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LSLSALLADPTLELTLLVPGSPGAVDREVLWLHNTELPDPSPYIRATELVLTNGLWRGTVDSTMFVDALL RARAAGVVFGLTEQTPAAPADLVEACSSAELPLATVSIAVPFTAITQAAARIQSDARQAALSKLVRRGNA LASSIARGGGAEGILDVLRRDHDLPLLVVDRLGRRLAGDIGDDEDVQVAADALNRHPPPLEVALPSGDTA SVYLVEGAMGDVDAGLFCLRPLPSLKPLERDALDQAARYLSLEVTRQQALQAIESRFSSELLEMVLSGAA RARDVAERLRAFGIDPSSALAVYTVVVGDGAVRPPGSTDEIEDFFNRHSIPAVVIPGSQDTVVVFGWHRD MTALVGLAEDLVQTLTARFPADRAVIGVGDLAADASALREPLIRARETCHVLRRRTTEPKVGTYADIGTH RMLLGLHDRSVLRRFADDILGPLDQHDEQYGTALVRTLRTFLANDGHWAKTATELYVHVNTLRNRIARIS ELTGRDVARLEDRVDLFLALEADALG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2971 | - | - | 100% (517) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1068 | - | 9e-26 | 26.67% (495) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 2e-24 | 24.50% (498) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 3e-08 | 25.78% (256) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_0801 | - | 3e-31 | 29.90% (495) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv2242 | - | 3e-08 | 25.78% (256) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01052 | - | 6e-07 | 22.22% (252) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_0825 | - | 3e-25 | 25.00% (508) | peptidase |
| M. marinum M | MMAR_3335 | - | 2e-06 | 25.00% (252) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_1987 | - | 1e-09 | 26.73% (303) | putative DNA-binding protein |
| M. thermoresistible (build 8) | TH_2137 | - | 2e-11 | 23.80% (500) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_3245 | - | 4e-06 | 25.28% (269) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0042 | - | 9e-31 | 30.23% (516) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2266|M.bovis_AF2122/97 -----------------------------------------MNDNQLAPV
Rv2242|M.tuberculosis_H37Rv -----------------------------------------MNDNQLAPV
MMAR_3335|M.marinum_M -----------------------------------------MNDNQFSAI
Mflv_0801|M.gilvum_PYR-GCK ----------------------------------------MSEDRAESAA
Mvan_0042|M.vanbaalenii_PYR-1 ----------------------------------------MSEVHAEPAA
MAV_1987|M.avium_104 ---------------MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIH
TH_2137|M.thermoresistible__bu ---------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALH
MLBr_01052|M.leprae_Br4923 ----------------------------------------------MAR-
MUL_3245|M.ulcerans_Agy99 ----------------------------------------------MASP
MSMEG_2971|M.smegmatis_MC2_155 ------MLSLSALLADPTLELTLLVPGSPGAVDREVLWLHNTELPDPSPY
MAB_0825|M.abscessus_ATCC_1997 MAEYRLTVPITVRDLTQRADLGLVLSAGEAGAARAIKWAHAIELNDPTPY
Mb2266|M.bovis_AF2122/97 ARP---RSPLELLDTVPDSLLRRLKQYSG--RLATEAVSAMQERLPFFAD
Rv2242|M.tuberculosis_H37Rv ARP---RSPLELLDTVPDSLLRRLKQYSG--RLATEAVSAMQERLPFFAD
MMAR_3335|M.marinum_M ARLGSARSPLELLETVPDSLLRRLKQYSG--RLATEAVSAMQERLPFFAD
Mflv_0801|M.gilvum_PYR-GCK PTLRDLLEAAQLSLSGPDPADRNLDREVS--WVHTTEMRDPSR---YLRG
Mvan_0042|M.vanbaalenii_PYR-1 PTLRDLATAG-LGLSVPDGTAQELDRPVS--WVHTTEMRDPSR---YLRG
MAV_1987|M.avium_104 ETPEDRPVVGDVLLAVGAGSLDEAVRWAA--SARAAVVVLRDDETPMTFD
TH_2137|M.thermoresistible__bu ENAGGLRVTGDVLLAVGAESVAEAVRWAE--TAQAVVVLTRAG-PDASRS
MLBr_01052|M.leprae_Br4923 QHP--SPRVRELIREGARIALNPTQEWID--QLDRATFAANPAIANDPVL
MUL_3245|M.ulcerans_Agy99 SNPSLSPRMRELIRHTARIALNPTQQWLD--ELDRTTLAANPALSDDPAL
MSMEG_2971|M.smegmatis_MC2_155 IRATELVLTNGLWRGTVDSTMFVDALLRA--RAAGVVFGLTEQTPAAPAD
MAB_0825|M.abscessus_ATCC_1997 LFGGELVMTTGLTVGLSHAEQYEYAARLSGKNVAALAFDTGTTFSEVPPG
: .
Mb2266|M.bovis_AF2122/97 LEASQR----ASVALVVQTAVVNFVEWMH-----DPHSDVGYTAQAFELV
Rv2242|M.tuberculosis_H37Rv LEASQR----ASVALVVQTAVVNFVEWMH-----DPHSDVGYTAQAFELV
MMAR_3335|M.marinum_M LEASQR----ASVALVVQTAVVNFAEWMQ-----NPRSDVSYTAQAFELV
Mflv_0801|M.gilvum_PYR-GCK GELVCT----VGISLHSAEDCSTFVDALAGAGAAGVCFGVGDGHDDVPAA
Mvan_0042|M.vanbaalenii_PYR-1 GELVCT----VGISLHTDQDCATFVDALSRARAAGVCFGVGDEHDAVPEA
MAV_1987|M.avium_104 GVTDVG----AVLVIDPTVSWSAVAAVVYGLVLEGRETESGRGPTDLFAL
TH_2137|M.thermoresistible__bu CSDGAV----AVLTVEPEVSWSELAAVVYGLVLEGRETESGRGPTDLFAL
MLBr_01052|M.leprae_Br4923 AKVVRR----ASRAHLVHWATANLRDPGA-------PVPAHLGPEPLTMA
MUL_3245|M.ulcerans_Agy99 VEIISR----ANRANLIHFAVAILRDPGG-------PVPANFGPEPLRMA
MSMEG_2971|M.smegmatis_MC2_155 LVEACSSAELPLATVSIAVPFTAITQAAARIQSDARQAALSKLVRRGNAL
MAB_0825|M.abscessus_ATCC_1997 ILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAVQRVVDQQDVL
.
Mb2266|M.bovis_AF2122/97 PQDLTRRIALRQTVDMVRVTMEFFE----------EVVPLLARSEEQLTA
Rv2242|M.tuberculosis_H37Rv PQDLTRRIALRQTVDMVRVTMEFFE----------EVVPLLARSEEQLTA
MMAR_3335|M.marinum_M PQDLTRRIALRHTVDMVRVTMEFFE----------EVVPLLARSEEQLTA
Mflv_0801|M.gilvum_PYR-GCK LLDACRRAGLPVLVAPPSVPFSVIS-RFVAESRLGTEIAVARATNALVPE
Mvan_0042|M.vanbaalenii_PYR-1 LLAQCRLHGLPLLVAPPSVPFSVVS-RFVAEYWLGSEIAVARATNALVPE
MAV_1987|M.avium_104 ADSLADGIGNPVVIQDRHLGVLAYS-RLAQADPALVETVLQRQTPEPLRA
TH_2137|M.thermoresistible__bu ADNLADAVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLRR
MLBr_01052|M.leprae_Br4923 RDLVRRGRDVLALDIYRVGQYTAWR-------RWMEIAFTLTSDPQELRE
MUL_3245|M.ulcerans_Agy99 QELLNRGLEALAADIYRIAHNVAWE-------RWTDIAFGLTSNPQELRD
MSMEG_2971|M.smegmatis_MC2_155 ASSIARGGGAEGILDVLRRDHDLPLLVVDRLGRRLAGDIGDDEDVQVAAD
MAB_0825|M.abscessus_ATCC_1997 VRATLRDGAPGVVSALSRSLAATVIVTATDGTLLAEAGHDAEHLAEITRG
Mb2266|M.bovis_AF2122/97 LTVG----------------ILKYSRDLAFTAATAYADAAEARGTWDSRM
Rv2242|M.tuberculosis_H37Rv LTVG----------------ILKYSRDLAFTAATAYADAAEARGTWDSRM
MMAR_3335|M.marinum_M LTVG----------------ILKYSRDLAFTAASAYADAAEARGTWDSRM
Mflv_0801|M.gilvum_PYR-GCK LLLS------LRRHDSPRRLLDAAGQVLGCYFLLEPEGAAKGDEAAVTVP
Mvan_0042|M.vanbaalenii_PYR-1 LLSS------LRRHDSPRQLLDSAGQLLGCYFLLEPEGGADSDDDAVTVP
MAV_1987|M.avium_104 LLEARGVFAHLQVADEPLFVAEDAERGLSGRMVVAVRAGAELIGSVWVAC
TH_2137|M.thermoresistible__bu LFEQLGVSEHLAAGDDPLFIAARPGHDLTGRTVIAVRAGRELLGSVWVVT
MLBr_01052|M.leprae_Br4923 ILNV----------------SAQSINEYVAATLEAIATHMQLERDELTRS
MUL_3245|M.ulcerans_Agy99 LLDV----------------AFRSSNDFIDATIAGIPAQLPLEYDALTRE
MSMEG_2971|M.smegmatis_MC2_155 ALNR----------HPPPLEVALPSGDTASVYLVEGAMGDVDAGLFCLRP
MAB_0825|M.abscessus_ATCC_1997 AFPN----------HSRKHASRVVADRDGYCTIQTVRAGKAERGYLAVRS
Mb2266|M.bovis_AF2122/97 EASVVDAVVRG------DTGPELLSR------------------------
Rv2242|M.tuberculosis_H37Rv EASVVDAVVRG------DTGPELLSR------------------------
MMAR_3335|M.marinum_M EASVVDAVVRG------DTGPELLSR------------------------
Mflv_0801|M.gilvum_PYR-GCK VPGLGALVWMGRGDRPEPALLDLIAR--------------FVRAAQGERD
Mvan_0042|M.vanbaalenii_PYR-1 VPGLGTLVWVGRGDHPEPALLDLIAR--------------FVRAAQGERD
MAV_1987|M.avium_104 EAPLQPAALRALADGARTVALHLLRSRASADLERQVESELVIRLLEGTAD
TH_2137|M.thermoresistible__bu PEPLDDGRRRALADGARTVALHLLRSRASADLERQVESDLVLRLLEGTSD
MLBr_01052|M.leprae_Br4923 THAERL-----------EVVDLILEG--------------------APVT
MUL_3245|M.ulcerans_Agy99 VSAQRR-----------KVVEQILGG--------------------APVN
MSMEG_2971|M.smegmatis_MC2_155 LPSLKPLERDALDQAARYLSLEVTRQQALQAIESRFSSELLEMVLSGAAR
MAB_0825|M.abscessus_ATCC_1997 EDALTAAQRLLVSHAMALIAIELEKP---------------ARVADAEQR
:
Mb2266|M.bovis_AF2122/97 AAALNWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAA
Rv2242|M.tuberculosis_H37Rv AAALNWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAA
MMAR_3335|M.marinum_M AAALNWDTTAPATVVVGTPASARDG--SDG-SERAIQDVRDAAAQHGRAA
Mflv_0801|M.gilvum_PYR-GCK IEAALTRERVGQLLSLVERRMLLPDALSQLVQWPGF-AGEIACSAWPAGA
Mvan_0042|M.vanbaalenii_PYR-1 IEAALARERVGQLLSLVERRMLLPDALSQLLEWPGFSAGEIACSAWPAGA
MAV_1987|M.avium_104 AATVASRLDLAHNGLRVVAVQAFVGADRDAPLLLAFERATTGFGWSRPGR
TH_2137|M.thermoresistible__bu AAGAAARLGLPQEALRIIAVRARSGVDRQGPLLLAFEHATTGFGWSRAGR
MLBr_01052|M.leprae_Br4923 QERAEARLGYRLGLTHTAAVIWSDDLDGDHGYLDQAAEAFSHVVESTQQL
MUL_3245|M.ulcerans_Agy99 RERAEAQLGYLLDRAHTAAIVWSDEPDGDHGQLDQAADAFCTALGCRAPL
MSMEG_2971|M.smegmatis_MC2_155 ARDVAERLRAFGIDPSSALAVYTVVVGDGAVRPPGSTDEIEDFFNRHSIP
MAB_0825|M.abscessus_ATCC_1997 LRGAVTRALLADPAAADRSVLRYFGFDPDTEVVVVLLCNVGSVLPGELHI
Mb2266|M.bovis_AF2122/97 LTDVHGTWLVAIVS-------GQLSPTEKFLKDLLAAFADAPVVIG----
Rv2242|M.tuberculosis_H37Rv LTDVHGTWLVAIVS-------GQLSPTEKFLKDLLAAFADAPVVIG----
MMAR_3335|M.marinum_M LTDVHGTWLVAIVS-------GHLSPTDKVFKDLLEAFSDGPVVIG----
Mflv_0801|M.gilvum_PYR-GCK GALLSISFPGALIG-------DAPDLCMMLTAG-AVEMPDDLALPTGHSA
Mvan_0042|M.vanbaalenii_PYR-1 GALVSMAFPDALIG-------DAPDLCLMLTVG-ALEVTDDLALPTGHSA
MAV_1987|M.avium_104 SALAGNSVYAVLPA-------DEASTARRWVGALRAALPERLTMIAGISG
TH_2137|M.thermoresistible__bu SALAGDTVYTVLPA-------DHAATARRWVEGLQAALPSEVTVSAGISG
MLBr_01052|M.leprae_Br4923 IVVASAATRWVWLA-------DALALDVPEVQKALLNLSKARVAIG----
MUL_3245|M.ulcerans_Agy99 IVVTNSATRWVWVN-------DAATPVGDRIQQVLTYAPTVRLVVG----
MSMEG_2971|M.smegmatis_MC2_155 AVVIPGSQDTVVVFGWHRDMTALVGLAEDLVQTLTARFPADRAVIGVGDL
MAB_0825|M.abscessus_ATCC_1997 DRQLARGGPYLMAS-------VSGEIVVVLAAKNVGRASELHRSLGTALG
.
Mb2266|M.bovis_AF2122/97 -PTAPMLTAAHRSASEAISGMNAVAGWRGAP---------------RPVL
Rv2242|M.tuberculosis_H37Rv -PTAPMLTAAHRSASEAISGMNAVAGWRGAP---------------RPVL
MMAR_3335|M.marinum_M -PTAPMLTAAYHSASEAISGMNAVAGWRGAP---------------RPVL
Mflv_0801|M.gilvum_PYR-GCK PVTLADLGSAIAQARIALTLAEHRGGRVGP---------------DQLST
Mvan_0042|M.vanbaalenii_PYR-1 PVPLTDIGSAIAQARIALTLAEHRGGRVGP---------------DQLST
MAV_1987|M.avium_104 VAEVGDLAAARQEADECLALHEMSPAAPPP--------------AYDESW
TH_2137|M.thermoresistible__bu IADHTELPDARREADECLALHDALHDARPDTGSPDSDSDALAAVVYDESW
MLBr_01052|M.leprae_Br4923 -TSSAGIEGFRRSHLEALTAQRTLARLKSHQQ--------------VAFF
MUL_3245|M.ulcerans_Agy99 -NTRRGIEGFRRSHRDAQTTQRMLTRLGAPQR--------------TAHF
MSMEG_2971|M.smegmatis_MC2_155 AADASALREPLIRARETCHVLRRRTTEPKVG-------------TYADIG
MAB_0825|M.abscessus_ATCC_1997 RTICAGISRRVRLDEVPLGLHQARSVARAHPD------------GRIAEF
:
Mb2266|M.bovis_AF2122/97 ARELLPERALMGDAS--AIVALHTDVMRPLADAGPTLIETLDAYLDCGGA
Rv2242|M.tuberculosis_H37Rv ARELLPERALMGDAS--AIVALHTDVMRPLADAGPTLIETLDAYLDCGGA
MMAR_3335|M.marinum_M ARELLPERALMGDAS--AIVALHTDVMRPLADAGPTLIETLDAYLDCGGA
Mflv_0801|M.gilvum_PYR-GCK LESLLEQLPLAQLAP--FRQLLIDPLTELDTSRGTQHVRTLRTFVACNGS
Mvan_0042|M.vanbaalenii_PYR-1 LESLLEQLPLAQLAP--FKQLLIAPLAELDSQRGTQHVRTLRVFLACNGS
MAV_1987|M.avium_104 DDILLQRLRAAARSGRAPTRGPVADLGRHDRANGTDYLATLRAWLQAQGD
TH_2137|M.thermoresistible__bu HDVLLQRLRTAARAGRIPSRGPIAALHEHDLRHATQYVATLRSWLAAQGD
MLBr_01052|M.leprae_Br4923 ADVQLVSLITQNPED---AKEFITSTLGDFESASPALQQTLLTFINEQCN
MUL_3245|M.ulcerans_Agy99 ADTQMVELLTQDLEG---VDEFIECTLGEFQSASPVLHAILLTYINQQCN
MSMEG_2971|M.smegmatis_MC2_155 THRMLLGLHDRSVLRR-FADDILGPLDQHDEQYGTALVRTLRTFLANDGH
MAB_0825|M.abscessus_ATCC_1997 DELDIYGVLLGGRDRGELAVLAQSVAPLLGTGADTTLLDTLESFLACNGQ
: . * ::
Mb2266|M.bovis_AF2122/97 IEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNY
Rv2242|M.tuberculosis_H37Rv IEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNY
MMAR_3335|M.marinum_M IEACARKLFVHPNTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNY
Mflv_0801|M.gilvum_PYR-GCK LSETAKELFLHTNTVRHRLGRIQEITGRDPLQHNDLTTFVIGMWAADRGE
Mvan_0042|M.vanbaalenii_PYR-1 LSETAKELFLHTNTVRHRLSRIQEITGRDPLQHNDLTAFVIGLWAADRAE
MAV_1987|M.avium_104 PAEAGRQLGVHENTVRYRLRKMAEITNLSLDDSKKRLAMMIELAAIHTD-
TH_2137|M.thermoresistible__bu PAAAGAVLGVHENTVRYRLRKMTAVTQLDLQDPDKRLAMMIELAAIEGPP
MLBr_01052|M.leprae_Br4923 ASRAAKRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVALEALQWRGDQ
MUL_3245|M.ulcerans_Agy99 AARTAKALYIHRNTLVHRLETAHRLLPQPVEANIVRIAVALEVLQWRSDR
MSMEG_2971|M.smegmatis_MC2_155 WAKTATELYVHVNTLRNRIARISELTGRDVARLEDRVDLFLALEADALG-
MAB_0825|M.abscessus_ATCC_1997 METAALNLGVHRHTMRNRIARIAALLDCDLHSADTRAALWIAIRARALLG
. * * :*: *: . . :
Mb2266|M.bovis_AF2122/97 PTPH----------------------
Rv2242|M.tuberculosis_H37Rv PTPH----------------------
MMAR_3335|M.marinum_M PTPPSGAANNTITPVPLPVRRGTEGP
Mflv_0801|M.gilvum_PYR-GCK --------------------------
Mvan_0042|M.vanbaalenii_PYR-1 RPAGL---------------------
MAV_1987|M.avium_104 --------------------------
TH_2137|M.thermoresistible__bu ILSG----------------------
MLBr_01052|M.leprae_Br4923 TNTSGPRAGRNDGVPA----------
MUL_3245|M.ulcerans_Agy99 DDDS-LRAIT----------------
MSMEG_2971|M.smegmatis_MC2_155 --------------------------
MAB_0825|M.abscessus_ATCC_1997 --------------------------