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LTDIQVGGAREGVPSAGPSALSVLRLLASGTAPDVFEARLKEMARESSPPWSAADLHRARGYAERIYGLI EGQNQREARLSNLVGIGIDLLGCHGLDEASTTLVKRARIMLDADFSFISVRDDSEPETRHHVRYVDGPTT AINHGLYFPIGDDVGLVSLYRPGQGPVWTADYPSDTRFSRASDGDAAMRSEGVHSLMVMPMEHEDQHFGN LYVGSRTVRSFSAAERSLFASLCSFAGIALARASEFSSNTEQISALERRLELRSILLDTGAGPGGMDGFV LTAGEQLGVAMRVTGHDGSEIASYKWEPDTQNILTTALTVGDDYHGELSVASLDDQPVSVYPLKIEDLAT TAAVVMCGDNRMSLSVSQLRNDLLHDVLDYRQRDSRLVQIYARRLALDLNQPHVVVIVRPERGGLDRASL WSASFASRVGGLRATQDEVVVLLIPGSDAGRIAQTVWDETTAHLRMPVTVSSAGPSERIESIEDTYQDAM RCLDAMSALGALGTAAAAHELGFLGVLLSRHQDVEGFVRSMVGPVIDYDEDRDTDLLQTLDVYFSVGASP TRAAKILHTHPNTVVRRLDRVNELLGDGWQDAERLLDTQLAIKLWKVRGSLLTRQTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0291 | - | - | 100% (617) | hypothetical protein MAB_0291 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2391c | - | 2e-07 | 26.81% (138) | hypothetical protein Mb2391c |
| M. gilvum PYR-GCK | Mflv_3844 | - | 7e-05 | 22.94% (279) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv2370c | - | 2e-07 | 26.81% (138) | hypothetical protein Rv2370c |
| M. leprae Br4923 | MLBr_01052 | - | 6e-06 | 26.45% (121) | hypothetical protein MLBr_01052 |
| M. marinum M | MMAR_2601 | - | 6e-08 | 26.17% (256) | hypothetical protein MMAR_2601 |
| M. avium 104 | MAV_2195 | - | 4e-05 | 25.38% (264) | hypothetical protein MAV_2195 |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 2e-19 | 23.67% (469) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_2938 | - | 2e-06 | 25.55% (274) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2422 | devS | 5e-05 | 24.01% (304) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 5e-17 | 23.10% (407) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2391c|M.bovis_AF2122/97 --------------------------------------------------
Rv2370c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MSMEG_6492|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5765|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3844|M.gilvum_PYR-GCK -------------------------MHDG-AVADADDHR---ARDGARPV
MUL_2422|M.ulcerans_Agy99 -------------------------MTDEPHPQDAGPSLGVPSGDGLRPL
TH_2938|M.thermoresistible__bu --------------------------------------------------
MMAR_2601|M.marinum_M --------------------------------------------------
MAB_0291|M.abscessus_ATCC_1997 MTDIQVGGAREGVPSAGPSALSVLRLLASGTAPDVFEARLKEMARESSPP
MAV_2195|M.avium_104 --------------------------------------------------
Mb2391c|M.bovis_AF2122/97 -----------------------------------------------MVL
Rv2370c|M.tuberculosis_H37Rv -----------------------------------------------MVL
MLBr_01052|M.leprae_Br4923 -----------------------------------------------MAR
MSMEG_6492|M.smegmatis_MC2_155 --------------------------MTWLGALRRLSASATAEEDLSHVL
Mvan_5765|M.vanbaalenii_PYR-1 --------------MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVL
Mflv_3844|M.gilvum_PYR-GCK RTTLSQLRLRELLTEVQDRVEQIIRGRDRLDGLVEAMLAVTSGLELDETL
MUL_2422|M.ulcerans_Agy99 RLTLSQLRLRELLVEVQERVEQIVEGRDRLDGLVEAMLVVTSGLELDATL
TH_2938|M.thermoresistible__bu --------------------------------------------------
MMAR_2601|M.marinum_M ---------------------------------------------MELQW
MAB_0291|M.abscessus_ATCC_1997 WSAADLHRARGYAERIYGLIEGQNQREARLSNLVGIGIDLLGCHGLDEAS
MAV_2195|M.avium_104 ----------------------------------------MNDNPFAGPF
Mb2391c|M.bovis_AF2122/97 PKPTPRGRELIRQAAKVALHP---------------TPEWLDELDR----
Rv2370c|M.tuberculosis_H37Rv PKPTPRGRELIRQAAKVALHP---------------TPEWLDELDR----
MLBr_01052|M.leprae_Br4923 QHPSPRVRELIREGARIALNP---------------TQEWIDQLDR----
MSMEG_6492|M.smegmatis_MC2_155 AEIAETARSLLGFDFCGVLLPDEQSRHLRVRGASGLSSDYVDRVNSDRPL
Mvan_5765|M.vanbaalenii_PYR-1 DRVARTACTLLGYDFCAVFLPDEQGRALTIEGSYGLSADYIAQVNANRPI
Mflv_3844|M.gilvum_PYR-GCK RTIVHTAIELVDAQYGALGVRGHDQELVEFIYEG-IDEPMRERIGHLPEG
MUL_2422|M.ulcerans_Agy99 RTIVHSATNLVDARYCALEVHDRDKRVLQFVYEG-IDEDTVARIGHLPEG
TH_2938|M.thermoresistible__bu VGYGPGSRQGSGCRQLLELLR--------------------DSVEG----
MMAR_2601|M.marinum_M PPACDAEAQRVWQRVLVPLAAEMG-------------TQAADLAQR----
MAB_0291|M.abscessus_ATCC_1997 TTLVKRARIMLDADFSFISVRDDSEP--ETRHHVRYVDGPTTAINHGLYF
MAV_2195|M.avium_104 AKHPRSPLETLDTVPESVLRR-------------------LKQYSG----
Mb2391c|M.bovis_AF2122/97 ------------------ATLAAHPSIAADPALATVVSRANRSHLIHFAT
Rv2370c|M.tuberculosis_H37Rv ------------------ATLAAHPSIAADPALATVVSRANRSHLIHFAT
MLBr_01052|M.leprae_Br4923 ------------------ATFAANPAIANDPVLAKVVRRASRAHLVHWAT
MSMEG_6492|M.smegmatis_MC2_155 VLHGG----SPSSRAFHTAEAVAIRDVTAEPGFELWAGIANEQGYRSMIA
Mvan_5765|M.vanbaalenii_PYR-1 LLDVRGDHEAPTSLAYRTGDVVTLEDIELVPDFT-WGGVAQEQGYRALIS
Mflv_3844|M.gilvum_PYR-GCK RGVLG----------VLINDPKPIRLEDISRHADSVGFPPNHPPMRTFLG
MUL_2422|M.ulcerans_Agy99 LGIIG----------LLIDEPKPLRLEDISQHPASIGFPSHHPPMRTFLG
TH_2938|M.thermoresistible__bu ------------------NIDTIFSAIQHDIPIEEVAPPTAALEYARRLA
MMAR_2601|M.marinum_M ---------------AVARMQAEVPQLFPDEQTVKENLVSTEASLRQLAQ
MAB_0291|M.abscessus_ATCC_1997 PIGDDVGLVSLYRPGQGPVWTADYPSDTRFSRASDGDAAMRSEGVHSLMV
MAV_2195|M.avium_104 -----------------RLATEAVSVMQDRLPFFADLEASQRASVSLVVQ
Mb2391c|M.bovis_AF2122/97 ANLRKPGQPVPANLG-------------------PDPLRMARDLVRRGLD
Rv2370c|M.tuberculosis_H37Rv ANLRKPGQPVPANLG-------------------PDPLRMARDLVRRGLD
MLBr_01052|M.leprae_Br4923 ANLRDPGAPVPAHLG-------------------PEPLTMARDLVRRGRD
MSMEG_6492|M.smegmatis_MC2_155 VPLVARGEVLGTLNGYYGAVHTYTRFEVERMTLLANHAAIAVSSARRLDE
Mvan_5765|M.vanbaalenii_PYR-1 APLRRPGTVVGALNGYRTAPHRFDRAEVSLVTTLATQVAIALGTA----Q
Mflv_3844|M.gilvum_PYR-GCK VPVRIRDEVFGNLYLTEKSDGQ----------PFSEDDEVLVQALAAAAG
MUL_2422|M.ulcerans_Agy99 VPVRVRDVSLGTLYLTDKTNGQ----------PFSDDDELLVQALAAAAG
TH_2938|M.thermoresistible__bu RHGVEP--------------------------------HALLRAYRLGQQ
MMAR_2601|M.marinum_M VIEAGADPRQVELPP-------------------STQAIARAAVPRQVAL
MAB_0291|M.abscessus_ATCC_1997 MPMEHEDQHFGNLYVGSRTVRSFS-------AAERSLFASLCSFAGIALA
MAV_2195|M.avium_104 TAVVNFAEWMQDPKSN------------------VRHTAQAFELVPQDLA
Mb2391c|M.bovis_AF2122/97 ASALDVYRVGQNVAWQRWTEIAFGLTTDPQE----------LHELLT---
Rv2370c|M.tuberculosis_H37Rv ASALDVYRVGQNVAWQRWTEIAFGLTTDPQE----------LHELLT---
MLBr_01052|M.leprae_Br4923 VLALDIYRVGQYTAWRRWMEIAFTLTSDPQE----------LREILN---
MSMEG_6492|M.smegmatis_MC2_155 LRALTASLRRQRDALTRSEQIHDRLLAVTLRSGGLDGIAAVLQGLIGRPI
Mvan_5765|M.vanbaalenii_PYR-1 LRAKEQATIR---ELRRAEEVHTLLTATALRGEGVSGVAAALSELLGRGV
Mflv_3844|M.gilvum_PYR-GCK IAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAGVFRRVADRAQKLS
MUL_2422|M.ulcerans_Agy99 IAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAEEALKLT
TH_2938|M.thermoresistible__bu KLLDIVLHEIRSLDWEREVSLEFVVG------------------------
MMAR_2601|M.marinum_M ADLLRFYRLAQELVWQWMFGRITADSRDAAEQAK----------------
MAB_0291|M.abscessus_ATCC_1997 RASEFSSNTEQISALERRLELRSILLDTGAGPGGMDGFVLTAGEQLGVAM
MAV_2195|M.avium_104 RRIALRHSVEMVRVTMEFFEEVVPLLARSEEQ------------------
Mb2391c|M.bovis_AF2122/97 ------------------------------------------------LP
Rv2370c|M.tuberculosis_H37Rv ------------------------------------------------LP
MLBr_01052|M.leprae_Br4923 ------------------------------------------------VS
MSMEG_6492|M.smegmatis_MC2_155 LIDDIQHEVLACSVVTTDFPDTTWRAAAEAGTGSSPVPVGQFDGTTYLAS
Mvan_5765|M.vanbaalenii_PYR-1 LIEDVYDEPLT---------DANWTAPDPR-------------AQDHVVA
Mflv_3844|M.gilvum_PYR-GCK G---------------------------------------AAATLVAVPD
MUL_2422|M.ulcerans_Agy99 S---------------------------------------ADAALVAIPV
TH_2938|M.thermoresistible__bu -------------------------------------------------V
MMAR_2601|M.marinum_M ---------------------------------------------AVELA
MAB_0291|M.abscessus_ATCC_1997 RVTGHDGSEIAS-------------------------YKWEPDTQNILTT
MAV_2195|M.avium_104 ----------------------------------------------LTAL
Mb2391c|M.bovis_AF2122/97 FRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQ
Rv2370c|M.tuberculosis_H37Rv FRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQ
MLBr_01052|M.leprae_Br4923 AQSINEYVAATLEAIATHMQLERDELTRSTHAERLEVVDLILEGAPVTQE
MSMEG_6492|M.smegmatis_MC2_155 AVHLGDEVAARIWFPETSIDLDPIMVRAVEHASIVTALELLRCQTAAEVE
Mvan_5765|M.vanbaalenii_PYR-1 TVTLDGSPVARIHVAASDSELSRLDVRAVEHATVVTALELLRARTAAEVE
Mflv_3844|M.gilvum_PYR-GCK DPDLPVGEVAELTVAASAGETIAAAH-DPIPVAGTAIGDAFVHRTPGMTD
MUL_2422|M.ulcerans_Agy99 DEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGTALAEVLLDSAPRQVD
TH_2938|M.thermoresistible__bu TNATFGYIDGISQRVVEVYQQERERWLENRNSLRAMRVRELLDGGEVDVD
MMAR_2601|M.marinum_M TGWIFGYVDAALMRAERAYDVEREAWLRGATVARASAIDDIVAERERDPQ
MAB_0291|M.abscessus_ATCC_1997 ALTVGDDYHGELSVASLDDQPVSVYPLKIEDLATTAAVVMCGDNRMSLSV
MAV_2195|M.avium_104 TVGVLKYSRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPEL
Mb2391c|M.bovis_AF2122/97 S-----------------------AEAKLGYPLDRSHTAAIIWYDDPDDN
Rv2370c|M.tuberculosis_H37Rv S-----------------------AEAKLGYPLDRSHTAAIIWYDDPDDN
MLBr_01052|M.leprae_Br4923 R-----------------------AEARLGYRLGLTHTAAVIWSDDLDGD
MSMEG_6492|M.smegmatis_MC2_155 QRLRGELLSDVLSSGAALSDRLLDRAHRLGHDLTVPHIAIVGAFTGLDPV
Mvan_5765|M.vanbaalenii_PYR-1 QRIRGSLVADLLSSDDAGIPALLDRARRLGWDLSG-----VQSLIALRPA
Mflv_3844|M.gilvum_PYR-GCK R---------------ADIGIGATVGPALLLPLRAPDAVPGVLIVLRSVG
MUL_2422|M.ulcerans_Agy99 KI------------AVEDVDELGDMGPALVLPLRATDAVAGVVVLLHPSS
TH_2938|M.thermoresistible__bu T-----------------------ASATVGYPLRRTHLAVCVWTPDGSAG
MMAR_2601|M.marinum_M R-----------------------ASKRLRYDVSTQHLAVIAWIDRLPED
MAB_0291|M.abscessus_ATCC_1997 SQLRNDLLHDVLDYRQRDSRLVQIYARRLALDLNQPHVVVIVRPE--RGG
MAV_2195|M.avium_104 LS----------------------RAAALNWDTTAPATVVVGTPAPGRDG
:
Mb2391c|M.bovis_AF2122/97 QNH----LDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIH
Rv2370c|M.tuberculosis_H37Rv QNH----LDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIH
MLBr_01052|M.leprae_Br4923 HGY----LDQAAEAFSHVVESTQQLIVVASAATRWVWLADALALDVPEVQ
MSMEG_6492|M.smegmatis_MC2_155 AERRAYERSLVLLAKESAAHRPKPVVAMHAGTIVMLWPAQDAADAAGAGE
Mvan_5765|M.vanbaalenii_PYR-1 DER-----TLAAADRFTAGVTPHPLVALHRGDLVFVWPA-DTGPAVPVAH
Mflv_3844|M.gilvum_PYR-GCK AQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTDRDRIARDLHD
MUL_2422|M.ulcerans_Agy99 PESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDRIARDLHD
TH_2938|M.thermoresistible__bu DNELDRLQRYVRGLAEALGAPGDSLFIALDRLTGCGWIPLPGDAATGAVA
MMAR_2601|M.marinum_M GDAQP-LLGRVVADLARATAAQSTLVHTLGSLAVAGWVSGRGSLSVRDAQ
MAB_0291|M.abscessus_ATCC_1997 LDRASLWSASFASRVGGLRATQDEVVVLLIPGSDAGRIAQTVWDETTAHL
MAV_2195|M.avium_104 STGPGDSERASQHVRDIAAQHGRAALTDVHGTWLVAIVSGQLSPTDKFLG
.
Mb2391c|M.bovis_AF2122/97 QVLDHAPHAR---IAVG-TTARGIDGFRRSHRDALATQRMLARLRSQQ--
Rv2370c|M.tuberculosis_H37Rv QVLDHAPHAR---IAVG-TTARGIDGFRRSHRDALATQRMLARLRSQQ--
MLBr_01052|M.leprae_Br4923 KALLNLSKAR---VAIG-TSSAGIEGFRRSHLEALTAQRTLARLKSHQ--
MSMEG_6492|M.smegmatis_MC2_155 VVRQAMRAAS---ADRQATVAVGPGDVASHR-ESYQTAKGALQVAIMSGR
Mvan_5765|M.vanbaalenii_PYR-1 RLLEFLNAAT---IPEAPTAAVSRQAAARELPGIFRTVRGALDLAGDR-D
Mflv_3844|M.gilvum_PYR-GCK HVIQRLFAVG---LSLQGSIARARSEEVQQRLSANVDDLQSVIQEIRT--
MUL_2422|M.ulcerans_Agy99 HVIQRLFAIG---LALQGSVPRTREPKVQQRLSEVIDDLQGVIQEIRT--
TH_2938|M.thermoresistible__bu GVRRYAAEHPDGPHLALGDPLPGLDGFRRSYRQALRTRAVAVAAGASAP-
MMAR_2601|M.marinum_M DGVAGAPAGVR---LAVGDPARGLKGFRRSYLEATYAHRVASLMGRRAD-
MAB_0291|M.abscessus_ATCC_1997 RMPVTVSSAG---------PSERIESIEDTYQDAMRCLDAMSALGALG--
MAV_2195|M.avium_104 DLLEAFSDGP-------VVVGPTAPMLTAAYHSASEAISGMNAVGGWRG-
Mb2391c|M.bovis_AF2122/97 --RLAFFADIHMIAVLT--ENPDSAADFITSTLG---DLESAS-PQLLTT
Rv2370c|M.tuberculosis_H37Rv --RLAFFADIHMIAVLT--ENPDSAADFITSTLG---DLESAS-PQLLTT
MLBr_01052|M.leprae_Br4923 --QVAFFADVQLVSLIT--QNPEDAKEFITSTLG---DFESAS-PALQQT
MSMEG_6492|M.smegmatis_MC2_155 TAAVVGLDDLGIAGLLLRINDPAALSTFARRTLAPILDYDHAHRTELLVT
Mvan_5765|M.vanbaalenii_PYR-1 TATVIDLDEPTIDHLLLQLDDPARLRDFASAVLGPAVDYDRTRSTELLHT
Mflv_3844|M.gilvum_PYR-GCK --AIFDLHGGSSAVTRLRQRLDAAVAAFPESGVRTSMQCAGPL-SVVDAG
MUL_2422|M.ulcerans_Agy99 --TIFDLHGSSQGVTRLRQRIDAAVAAFGSSGLRTTVQFIGPL-SVVDNV
TH_2938|M.thermoresistible__bu --RVTAAADPGLSAAALLTGDLAEARTWVQEVLGP-LSADTKNDARLRET
MMAR_2601|M.marinum_M --AVTLYRGVAVAALAS--ADRDHAVFFATRVLGG-LAAADEDTYRIATT
MAB_0291|M.abscessus_ATCC_1997 ----TAAAAHELGFLGVLLSRHQDVEGFVRSMVGPVIDYDEDRDTDLLQT
MAV_2195|M.avium_104 --APRPVLARELLPERALMGDASAIVALHTDVMGP----LADAGPTLIET
: :
Mb2391c|M.bovis_AF2122/97 VLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVA
Rv2370c|M.tuberculosis_H37Rv VLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVA
MLBr_01052|M.leprae_Br4923 LLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVA
MSMEG_6492|M.smegmatis_MC2_155 LRAYLECRQERSATATRLVIHPNTVAQRLRRIESLCSVTLTDPAVILQFS
Mvan_5765|M.vanbaalenii_PYR-1 VRVLLEHGLDRRAAAQALHLHPNTVAQRVRRLEELTGLSLARPADLLRLT
Mflv_3844|M.gilvum_PYR-GCK LADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIAADV
MUL_2422|M.ulcerans_Agy99 LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMPKTY
TH_2938|M.thermoresistible__bu LGVFLRHGSSYTAAADELNLHFNTVKYRVQRAVERRGRPIVPDRLDVELA
MMAR_2601|M.marinum_M LAVFLAENRSRTRAAKRLNVHPNTVSYRVNQAEAILGRAVDADVLELSVA
MAB_0291|M.abscessus_ATCC_1997 LDVYFSVGASPTRAAKILHTHPNTVVRRLDRVNELLGDGWQDAERLLDTQ
MAV_2195|M.avium_104 LDAFLDSGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPMQPRDAYVLR
: . .*: :
Mb2391c|M.bovis_AF2122/97 ISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER
Rv2370c|M.tuberculosis_H37Rv ISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER
MLBr_01052|M.leprae_Br4923 LEALQWRGDQTN----------TSGP--RAGRNDGVPA----
MSMEG_6492|M.smegmatis_MC2_155 AALTVYDIAALD------------------------------
Mvan_5765|M.vanbaalenii_PYR-1 AALTVSRIASLS------------------------------
Mflv_3844|M.gilvum_PYR-GCK TGSGLANLARRAQDVGGSFSVRRGAQVG-TTLTWRAPLP---
MUL_2422|M.ulcerans_Agy99 TSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ--
TH_2938|M.thermoresistible__bu LLICQWFGAAVLRPQR--------------------------
MMAR_2601|M.marinum_M LALLPVLPGLAQGRSGEL------------------------
MAB_0291|M.abscessus_ATCC_1997 LAIKLWKVRGSLLTRQTG------------------------
MAV_2195|M.avium_104 VAATVGQLNYPTHPPSAAGAAMPAVPLPVNGAARGQSGG---