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TTTDDRYAGVLRLDGKRALITGATKGIGADIARAFAAAGARLVLSGRDVSELDAARRALGEQFGTDVHTV AIDLAEPDAPAELARRAAEAFGGLDVLVNNAGISHPQPVVDTDPQLFDATIAVNLRAPALLASAVGKAMV AAGEGGAIITVASAAALAPLPDHYAYCTSKAGLVMATKVLARELGPHGIRANSVCPTVVLTEMGQRVWGD EAKSAPMIARIPLGRFAVPHEVSDAVVWLASDAASMINGVDIPVDGGYTMG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3262 | - | - | 100% (262) | L-xylulose reductase |
| M. smegmatis MC2 155 | MSMEG_3607 | - | 1e-53 | 46.18% (249) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5584 | - | 1e-38 | 40.00% (250) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 3e-38 | 37.75% (249) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 6e-35 | 41.20% (250) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1928c | - | 3e-38 | 37.75% (249) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-26 | 33.74% (243) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4632 | - | 7e-33 | 35.22% (247) | short chain dehydrogenase |
| M. marinum M | MMAR_1952 | fabG | 9e-39 | 39.13% (253) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2775 | - | 2e-38 | 36.95% (249) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3708 | - | 5e-41 | 41.60% (250) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2173 | fabG | 2e-38 | 38.74% (253) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_4593 | - | 7e-36 | 38.65% (251) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3262|M.smegmatis_MC2_155 MTTTDDRYAGVLRLDGKRALITGATKGIGADIARAFAAAGARLVLSGRDV
Mflv_4505|M.gilvum_PYR-GCK MTG---------RLAGKVALISGAARGMGASHARVMAGHGAKVVCG----
MAB_4632|M.abscessus_ATCC_1997 ---MILD---RFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTE
TH_3708|M.thermoresistible__bu ---MTPDPLAAFRLDGKVALVTGGSRGLGFEMARAFAGAGADVIISSRDE
MMAR_1952|M.marinum_M --------MTSLDLTGRTAIITGASRGIGLAIAQRLAGAGANVVLTARKQ
MUL_2173|M.ulcerans_Agy99 --------MTSLDLTGRTAIITGASRGIGLAIAQRLAGAGANVVLTARKQ
Mvan_4593|M.vanbaalenii_PYR-1 ------MSPNSTRLTGRTALVTGSTGGLGVTIAHALAADGAVVVVTGRDV
Mb1963c|M.bovis_AF2122/97 -----MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHL
Rv1928c|M.tuberculosis_H37Rv -----MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHL
MAV_2775|M.avium_104 -------MLDLFDLRGRRALVTGASTGIGKQVAQAYLQAGARVAIAARDF
MLBr_01807|M.leprae_Br4923 --------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLV
* * :. * :
MSMEG_3262|M.smegmatis_MC2_155 SELDAARRALGEQFGTDVHTVAIDLA--EPDAPAELARRAAEAFGG-LDV
Mflv_4505|M.gilvum_PYR-GCK DILDSDGEAVAAELGDAARYVHLDVT--SPDDWDRAVAAAVADFGG-LDV
MAB_4632|M.abscessus_ATCC_1997 SQLREVAAKV-QAAGRQAEVVVADLS--DTEASAALAQKAVDRFGR-LDV
TH_3708|M.thermoresistible__bu ESCRRAAEEIGRTFAVRAVPMPCHVG--RWAELDALADRALATFGH-VDV
MMAR_1952|M.marinum_M ESADAAAAEV----GERAVGVGAHAV--DEEAARGCVDLALERFGS-VDI
MUL_2173|M.ulcerans_Agy99 ESADAAAAEV----GERAVGVGAHAV--DEEAARGCVDLALERFGS-VDI
Mvan_4593|M.vanbaalenii_PYR-1 ARGESVVAGIR-ADGASAHFVAADLGGADEQAIDGLAQRAAEAASAGIDI
Mb1963c|M.bovis_AF2122/97 DALEKLADEIG-TSG--GKVVPVCCDVSQHQQVTSMLDQVTAELGG-IDI
Rv1928c|M.tuberculosis_H37Rv DALEKLADEIG-TSG--GKVVPVCCDVSQHQQVTSMLDQVTAELGG-IDI
MAV_2775|M.avium_104 EALQRTADELT-AGGT-GGVVAIRCDVTQPDEVSGMVDRMIAELGG-IDI
MLBr_01807|M.leprae_Br4923 ADGHRVAVTHR-ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGP-VEV
. . :::
MSMEG_3262|M.smegmatis_MC2_155 LVNNAGIS-HPQPVVDTDPQLFDATIAVNLRAPALLASAVGKAMVAAGEG
Mflv_4505|M.gilvum_PYR-GCK LVNNAGIL-NIGTVEDYELSEWHRILDVNLTGVFLGIRAATPTMKAAGRG
MAB_4632|M.abscessus_ATCC_1997 VVNNVGGT-MPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLKSDNA
TH_3708|M.thermoresistible__bu LVNNAGMSPLYDKVADITETMWEKTLAVNLRAPFRLTALLAPAMVDNGGG
MMAR_1952|M.marinum_M LINNAGTNPAYGPLIEQDHARFTKIFDVNLWAPLMWTSLVVKAWMGEHGG
MUL_2173|M.ulcerans_Agy99 LINNAGTNPAYGPLIEQDHARFTKIFDVNLWAPLMWTSLVVKAWMGEHGG
Mvan_4593|M.vanbaalenii_PYR-1 LVNNAAKLLLPEPTATLSAGEVAEAFTVNVVAPMLLTGRLASAMAARGSG
Mb1963c|M.bovis_AF2122/97 AVCNAGII-TVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQG
Rv1928c|M.tuberculosis_H37Rv AVCNAGII-TVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQG
MAV_2775|M.avium_104 AVCNAGII-SVSPMLEMPAAEFQRIQDTNVTGVFLTAQAAARAMVRQGRG
MLBr_01807|M.leprae_Br4923 LVANAGIT-SDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFG
: *.. *: . .
MSMEG_3262|M.smegmatis_MC2_155 GAIITVASAAA--LAPLPDHYAYCTSKAGLVMATKVLARELGPHGIRANS
Mflv_4505|M.gilvum_PYR-GCK -SIINIASIEG--MAGTVGCHGYTATKFAVRGLTKSTALELGPFGIRVNS
MAB_4632|M.abscessus_ATCC_1997 -SVINITSTMG--RLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNG
TH_3708|M.thermoresistible__bu -SVINLSSIGA--VRPTADIVPYAAAKAGLNAMTAALAKEYGPH-VRVNA
MMAR_1952|M.marinum_M -VVINTASIGG--MHQSPAMGMYNATKAALIHVTKQLALELSPR-VRVNA
MUL_2173|M.ulcerans_Agy99 -VVINTASIGG--MHQSPAMGMYNATNAALIHVTKQLALELSPR-VRVNA
Mvan_4593|M.vanbaalenii_PYR-1 -SVVNIGSITG--LRGTAGSAVYDATKASVHSLTRSWAAEYGPSGVRVNA
Mb1963c|M.bovis_AF2122/97 GVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNS
Rv1928c|M.tuberculosis_H37Rv GVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNS
MAV_2775|M.avium_104 GAIITTASMSGHIINVPQQVGHYCASKAAVIQLTKAMAVEFAPHDIRVNS
MLBr_01807|M.leprae_Br4923 RYIFMGSVVG--LSGVPGQAN-YAASKSGLIGMARSLARELGSRSITANV
:. * ::: .: : * : .. : .*
MSMEG_3262|M.smegmatis_MC2_155 VCPTVVLTEMGQRVWGDEAKSAPMIARIPLGRFAVPHEVSDAVVWLASDA
Mflv_4505|M.gilvum_PYR-GCK VHPGLVKTPMADWVPEDIFQSA-------LGRIAQPHEVSNLVVYLASDE
MAB_4632|M.abscessus_ATCC_1997 IAPGSILTSALEVVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASPA
TH_3708|M.thermoresistible__bu IMPGAFATDVSEYWSAEAVAR--VVDQTALGRIGDPREIVGTALYLASDA
MMAR_1952|M.marinum_M ICPGVVRTKLAEALWKDHEDP--LAANIALGRIGEPVDVAEAVGFLVSDA
MUL_2173|M.ulcerans_Agy99 ICPGVVRTKLAEALWKDHEDP--LAANIALGRIGEPVDVAEAVGFLVSDA
Mvan_4593|M.vanbaalenii_PYR-1 VAPGPIATERAAEFAEHIAPA---LARVPSRRMSTPQEVAAAVVFLASDD
Mb1963c|M.bovis_AF2122/97 VSPGYILTELVEPYT-EYQPLW--EPKIPLGRLGRPEELAGLYLYLASEA
Rv1928c|M.tuberculosis_H37Rv VSPGYILTELVEPYT-EYQPLW--EPKIPLGRLGRPEELAGLYLYLASEA
MAV_2775|M.avium_104 VSPGYIRTELVEPLH-EYHRQW--QPKIPLGRMGRPDELAGIYLYLASAA
MLBr_01807|M.leprae_Br4923 VAPGFIDTEMTRAMDSKYQEAA--LQAIPLGRIGAVEEIAGAVSFLASED
: * . * . *:. :: :*.*
MSMEG_3262|M.smegmatis_MC2_155 ASMINGVDIPVDGGYTMG-------------------
Mflv_4505|M.gilvum_PYR-GCK SSYSTGAEFVVDGGTLAGLAHKDFSAVDVDQQPEWIT
MAB_4632|M.abscessus_ATCC_1997 GSFLTGKVLEVDGGLIAPNLDIPLPDLA---------
TH_3708|M.thermoresistible__bu ASFTSGAVITVDGGRD---------------------
MMAR_1952|M.marinum_M ASWITGETMVIDGGLLLGSAAGFQSRPGSAS------
MUL_2173|M.ulcerans_Agy99 ASWITGETMVIDGGLLLGSAAGFQSRPGSAS------
Mvan_4593|M.vanbaalenii_PYR-1 AANIQGAVLSVDGGWAAT-------------------
Mb1963c|M.bovis_AF2122/97 SSYMTGSDIVIDGGYTCP-------------------
Rv1928c|M.tuberculosis_H37Rv SSYMTGSDIVIDGGYTCP-------------------
MAV_2775|M.avium_104 SSYMTGSDIVIDGGYSCP-------------------
MLBr_01807|M.leprae_Br4923 AGYISGAVIPVDGGLGMGH------------------
.. * : :***