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TKLAQTLGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHEIVEQTRSIGLFGLMIPEQYGGLGESL LTYALCVEELARGWMSVSGVLNTHFIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAI RTRATRGADGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGAAQPHRNLTAFLVEKPTGFGEVLPGLTIPGK IDKLGYKGIDTTEVIFDGYRATADDILGGTPGQGFFPMMDGIEVGRVNVSARACGVGLRAFELAVRYAQQ RHTFGKPIAEHQAISFQLAEMATKVEAAHLMMVHAARLKDSGERNDVAAGMAKYLASEYCSEVTQQSFRI HGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKSIISKRLLHEYRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3895 | - | - | 100% (397) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 4e-98 | 47.00% (383) | acyl-CoA dehydrogenase FadE3 |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 2e-61 | 35.06% (385) | acyl-CoA dehydrogenase FadE25 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 7e-95 | 46.37% (386) | acyl-CoA dehydrogenase FADE3 |
| M. gilvum PYR-GCK | Mflv_4367 | - | 0.0 | 85.35% (396) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv0215c | fadE3 | 1e-85 | 46.24% (359) | acyl-CoA dehydrogenase FADE3 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 7e-60 | 35.23% (386) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1188c | - | 6e-62 | 35.75% (386) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4030 | - | 0.0 | 99.24% (397) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1575 | - | 0.0 | 88.13% (396) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2208 | - | 0.0 | 86.62% (396) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3384 | - | 0.0 | 87.12% (396) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. vanbaalenii PYR-1 | Mvan_1977 | - | 0.0 | 86.36% (396) | butyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0221c|M.bovis_AF2122/97 ----------MRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
Rv0215c|M.tuberculosis_H37Rv ----------MRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
MUL_3895|M.ulcerans_Agy99 -----MTKLAQTLGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHE
MMAR_4030|M.marinum_M -----MTKLAQTLGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHE
Mflv_4367|M.gilvum_PYR-GCK -----MSRLAQTLGLTEFQTEIVSTVRQFVDKEVIPTAQELEHADTYPQA
Mvan_1977|M.vanbaalenii_PYR-1 -----MTKLAQTLGLTEFQAEIVSTVRQFVDKEVIPTAQELEHSDTYPQA
MSMEG_2208|M.smegmatis_MC2_155 -----MTKLAQTLGLTEFQTEIISTVRQLVDKEIIPAAQELEHSDTYPQA
TH_3384|M.thermoresistible__bu -----MTRLAQTLGLTEFQTEILRTVREFVDREIIPNAAEFERTDTYPQP
MAV_1575|M.avium_104 -----MTRLAQTLGLTEFQTEIIATVRQFVDKEVIPHAAELERADTYPQD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MAB_1188c|M.abscessus_ATCC_199 -----------MFNLTEEQREIWNTAREFADIHIAPHALDWDRDKYFPVE
* : . : * * : : .: * . : :: :*
Mb0221c|M.bovis_AF2122/97 WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
Rv0215c|M.tuberculosis_H37Rv WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MUL_3895|M.ulcerans_Agy99 IVEQTRSIGLFGLMIPEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH
MMAR_4030|M.marinum_M IVEQMRSIGLFGLMIPEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH
Mflv_4367|M.gilvum_PYR-GCK IVDAMREMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTH
Mvan_1977|M.vanbaalenii_PYR-1 IVDAMKEMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTH
MSMEG_2208|M.smegmatis_MC2_155 IVDQMKQMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTH
TH_3384|M.thermoresistible__bu IVDQMREMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSISGVINTH
MAV_1575|M.avium_104 IVDQMRDMGLFGLMIPQEYGGLGESLLTYALCVEELARGWMSVSGVLNTH
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MAB_1188c|M.abscessus_ATCC_199 IFPKAAALGMGGIYVNPDVGGSGLTRLDASLIFEAMATGCSAVSAFISIH
. *: .: : : ** : :* : : :
Mb0221c|M.bovis_AF2122/97 TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
Rv0215c|M.tuberculosis_H37Rv TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
MUL_3895|M.ulcerans_Agy99 FIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRA
MMAR_4030|M.marinum_M FIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRA
Mflv_4367|M.gilvum_PYR-GCK FIVAYMIRQHGTDAQKSHYLPRMATGETRGAFSMSEPELGSDVAAIRTRA
Mvan_1977|M.vanbaalenii_PYR-1 FIVAYMIRQHGTDAQKSRYLTRMATGETRGAFSMSEPELGSDVAAIRTRA
MSMEG_2208|M.smegmatis_MC2_155 FIVAYMIRQHGTDEQKRKFLPRMATGETRGAFSMSEPELGSDVAAIRTRA
TH_3384|M.thermoresistible__bu FIVAYMIRQHGTEEQKQRFLPRMATGETRGAFSMSEPELGSDVAAIRTRA
MAV_1575|M.avium_104 FIVAYMLRQHGTDEQKQRFLPRMAVGETRGAFSMSEPELGSDVAAIRTRA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
MAB_1188c|M.abscessus_ATCC_199 NMAAWMIDEFGDEEQRRRWLPSMCTMETIGAYCLTEPECGSDAAALRTSA
: : : * : : *. :. .: .::* *** : * *
Mb0221c|M.bovis_AF2122/97 LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
Rv0215c|M.tuberculosis_H37Rv LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
MUL_3895|M.ulcerans_Agy99 TRGA---DGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGAAQPHRNLTAFL
MMAR_4030|M.marinum_M TRGA---DGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGAAQPHRNLTAFL
Mflv_4367|M.gilvum_PYR-GCK KNNG---DGTYTIDGQKMWLTNGGSSTLVATLVRTDEGADKPHRNLTAFL
Mvan_1977|M.vanbaalenii_PYR-1 RDNG---DGTYTIDGQKMWLTNGGSSTLVAALVRTDEGADKPHRNLTAFL
MSMEG_2208|M.smegmatis_MC2_155 RNND---DGTYTIDGQKMWLTNGGSSTLVAALVRTDEGADKPHRNLTAFL
TH_3384|M.thermoresistible__bu TRNG---DGTYTIDGQKMWLTNGATSTLVAVLVRTDEGADKPHRNLTTFL
MAV_1575|M.avium_104 RRDP---DGGYTIDGQKMWLTNGATSTLIAVLVRTDEGSDKPHRNLTAFL
MLBr_00737|M.leprae_Br4923 KADG----DDWILNGFKCWITNGGKSTWYTVMAVTDP--DKGANGISAFI
MAB_1188c|M.abscessus_ATCC_199 IRQG----DEYVLNGVKQFISGAGAADLYVVMARTG---GPGPRGISTIV
::* * :::.. : ..: *. ..:: .:
Mb0221c|M.bovis_AF2122/97 VEPG-------PGLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAM
Rv0215c|M.tuberculosis_H37Rv VEPG-------PGLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAM
MUL_3895|M.ulcerans_Agy99 VEKPTGFGEVLPGLTIPGKIDKLGYKGIDTTEVIFDGYRATADDILGGTP
MMAR_4030|M.marinum_M VEKPTGFGEVLPGLTIPGKIDKLGYKGIDTTELIFDGYRATADDILGGTP
Mflv_4367|M.gilvum_PYR-GCK IEKPTGFGEVAPGLTIPGKLDKLGYKGIDTTELIFDGYRADAGDILGEAP
Mvan_1977|M.vanbaalenii_PYR-1 IEKPTGFGEVAPGLTIPGKLDKLGYKGIDTTELIFDGYRAGATDILGEAP
MSMEG_2208|M.smegmatis_MC2_155 IEKPEGFGEVLPGLTIPGKLDKLGYKGIDTTELIFDGYRADAADILGGTP
TH_3384|M.thermoresistible__bu IEKPTGFGEVAPGLTIPGKIDKLGYKGIDTTELIFDGYRADAGDILGERP
MAV_1575|M.avium_104 VEKPVGFGEVVAGLRIPGKIDKLGYKGIETTELIFDGYRAAADDILGGTP
MLBr_00737|M.leprae_Br4923 VHKDD------EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGE-P
MAB_1188c|M.abscessus_ATCC_199 VPKGT------PGLSFGAPERKMGWHAQPTAQVVFEDVRVPVANRIGE-E
: *: . *:* :. : :: *: * :*
Mb0221c|M.bovis_AF2122/97 GQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQH
Rv0215c|M.tuberculosis_H37Rv GQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQH
MUL_3895|M.ulcerans_Agy99 GQGFFPMMDGIEVGRVNVSARACGVGLRAFELAVRYAQQRHTFGKPIAEH
MMAR_4030|M.marinum_M GQGFFQMMDGIEVGRVNVSARACGVGLRAFELAVRYAQQRHTFGKPIAEH
Mflv_4367|M.gilvum_PYR-GCK GQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVKYAQQRSTFGKPIAEH
Mvan_1977|M.vanbaalenii_PYR-1 GQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVRYAQQRSTFGKPIAEH
MSMEG_2208|M.smegmatis_MC2_155 GQGFFQMMDGVEVGRVNVSARACGVGLRAFELAVRYAQQRETFGKPIAEH
TH_3384|M.thermoresistible__bu GQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVRYAQQRHTFGKPIAEH
MAV_1575|M.avium_104 GQGFFQMMDGIEVGRVNVSARACGVAIRAFELAVRYAQQRETFGKPIAEH
MLBr_00737|M.leprae_Br4923 GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTF
MAB_1188c|M.abscessus_ATCC_199 GIGFTIAMRGLNGGRLNIASCSLGGARSALEKVIEYLRTRKAFGEELIKF
* ** : :: * :.: : * . *:: : * : * **. : .
Mb0221c|M.bovis_AF2122/97 QAVGNYLADMATKLTAARQLTRYAAERYDSGQ-RCDMEAGMAKLFASEVA
Rv0215c|M.tuberculosis_H37Rv QAVGNYLADMATKLTAARQLTRYAAERYDSGQ-RCDMEAGMAKLFASEVA
MUL_3895|M.ulcerans_Agy99 QAISFQLAEMATKVEAAHLMMVHAARLKDSGE-RNDVAAGMAKYLASEYC
MMAR_4030|M.marinum_M QAISFQLAEMATKVEAAHLMMVHAARLKDSGE-RNDVAAGMAKYLASEYC
Mflv_4367|M.gilvum_PYR-GCK QAIAFQLAEMATKVEAAHLMMVNAARHKDSGE-RNDVAAGMAKYFASEVC
Mvan_1977|M.vanbaalenii_PYR-1 QAIAFQLAEMATKVEAAHLMMVNAARLKDSGE-RNDVAAGMAKYFASEVC
MSMEG_2208|M.smegmatis_MC2_155 QAVAFQLAEMATKVEAAHLMMVNAARLKDSGE-RNDVAAGMAKYLASEFC
TH_3384|M.thermoresistible__bu QAIAFQLAEMATKVEAAHLMMVNAARLKDSGE-RNDVAAGMAKYLASEFC
MAV_1575|M.avium_104 QAIAFQLAEMATKVEAAHLMMVNAARLKDSGE-RNDVAAGMAKYLASEYC
MLBr_00737|M.leprae_Br4923 QSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIA
MAB_1188c|M.abscessus_ATCC_199 QALQFRLADMATELEAARTMVWRAAAAVTEGDPRAAELCAMAKRIATDVG
*:: **:** :: **: : ** *: .. :* :*::
Mb0221c|M.bovis_AF2122/97 MEIALNAVRIHGGYGYSTEYDVERYFRDAPLMILGEGTNEIQRNVIAGQL
Rv0215c|M.tuberculosis_H37Rv MEIALNAVRIHGGYGYSTEYDVERR-------------------------
MUL_3895|M.ulcerans_Agy99 SEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKSIISKRL
MMAR_4030|M.marinum_M SEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKSIISKRL
Mflv_4367|M.gilvum_PYR-GCK AEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
Mvan_1977|M.vanbaalenii_PYR-1 AEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
MSMEG_2208|M.smegmatis_MC2_155 SEVTQQAFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
TH_3384|M.thermoresistible__bu AEVTEQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
MAV_1575|M.avium_104 AEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRAL
MAB_1188c|M.abscessus_ATCC_199 FTVANEALQLHGGYGYLAEYGIEKIVRDLRVHQILEGTNEIMRVIVSRKL
:: ::.::.** ** :: :*:
Mb0221c|M.bovis_AF2122/97 VARGGI-
Rv0215c|M.tuberculosis_H37Rv -------
MUL_3895|M.ulcerans_Agy99 LHEYRE-
MMAR_4030|M.marinum_M LHEYRE-
Mflv_4367|M.gilvum_PYR-GCK LADYRV-
Mvan_1977|M.vanbaalenii_PYR-1 LADYRV-
MSMEG_2208|M.smegmatis_MC2_155 LADYKV-
TH_3384|M.thermoresistible__bu LADYRI-
MAV_1575|M.avium_104 LAEYRV-
MLBr_00737|M.leprae_Br4923 LR-----
MAB_1188c|M.abscessus_ATCC_199 IEQGLPA