLLQLDDPA
MSMEG_6492|M.smegmatis_MC2_155 TAKGALQVAIMSGRTAAV-------------VGLDDLGIAGLLLRINDPA
MMAR_3335|M.marinum_M AISGMNAVAGWRGAPRPV-------------LARELLPERALMG---DAS
MUL_1307|M.ulcerans_Agy99 AISGMNAVAGWRGASRPV-------------LARELLPERALMG---DAS
Mb2266|M.bovis_AF2122/97 AISGMNAVAGWRGAPRPV-------------LARELLPERALMG---DAS
Rv2242|M.tuberculosis_H37Rv AISGMNAVAGWRGAPRPV-------------LARELLPERALMG---DAS
MLBr_01652|M.leprae_Br4923 AVSGMNAVAGWSGAPRPV-------------QARELLPERALMG---DAS
MAV_1987|M.avium_104 EADECLALHEMSPAAPPP--------------AYDESWDDILLQRLRAAA
TH_2137|M.thermoresistible__bu EADECLALHDALHDARPDTGSPDSDSDALAAVVYDESWHDVLLQRLRTAA
Mflv_1946|M.gilvum_PYR-GCK EADECLALQESTDAGEPP--------------AYDESWDDLLLRRLKTAA
MAB_0291|M.abscessus_ATCC_1997 DAMRCLDAMSALGALGTA----------------AAAHELGFLGVLLSRH
. ::
Mvan_5765|M.vanbaalenii_PYR-1 RLRDFAS-AVLGPAVDYDRTRSTELLHTVRVLLEHGLDRRAAAQALHLHP
MSMEG_6492|M.smegmatis_MC2_155 ALSTFAR-RTLAPILDYDHAHRTELLVTLRAYLECRQERSATATRLVIHP
MMAR_3335|M.marinum_M AIVALHT-DVMRPLADAG----PTLIETLDAYLDCGGAIEACARKLFVHP
MUL_1307|M.ulcerans_Agy99 AIVALHT-DVMRPLADAG----PTLIETLDAYLDCGGAIEACARKLFVHP
Mb2266|M.bovis_AF2122/97 AIVALHT-DVMRPLADAG----PTLIETLDAYLDCGGAIEACARKLFVHP
Rv2242|M.tuberculosis_H37Rv AIVALHT-DVMRPLADAG----PTLIETLDAYLDCGGAIEACARKLFVHP
MLBr_01652|M.leprae_Br4923 AIVALHT-DVMLPLADAG----PTLIETLDAYLDCGGAIEACARKLFVHP
MAV_1987|M.avium_104 RSGRAPTRGPVADLGRHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHE
TH_2137|M.thermoresistible__bu RAGRIPSRGPIAALHEHDLRHATQYVATLRSWLAAQGDPAAAGAVLGVHE
Mflv_1946|M.gilvum_PYR-GCK RSGRTPTRGAVAELREHDSAHGTAYVPTLRAWLQERGDPVRTAAHLGVHE
MAB_0291|M.abscessus_ATCC_1997 QDVEGFVRSMVGPVIDYDEDRDTDLLQTLDVYFSVGASPTRAAKILHTHP
: . . : *: : . * *
Mvan_5765|M.vanbaalenii_PYR-1 NTVAQRVRRLEELTGLSLARPADLLRLTAALTVSRIASLS----------
MSMEG_6492|M.smegmatis_MC2_155 NTVAQRLRRIESLCSVTLTDPAVILQFSAALTVYDIAALD----------
MMAR_3335|M.marinum_M NTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTI
MUL_1307|M.ulcerans_Agy99 NTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTI
Mb2266|M.bovis_AF2122/97 NTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH--------
Rv2242|M.tuberculosis_H37Rv NTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH--------
MLBr_01652|M.leprae_Br4923 NTVRYRLKRITDFTGHDPTLPRDAYVLRVAATVGKLNYPTHH--------
MAV_1987|M.avium_104 NTVRYRLRKMAEITNLSLDDSKKRLAMMIELAAIHTD-------------
TH_2137|M.thermoresistible__bu NTVRYRLRKMTAVTQLDLQDPDKRLAMMIELAAIEGPPILSG--------
Mflv_1946|M.gilvum_PYR-GCK NTVRYRMRRMAELTELHLDDARKRFAMTIELAVLD---------------
MAB_0291|M.abscessus_ATCC_1997 NTVVRRLDRVNELLGDGWQDAERLLDTQLAIKLWKVRGSLLTRQTG----
**: *: :: . .
Mvan_5765|M.vanbaalenii_PYR-1 --------------
MSMEG_6492|M.smegmatis_MC2_155 --------------
MMAR_3335|M.marinum_M TPVPLPVRRGTEGP
MUL_1307|M.ulcerans_Agy99 TPVPLPVRRGTEGP
Mb2266|M.bovis_AF2122/97 --------------
Rv2242|M.tuberculosis_H37Rv --------------
MLBr_01652|M.leprae_Br4923 --------------
MAV_1987|M.avium_104 --------------
TH_2137|M.thermoresistible__bu --------------
Mflv_1946|M.gilvum_PYR-GCK --------------
MAB_0291|M.abscessus_ATCC_1997 --------------