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TATSATRIGSAKDALIEAARLSAVFAEGAGARDADRRLPHDEIRALKESGLLAITVPVAHGGIDMPSTVL AEVIRLLSHGDSSIGQIPHSHFTFLEALRLQGTESQRAFFYGLVLDGALFANAQAERGPHPTDVDTTTLR PAGDGYVLSGRKFYSTGALFADWILVRASLSDGSVTVPTASTPKAVAFVPRDAAGVTIVDDWDGMGQRTT ASGTVTLDDVQVPAEHVVPFTAIFTEPTVYGSRAQLLHTAIDVGIATAALDEGVRQAARARPHFESKVAS VADDPTVVQAAGELAVTVRSAQALLAEAARQVDAARADLTDETAAAASIAVAVAKVAAVRASLDASSALF ELGGTRSASAGGNLSRYWRDARTHTLHDSTRWKLRHIGRYTLSGTKPPRHSQI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2650 | - | - | 100% (404) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3668 | - | 2e-69 | 40.84% (404) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4592 | - | 5e-68 | 40.26% (385) | acyl-CoA dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 4e-15 | 24.04% (366) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_4943 | - | 4e-16 | 25.79% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 5e-15 | 24.04% (366) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-15 | 25.07% (363) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1422c | - | 3e-56 | 37.24% (392) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1262 | fadE25 | 1e-14 | 23.16% (354) | acyl-CoA dehydrogenase FadE25 |
| M. avium 104 | MAV_3422 | - | 2e-39 | 30.50% (400) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3393 | - | 1e-166 | 72.93% (399) | PUTATIVE Acyl-CoA dehydrogenase, type 2, C-terminal domain |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 1e-14 | 23.16% (354) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 4e-67 | 39.16% (406) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1262|M.marinum_M MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
MUL_2626|M.ulcerans_Agy99 MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
Mb3302c|M.bovis_AF2122/97 MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
Rv3274c|M.tuberculosis_H37Rv MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mflv_4943|M.gilvum_PYR-GCK MP-------VDRLLPTDDARDLVELARQIADKVLDPIVDRHEKDETYPEG
MSMEG_2650|M.smegmatis_MC2_155 ------MTATSATRIGSAKDALIEAARLSAVFAEGAGARDADR--RLPHD
TH_3393|M.thermoresistible__bu -----VTEPLTMARIVDTAEALAVAARLSGSFAAEASTRDAER--LLPYE
Mvan_3173|M.vanbaalenii_PYR-1 -MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAERERAG--AVLTP
MAB_1422c|M.abscessus_ATCC_199 ------MTSAPSVLEIRALPGTDTYRNLLAQVAEGARDRDLD--DENPFD
MAV_3422|M.avium_104 ------MPVAFHRQDT--PAGAAAVQPVLAEIAADYRLRLADGGTEPPLR
MMAR_1262|M.marinum_M ALDALNASGFNAVHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MUL_2626|M.ulcerans_Agy99 ALDALNASGFNALHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
Mb3302c|M.bovis_AF2122/97 ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
Rv3274c|M.tuberculosis_H37Rv ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
Mflv_4943|M.gilvum_PYR-GCK VFATLGEAGLLSLPYPEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH
MSMEG_2650|M.smegmatis_MC2_155 EIRALKESGLLAITVPVAHGGIDMPSTVLAEVIRLLSHGDSSIGQIPHSH
TH_3393|M.thermoresistible__bu QVCELKRSGLLTLSVPAEHGGLDVPATVLAEVFRLLAHGDPSVAQIPHSH
Mvan_3173|M.vanbaalenii_PYR-1 QLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAVGQLLLSH
MAB_1422c|M.abscessus_ATCC_199 QVRLLKEAGFGRLRIPTELGGAGLSVRQLFSAIIDVAQADPIVAHIFRTH
MAV_3422|M.avium_104 GLKLVRDHRLGALRLARELGGAGYTAPEFFDYLVALAAADPDLAHILRIH
. : : : . ** . : :: . :
MMAR_1262|M.marinum_M KLGTMGLILRGSDDLKKQVLPSLADGAAMASYALSEREAGSDAGAMRTRA
MUL_2626|M.ulcerans_Agy99 KLGTMGLILRGSDELKKQVLPSLADGAAMASYALSEREAGSDAGAMRTRA
Mb3302c|M.bovis_AF2122/97 KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
Rv3274c|M.tuberculosis_H37Rv KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
Mflv_4943|M.gilvum_PYR-GCK SLSCHPLMSFGSDEQRQRWLPDMLGGSTIGAYSLSEPQAGSDAAALTCRA
MSMEG_2650|M.smegmatis_MC2_155 FTFLEALRLQGTESQRAFFYGLVLDGALFANAQAERG-PHPTDVDTTTLR
TH_3393|M.thermoresistible__bu FTFLEVLRLQGTERQRGFFYGLVLEGALFANAQSERG-PHPIDVDTTVLL
Mvan_3173|M.vanbaalenii_PYR-1 FVVAQAISGLGHTQPAPRIYADLLAGAQLGNASAERGTAHALDRRTTVTR
MAB_1422c|M.abscessus_ATCC_199 FWFVEERLRTLADPVSAAWLTKVNEGNLFANAFSEKGSLAVGSLVFNTRL
MAV_3422|M.avium_104 YALVEELQVTPRRPGSDRWIAVVAEGGLIGGANAEQSQKSVGGNHRDTRL
: :. ..
MMAR_1262|M.marinum_M KADGDDWILNGTKCWITNGGKSSWYTVMAVTDPE-----KGANGISAFMV
MUL_2626|M.ulcerans_Agy99 KADGDDWILNGTKCWITNGGKSSWYTVMAVTDPE-----NGANGISAFVV
Mb3302c|M.bovis_AF2122/97 KADGDHWILNGAKCWITNGGKSTWYTVMAVTDPD-----RGANGISAFMV
Rv3274c|M.tuberculosis_H37Rv KADGDHWILNGAKCWITNGGKSTWYTVMAVTDPD-----RGANGISAFMV
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPD-----KGANGISAFIV
Mflv_4943|M.gilvum_PYR-GCK TAVDGGYRITGSKAWITHGGIADFYNLFARTG-------EGSQGISCFLV
MSMEG_2650|M.smegmatis_MC2_155 PAGDG-YVLSGRKFYSTGALFADWILVRASLSDGSVTVPTASTPKAVAFV
TH_3393|M.thermoresistible__bu RRGAGDYLLTGRKFYSTGALFADWIVVRASVPADAADAPTAATPKAVAFV
Mvan_3173|M.vanbaalenii_PYR-1 R--DGHWVLNGTKYYATGTLGATWIAVAARIEG------RENGDTATAFV
MAB_1422c|M.abscessus_ATCC_199 LPVGDAYRLNGEKFYSTGTLFADYLTVTATTDR---------DSVASVIV
MAV_3422|M.avium_104 VTTPDGLRLRGRKFYSTGAQFSDYLRITAQDDD---------GAPTAVVI
. : * * : * : : : * : .:
MMAR_1262|M.marinum_M HKDDEGFVVGPKERK-LGIKGSPTTELYFENCRVPGDRMIG---EPGTGF
MUL_2626|M.ulcerans_Agy99 HKDDEGFVVGPKERK-LGIKGSPTTELYFENCRVPGDRMIG---EPGTGF
Mb3302c|M.bovis_AF2122/97 HKDDEGFTVGPKERK-LGIKGSPTTELYFENCRIPGDRIIG---EPGTGF
Rv3274c|M.tuberculosis_H37Rv HKDDEGFTVGPKERK-LGIKGSPTTELYFENCRIPGDRIIG---EPGTGF
MLBr_00737|M.leprae_Br4923 HKDDEGFSIGPKEKK-LGIKGSPTTELYFDKCRIPGDRIIG---EPGTGF
Mflv_4943|M.gilvum_PYR-GCK PRDTEGLTFGKPEEK-MGLHAVPTTAAHYDDANLDSDRRIG---TEGQGL
MSMEG_2650|M.smegmatis_MC2_155 PRDAAGVTI-VDDWDGMGQRTTASGTVTLDDVQVPAEHVV----PFTAIF
TH_3393|M.thermoresistible__bu PRHAPGLTV-IDDWDGMGQRTTASGSVTLDEVRVPADHVV----PFTPIF
Mvan_3173|M.vanbaalenii_PYR-1 RPDQEGVTLDLESWSAFGQRGTASGEVRLNNVVVDDDLLIDEGPPPDPIT
MAB_1422c|M.abscessus_ATCC_199 PGDRDGVRL-VDDWDGFGQRRTGTGTTIFSQVDVAADEIL--SETPYDAA
MAV_3422|M.avium_104 PVDRAGVEH-LDDWDGIGQRQTGSGTTVFNDVAVADDEVF--PLG--STI
. *. . . :* : : .. : : .
MMAR_1262|M.marinum_M KTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFG--------KS
MUL_2626|M.ulcerans_Agy99 KTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFG--------KS
Mb3302c|M.bovis_AF2122/97 KTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFG--------ES
Rv3274c|M.tuberculosis_H37Rv KTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFG--------ES
MLBr_00737|M.leprae_Br4923 KTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFG--------ES
Mflv_4943|M.gilvum_PYR-GCK QIAFSALDSGRLGIAAVAVGLAQAALDEAVAYSQERTTFG--------RK
MSMEG_2650|M.smegmatis_MC2_155 TEPTVYGSRAQLLHTAIDVGIATAALDEG-VRQAARARP---HFESKVAS
TH_3393|M.thermoresistible__bu RRPTVYGARAQLWHAALDVGIATAALEEG-VRLAARARP---HFESGAPV
Mvan_3173|M.vanbaalenii_PYR-1 ADPSVLGAFDQALHAAIDIGIARAALEDGAVFVRTRSRPWKEALDAGIER
MAB_1422c|M.abscessus_ATCC_199 PVPTTQYASLQLYILAIVAGVLRAVVDDGEALLRSRQRN---FSHALTER
MAV_3422|M.avium_104 GVNRARGALVQLYLHAVAAGILRSLTEDAAALVRGRRRT---YTFASADT
: * *: . : . . *
MMAR_1262|M.marinum_M ISDFQAVQFMLADMAMKVESARLMVYSAAARAERGESN------------
MUL_2626|M.ulcerans_Agy99 ISDFQAVQFMLADMAMKVESARLMVYSAAARAERGESN------------
Mb3302c|M.bovis_AF2122/97 ISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPD------------
Rv3274c|M.tuberculosis_H37Rv ISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPD------------
MLBr_00737|M.leprae_Br4923 ISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPD------------
Mflv_4943|M.gilvum_PYR-GCK IIDHQGLAFLLADMAAAVDSARATYLDAARRRDAGLPY------------
MSMEG_2650|M.smegmatis_MC2_155 VADDPTVVQAAGELAVTVRSAQALLAEAARQVDAARAD-----LTDETAA
TH_3393|M.thermoresistible__bu ATDDPTLIQSAGEVAVTVRAAQALLGEAARAVDAATAD-----LTEDTAA
Mvan_3173|M.vanbaalenii_PYR-1 ADQEPHVVRRFGELTARLYALEALLARGTALIDEAYAAP---EVTRDAAA
MAB_1422c|M.abscessus_ATCC_199 PVDDPLLQRTLGELSATAFAAEATVLAAADAIEAATATLRDGVPDAQLAQ
MAV_3422|M.avium_104 PTADPQLLQIVGEIDAVAYTAHALVRNAAAELAPALQAARDTGIDPELEA
: .:: : . .: .
MMAR_1262|M.marinum_M -LGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRDAKITQ
MUL_2626|M.ulcerans_Agy99 -LGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRDAKITQ
Mb3302c|M.bovis_AF2122/97 -LGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQ
Rv3274c|M.tuberculosis_H37Rv -LGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQ
MLBr_00737|M.leprae_Br4923 -LGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQ
Mflv_4943|M.gilvum_PYR-GCK -SRHASVA-KLVATDAAMKVTTDAVQVLGGAGYTRDYRVERYMREAKITQ
MSMEG_2650|M.smegmatis_MC2_155 AASIAVAVAKVAAVRASLDASSALFELGGTRSASAGGNLSRYWRDARTHT
TH_3393|M.thermoresistible__bu AASIAVATAKVAAERAALRASTALFELGGTRSATVSANLSRFWRDARTHT
Mvan_3173|M.vanbaalenii_PYR-1 QASLTVAAAKALAQQDAVEIAGAIFELTGTSGTDGAVNLDRHWRNVRVHS
MAB_1422c|M.abscessus_ATCC_199 EAQVAVAKAKVHIDAVALDAATKLLDLGGASAASRTRNLDRHWRNIRTIS
MAV_3422|M.avium_104 AASIAAARVKVAIQEPALRAASRVFDAGGASAVQASALLDRHWRNLRTLF
. * :: : .: * . :.* *: :
MMAR_1262|M.marinum_M IYEGTNQIQRVVMSRALLR----------
MUL_2626|M.ulcerans_Agy99 IYEGTNQIQRVVMSRALLR----------
Mb3302c|M.bovis_AF2122/97 IYEGTNQIQRVVMSRALLR----------
Rv3274c|M.tuberculosis_H37Rv IYEGTNQIQRVVMSRALLR----------
MLBr_00737|M.leprae_Br4923 IYEGTNQIQRVVMSRALLR----------
Mflv_4943|M.gilvum_PYR-GCK IFEGTNQIQRLVISRHLTRG---------
MSMEG_2650|M.smegmatis_MC2_155 LHDSTRWKLRHIGRYTLSGTKPPRHSQI-
TH_3393|M.thermoresistible__bu LHDPTRWKLHHIGRYLLSGTRPPRHGQL-
Mvan_3173|M.vanbaalenii_PYR-1 LHDPARWKYVHLGNHTLHDTRPPRLGLIL
MAB_1422c|M.abscessus_ATCC_199 LHNPVHYKARVIGQNLLHGTPLPANAYF-
MAV_3422|M.avium_104 SHNPTVYKARVLGDVVVNGAALPDTSFF-
.: . : :