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MTVTVPATGSHSPNHLPTDVGVLHTAQEALAAADALATEFAADSAERELHGKSLLPQLRRVAESGLLGIV VPAAHGGPGLPASTKVEVVRRLSRGDGALGQLLLSHFVIGEAISGLGEAAPAPRIYADTLAGAQLGNATA ERGTATALDRRTSVTQRPDGKWVLNGTKYYATGALGAAWIAVAAVIAGREDETATVFVRPEQDGVTLDLD KWSAFGQRGTASGEVRLTDVVVDADLVIEEGAAPDPVDAPPTVLGAYDQALHAAIDIGIARAALEDGAHF VRTTSRPWKEAVLAGVTSAAEEPHVVRRFGELTARLYALEALLARGTAIIDAGQSEAELSRDTAAEASLT VAAAKALAQEYAVEIASGIFELTGASGTDSAVNLDRHWRNVRTHSLHDPARWKYVHLGNHTLHGTRPPRL GLVL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3668 | - | - | 100% (424) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2650 | - | 2e-69 | 40.84% (404) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4592 | - | 1e-42 | 32.99% (391) | acyl-CoA dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0897 | fadE10 | 6e-12 | 23.84% (365) | acyl-CoA dehydrogenase FADE10 |
| M. gilvum PYR-GCK | Mflv_4370 | - | 2e-11 | 24.80% (383) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0873 | fadE10 | 7e-12 | 23.84% (365) | acyl-CoA dehydrogenase FADE10 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-09 | 21.52% (395) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1422c | - | 2e-40 | 30.96% (394) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4034 | fadE | 8e-12 | 25.14% (346) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_3422 | - | 2e-31 | 29.87% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3393 | - | 2e-67 | 40.45% (403) | PUTATIVE Acyl-CoA dehydrogenase, type 2, C-terminal domain |
| M. ulcerans Agy99 | MUL_3895 | - | 5e-10 | 23.06% (360) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 1e-175 | 77.48% (404) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00737|M.leprae_Br4923 ---------------------------------MVGWSGNPLFDLFKLPE
MUL_3895|M.ulcerans_Agy99 --------------------------------------MTKLAQTLGLTE
Mflv_4370|M.gilvum_PYR-GCK -----------------------------MASPPANAAEAGIPSAEVNDE
MMAR_4034|M.marinum_M -----------------------------MTAP------------QVSDE
Mb0897|M.bovis_AF2122/97 MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPS
Rv0873|M.tuberculosis_H37Rv MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPS
MSMEG_3668|M.smegmatis_MC2_155 ---------------------------MTVTVPATGSHSPNHLPTDVGVL
Mvan_3173|M.vanbaalenii_PYR-1 ----------------------------------MATDITDRIPDTL--L
TH_3393|M.thermoresistible__bu --------------------------------------VTEPLTMAR--I
MAB_1422c|M.abscessus_ATCC_199 ------------------------------------MTSAPSVLEIR---
MAV_3422|M.avium_104 ------------------------------------MPVAFHRQDT----
MLBr_00737|M.leprae_Br4923 EHNELRATIRALAEKEIAPHAA--DVDQRARFPEEALAALNASGFNAIHV
MUL_3895|M.ulcerans_Agy99 LQAEIVATVRQFVDKEVIPNAS--ELERKDAYPHEIVEQTRSIGLFGLMI
Mflv_4370|M.gilvum_PYR-GCK DFQAILAATREFVRTAVVPREQ--EILSTDQVPDDLREQTKSMGLFGYAI
MMAR_4034|M.marinum_M DFAQILAQTRHFVRSVVLPREQ--QILDEDRVPEDLRDQAKQMGLFGYAI
Mb0897|M.bovis_AF2122/97 DAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKI
Rv0873|M.tuberculosis_H37Rv DAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKI
MSMEG_3668|M.smegmatis_MC2_155 HTAQEALAAADALATEFAADSAERELHG--KSLLPQLRRVAESGLLGIVV
Mvan_3173|M.vanbaalenii_PYR-1 RTPADALAAAEEVAEAIAAGSAERERAG--AVLTPQLRLVAESGLLGISV
TH_3393|M.thermoresistible__bu VDTAEALAVAARLSGSFAAEASTRDAER--LLPYEQVCELKRSGLLTLSV
MAB_1422c|M.abscessus_ATCC_199 --ALPGTDTYRNLLAQVAEGARDRDLD--DENPFDQVRLLKEAGFGRLRI
MAV_3422|M.avium_104 ---PAGAAAVQPVLAEIAADYRLRLADGGTEPPLRGLKLVRDHRLGALRL
. :
MLBr_00737|M.leprae_Br4923 PEEYGGQGADSVAACIVIEEVARVDASASLIPAVN-KLGTMG-LILRGSE
MUL_3895|M.ulcerans_Agy99 PEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH-FIVAYM-LRQHGTE
Mflv_4370|M.gilvum_PYR-GCK PQEWGGLGLNLAQDVELAMELGYTSLALRSMFGTNNGIAGQV-LVGYGTD
MMAR_4034|M.marinum_M PPQWGGLGLNLVQDVELAMELGYTSLAVRSMFGTNNGIAGQV-LVGFGTD
Mb0897|M.bovis_AF2122/97 PSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTA
Rv0873|M.tuberculosis_H37Rv PSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTA
MSMEG_3668|M.smegmatis_MC2_155 PAAHGGPGLPASTKVEVVRRLSRGDGALGQLLLSHFVIGEAI--SGLGEA
Mvan_3173|M.vanbaalenii_PYR-1 PTAHGGPGLPASTVVEVLRRLARADGAVGQLLLSHFVVAQAI--SGLGHT
TH_3393|M.thermoresistible__bu PAEHGGLDVPATVLAEVFRLLAHGDPSVAQIPHSHFTFLEVL--RLQGTE
MAB_1422c|M.abscessus_ATCC_199 PTELGGAGLSVRQLFSAIIDVAQADPIVAHIFRTHFWFVEER--LRTLAD
MAV_3422|M.avium_104 ARELGGAGYTAPEFFDYLVALAAADPDLAHILRIHYALVEEL--QVTPRR
. ** . : : : .
MLBr_00737|M.leprae_Br4923 ELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGD----DWIL
MUL_3895|M.ulcerans_Agy99 EQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRATRGADG---NYTI
Mflv_4370|M.gilvum_PYR-GCK EQKKTWLERIASGEIVASFALTEPGAGSNPSGLRTKAVRDGDGPHSGWIL
MMAR_4034|M.marinum_M EQKARWLEPIASGDVVASFALTEPGAGSSPAGLRTKAVRDGDD----WLI
Mb0897|M.bovis_AF2122/97 EQKRRFLPRCAAG-AISAFLLTEPDVGSDPARMASTATPIDDG--QAYEL
Rv0873|M.tuberculosis_H37Rv EQKRRFLPRCAAG-AISAFLLTEPDVGSDPARMASTATPIDDG--QAYEL
MSMEG_3668|M.smegmatis_MC2_155 APAPRIYADTLAGAQLGNATAERGTATALDRRTSVTQRP-DGK----WVL
Mvan_3173|M.vanbaalenii_PYR-1 QPAPRIYADLLAGAQLGNASAERGTAHALDRRTTVTRR--DGH----WVL
TH_3393|M.thermoresistible__bu RQRGFFYGLVLEGALFANAQSERG-PHPIDVDTTVLLRRGAGD----YLL
MAB_1422c|M.abscessus_ATCC_199 PVSAAWLTKVNEGNLFANAFSEKGSLAVGSLVFNTRLLPVGDA----YRL
MAV_3422|M.avium_104 PGSDRWIAVVAEGGLIGGANAEQSQKSVGGNHRDTRLVTTPDG----LRL
. . . :
MLBr_00737|M.leprae_Br4923 NGFKCWITNGGKSTWYTVMAVTDP------DKGANGISAFIVHKDD----
MUL_3895|M.ulcerans_Agy99 DGQKMWLTNGGSSTLVAVLVRTDEGA----AQPHRNLTAFLVEKPTGFGE
Mflv_4370|M.gilvum_PYR-GCK NGQKRFITNAPNADLFVTFARSRPAD----DKGA-GIAVFLVPADT----
MMAR_4034|M.marinum_M TGQKRFITNAPVADLFVVFARTRPAS----DKSP-GIAVFLVPAQS----
Mb0897|M.bovis_AF2122/97 EGVKLWTTNGVVADLLVVMARVPRSE----GHRG-GISAFVVEADS----
Rv0873|M.tuberculosis_H37Rv EGVKLWTTNGVVADLLVVMARVPRSE----GHRG-GISAFVVEADS----
MSMEG_3668|M.smegmatis_MC2_155 NGTKYYATGALGAAWIAVAAVIAG------RED-ETATVFVRPEQD----
Mvan_3173|M.vanbaalenii_PYR-1 NGTKYYATGTLGATWIAVAARIEG------RENGDTATAFVRPDQE----
TH_3393|M.thermoresistible__bu TGRKFYSTGALFADWIVVRASVPADAADAPTAATPKAVAFVPRHAP----
MAB_1422c|M.abscessus_ATCC_199 NGEKFYSTGTLFADYLTVTATTDR----------DSVASVIVPGDR----
MAV_3422|M.avium_104 RGRKFYSTGAQFSDYLRITAQDDD----------GAPTAVVIPVDR----
* * : *. : . .:
MLBr_00737|M.leprae_Br4923 --EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIG---EPGTGFKTA
MUL_3895|M.ulcerans_Agy99 VLPGLTIPGKIDKLGYKGIDTTEVIFDGYRATADDILGG--TPGQGFFPM
Mflv_4370|M.gilvum_PYR-GCK --PGVDIGAKDKKMGQEGAWTADVNFTDVEVPDTALVGG--SEDLGYRAA
MMAR_4034|M.marinum_M --AGVEVGAKDAKMGQEGAWTADVSFTDVRVDDAALVGG--SEDIGYRAA
Mb0897|M.bovis_AF2122/97 --PGITVERRNKFMGLRGIENGVTRLHRVRVPKDNLIG---REGDGLKIA
Rv0873|M.tuberculosis_H37Rv --PGITVERRNKFMGLRGIENGVTRLHRVRVPKDNLIG---REGDGLKIA
MSMEG_3668|M.smegmatis_MC2_155 --GVTLDLDKWSAFGQRGTASGEVRLTDVVVDADLVIEEGAAPDPVDAPP
Mvan_3173|M.vanbaalenii_PYR-1 --GVTLDLESWSAFGQRGTASGEVRLNNVVVDDDLLIDEGPPPDPITADP
TH_3393|M.thermoresistible__bu --GLTV-IDDWDGMGQRTTASGSVTLDEVRVPADHVV----PFTPIFRRP
MAB_1422c|M.abscessus_ATCC_199 --DGVRLVDDWDGFGQRRTGTGTTIFSQVDVAADEILSETPYDAAPVP--
MAV_3422|M.avium_104 --AGVEHLDDWDGIGQRQTGSGTTVFNDVAVADDEVFPLG--STIGVN--
:* . . : :.
MLBr_00737|M.leprae_Br4923 LATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQ--------FGESIST
MUL_3895|M.ulcerans_Agy99 MDGIEVGRVNVSARACGVGLRAFELAVRYAQQRHT--------FGKPIAE
Mflv_4370|M.gilvum_PYR-GCK MTSLARGRVHIAALAVGAAQRALDESVAYAATATQ--------GGTPIGD
MMAR_4034|M.marinum_M MTSLARGRVHIAAIAVGAAQRALDESVAYASTATQ--------GGVTIGS
Mb0897|M.bovis_AF2122/97 LTTLNAGRLSLPAIATGVAKQALKIAREWSVERVQ--------WGKPVGQ
Rv0873|M.tuberculosis_H37Rv LTTLNAGRLSLPAIATGVAKQALKIAREWSVERVQ--------WGKPVGQ
MSMEG_3668|M.smegmatis_MC2_155 TVLGAYDQALHAAIDIGIARAALEDGAHFVRTTSRPWKEAVLAGVTSAAE
Mvan_3173|M.vanbaalenii_PYR-1 SVLGAFDQALHAAIDIGIARAALEDGAVFVRTRSRPWKEALDAGIERADQ
TH_3393|M.thermoresistible__bu TVYGARAQLWHAALDVGIATAALEEG---VRLAAR-ARPHFESGAPVATD
MAB_1422c|M.abscessus_ATCC_199 TTQYASLQLYILAIVAGVLRAVVDDGEALLRSRQR---NFSHALTERPVD
MAV_3422|M.avium_104 RARGALVQLYLHAVAAGILRSLTEDAAALVRGRRR---TYTFASADTPTA
: * * . .
MLBr_00737|M.leprae_Br4923 FQSIQFMLADMAMKVEAARLIVYAAAARAERGE-------------PDLG
MUL_3895|M.ulcerans_Agy99 HQAISFQLAEMATKVEAAHLMMVHAARLKDSGE-------------RND-
Mflv_4370|M.gilvum_PYR-GCK FQLVQAMLADQQTGVMAGRALVRDAARLWVTG--------------QDRR
MMAR_4034|M.marinum_M FQLVQAMLADQQTGVLAGRALVRDAARMWVSG--------------ADRR
Mb0897|M.bovis_AF2122/97 HEAVASKISFIAATNYALDAVVELSSQMADEGR-------------NDIR
Rv0873|M.tuberculosis_H37Rv HEAVASKISFIAATNYALDAVVELSSQMADEGR-------------NDIR
MSMEG_3668|M.smegmatis_MC2_155 EPHVVRRFGELTARLYALEALLARGTAIIDAGQS---EAELSRDTAAEAS
Mvan_3173|M.vanbaalenii_PYR-1 EPHVVRRFGELTARLYALEALLARGTALIDEAYA---APEVTRDAAAQAS
TH_3393|M.thermoresistible__bu DPTLIQSAGEVAVTVRAAQALLGEAARAVDAAT-----ADLTEDTAAAAS
MAB_1422c|M.abscessus_ATCC_199 DPLLQRTLGELSATAFAAEATVLAAADAIEAATATLRDGVPDAQLAQEAQ
MAV_3422|M.avium_104 DPQLLQIVGEIDAVAYTAHALVRNAAAELAPALQAARDTGIDPELEAAAS
: . : : .: .
MLBr_00737|M.leprae_Br4923 FISAASKCFASDIAMEVTTDAVQLFGGAGYT----------SDFPVERFM
MUL_3895|M.ulcerans_Agy99 VAAGMAKYLASEYCSEVTQQSFRIHGGYGYS----------KEYEIERLM
Mflv_4370|M.gilvum_PYR-GCK IAPSAAKLFCTEMAGKVADLAVQIHGGSGYM----------REVPVERIY
MMAR_4034|M.marinum_M IAPSAAKLFCTEMAGKVADLAVQIHGGSGYM----------RGVPVERIY
Mb0897|M.bovis_AF2122/97 IEAALAKLWSSEMACLVGDELLQIRGGRGYETAESLAARGERAVPVEQMV
Rv0873|M.tuberculosis_H37Rv IEAALAKLWSSEMACLVGDELLQIRGGRGYETAESLAARGERAVPVEQMV
MSMEG_3668|M.smegmatis_MC2_155 LTVAAAKALAQEYAVEIASGIFELTGASGTD----------SAVNLDRHW
Mvan_3173|M.vanbaalenii_PYR-1 LTVAAAKALAQQDAVEIAGAIFELTGTSGTD----------GAVNLDRHW
TH_3393|M.thermoresistible__bu IAVATAKVAAERAALRASTALFELGGTRSAT----------VSANLSRFW
MAB_1422c|M.abscessus_ATCC_199 VAVAKAKVHIDAVALDAATKLLDLGGASAAS----------RTRNLDRHW
MAV_3422|M.avium_104 IAAARVKVAIQEPALRAASRVFDAGGASAVQ----------ASALLDRHW
. . * . . * . :.:
MLBr_00737|M.leprae_Br4923 RDAKITQIYEGTNQIQRVVMSRALLR------------------------
MUL_3895|M.ulcerans_Agy99 RDAPFLLIGEGTSEIQKSIISKRLLHEYRE--------------------
Mflv_4370|M.gilvum_PYR-GCK RDVRLLRLYEGTSEIQKLIIGGGLVKGAKGK-------------------
MMAR_4034|M.marinum_M RDVRLLRLYEGTSEIQQLIIGSNLIKAANR--------------------
Mb0897|M.bovis_AF2122/97 RDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDLANPKADLRQKAAAAA
Rv0873|M.tuberculosis_H37Rv RDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDLANPKADLRQKAAAAA
MSMEG_3668|M.smegmatis_MC2_155 RNVRTHSLHD-PARWKYVHLGNHTLHGTRPPRLGLVL-------------
Mvan_3173|M.vanbaalenii_PYR-1 RNVRVHSLHD-PARWKYVHLGNHTLHDTRPPRLGLIL-------------
TH_3393|M.thermoresistible__bu RDARTHTLHD-PTRWKLHHIGRYLLSGTRPPRHGQL--------------
MAB_1422c|M.abscessus_ATCC_199 RNIRTISLHN-PVHYKARVIGQNLLHGTPLPANAYF--------------
MAV_3422|M.avium_104 RNLRTLFSHN-PTVYKARVLGDVVVNGAALPDTSFF--------------
*: : . :. :
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MUL_3895|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4034|M.marinum_M --------------------------------------------------
Mb0897|M.bovis_AF2122/97 GASGFYAKWLPKLVFGEGQLPTTYREFGALATHLRFVERSSRKLARNTFY
Rv0873|M.tuberculosis_H37Rv GASGFYAKWLPKLVFGEGQLPTTYREFGALATHLRFVERSSRKLARNTFY
MSMEG_3668|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3393|M.thermoresistible__bu --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3422|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MUL_3895|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4034|M.marinum_M --------------------------------------------------
Mb0897|M.bovis_AF2122/97 GMARWQASLEKKQGFLGRIVDIGAELFAISAACVRAEAQRTADPVEGEQA
Rv0873|M.tuberculosis_H37Rv GMARWQASLEKKQGFLGRIVDIGAELFAISAACVRAEAQRTADPVEGEQA
MSMEG_3668|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3393|M.thermoresistible__bu --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3422|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MUL_3895|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4034|M.marinum_M --------------------------------------------------
Mb0897|M.bovis_AF2122/97 YELAEAFCQQATLRVEALFDALWSNTDSIDVRLANDVLEGRYTWLEQGIL
Rv0873|M.tuberculosis_H37Rv YELAEAFCQQATLRVEALFDALWSNTDSIDVRLANDVLEGRYTWLEQGIL
MSMEG_3668|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3393|M.thermoresistible__bu --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3422|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------
MUL_3895|M.ulcerans_Agy99 --------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------
MMAR_4034|M.marinum_M --------------------------------------
Mb0897|M.bovis_AF2122/97 DQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSEAKL
Rv0873|M.tuberculosis_H37Rv DQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSEAKL
MSMEG_3668|M.smegmatis_MC2_155 --------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------
TH_3393|M.thermoresistible__bu --------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------
MAV_3422|M.avium_104 --------------------------------------