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PVAFHRQDTPAGAAAVQPVLAEIAADYRLRLADGGTEPPLRGLKLVRDHRLGALRLARELGGAGYTAPEF FDYLVALAAADPDLAHILRIHYALVEELQVTPRRPGSDRWIAVVAEGGLIGGANAEQSQKSVGGNHRDTR LVTTPDGLRLRGRKFYSTGAQFSDYLRITAQDDDGAPTAVVIPVDRAGVEHLDDWDGIGQRQTGSGTTVF NDVAVADDEVFPLGSTIGVNRARGALVQLYLHAVAAGILRSLTEDAAALVRGRRRTYTFASADTPTADPQ LLQIVGEIDAVAYTAHALVRNAAAELAPALQAARDTGIDPELEAAASIAAARVKVAIQEPALRAASRVFD AGGASAVQASALLDRHWRNLRTLFSHNPTVYKARVLGDVVVNGAALPDTSFF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3422 | - | - | 100% (403) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_3806 | - | 2e-19 | 33.83% (201) | dibenzothiophene desulfurization enzyme C |
| M. avium 104 | MAV_1571 | - | 1e-08 | 23.76% (303) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1706 | fadE16 | 5e-09 | 26.29% (388) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4370 | - | 3e-08 | 24.33% (300) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1679 | fadE16 | 5e-09 | 26.29% (388) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1422c | - | 2e-79 | 41.22% (393) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1556 | - | 6e-06 | 25.10% (243) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3259 | - | 1e-153 | 69.59% (388) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3721 | - | 3e-43 | 36.30% (303) | PUTATIVE putative acyl-CoA dehydrogenase family protein |
| M. ulcerans Agy99 | MUL_4958 | fadE6_1 | 2e-05 | 27.38% (347) | acyl-CoA dehydrogenase FadE6_1 |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 7e-31 | 29.70% (404) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3422|M.avium_104 -------MPVAFHRQDTPAGAAAVQPVLAEIAADYRLR----------LA
MSMEG_3259|M.smegmatis_MC2_155 -----MSLHTAVSLPGSAPHPDVITDLLGRISADHRRR----------LD
MAB_1422c|M.abscessus_ATCC_199 -----MTSAPSVLEIRALPGTDTYRNLLAQVAEGARDRD---------LD
TH_3721|M.thermoresistible__bu --------VPYFDEQRFEALAAEFRPVFDRIRAGAVQR------------
Mb1706|M.bovis_AF2122/97 -----------------MATPGVVQEVVS-VAAEHAER-----------V
Rv1679|M.tuberculosis_H37Rv -----------------MATPGVVQEVVS-VAAEHAER-----------V
Mvan_3173|M.vanbaalenii_PYR-1 MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAER------------
Mflv_4370|M.gilvum_PYR-GCK -----MASPPANAAEAGIPSAEVNDEDFQAILAATREFVRTAVVPREQEI
MMAR_1556|M.marinum_M ------MNQPDLSAAPLRRADSEMENLAEKIALTAREMS--------AEI
MUL_4958|M.ulcerans_Agy99 -----MALAITAEQEQLAQAVAQFAARHAPIDKTRAAWDSIAAGELPPWW
:
MAV_3422|M.avium_104 DGGTEPPLRGLKLVRDHR-----LGALRLARELGGAGYTAPEFFDYLVAL
MSMEG_3259|M.smegmatis_MC2_155 DGGHEPPSLGVELVKAHR-----VGAAPLDRDLGGWGLSTEEFFDLVMAL
MAB_1422c|M.abscessus_ATCC_199 D---ENPFDQVRLLKEAG-----FGRLRIPTELGGAGLSVRQLFSAIIDV
TH_3721|M.thermoresistible__bu ERDRELPFEQIGWLKAAG-----FGAVRLPVSAGGRGATIPELTRLLIEL
Mb1706|M.bovis_AF2122/97 DTDCAFPAEAVDALRKTG-----LLGLVLPREIGGMGSGPVEFTEVVAQL
Rv1679|M.tuberculosis_H37Rv DTDCAFPAEAVDALRKTG-----LLGLVLPREIGGMGSGPVEFTEVVAQL
Mvan_3173|M.vanbaalenii_PYR-1 ERAGAVLTPQLRLVAESG-----LLGISVPTAHGGPGLPASTVVEVLRRL
Mflv_4370|M.gilvum_PYR-GCK LSTDQVPDDLREQTKSMG-----LFGYAIPQEWGGLGLNLAQDVELAMEL
MMAR_1556|M.marinum_M DRDRRLPDELVARLGEAG-----LLRATMPREVQAAELAPGPALRCAEAV
MUL_4958|M.ulcerans_Agy99 EESTAHGFHAVHLSEDAGGQGGTLADMACVLEAAAAALLPGPLLSTATAS
. .
MAV_3422|M.avium_104 AAADPDLAHILRIHYALVEELQV-TPRRPGSDRWIAVVAEGGLIGGANAE
MSMEG_3259|M.smegmatis_MC2_155 GEADPDLAHILRVHFSVVEELQR-APRRPNAERWIAVVADGGLIGGVTSE
MAB_1422c|M.abscessus_ATCC_199 AQADPIVAHIFRTHFWFVEERLR-TLADPVSAAWLTKVNEGNLFANAFSE
TH_3721|M.thermoresistible__bu STADSNITQALRGHFAFAEDRLV-AAPGPGRDRWWQRFAAGDLAGNAWTE
Mb1706|M.bovis_AF2122/97 SAACGSTAMIYLMHMAAAVTVAA-SPP-PGLPDLLADMASGKQLGTLAFS
Rv1679|M.tuberculosis_H37Rv SAACGSTAMIYLMHMAAAVTVAA-SPP-PGLPDLLADMASGKQLGTLAFS
Mvan_3173|M.vanbaalenii_PYR-1 ARADGAVGQLLLSHFVVAQAISG-LGHTQPAPRIYADLLAGAQLGNASAE
Mflv_4370|M.gilvum_PYR-GCK GYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFALT
MMAR_1556|M.marinum_M ARGDASAGWCVSIAITSALLVAY-----------LPASSRDEMFG----A
MUL_4958|M.ulcerans_Agy99 AVAGLADTSAAALIAELAGGATAAVVLPEHCDVRAARVAAGWRLDGSSQT
. . .
MAV_3422|M.avium_104 QSQKSVGGNHRDTRLVTTPDG----LRLRGRKFYSTG-------------
MSMEG_3259|M.smegmatis_MC2_155 QSTNQVGGQTYDTRLIRTDDGR---LILRGRKYYSTG-------------
MAB_1422c|M.abscessus_ATCC_199 KGSLAVGSLVFNTRLLPVGDA----YRLNGEKFYSTG-------------
TH_3721|M.thermoresistible__bu IGDVVLG--EANTKVAPSGDPGT--FVVNGQKFYSTG-------------
Mb1706|M.bovis_AF2122/97 EPGSRSHFWAPVSTASADGDG----IAVRADKSWVTS-------------
Rv1679|M.tuberculosis_H37Rv EPGSRSHFWAPVSTASADGDG----IAVRADKSWVTS-------------
Mvan_3173|M.vanbaalenii_PYR-1 RG----TAHALDRRTTVTRRDGH--WVLNGTKYYATG-------------
Mflv_4370|M.gilvum_PYR-GCK EPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITN-------------
MMAR_1556|M.marinum_M GRSVAAGVWAPRGKAKSVDGG----VVVSGRWPFCSG-------------
MUL_4958|M.ulcerans_Agy99 TLGICAAQRVLLAARSEDGAQLWFVLDPRSPGSGLSVQPQRGTDLCTDVG
. :
MAV_3422|M.avium_104 -AQFSDYLRITAQ-----DDDGA--PTAVVIPVDRAGVEH---------L
MSMEG_3259|M.smegmatis_MC2_155 -AQYSDHLRVSAQ-----GDDGA--PVGAIIPADRVGVVH---------T
MAB_1422c|M.abscessus_ATCC_199 -TLFADYLTVTAT-----TDRDS--VASVIVPGDRDGVRL---------V
TH_3721|M.thermoresistible__bu -SIFADWIDLYAQR----TDTGE--FVIAAVDAHADGVTH---------A
Mb1706|M.bovis_AF2122/97 -AGFADVYVVSVGS----ADGAAGDVDLYAVPADTPGLRV---------A
Rv1679|M.tuberculosis_H37Rv -AGFADVYVVSVGS----ADGAAGDVDLYAVPADTPGLRV---------A
Mvan_3173|M.vanbaalenii_PYR-1 -TLGATWIAVAARI----EGRENGDTATAFVRPDQEGVTLD--------L
Mflv_4370|M.gilvum_PYR-GCK -APNADLFVTFARSRP--ADDKGAGIAVFLVPADTPGVDIG--------A
MMAR_1556|M.marinum_M -INHADMMFAGCFVE--------GQPVPSVVALPKDDLRA---------L
MUL_4958|M.ulcerans_Agy99 VLTLADHVVAAESLVSGIATERARCLVVALAACAAAGTVRRGAEAAVDYI
: .
MAV_3422|M.avium_104 DDWDGIGQRQTGSGTTVFNDVAVADDEVFPLG------STIGVNRARGAL
MSMEG_3259|M.smegmatis_MC2_155 DDWDGIGQRHTGSGTTVLDDVVVHDDELFPLG------TKVGVDRPRGAL
MAB_1422c|M.abscessus_ATCC_199 DDWDGFGQRRTGTGTTIFSQVDVAADEILSETPY----DAAPVPTTQYAS
TH_3721|M.thermoresistible__bu DDWDGFGQRTTGSGTSTYRDVRVPAENLIPFA---------TRFRYQTAF
Mb1706|M.bovis_AF2122/97 GTFTGMGLRGNAS-APMAVDIRIPDSYRLGEAG-------GGFGIMMQTV
Rv1679|M.tuberculosis_H37Rv GTFTGMGLRGNAS-APMAVDIRIPDSYRLGEAG-------GGFGIMMQTV
Mvan_3173|M.vanbaalenii_PYR-1 ESWSAFGQRGTASGEVRLNNVVVDDDLLIDEGPPP--DPITADPSVLGAF
Mflv_4370|M.gilvum_PYR-GCK KDKK-MGQEGAWTADVNFTDVEVPDTALVGGSE----------DLGYRAA
MMAR_1556|M.marinum_M DTWHTLGLRGTGSHDCVAEEVFVPADRVFSVFDG----PSIDRPLYRFPV
MUL_4958|M.ulcerans_Agy99 RTREQFGKPVGAFQALQHKAAVLLVNAELAAAATWDAVRAADEPLEQHRL
:* : .
MAV_3422|M.avium_104 VQLYLHAVAAGILRSLTEDAAALVRGRRRTYTFASAD----------TPT
MSMEG_3259|M.smegmatis_MC2_155 LQLYLHAIAAGILRSLRTDAVALVRGRQRSYTFATEA----------SPT
MAB_1422c|M.abscessus_ATCC_199 LQLYILAIVAGVLRAVVDDGEALLRSRQRNFSHALTE----------RPV
TH_3721|M.thermoresistible__bu YQLFHLATLAGIAHAATAELAQRVRGRTRTFSHGNAP----------RYA
Mb1706|M.bovis_AF2122/97 LPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGG----------SLA
Rv1679|M.tuberculosis_H37Rv LPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGG----------SLA
Mvan_3173|M.vanbaalenii_PYR-1 DQALHAAIDIGIARAALEDGAVFVRTRSRPWKEALDAGI-------ERAD
Mflv_4370|M.gilvum_PYR-GCK MTSLARGRVHIAALAVGAAQRALDESVAYAATATQGG---------TPIG
MMAR_1556|M.marinum_M FGFFALSIGAAALGNARAAIDDLVELAGDKKGLGAKR----------TLA
MUL_4958|M.ulcerans_Agy99 AAASAALVAVGPAPDLTLDALLMFGAIGYTWEHDMHLYWRRAISLAASLG
MAV_3422|M.avium_104 ADPQLLQIVGEIDAVAYTAHALVRNAAAELAPA-------LQAARDTGID
MSMEG_3259|M.smegmatis_MC2_155 ADPQLLQVVGEIDAVAYAASAVVRSAARELGVA-------LQAARAGGFD
MAB_1422c|M.abscessus_ATCC_199 DDPLLQRTLGELSATAFAAEATVLAAADAIEAA-------TATLRDGVPD
TH_3721|M.thermoresistible__bu ADPQIQQVVGEVMAAAFAAEAIALRAAEDXXXR-------RRSS------
Mb1706|M.bovis_AF2122/97 ELPTIRAQIARMGTTLAAQKAYLEVAANSVSSP-------DDTTLTHVLG
Rv1679|M.tuberculosis_H37Rv ELPTIRAQIARMGTTLAAQKAYLEVAANSVSSP-------DDTTLTHVLG
Mvan_3173|M.vanbaalenii_PYR-1 QEPHVVRRFGELTARLYALEALLARGTALIDEA-------YAAPEVTRDA
Mflv_4370|M.gilvum_PYR-GCK DFQLVQAMLADQQTGVMAGRALVRDAARLWVTG-------QDRRIAPS--
MMAR_1556|M.marinum_M ERSATQTAVATAEAALGAARALFYEAIDSAWQA-------SHNPDPVPVA
MUL_4958|M.ulcerans_Agy99 PTTRFSRAAGELARTLGRSTAVNLGNVESEFRARVAATLDRAQALANEHP
. *
MAV_3422|M.avium_104 PELEAAASIAAARVKVAIQEPALRAASRVFDAGGASAVQASALLDRHWR-
MSMEG_3259|M.smegmatis_MC2_155 HELEHRASVAAARVKVAIEEPALRAAGRIFDVGGASAIRASANLDRHWR-
MAB_1422c|M.abscessus_ATCC_199 AQLAQEAQVAVAKAKVHIDAVALDAATKLLDLGGASAASRTRNLDRHWR-
TH_3721|M.thermoresistible__bu ----------------------------------AAPPRRRTRPRSCWD-
Mb1706|M.bovis_AF2122/97 -------------VKASVNDAALTITESAMRVCGGAAFSKHLPIERAFR-
Rv1679|M.tuberculosis_H37Rv -------------VKASVNDAALTITESAMRVCGGAAFSKHLPIERAFR-
Mvan_3173|M.vanbaalenii_PYR-1 AAQAS---LTVAAAKALAQQDAVEIAGAIFELTGTSGTDGAVNLDRHWR-
Mflv_4370|M.gilvum_PYR-GCK ------------AAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYR-
MMAR_1556|M.marinum_M LRN------RLRLAATHAARTSADVVRIMYDLAGSSAIYDGSPLQRRFR-
MUL_4958|M.ulcerans_Agy99 TDDSRNPGLAHGSQRDLLAEAGLAAPHLAKPWGLAATPVQQVIIAEEFSK
: :
MAV_3422|M.avium_104 --------------------------------------------------
MSMEG_3259|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3721|M.thermoresistible__bu --------------------------------------------------
Mb1706|M.bovis_AF2122/97 --------------------------------------------------
Rv1679|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1556|M.marinum_M --------------------------------------------------
MUL_4958|M.ulcerans_Agy99 RPGVTKPSLGIAEWIFPTILDRGSDLQRDRFGWPILRRTQRWCQLFSEPG
MAV_3422|M.avium_104 ---NLRTLFSHNPTVYKARVLGDVVVNGAALPDTSFF-------------
MSMEG_3259|M.smegmatis_MC2_155 ---NLRTLFSHNPTVYKARVLGDVAVNHAPLPDSSFF-------------
MAB_1422c|M.abscessus_ATCC_199 ---NIRTISLHNPVHYKARVIGQNLLHGTPLPANAYF-------------
TH_3721|M.thermoresistible__bu ---ATRSSSVCVPRSRPPRCT----SPWAPRPMSG---------------
Mb1706|M.bovis_AF2122/97 ---DARAGSVMAPTADALYDFYGRAVTGLPLF------------------
Rv1679|M.tuberculosis_H37Rv ---DARAGSVMAPTADALYDFYGRAVTGLPLF------------------
Mvan_3173|M.vanbaalenii_PYR-1 ---NVRVHSLHDPARWKYVHLGNHTLHDTRPPRLGLIL------------
Mflv_4370|M.gilvum_PYR-GCK ---DVRLLRLYEGTSEIQKLIIGGGLVKGAKGK-----------------
MMAR_1556|M.marinum_M ---DAFTATAHFQVNEASRELPGRVLLGQHCDTSML--------------
MUL_4958|M.ulcerans_Agy99 AGSDLASLRTRAVKVDGGWLVNGHKIWTSHADRAQFGALLARTDPDAAKH
MAV_3422|M.avium_104 --------------------------------------------------
MSMEG_3259|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3721|M.thermoresistible__bu --------------------------------------------------
Mb1706|M.bovis_AF2122/97 --------------------------------------------------
Rv1679|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1556|M.marinum_M --------------------------------------------------
MUL_4958|M.ulcerans_Agy99 RGISYFLVDMASPGIEVSPIKQASGRFDFNEVFFTDVFVADDMLVGNPGD
MAV_3422|M.avium_104 --------------------------------------------------
MSMEG_3259|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3721|M.thermoresistible__bu --------------------------------------------------
Mb1706|M.bovis_AF2122/97 --------------------------------------------------
Rv1679|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1556|M.marinum_M --------------------------------------------------
MUL_4958|M.ulcerans_Agy99 GWDLAVATMAVERTAIGNYVNIDRTQVLRHVAMADGLDQDAALRAVGDVE
MAV_3422|M.avium_104 --------------------------------------------------
MSMEG_3259|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3721|M.thermoresistible__bu --------------------------------------------------
Mb1706|M.bovis_AF2122/97 --------------------------------------------------
Rv1679|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1556|M.marinum_M --------------------------------------------------
MUL_4958|M.ulcerans_Agy99 SHTTAIKAMMLRETLRRIQGQVAGPTSSIAKYAMVLLLRRVWTATLGLAG
MAV_3422|M.avium_104 ----------------------------------------------
MSMEG_3259|M.smegmatis_MC2_155 ----------------------------------------------
MAB_1422c|M.abscessus_ATCC_199 ----------------------------------------------
TH_3721|M.thermoresistible__bu ----------------------------------------------
Mb1706|M.bovis_AF2122/97 ----------------------------------------------
Rv1679|M.tuberculosis_H37Rv ----------------------------------------------
Mvan_3173|M.vanbaalenii_PYR-1 ----------------------------------------------
Mflv_4370|M.gilvum_PYR-GCK ----------------------------------------------
MMAR_1556|M.marinum_M ----------------------------------------------
MUL_4958|M.ulcerans_Agy99 RVATLEDSDPAVLGPYFAMPSELIGGGTAEIQLTVIASMILGLTRK