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MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPSDAEEARTEAFLVKLREFLDT VDGSVIERAAQIPDEYVKGLAELGCFGLKIPSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGV PEPLKLAGTAEQKRRFLPRCAAGAISAFLLTEPDVGSDPARMASTATPIDDGQAYELEGVKLWTTNGVVA DLLVVMARVPRSEGHRGGISAFVVEADSPGITVERRNKFMGLRGIENGVTRLHRVRVPKDNLIGREGDGL KIALTTLNAGRLSLPAIATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKISFIAATNYALDAVVELS SQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGYETAESLAARGERAVPVEQMVRDLRINRI FEGSSEIMRLLIAREAVDAHLTAAGDLANPKADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFG ALATHLRFVERSSRKLARNTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVRAEAQRTADPVEGE QAYELAEAFCQQATLRVEALFDALWSNTDSIDVRLANDVLEGRYTWLEQGILDQSEGTGPWIASWEPGPS TEANLARRFLTVSPSSEAKL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0873 | fadE10 | - | 100% (650) | PROBABLE ACYL-CoA DEHYDROGENASE FADE10 |
M. tuberculosis H37Rv | Rv3274c | fadE25 | 5e-44 | 31.54% (390) | acyl-CoA dehydrogenase FADE25 |
M. tuberculosis H37Rv | Rv2500c | fadE19 | 7e-38 | 31.75% (359) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0897 | fadE10 | 0.0 | 100.00% (650) | acyl-CoA dehydrogenase FADE10 |
M. gilvum PYR-GCK | Mflv_4370 | - | 4e-45 | 33.51% (385) | acyl-CoA dehydrogenase domain-containing protein |
M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-43 | 31.39% (360) | putative acyl-CoA dehydrogenase |
M. abscessus ATCC 19977 | MAB_3618c | - | 7e-41 | 31.67% (360) | acyl-CoA dehydrogenase FadE |
M. marinum M | MMAR_4660 | fadE10 | 0.0 | 85.85% (650) | acyl-CoA dehydrogenase FadE10 |
M. avium 104 | MAV_1001 | - | 0.0 | 85.51% (642) | putative acyl-CoA dehydrogenase |
M. smegmatis MC2 155 | MSMEG_2205 | - | 3e-44 | 33.52% (361) | putative acyl-CoA dehydrogenase |
M. thermoresistible (build 8) | TH_3736 | - | 9e-48 | 33.66% (413) | PUTATIVE acyl-CoA dehydrogenase domain protein |
M. ulcerans Agy99 | MUL_0278 | fadE10 | 0.0 | 85.69% (650) | acyl-CoA dehydrogenase FadE10 |
M. vanbaalenii PYR-1 | Mvan_1476 | - | 1e-44 | 33.70% (359) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Rv0873|M.tuberculosis_H37Rv MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPS Mb0897|M.bovis_AF2122/97 MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPS MMAR_4660|M.marinum_M MAQQAQVTEEQARALAEESRESGWNKPSFAKELFLGRFPLELINPFPRPS MUL_0278|M.ulcerans_Agy99 MAQQAQVTEEQARALAEESRESGWNKPSFAKELFLGRFPLELINPFPRPS MAV_1001|M.avium_104 MAQQTQVTEEQARALAEESRETGWDKPSFAKELFLGRFPLELIHPFPQPS MSMEG_2205|M.smegmatis_MC2_155 ------------------MTGTVTDG---------------QSAAEVGDE TH_3736|M.thermoresistible__bu ------------------MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDE Mflv_4370|M.gilvum_PYR-GCK ------------------MASPPANAAEAG-----------IPSAEVNDE MLBr_00737|M.leprae_Br4923 ---------------------------------MVGWSGNPLFDLFKLPE MAB_3618c|M.abscessus_ATCC_199 ------------------------------------MAGNPSFDLFKLGE Mvan_1476|M.vanbaalenii_PYR-1 ----------------------------------------MAVDRLLPTD . Rv0873|M.tuberculosis_H37Rv DAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKI Mb0897|M.bovis_AF2122/97 DAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKI MMAR_4660|M.marinum_M DAEEARTAAFLCRLQEFLGTIDGSVIERDAQIPDEYVNGLAELGCFGMKI MUL_0278|M.ulcerans_Agy99 DAEEARTAAFLCRLQEFLGTIDGSVIERDAQIPDEYVKGLAELGCFGMKI MAV_1001|M.avium_104 DADEARTRAFLDQLRKFLDTVDGSVIERDAEIPAEYVRGLADLGCFGMKI MSMEG_2205|M.smegmatis_MC2_155 DFEEILAQARSFIRNAVVPREN--EILATDKVPDDIREQAKNMGLFGYAI TH_3736|M.thermoresistible__bu DFRQILRQTREFVRTAVVPREL--EILNEDRVPDDLREQAKQMGLFGYAI Mflv_4370|M.gilvum_PYR-GCK DFQAILAATREFVRTAVVPREQ--EILSTDQVPDDLREQTKSMGLFGYAI MLBr_00737|M.leprae_Br4923 EHNELRATIRALAEKEIAPHAA--DVDQRARFPEEALAALNASGFNAIHV MAB_3618c|M.abscessus_ATCC_199 EHDELRAAIRGLAEKEIAPHAK--DVDEKARFPQEALDALVASGFNAVHV Mvan_1476|M.vanbaalenii_PYR-1 EARELVDLARQIADKALDPIVD--QHEKDETYPDGVFATLGEAGLLSLPY : . * * . Rv0873|M.tuberculosis_H37Rv PSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTA Mb0897|M.bovis_AF2122/97 PSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTA MMAR_4660|M.marinum_M PSEYGGLSMSQVAYNRALMLASTVHTSLGALLSAHQSIGVPEPLKLAGSP MUL_0278|M.ulcerans_Agy99 PSEYGGLSMSQVAYNRALMLASTVHTSLGALLSAHQSIGVPEPLKLAGSP MAV_1001|M.avium_104 PSEFGGLNMSQVAYNRALMMISSVHPSLGALLSAHQSIGVPEPLKLAGTP MSMEG_2205|M.smegmatis_MC2_155 PQQWGGLGLNLAQDVELAMEFGYTSLALRSMFGTNNGIAGQVLVGFGTDE TH_3736|M.thermoresistible__bu PQQWGGLGLDLAQDVELAMELGYTSLALRSMFGTNNGIAGQVLVGFGTEE Mflv_4370|M.gilvum_PYR-GCK PQEWGGLGLNLAQDVELAMELGYTSLALRSMFGTNNGIAGQVLVGYGTDE MLBr_00737|M.leprae_Br4923 PEEYGGQGADSVAACIVIEEVARVDASASLIPAVN-KLGTMGLILRGSEE MAB_3618c|M.abscessus_ATCC_199 PEEYDGQGADSVAACIVIEEVARVCASSSLIPAVN-KLGTMGLILNGSDE Mvan_1476|M.vanbaalenii_PYR-1 PEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH-SLSCHPLMSFGTDE *.::.* . : ..: :. : . Rv0873|M.tuberculosis_H37Rv EQKRRFLPRCAAGAISAFLLTEPDVGSDPARMASTATPIDDG--QAYELE Mb0897|M.bovis_AF2122/97 EQKRRFLPRCAAGAISAFLLTEPDVGSDPARMASTATPIDDG--QAYELE MMAR_4660|M.marinum_M EQKKKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPIDGG--QAYELE MUL_0278|M.ulcerans_Agy99 EQKKKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPIDDG--QAYELE MAV_1001|M.avium_104 EQKRKFLPRCAAGAISAFLLTEPDVGSDPARLASTATPVDDG--KAYELN MSMEG_2205|M.smegmatis_MC2_155 QKQQWLEGIASGEVVASFALTEPGAGSNPAGLRTKAVRDGS----DWVIN TH_3736|M.thermoresistible__bu QKARWLEPIASGEVVASFALTEPGAGSNPAGLRSRAVRDGSGADADWIIN Mflv_4370|M.gilvum_PYR-GCK QKKTWLERIASGEIVASFALTEPGAGSNPSGLRTKAVRDGDGPHSGWILN MLBr_00737|M.leprae_Br4923 LKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGD----DWILN MAB_3618c|M.abscessus_ATCC_199 LKKQVLPAIASGEAMASYALSEREAGSDAASMRTRAKADGD----DWIIN Mvan_1476|M.vanbaalenii_PYR-1 QRQRWLPEMLGGSTIGAYSLSEPQAGSDAAALTCKAVAADG----GYRIN : : . :.:: *:* .**:.: : * .. : :: Rv0873|M.tuberculosis_H37Rv GVKLWTTNGVVADLLVVMARVPRSEGHRGGISAFVVEADSPGITVERRNK Mb0897|M.bovis_AF2122/97 GVKLWTTNGVVADLLVVMARVPRSEGHRGGISAFVVEADSPGITVERRNK MMAR_4660|M.marinum_M GVKLWTTNGVVAELLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNK MUL_0278|M.ulcerans_Agy99 GIKLWTTNGVVAELLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNK MAV_1001|M.avium_104 GVKLWTTNGVVAELLVVMARVPKSEGHRGGISAFVVEADSPGITVERRNK MSMEG_2205|M.smegmatis_MC2_155 GQKRFITNAPTAGLFVVFARTRPADADGAGIAVFLVPADTPGVEVGPKDA TH_3736|M.thermoresistible__bu GQKRFITNAPVADLFVVFARSRPADERGAGIAVFLVPADAPGVEVGAKDA Mflv_4370|M.gilvum_PYR-GCK GQKRFITNAPNADLFVTFARSRPADDKGAGIAVFLVPADTPGVDIGAKDK MLBr_00737|M.leprae_Br4923 GFKCWITNGGKSTWYTVMAVTDPD-KGANGISAFIVHKDDEGFSIGPKEK MAB_3618c|M.abscessus_ATCC_199 GSKCWITNGGKSSWYTVMAVTDPE-KKANGISAFMVHKDDEGFTVGPLEH Mvan_1476|M.vanbaalenii_PYR-1 GAKAWITHGGIADFYNLFARTG---EGSQGISCFLVPRDTEGLTFGKPEE * * : *:. : :* **: *:* * *. . : Rv0873|M.tuberculosis_H37Rv FMGLRGIENGVTRLHRVRVPKDNLIG-REGDGLKIALTTLNAGRLSLPAI Mb0897|M.bovis_AF2122/97 FMGLRGIENGVTRLHRVRVPKDNLIG-REGDGLKIALTTLNAGRLSLPAI MMAR_4660|M.marinum_M FMGLRGIENGVTRLHRVRVPKENLIG-REGDGLRIALTTLNAGRLAIPAM MUL_0278|M.ulcerans_Agy99 FMGLRGIENGVTRLHRVRVPKENLIG-REGDGLRIALTTLNAGRLAIPAM MAV_1001|M.avium_104 FMGLRGIENGVTRLHRVRVPSENLVG-REGDGLKIALTTLNAGRLSIPAS MSMEG_2205|M.smegmatis_MC2_155 KMGQEGAWTADVNFTDVRVPAAALVGGSEDVGYRAAMTSLARGRVHIAAL TH_3736|M.thermoresistible__bu KMGQEGAWTADVTFTDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAAL Mflv_4370|M.gilvum_PYR-GCK KMGQEGAWTADVNFTDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAAL MLBr_00737|M.leprae_Br4923 KLGIKGSPTTELYFDKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQ MAB_3618c|M.abscessus_ATCC_199 KLGIKGSPTAELYFENCRIPGDRIIG-EPGTGFKTALQTLDHTRPTIGAQ Mvan_1476|M.vanbaalenii_PYR-1 KMGLHAVPTTAAHYENAFVEADRRIG-AEGQGLQIAFSALDSGRLGIAAV :* .. . : :* . * : *: :* * : * Rv0873|M.tuberculosis_H37Rv ATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKISFIAATNYALDAVV Mb0897|M.bovis_AF2122/97 ATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKISFIAATNYALDAVV MMAR_4660|M.marinum_M VTGAAKWSLKIAREWSGERVQWGKPLGKHEAVAGKISFIAATTYALEAVV MUL_0278|M.ulcerans_Agy99 VTGAAKWSLKIAREWSGERVQWGKPLGKDEAVAGKISFIAATTYALEAVV MAV_1001|M.avium_104 ATGSAKWALKIAREWSGERVQWGKPLAEHEAVARKLSFIAATVYALDAVL MSMEG_2205|M.smegmatis_MC2_155 AVGTAQRALDESVAYAATATQGGQPIGNFQLVQAMIADQQTGVMAGRALV TH_3736|M.thermoresistible__bu AVGTAQRALDESVAYAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALV Mflv_4370|M.gilvum_PYR-GCK AVGAAQRALDESVAYAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALV MLBr_00737|M.leprae_Br4923 AVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIV MAB_3618c|M.abscessus_ATCC_199 ALGIAQGALDQAIAYTKDRKQFGKSISDFQGVQFMLADMAMKVEAARLMV Mvan_1476|M.vanbaalenii_PYR-1 AVGLAQAALDAAVDYSQERTTFGRKIIDHQGLAFLLADMAAAVDAARATY . * *: :*. : :: * : : : :: * Rv0873|M.tuberculosis_H37Rv ELSSQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGYETAES Mb0897|M.bovis_AF2122/97 ELSSQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGYETAES MMAR_4660|M.marinum_M EISGQMADEGRNDIRIEAALAKLWSSEMACQVADELLQIRGGRGYETAES MUL_0278|M.ulcerans_Agy99 EISGQMADEGRNDIRIEAALAKLWSSEMACQVADELLQIRGGRGYETAES MAV_1001|M.avium_104 ELSAQMADEGRNDIRIEAALAKLWSSEMACVIADEVMQIRGGRGYETAES MSMEG_2205|M.smegmatis_MC2_155 RDAAQKWVTGED-RRIAPSAAKLYCTEMAGTVADLAVQIHGGTGYM---- TH_3736|M.thermoresistible__bu RDAARKWVSGED-RRVAPSAAKLFCTEMAGQVADLAVQIHGGTGYM---- Mflv_4370|M.gilvum_PYR-GCK RDAARLWVTGQD-RRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYM---- MLBr_00737|M.leprae_Br4923 YAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYT---- MAB_3618c|M.abscessus_ATCC_199 YTAAARAERGEKNLGFISSASKCFASDVAMEVTTDAVQLFGGAGYT---- Mvan_1476|M.vanbaalenii_PYR-1 LDAARRRDAGLP-YSRHASVAKLTATDAAMKVTTDAVQVFGGAGYT---- :. * .: :* .:: * : :*: ** ** Rv0873|M.tuberculosis_H37Rv LAARGERAVPVEQMVRDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL Mb0897|M.bovis_AF2122/97 LAARGERAVPVEQMVRDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL MMAR_4660|M.marinum_M LAARGERAAPVEQSLRDVRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL MUL_0278|M.ulcerans_Agy99 LAARGERAAPVEQSLRDVRINRIFEGSSEIMRLLIAREAVDAHLTAAGDL MAV_1001|M.avium_104 LAARGERAVPVEQVLRDLRINRIFEGASEIMRLLIAREAVDAHLAAAGDL MSMEG_2205|M.smegmatis_MC2_155 ------REVPVERIYREVRLLRLYEGTSEIQRLIIGGGLVKAAQRQL--- TH_3736|M.thermoresistible__bu ------REVPVERIYRDVRLLRLYEGTSEIQRLIIGGGLVKAAQRQTN-- Mflv_4370|M.gilvum_PYR-GCK ------REVPVERIYRDVRLLRLYEGTSEIQKLIIGGGLVKGAKGK---- MLBr_00737|M.leprae_Br4923 ------SDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR--------- MAB_3618c|M.abscessus_ATCC_199 ------TDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLTS-------- Mvan_1476|M.vanbaalenii_PYR-1 ------RDYRVERYMREAKITQIFEGTNQIQRLVISRHLARD-------- **: *: :: :::**:.:* ::::. Rv0873|M.tuberculosis_H37Rv ANPKADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFGALATHLR Mb0897|M.bovis_AF2122/97 ANPKADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFGALATHLR MMAR_4660|M.marinum_M AKPNTDLRKKAAAAVGASGFYAKWLPQLVFGEGQRPKAYHEFGPLAAHLR MUL_0278|M.ulcerans_Agy99 AKPNTDLRKKAAAAVGASGFYAKWLPQLVFGEGQRPKAYHEFGPLAAHLR MAV_1001|M.avium_104 AKPDAGLREKAAAAVGASGFYAKWLPQLVFGEGQRPRAYHEFGALARHLR MSMEG_2205|M.smegmatis_MC2_155 -------------------------------------------------- TH_3736|M.thermoresistible__bu -------------------------------------------------- Mflv_4370|M.gilvum_PYR-GCK -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MAB_3618c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1476|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv0873|M.tuberculosis_H37Rv FVERSSRKLARNTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVR Mb0897|M.bovis_AF2122/97 FVERSSRKLARNTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVR MMAR_4660|M.marinum_M FIERSTRKLARNTFYGMARWQAKLEQKQGFLGRIVDIGAELFAMSAVCVR MUL_0278|M.ulcerans_Agy99 FIERSTRKLARNTFYGMARWQAKLEQKQGFFGRIVDIGAELFAMSAVCVR MAV_1001|M.avium_104 FIERSSRKLARNTFYGMARWQAKLEQRQGFLGRVVDIGAELFAMSAACVR MSMEG_2205|M.smegmatis_MC2_155 -------------------------------------------------- TH_3736|M.thermoresistible__bu -------------------------------------------------- Mflv_4370|M.gilvum_PYR-GCK -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MAB_3618c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1476|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv0873|M.tuberculosis_H37Rv AEAQRTADPVEGEQAYELAEAFCQQATLRVEALFDALWSNTDSIDVRLAN Mb0897|M.bovis_AF2122/97 AEAQRTADPVEGEQAYELAEAFCQQATLRVEALFDALWSNTDSIDVRLAN MMAR_4660|M.marinum_M AEAQRVADPIVGRQAYELAEAFCGQATLRVEALFHGLWTNTDVGDVRLTN MUL_0278|M.ulcerans_Agy99 AEAQRVADPIVGRQAYELAEAFCGQATLRVEALFHGLWTNTDVGDVRLTN MAV_1001|M.avium_104 AEAQRNADPVLGQQAYELAEAFCAHATLRVEALFQALWDNTDTGDVALTR MSMEG_2205|M.smegmatis_MC2_155 -------------------------------------------------- TH_3736|M.thermoresistible__bu -------------------------------------------------- Mflv_4370|M.gilvum_PYR-GCK -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MAB_3618c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1476|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv0873|M.tuberculosis_H37Rv DVLEGRYTWLEQGILDQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSE Mb0897|M.bovis_AF2122/97 DVLEGRYTWLEQGILDQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSE MMAR_4660|M.marinum_M DVLEGRYAWLEDGIIDPSEGTGPWIAHWEPGPSTQPNVARRFLPDSTSAE MUL_0278|M.ulcerans_Agy99 DVLEGRYAWLEDGIIDPSEGTGPWIAHWEPGPSTQPNVARRFLPDSTSVE MAV_1001|M.avium_104 NLQRGRYAWLEDGIIDQSEGSGPWIAHWEEGPSTEANLARRFLTI----- MSMEG_2205|M.smegmatis_MC2_155 -------------------------------------------------- TH_3736|M.thermoresistible__bu -------------------------------------------------- Mflv_4370|M.gilvum_PYR-GCK -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MAB_3618c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1476|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv0873|M.tuberculosis_H37Rv AKL Mb0897|M.bovis_AF2122/97 AKL MMAR_4660|M.marinum_M AKL MUL_0278|M.ulcerans_Agy99 AKL MAV_1001|M.avium_104 --- MSMEG_2205|M.smegmatis_MC2_155 --- TH_3736|M.thermoresistible__bu --- Mflv_4370|M.gilvum_PYR-GCK --- MLBr_00737|M.leprae_Br4923 --- MAB_3618c|M.abscessus_ATCC_199 --- Mvan_1476|M.vanbaalenii_PYR-1 ---