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MASPPANAAEAGIPSAEVNDEDFQAILAATREFVRTAVVPREQEILSTDQVPDDLREQTKSMGLFGYAIP QEWGGLGLNLAQDVELAMELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFALT EPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPNADLFVTFARSRPADDKGAGIAVFLVPADTP GVDIGAKDKKMGQEGAWTADVNFTDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDE SVAYAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQDRRIAPSAAKLFCTEMAGKV ADLAVQIHGGSGYMREVPVERIYRDVRLLRLYEGTSEIQKLIIGGGLVKGAKGK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4370 | - | - | 100% (404) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_5011 | - | 5e-60 | 36.27% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2446 | - | 4e-58 | 35.62% (379) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 6e-63 | 36.55% (383) | acyl-CoA dehydrogenase FADE3 |
| M. tuberculosis H37Rv | Rv0752c | fadE9 | 7e-58 | 34.74% (380) | acyl-CoA dehydrogenase FADE9 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-51 | 33.07% (381) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0065c | - | 1e-55 | 34.66% (378) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4034 | fadE | 0.0 | 82.08% (385) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1571 | - | 0.0 | 81.91% (387) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2205 | - | 0.0 | 84.65% (391) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 0.0 | 83.58% (402) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 6e-58 | 35.53% (380) | acyl-CoA dehydrogenase FadE3 |
| M. vanbaalenii PYR-1 | Mvan_1974 | - | 0.0 | 91.79% (390) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0221c|M.bovis_AF2122/97 --------------------MRN-----ELNDDEAMLVATVRAFIDRDVK
MUL_4024|M.ulcerans_Agy99 -------------------MMNNDSPDSQLDEDEAMLVATVRAFIDRDVR
Mflv_4370|M.gilvum_PYR-GCK MASPPANAAEAG-----------IPSAEVNDEDFQAILAATREFVRTAVV
Mvan_1974|M.vanbaalenii_PYR-1 -----------------------MSTAEVGDEDFRQILAQTRQFVRTAVV
MSMEG_2205|M.smegmatis_MC2_155 MTGTVTDG---------------QSAAEVGDEDFEEILAQARSFIRNAVV
TH_3736|M.thermoresistible__bu MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
MMAR_4034|M.marinum_M MT-----------------------APQVSDEDFAQILAQTRHFVRSVVL
MAV_1571|M.avium_104 MTSA--------------------EVAEVSEQDFGEILAQTRQFVRTAVV
MAB_0065c|M.abscessus_ATCC_199 ------------------------MQRTIYTEDHEAFRESVKAFVQRHVD
Rv0752c|M.tuberculosis_H37Rv --------------------------MFVLNDDERVIVETAAAFAGKRLA
MLBr_00737|M.leprae_Br4923 ---------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA
:: : : :
Mb0221c|M.bovis_AF2122/97 PTVREVEHANSYPEAWIEQMKHIGIYGLAIDEQYGG-SPVSMPCYVQVTQ
MUL_4024|M.ulcerans_Agy99 PSVREVEHANTYPQAWIEQMKRIGIYGLAIGEAYGG-SPVSMPCYVQVTQ
Mflv_4370|M.gilvum_PYR-GCK PREQEILSTDQVPDDLREQTKSMGLFGYAIPQEWGG-LGLNLAQDVELAM
Mvan_1974|M.vanbaalenii_PYR-1 PREQEILTTDRVPDELREQAKSMGLFGYAIPQEWGG-LGLDLTQDVELAM
MSMEG_2205|M.smegmatis_MC2_155 PRENEILATDKVPDDIREQAKNMGLFGYAIPQQWGG-LGLNLAQDVELAM
TH_3736|M.thermoresistible__bu PRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGG-LGLDLAQDVELAM
MMAR_4034|M.marinum_M PREQQILDEDRVPEDLRDQAKQMGLFGYAIPPQWGG-LGLNLVQDVELAM
MAV_1571|M.avium_104 PREQEILDGDRVPDDLRDQAKKMGLFGYAIPQQWGG-LGLNLMQDVELAM
MAB_0065c|M.abscessus_ATCC_199 PRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEFGGSSAGDYRYNAVLQE
Rv0752c|M.tuberculosis_H37Rv PHALEWDAAKHFPVDVLREAAELGMAAIYCRDDVGG-SGLRRLDGVRIFE
MLBr_00737|M.leprae_Br4923 PHAADVDQRARFPEEALAALNASGFNAIHVPEEYGG-QGADSVAACIVIE
* * . ** :
Mb0221c|M.bovis_AF2122/97 ELARGWMSLAGAMGG-HTVVAKLLTLFGTEEQRRTYLPPMASGELRATMA
MUL_4024|M.ulcerans_Agy99 ELARGWMSLAGAMGG-HTVVAKLLMLFGTDEQKSTYLPAMATGELRATMA
Mflv_4370|M.gilvum_PYR-GCK ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFA
Mvan_1974|M.vanbaalenii_PYR-1 ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKSTWLERIASGEVVASFA
MSMEG_2205|M.smegmatis_MC2_155 EFGYTSLALRSMFGTNNGIAGQVLVGFGTDEQKQQWLEGIASGEVVASFA
TH_3736|M.thermoresistible__bu ELGYTSLALRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEVVASFA
MMAR_4034|M.marinum_M ELGYTSLAVRSMFGTNNGIAGQVLVGFGTDEQKARWLEPIASGDVVASFA
MAV_1571|M.avium_104 ELGYTSLALRSMFGTNNGIAGQVLVGFGTEAQKARWLEPMAAGDVVASFA
MAB_0065c|M.abscessus_ATCC_199 ELARSSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGEMITAIG
Rv0752c|M.tuberculosis_H37Rv QLAIADP-VTAAFLSIHNMCAWMIDSFGTDEQRKDWIPRLATMGVIASYC
MLBr_00737|M.leprae_Br4923 EVARVDA-SASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYA
:.. . : : : :: : : :.: ::
Mb0221c|M.bovis_AF2122/97 LTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWISNARRSGLFAVLC
MUL_4024|M.ulcerans_Agy99 LTEPGGGSDLQNMSTTAMADGPDQ---LLITGAKTWISNARRSGLIALLC
Mflv_4370|M.gilvum_PYR-GCK LTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPNADLFVTFA
Mvan_1974|M.vanbaalenii_PYR-1 LTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPNANLFVTFA
MSMEG_2205|M.smegmatis_MC2_155 LTEPGAGSNPAGLRTKAVRDGS----DWVINGQKRFITNAPTAGLFVVFA
TH_3736|M.thermoresistible__bu LTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPVADLFVVFA
MMAR_4034|M.marinum_M LTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPVADLFVVFA
MAV_1571|M.avium_104 LTEPGAGSNPAGLRTKAVADGD----NWVISGQKRFITNAPVANLFVVFA
MAB_0065c|M.abscessus_ATCC_199 MTEPSGGSDLAALKTTAVKDGD----DWVINGSKTFITNGARADLVVVAA
Rv0752c|M.tuberculosis_H37Rv LTEPGAGSDAGALSTRAVRHGSGKGGDYVLDGVKQFISGAAASDVYVVMA
MLBr_00737|M.leprae_Br4923 LSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMA
::* .**. : : * .* :: * * :*:.. : . .
Mb0221c|M.bovis_AF2122/97 KTDPNATPRHQGMSIVLVEPGPGLTVSRDLPKLGYKGVESCELSFDNLRV
MUL_4024|M.ulcerans_Agy99 KTDPHATPRHHGISIVLVEPGPGLNISADLPKLGYKGVEACELSFDNYRA
Mflv_4370|M.gilvum_PYR-GCK RSRPADDKGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNFTDVEV
Mvan_1974|M.vanbaalenii_PYR-1 RSRPADDKGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNFTDVRV
MSMEG_2205|M.smegmatis_MC2_155 RTRPADADGAGIAVFLVPADTPGVEVGPKDAKMGQEGAWTADVNFTDVRV
TH_3736|M.thermoresistible__bu RSRPADERGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTFTDVRV
MMAR_4034|M.marinum_M RTRPASDKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSFTDVRV
MAV_1571|M.avium_104 RTRPADDQGPGIAVFLVPADAAGVQIGAKDAKMGQEGAWTADVSFDDVRV
MAB_0065c|M.abscessus_ATCC_199 RTAP-ELKAKGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFFTDVRV
Rv0752c|M.tuberculosis_H37Rv RTGAEGPRG--VSAFIVEKGTPGLSFGAPEAKMGWHAQPTAQVVLDGVRV
MLBr_00737|M.leprae_Br4923 VTDP-DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRI
: . : : *. . *:* : :: : .
Mb0221c|M.bovis_AF2122/97 PVSAILGGAMGQG--FSQMMKGLETGRIQVAARALGVATAALEDSLAYAQ
MUL_4024|M.ulcerans_Agy99 PTSAILGGQPGQG--FSQMMKGLETGRIQVAARALGVASAALDDALAYAQ
Mflv_4370|M.gilvum_PYR-GCK PDTALVGGSEDLG--YRAAMTSLARGRVHIAALAVGAAQRALDESVAYAA
Mvan_1974|M.vanbaalenii_PYR-1 PDAALVGGSEDIG--YRAAMTSLARGRVHIAALAVGAAQRALDESVTYAA
MSMEG_2205|M.smegmatis_MC2_155 PAAALVGGSEDVG--YRAAMTSLARGRVHIAALAVGTAQRALDESVAYAA
TH_3736|M.thermoresistible__bu PASALVGGEEDIG--YRAAMTSLARGRVHIAALAVGTAQRALDESVAYAA
MMAR_4034|M.marinum_M DDAALVGGSEDIG--YRAAMTSLARGRVHIAAIAVGAAQRALDESVAYAS
MAV_1571|M.avium_104 GGDALIGGSEDIG--YRAAMTSLARGRVHIAALAVGAAQRALDESVSYAS
MAB_0065c|M.abscessus_ATCC_199 PAENVIG-EVNQG--FISMMQRLPQERMGCAVANIAHAVAVLEETVEYAK
Rv0752c|M.tuberculosis_H37Rv PAEAMLGGADGEGAGFGIAMSGLNGGRLNIAACSLGGAQAAFDKAGAYVR
MLBr_00737|M.leprae_Br4923 PGDRIIG-EPGTG--FKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTK
::* . * : : * * .. :. * .:: : *.
Mb0221c|M.bovis_AF2122/97 QRESFGRPIWQHQAVGNYLADMATKLTAARQLTRYAAERYDSGQRCDMEA
MUL_4024|M.ulcerans_Agy99 QRHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYDSGQRCDMEA
Mflv_4370|M.gilvum_PYR-GCK TATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQDRRIAP
Mvan_1974|M.vanbaalenii_PYR-1 TATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETARQWVTGEDRRIAP
MSMEG_2205|M.smegmatis_MC2_155 TATQGGQPIGNFQLVQAMIADQQTGVMAGRALVRDAAQKWVTGEDRRIAP
TH_3736|M.thermoresistible__bu SATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAARKWVSGEDRRVAP
MMAR_4034|M.marinum_M TATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSGADRRIAP
MAV_1571|M.avium_104 TATQGGTPIGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGEDRRVAP
MAB_0065c|M.abscessus_ATCC_199 ERKAFGQQIGSLQYNKFLIAELVTKLEAAQVYVDQAVLAHSKGELTAIDA
Rv0752c|M.tuberculosis_H37Rv DRQAFGGSLLDEPTVRFTLADMATGLQTSRMLLWRAASALDDDDADKVEL
MLBr_00737|M.leprae_Br4923 DRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFI
* : :*: : :.: :. .
Mb0221c|M.bovis_AF2122/97 -GMAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMILGEGT
MUL_4024|M.ulcerans_Agy99 -GMAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMIVGEGT
Mflv_4370|M.gilvum_PYR-GCK -SAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLYEGT
Mvan_1974|M.vanbaalenii_PYR-1 -SAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLYEGT
MSMEG_2205|M.smegmatis_MC2_155 -SAAKLYCTEMAGTVADLAVQIHGGTGYMREVPVERIYREVRLLRLYEGT
TH_3736|M.thermoresistible__bu -SAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRDVRLLRLYEGT
MMAR_4034|M.marinum_M -SAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRDVRLLRLYEGT
MAV_1571|M.avium_104 -SAAKLYCTEMAGRVADLAVQVHGGSGYMRGVPVERIYRDVRLLRLYEGT
MAB_0065c|M.abscessus_ATCC_199 -AKAKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARVTKIWAGS
Rv0752c|M.tuberculosis_H37Rv CAMAKRYVTDTCFEVADQALQLHGGYGYLREYGLEKIVRDLRVHRILEGT
MLBr_00737|M.leprae_Br4923 SAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGT
. :* : :: : .:::.** ** : : : : : *:
Mb0221c|M.bovis_AF2122/97 NEIQRNVIAGQLVARGGI-------
MUL_4024|M.ulcerans_Agy99 NEIQRNVIARQLIARGGI-------
Mflv_4370|M.gilvum_PYR-GCK SEIQKLIIGGGLVKGAKGK------
Mvan_1974|M.vanbaalenii_PYR-1 SEIQRLIIGGGLVKGAKAR------
MSMEG_2205|M.smegmatis_MC2_155 SEIQRLIIGGGLVKAAQRQL-----
TH_3736|M.thermoresistible__bu SEIQRLIIGGGLVKAAQRQTN----
MMAR_4034|M.marinum_M SEIQQLIIGSNLIKAANR-------
MAV_1571|M.avium_104 SEIQRLIIGSNLVKAAQRATTTKER
MAB_0065c|M.abscessus_ATCC_199 NEIMKELIGRDLGF-----------
Rv0752c|M.tuberculosis_H37Rv NEIMRLVIGRAEAARFRATV-----
MLBr_00737|M.leprae_Br4923 NQIQRVVMSRALLR-----------
.:* : ::.