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MELQWPPACDAEAQRVWQRVLVPLAAEMGTQAADLAQRAVARMQAEVPQLFPDEQTVKENLVSTEASLRQ LAQVIEAGADPRQVELPPSTQAIARAAVPRQVALADLLRFYRLAQELVWQWMFGRITADSRDAAEQAKAV ELATGWIFGYVDAALMRAERAYDVEREAWLRGATVARASAIDDIVAERERDPQRASKRLRYDVSTQHLAV IAWIDRLPEDGDAQPLLGRVVADLARATAAQSTLVHTLGSLAVAGWVSGRGSLSVRDAQDGVAGAPAGVR LAVGDPARGLKGFRRSYLEATYAHRVASLMGRRADAVTLYRGVAVAALASADRDHAVFFATRVLGGLAAA DEDTYRIATTLAVFLAENRSRTRAAKRLNVHPNTVSYRVNQAEAILGRAVDADVLELSVALALLPVLPGL AQGRSGEL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2601 | - | - | 100% (428) | hypothetical protein MMAR_2601 |
| M. marinum M | MMAR_4951 | - | e-113 | 53.81% (407) | hypothetical protein MMAR_4951 |
| M. marinum M | MMAR_1323 | - | 1e-36 | 28.07% (399) | hypothetical protein MMAR_1323 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1226c | - | 8e-31 | 30.26% (304) | hypothetical protein Mb1226c |
| M. gilvum PYR-GCK | Mflv_4621 | - | 4e-36 | 29.90% (418) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv1194c | - | 8e-31 | 30.26% (304) | hypothetical protein Rv1194c |
| M. leprae Br4923 | MLBr_01052 | - | 5e-25 | 28.70% (345) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 2e-28 | 24.34% (419) | hypothetical protein MAB_2657c |
| M. avium 104 | MAV_4933 | - | 8e-06 | 26.32% (380) | hypothetical protein MAV_4933 |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 4e-09 | 26.18% (275) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_2938 | - | 5e-36 | 32.21% (357) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0453 | - | 1e-107 | 52.27% (396) | hypothetical protein MUL_0453 |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 2e-05 | 38.75% (80) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2601|M.marinum_M --------------------------------------------------
MUL_0453|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mb1226c|M.bovis_AF2122/97 --------------------------------------------------
Rv1194c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6492|M.smegmatis_MC2_155 ------------MTWLGALRRLSASATAEEDLSHVLAEIAETARSLLGFD
Mvan_5765|M.vanbaalenii_PYR-1 MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVLDRVARTACTLLGYD
MAV_4933|M.avium_104 --------------------------------------------------
MMAR_2601|M.marinum_M --------------------------------------------------
MUL_0453|M.ulcerans_Agy99 ------------------------------------------------MR
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mb1226c|M.bovis_AF2122/97 --------------------------------------------------
Rv1194c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6492|M.smegmatis_MC2_155 FCGVLLPDEQSRHLRVRGASGLSSDYVDRVNSDRPLVLHGG----SPSSR
Mvan_5765|M.vanbaalenii_PYR-1 FCAVFLPDEQGRALTIEGSYGLSADYIAQVNANRPILLDVRGDHEAPTSL
MAV_4933|M.avium_104 --------------------------------------------------
MMAR_2601|M.marinum_M --------------MELQWPPACDAEAQRVWQRVLVPLAAEMGTQAADLA
MUL_0453|M.ulcerans_Agy99 GRCAGSTTRLDFVDMKPRWPPFQEPSARRVWQQVLRPLAAEMQTCATQLA
Mflv_4621|M.gilvum_PYR-GCK --------------------MLDSSEVQDTPGHAVHHLFRDLGDLVRELP
TH_2938|M.thermoresistible__bu ---------------------------------------------VGYGP
Mb1226c|M.bovis_AF2122/97 -----------------MAWQQPSPRIRELIREGARIALNPSPEWIEELD
Rv1194c|M.tuberculosis_H37Rv -----------------MAWQQPSPRIRELIREGARIALNPSPEWIEELD
MLBr_01052|M.leprae_Br4923 -----------------MARQHPSPRVRELIREGARIALNPTQEWIDQLD
MAB_2657c|M.abscessus_ATCC_199 -MNEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEVAGDLT
MSMEG_6492|M.smegmatis_MC2_155 AFHTAEAVAIRDVTAEPGFELWAGIANEQGYRSMIAVPLVARGEVLGTLN
Mvan_5765|M.vanbaalenii_PYR-1 AYRTGDVVTLEDIELVPDFT-WGGVAQEQGYRALISAPLRRPGTVVGALN
MAV_4933|M.avium_104 ------MKDFRAPVNGVDGDSASALVAVPKSQGAQTIRPDSVSRLVGALL
MMAR_2601|M.marinum_M QRAVARMQAEVPQLFPDEQTVKENLVSTEAS-------------------
MUL_0453|M.ulcerans_Agy99 RDIVDRYQSELPSIVPDPPAVADQLASVEAS-------------------
Mflv_4621|M.gilvum_PYR-GCK ESIHGLLIEQVAELAADQQLKELLSDTVAAN-------------------
TH_2938|M.thermoresistible__bu GSRQG---------SGCRQLLELLRDSVEGN-------------------
Mb1226c|M.bovis_AF2122/97 RATIAAN----PAIANDPVLAKVVQTANRAN-------------------
Rv1194c|M.tuberculosis_H37Rv RATIAAN----PAIANDPVLAKVVQTANRAN-------------------
MLBr_01052|M.leprae_Br4923 RATFAAN----PAIANDPVLAKVVRRASRAH-------------------
MAB_2657c|M.abscessus_ATCC_199 AASLEDPR--YRTIADDPVIAEVDARLTVSN-------------------
MSMEG_6492|M.smegmatis_MC2_155 GYYGAVHTYTRFEVERMTLLANHAAIAVSSARRLDELRALTASLRRQRDA
Mvan_5765|M.vanbaalenii_PYR-1 GYRTAPHRFDRAEVSLVTTLATQVAIALGTA----QLRAKEQATIR---E
MAV_4933|M.avium_104 DDHAAVVGRVRSVIRSRLPVYRSVADEALEA-------------------
MMAR_2601|M.marinum_M LRQLAQVIEAGADPRQ-VELPPSTQAIARAAVPRQVALADLLRFYRLAQ-
MUL_0453|M.ulcerans_Agy99 VRQIAECIDSGEGPRL-LDLTPATAAIGRSGVQRNIALNDLFRSVRMAQ-
Mflv_4621|M.gilvum_PYR-GCK VDTWFSVVRHSIPFDR-MESPTAALEHARRMAQREVPVNALLRAYRLGH-
TH_2938|M.thermoresistible__bu IDTIFSAIQHDIPIEE-VAPPTAALEYARRLARHGVEPHALLRAYRLGQ-
Mb1226c|M.bovis_AF2122/97 LVYWAAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFN-IYRTGE-
Rv1194c|M.tuberculosis_H37Rv LVYWAAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFN-IYRTGE-
MLBr_01052|M.leprae_Br4923 LVHWATANLRDPGAPVPAHLGPEPLTMARDLVRRGRDVLALD-IYRVGQ-
MAB_2657c|M.abscessus_ATCC_199 LKHWLTSNISEPGHRVRPATGSAMRTYARDVVLRGLTTDDIQ-SWRAVQ-
MSMEG_6492|M.smegmatis_MC2_155 LTRSEQIHDRLLAVTLRSGGLDGIAAVLQGLIGRPILIDDIQHEVLACSV
Mvan_5765|M.vanbaalenii_PYR-1 LRRAEEVHTLLTATALRGEGVSGVAAALSELLGRGVLIEDVYDEPLT---
MAV_4933|M.avium_104 ELEWVLRSAVGGREALHEPQIAGLAAIGEARARDGVPVDDMLRAWRIGV-
.
MMAR_2601|M.marinum_M ------ELVWQWMFGR------------------ITADSRDAAEQAKAVE
MUL_0453|M.ulcerans_Agy99 ------ERTWQWLFDR------------------ITASS-AATDHDRALD
Mflv_4621|M.gilvum_PYR-GCK ------QYGLNLIIAG------------------LRSADLPPEEKLALIE
TH_2938|M.thermoresistible__bu ------QKLLDIVLHE------------------IRSLDWEREVSLEFVV
Mb1226c|M.bovis_AF2122/97 ------HIGWRFWMGI------------------AFELTSDPQELRELLD
Rv1194c|M.tuberculosis_H37Rv ------HIGWRFWMGI------------------AFELTSDPQELRELLD
MLBr_01052|M.leprae_Br4923 ------YTAWRRWMEI------------------AFTLTSDPQELREILN
MAB_2657c|M.abscessus_ATCC_199 ------RVGWKWWLAA------------------CFQVTDDKEQLCELIE
MSMEG_6492|M.smegmatis_MC2_155 VTTDFPDTTWRAAAEAGTGSSPVPVGQFDGTTYLASAVHLGDEVAARIWF
Mvan_5765|M.vanbaalenii_PYR-1 ------DANWTAPDPR-------------AQDHVVATVTLDGSPVARIHV
MAV_4933|M.avium_104 ------EVVVECAREA------------------ARRLGVDDARVLELVQ
MMAR_2601|M.marinum_M LATGWIFGYVDAALMRAERAYDVEREAWLRGATVARASAIDDIVAERERD
MUL_0453|M.ulcerans_Agy99 LATNWLFGYVDVVLIRAERLYEVEREAWLTGAAAARAAAVEDILTEREDD
Mflv_4621|M.gilvum_PYR-GCK HITRVSFRYIDWMSEQVLETYQTERAEWDERRRSLRAQAIRDILNGRDVD
TH_2938|M.thermoresistible__bu GVTNATFGYIDGISQRVVEVYQQERERWLENRNSLRAMRVRELLDGGEVD
Mb1226c|M.bovis_AF2122/97 VSARSVNDFIEATLTGIAAQVQSEHDELTRSTHAERLEVVGLILDGAPIS
Rv1194c|M.tuberculosis_H37Rv VSARSVNDFIEATLTGIAAQVQSEHDELTRSTHAERLEVVGLILDGAPIS
MLBr_01052|M.leprae_Br4923 VSAQSINEYVAATLEAIATHMQLERDELTRSTHAERLEVVDLILEGAPVT
MAB_2657c|M.abscessus_ATCC_199 VTSNSLTTFVDDSIAELAEHVRRVREELAGGSQLQRYATVELLLQGADIA
MSMEG_6492|M.smegmatis_MC2_155 PETSIDLDPIMVRAVEHASIVTALELLRCQTAAEVEQRLRGELLSDVLSS
Mvan_5765|M.vanbaalenii_PYR-1 AASDSELSRLDVRAVEHATVVTALELLRARTAAEVEQRIRGSLVADLLSS
MAV_4933|M.avium_104 SA----LAWSDIAMATSAKAHRRTERALALEAEESDAEFVRGALMG---S
. :
MMAR_2601|M.marinum_M PQRASKRLRYDVSTQHLAVIAWIDRLPEDG-DAQPLLGR------VVADL
MUL_0453|M.ulcerans_Agy99 AQRASTRLRYDVNRHHVGVSVWRDVTQDAC-AGPVTLTE------ALTQL
Mflv_4621|M.gilvum_PYR-GCK LTEASSAMRYFLGATHVALMVWLDRDAGADTDEFIAMER------FMQHA
TH_2938|M.thermoresistible__bu VDTASATVGYPLRRTHLAVCVWTP-DGSAGDNELDRLQR------YVRGL
Mb1226c|M.bovis_AF2122/97 PERAEAKLGYPLSRAHTAAIIWSD----ELDGDHSYLDR------AADLF
Rv1194c|M.tuberculosis_H37Rv PERAEAKLGYPLSRAHTAAIIWSD----ELDGDHSYLDR------AADLF
MLBr_01052|M.leprae_Br4923 QERAEARLGYRLGLTHTAAVIWSD----DLDGDHGYLDQ------AAEAF
MAB_2657c|M.abscessus_ATCC_199 PARAEAQLGYALTGSHIGAVVWVD----SEK-EIAALER------ASEQV
MSMEG_6492|M.smegmatis_MC2_155 GAALSDRLLDRAHRLGHDLTVPHIAIVGAFTGLDPVAERRAYERSLVLLA
Mvan_5765|M.vanbaalenii_PYR-1 DDAGIPALLDRARRLGWDLSG-----VQSLIALRPADER-----TLAAAD
MAV_4933|M.avium_104 LPAAELRMHAELRGLDPGAEYVAVRARLGGDGPHLRLEQ-------SLGF
: .
MMAR_2601|M.marinum_M ARATAAQ-STLVHTLGSLAVAGWVSGRGSLSVRDAQDG-VAG---APAGV
MUL_0453|M.ulcerans_Agy99 TRAIAAQ-SVLAHPAGSKAIAGWLSRPQAFTAAELDAANICSGIHLPQDV
Mflv_4621|M.gilvum_PYR-GCK VSATGAK-QSVYFSIDRLVGCAWMTVH--RPSDYLSQLRDFVR-AQPDGP
TH_2938|M.thermoresistible__bu AEALGAPGDSLFIALDRLTGCGWIPLPGDAATGAVAGVRRYAA-EHPDGP
Mb1226c|M.bovis_AF2122/97 CHAVGST-RPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAP-----GA
Rv1194c|M.tuberculosis_H37Rv CHAVGST-RPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAP-----GA
MLBr_01052|M.leprae_Br4923 SHVVEST-QQLIVVASAATRWVWLADALALDVPEVQKALLNLS-----KA
MAB_2657c|M.abscessus_ATCC_199 MRACGAD-RRLTVVAGTVALWLWIPAKTTPTVAVLMDSLGRRS-----GV
MSMEG_6492|M.smegmatis_MC2_155 KESAAHRPKPVVAMHAGTIVMLWPAQDAADAAGAGEVVRQAMR--AASAD
Mvan_5765|M.vanbaalenii_PYR-1 RFTAGVTPHPLVALHRGDLVFVWPA-DTGPAVPVAHRLLEFLN--AATIP
MAV_4933|M.avium_104 QDPAHSRRGLCALLDGDLAGFLIEPPRDVEGVVGFGPPRPLTR-------
.
MMAR_2601|M.marinum_M RLAVGDPARGLKGFRRSYLEATYAHRVASLM-GRRADAVTLYR--GVAVA
MUL_0453|M.ulcerans_Agy99 RVAIGEPGWGISGFRRTHVEASHAQRFVSLL-GDRAEVVTCYR--NVAVA
Mflv_4621|M.gilvum_PYR-GCK RLSVGEPLPGIEGFRRTYRQAEQARVVAVAADGSSRHRIVAARDPGVALA
TH_2938|M.thermoresistible__bu HLALGDPLPGLDGFRRSYRQALRTRAVAVAA-GASAPRVTAAADPGLSAA
Mb1226c|M.bovis_AF2122/97 RIAIGTTANGVEGFRRSHLEALITQRTLSRL----RSTQRVAFFADVKMV
Rv1194c|M.tuberculosis_H37Rv RIAIGTTANGVEGFRRSHLEALITQRTLSRL----RSTQRVAFFADVKMV
MLBr_01052|M.leprae_Br4923 RVAIGTSSAGIEGFRRSHLEALTAQRTLARL----KSHQQVAFFADVQLV
MAB_2657c|M.abscessus_ATCC_199 RVALGRAATGMAGFRRTHMDAAAAQRLLARL----GSPLSVVRYEDVHLM
MSMEG_6492|M.smegmatis_MC2_155 RQATVAVGPGDVASHR-ESYQTAKGALQVAIMSGRTAAVVGLDDLGIAGL
Mvan_5765|M.vanbaalenii_PYR-1 EAPTAAVSRQAAARELPGIFRTVRGALDLAGDR-DTATVIDLDEPTIDHL
MAV_4933|M.avium_104 ---------LSESYRMAARALVTAEACGLRG---------AYDIAALGLR
. . :
MMAR_2601|M.marinum_M ALASADRDHAVFFATRVLG-GLAAADEDTYRIATTLAVFLAENRSRTRAA
MUL_0453|M.ulcerans_Agy99 ALAGTDRGHAVAFVRRVLG-PLAANDEGTYRIAATLAVYLEENRSPAKAA
Mflv_4621|M.gilvum_PYR-GCK SMLMTDDATLKEWIHDVLG-PLAQNTASDQRLRDTLRVFLRAGSSFKAAA
TH_2938|M.thermoresistible__bu ALLTGDLAEARTWVQEVLG-PLSADTKNDARLRETLGVFLRHGSSYTAAA
Mb1226c|M.bovis_AF2122/97 ALISQNPDAASEFITSTLG-DLESASP---DLQTALLTFINEQCNASRAA
Rv1194c|M.tuberculosis_H37Rv ALISQNPDAASEFITSTLG-DLESASP---DLQTALLTFINEQCNASRAA
MLBr_01052|M.leprae_Br4923 SLITQNPEDAKEFITSTLG-DFESASP---ALQQTLLTFINEQCNASRAA
MAB_2657c|M.abscessus_ATCC_199 DLLSADPASADQFVTDVLG-EFQSASP---VLHQTVLTYVEEALNRTSTA
MSMEG_6492|M.smegmatis_MC2_155 LLRINDPAALSTFARRTLAPILDYDHAHRTELLVTLRAYLECRQERSATA
Mvan_5765|M.vanbaalenii_PYR-1 LLQLDDPARLRDFASAVLGPAVDYDRTRSTELLHTVRVLLEHGLDRRAAA
MAV_4933|M.avium_104 TAVAIDADVGELLRKRYLEPLSVGGSSR--ELIATVRTYLACGMHVERTA
: * : :: . : :*
MMAR_2601|M.marinum_M KRLNVHPNTVSYRVNQAEAILGRAVDADVLELSVALALLPVLPGLAQGRS
MUL_0453|M.ulcerans_Agy99 QRLGVHP-------RAPALLISRLVSWGIVD-------------------
Mflv_4621|M.gilvum_PYR-GCK NELQIHANTVKYRVNRALERRGRPIAAERLDVEVALLMCYWLGEVALNPT
TH_2938|M.thermoresistible__bu DELNLHFNTVKYRVQRAVERRGRPIVPDRLDVELALLICQWFGAAVLRPQ
Mb1226c|M.bovis_AF2122/97 KRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQWRGNKAHALS
Rv1194c|M.tuberculosis_H37Rv KRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQWRGNKAHALS
MLBr_01052|M.leprae_Br4923 KRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVALEALQWRGDQTNTSG
MAB_2657c|M.abscessus_ATCC_199 ERLYTHRNTIDRRLARVDELLPKPFARNPIEVAAALTLLRVRAGR-----
MSMEG_6492|M.smegmatis_MC2_155 TRLVIHPNTVAQRLRRIESLCSVTLTDPAVILQFSAALTVYDIAALD---
Mvan_5765|M.vanbaalenii_PYR-1 QALHLHPNTVAQRVRRLEELTGLSLARPADLLRLTAALTVSRIASLS---
MAV_4933|M.avium_104 TRLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLELAAMRL-----
* * .
MMAR_2601|M.marinum_M GEL--------
MUL_0453|M.ulcerans_Agy99 -----------
Mflv_4621|M.gilvum_PYR-GCK QALGRS-----
TH_2938|M.thermoresistible__bu R----------
Mb1226c|M.bovis_AF2122/97 SPGRRSNSVPA
Rv1194c|M.tuberculosis_H37Rv SPGRRSNSVPA
MLBr_01052|M.leprae_Br4923 PRAGRNDGVPA
MAB_2657c|M.abscessus_ATCC_199 -----------
MSMEG_6492|M.smegmatis_MC2_155 -----------
Mvan_5765|M.vanbaalenii_PYR-1 -----------
MAV_4933|M.avium_104 -----------