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MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAERERAGAVLTPQLRLVAESGLLGISVPTAHGGPG LPASTVVEVLRRLARADGAVGQLLLSHFVVAQAISGLGHTQPAPRIYADLLAGAQLGNASAERGTAHALD RRTTVTRRDGHWVLNGTKYYATGTLGATWIAVAARIEGRENGDTATAFVRPDQEGVTLDLESWSAFGQRG TASGEVRLNNVVVDDDLLIDEGPPPDPITADPSVLGAFDQALHAAIDIGIARAALEDGAVFVRTRSRPWK EALDAGIERADQEPHVVRRFGELTARLYALEALLARGTALIDEAYAAPEVTRDAAAQASLTVAAAKALAQ QDAVEIAGAIFELTGTSGTDGAVNLDRHWRNVRVHSLHDPARWKYVHLGNHTLHDTRPPRLGLIL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | - | 100% (415) | acyl-CoA dehydrogenase type 2 |
| M. vanbaalenii PYR-1 | Mvan_2892 | - | 9e-15 | 24.42% (389) | acyl-CoA dehydrogenase type 2 |
| M. vanbaalenii PYR-1 | Mvan_1719 | - | 3e-13 | 22.19% (383) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 2e-15 | 22.60% (385) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_4743 | - | 2e-13 | 22.45% (383) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 2e-15 | 22.60% (385) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-15 | 22.60% (385) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1422c | - | 2e-39 | 32.48% (391) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1262 | fadE25 | 6e-14 | 22.34% (385) | acyl-CoA dehydrogenase FadE25 |
| M. avium 104 | MAV_3422 | - | 6e-31 | 29.70% (404) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3668 | - | 1e-175 | 77.48% (404) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3393 | - | 1e-65 | 39.37% (414) | PUTATIVE Acyl-CoA dehydrogenase, type 2, C-terminal domain |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 4e-14 | 22.34% (385) | acyl-CoA dehydrogenase FadE25 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3302c|M.bovis_AF2122/97 ----------------------------MVGWAGNPSFDLFKLPEEHDEM
Rv3274c|M.tuberculosis_H37Rv ----------------------------MVGWAGNPSFDLFKLPEEHDEM
MLBr_00737|M.leprae_Br4923 ----------------------------MVGWSGNPLFDLFKLPEEHNEL
MMAR_1262|M.marinum_M ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MUL_2626|M.ulcerans_Agy99 ----------------------------MAGWAGNPSFDLFQLPEEHQEL
Mflv_4743|M.gilvum_PYR-GCK MQAEKSVPRNSLPAATALKLPTSSKEMLMASWAGNPSFDLFQLPEEHQEL
Mvan_3173|M.vanbaalenii_PYR-1 ---------------------------MATDITDRIPDTL--LRTPADAL
MSMEG_3668|M.smegmatis_MC2_155 --------------------MTVTVPATGSHSPNHLPTDVGVLHTAQEAL
TH_3393|M.thermoresistible__bu -------------------------------VTEPLTMAR--IVDTAEAL
MAB_1422c|M.abscessus_ATCC_199 -----------------------------MTSAPSVLEIR-----ALPGT
MAV_3422|M.avium_104 -----------------------------MPVAFHRQDT-------PAGA
.
Mb3302c|M.bovis_AF2122/97 RSAIRALAEKEIAPHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQ
Rv3274c|M.tuberculosis_H37Rv RSAIRALAEKEIAPHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQ
MLBr_00737|M.leprae_Br4923 RATIRALAEKEIAPHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQ
MMAR_1262|M.marinum_M RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNAVHVPEEYGGQ
MUL_2626|M.ulcerans_Agy99 RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNALHVPEEYGGQ
Mflv_4743|M.gilvum_PYR-GCK RAAIRALAEKEIAPHAADVDENARFPQEALDALVANGFNAVHVPEEYGGQ
Mvan_3173|M.vanbaalenii_PYR-1 AAAEEVAEAIAAGSAERERAG--AVLTPQLRLVAESGLLGISVPTAHGGP
MSMEG_3668|M.smegmatis_MC2_155 AAADALATEFAADSAERELHG--KSLLPQLRRVAESGLLGIVVPAAHGGP
TH_3393|M.thermoresistible__bu AVAARLSGSFAAEASTRDAER--LLPYEQVCELKRSGLLTLSVPAEHGGL
MAB_1422c|M.abscessus_ATCC_199 DTYRNLLAQVAEGARDRDLD--DENPFDQVRLLKEAGFGRLRIPTELGGA
MAV_3422|M.avium_104 AAVQPVLAEIAADYRLRLADGGTEPPLRGLKLVRDHRLGALRLARELGGA
: : : : :. **
Mb3302c|M.bovis_AF2122/97 GADSVATCIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPA
Rv3274c|M.tuberculosis_H37Rv GADSVATCIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPA
MLBr_00737|M.leprae_Br4923 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPS
MMAR_1262|M.marinum_M GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDDLKKQVLPS
MUL_2626|M.ulcerans_Agy99 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKKQVLPS
Mflv_4743|M.gilvum_PYR-GCK GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKQKVLPS
Mvan_3173|M.vanbaalenii_PYR-1 GLPASTVVEVLRRLARADGAVGQLLLSHFVVAQAISGLGHTQPAPRIYAD
MSMEG_3668|M.smegmatis_MC2_155 GLPASTKVEVVRRLSRGDGALGQLLLSHFVIGEAISGLGEAAPAPRIYAD
TH_3393|M.thermoresistible__bu DVPATVLAEVFRLLAHGDPSVAQIPHSHFTFLEVLRLQGTERQRGFFYGL
MAB_1422c|M.abscessus_ATCC_199 GLSVRQLFSAIIDVAQADPIVAHIFRTHFWFVEERLRTLADPVSAAWLTK
MAV_3422|M.avium_104 GYTAPEFFDYLVALAAADPDLAHILRIHYALVEELQVTPRRPGSDRWIAV
. . :: * . : :
Mb3302c|M.bovis_AF2122/97 LAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAKCWITNGGKS
Rv3274c|M.tuberculosis_H37Rv LAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAKCWITNGGKS
MLBr_00737|M.leprae_Br4923 LAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKS
MMAR_1262|M.marinum_M LADGAAMASYALSEREAGSDAGAMRTRAKADGDDWILNGTKCWITNGGKS
MUL_2626|M.ulcerans_Agy99 LADGAAMASYALSEREAGSDAGAMRTRAKADGDDWILNGTKCWITNGGKS
Mflv_4743|M.gilvum_PYR-GCK LAAGESMASYALSEREAGSDAASMRTRAKADGDDWILNGAKCWITNGGKS
Mvan_3173|M.vanbaalenii_PYR-1 LLAGAQLGNASAERGTAHALDRRTTVTRR--DGHWVLNGTKYYATGTLGA
MSMEG_3668|M.smegmatis_MC2_155 TLAGAQLGNATAERGTATALDRRTSVTQRP-DGKWVLNGTKYYATGALGA
TH_3393|M.thermoresistible__bu VLEGALFANAQSERG-PHPIDVDTTVLLRRGAGDYLLTGRKFYSTGALFA
MAB_1422c|M.abscessus_ATCC_199 VNEGNLFANAFSEKGSLAVGSLVFNTRLLPVGDAYRLNGEKFYSTGTLFA
MAV_3422|M.avium_104 VAEGGLIGGANAEQSQKSVGGNHRDTRLVTTPDGLRLRGRKFYSTGAQFS
:.. .. . . * * * : *. :
Mb3302c|M.bovis_AF2122/97 TWYTVMAVTDP------DRGANGISAFMVHKDDEGFTVGPKERKLGIKGS
Rv3274c|M.tuberculosis_H37Rv TWYTVMAVTDP------DRGANGISAFMVHKDDEGFTVGPKERKLGIKGS
MLBr_00737|M.leprae_Br4923 TWYTVMAVTDP------DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGS
MMAR_1262|M.marinum_M SWYTVMAVTDP------EKGANGISAFMVHKDDEGFVVGPKERKLGIKGS
MUL_2626|M.ulcerans_Agy99 SWYTVMAVTDP------ENGANGISAFVVHKDDEGFVVGPKERKLGIKGS
Mflv_4743|M.gilvum_PYR-GCK DWYTVMAVNDP------DKGANGISAFMVHVDDEGFSIGPKERKLGIKGS
Mvan_3173|M.vanbaalenii_PYR-1 TWIAVAARIEG------RENGDTATAFVRPDQEGVTLDLESWSAFGQRGT
MSMEG_3668|M.smegmatis_MC2_155 AWIAVAAVIAG------RED-ETATVFVRPEQDGVTLDLDKWSAFGQRGT
TH_3393|M.thermoresistible__bu DWIVVRASVPADAADAPTAATPKAVAFVPRHAPGLTV-IDDWDGMGQRTT
MAB_1422c|M.abscessus_ATCC_199 DYLTVTATTDR----------DSVASVIVPGDRDGVRLVDDWDGFGQRRT
MAV_3422|M.avium_104 DYLRITAQDDD----------GAPTAVVIPVDRAGVEHLDDWDGIGQRQT
: : * .: . :* : :
Mb3302c|M.bovis_AF2122/97 PTTELYFENCRIPGDRIIGE---PGTGFKTALATLDHTRPTIGAQAVGIA
Rv3274c|M.tuberculosis_H37Rv PTTELYFENCRIPGDRIIGE---PGTGFKTALATLDHTRPTIGAQAVGIA
MLBr_00737|M.leprae_Br4923 PTTELYFDKCRIPGDRIIGE---PGTGFKTALATLDHTRPTIGAQAVGIA
MMAR_1262|M.marinum_M PTTELYFENCRVPGDRMIGE---PGTGFKTALATLDHTRPTIGAQAVGIA
MUL_2626|M.ulcerans_Agy99 PTTELYFENCRVPGDRMIGE---PGTGFKTALATLDHTRPTIGAQAVGIA
Mflv_4743|M.gilvum_PYR-GCK PTTELYFENCRIPGDRIIGE---PGTGFKTALATLDHTRPTIGAQAVGIA
Mvan_3173|M.vanbaalenii_PYR-1 ASGEVRLNNVVVDDDLLIDEGPPPDPITADPSVLGAFDQALHAAIDIGIA
MSMEG_3668|M.smegmatis_MC2_155 ASGEVRLTDVVVDADLVIEEGAAPDPVDAPPTVLGAYDQALHAAIDIGIA
TH_3393|M.thermoresistible__bu ASGSVTLDEVRVPADHVV----PFTPIFRRPTVYGARAQLWHAALDVGIA
MAB_1422c|M.abscessus_ATCC_199 GTGTTIFSQVDVAADEILSETPYDAAPVP--TTQYASLQLYILAIVAGVL
MAV_3422|M.avium_104 GSGTTVFNDVAVADDEVFPLG--STIGVN--RARGALVQLYLHAVAAGIL
: : . : * :. . : * *:
Mb3302c|M.bovis_AF2122/97 QGALDAAIAYTKDRKQ--------FGESISTFQAVQFMLADMAMKVEAAR
Rv3274c|M.tuberculosis_H37Rv QGALDAAIAYTKDRKQ--------FGESISTFQAVQFMLADMAMKVEAAR
MLBr_00737|M.leprae_Br4923 QGALDAAIVYTKDRKQ--------FGESISTFQSIQFMLADMAMKVEAAR
MMAR_1262|M.marinum_M QGALDAAIAYTKDRKQ--------FGKSISDFQAVQFMLADMAMKVESAR
MUL_2626|M.ulcerans_Agy99 QGALDAAIAYTKDRKQ--------FGKSISDFQAVQFMLADMAMKVESAR
Mflv_4743|M.gilvum_PYR-GCK QGALDAAIEYTKDRKQ--------FGKSISDFQAVQFMLADMAMKVEAAR
Mvan_3173|M.vanbaalenii_PYR-1 RAALEDGAVFVRTRSRPWKEALDAGIERADQEPHVVRRFGELTARLYALE
MSMEG_3668|M.smegmatis_MC2_155 RAALEDGAHFVRTTSRPWKEAVLAGVTSAAEEPHVVRRFGELTARLYALE
TH_3393|M.thermoresistible__bu TAALEEG---VRLAAR-ARPHFESGAPVATDDPTLIQSAGEVAVTVRAAQ
MAB_1422c|M.abscessus_ATCC_199 RAVVDDGEALLRSRQR---NFSHALTERPVDDPLLQRTLGELSATAFAAE
MAV_3422|M.avium_104 RSLTEDAAALVRGRRR---TYTFASADTPTADPQLLQIVGEIDAVAYTAH
. : . : : : .:: : .
Mb3302c|M.bovis_AF2122/97 LMVYSAAARAERGEP-------------DLGFISAASKCFASDVAMEVTT
Rv3274c|M.tuberculosis_H37Rv LMVYSAAARAERGEP-------------DLGFISAASKCFASDVAMEVTT
MLBr_00737|M.leprae_Br4923 LIVYAAAARAERGEP-------------DLGFISAASKCFASDIAMEVTT
MMAR_1262|M.marinum_M LMVYSAAARAERGES-------------NLGFISAASKCLASDVAMEVTT
MUL_2626|M.ulcerans_Agy99 LMVYSAAARAERGES-------------NLGFISAASKCLASDVAMEVTT
Mflv_4743|M.gilvum_PYR-GCK LMVYSAAARAERGEG-------------NLGFISAASKCLASDVAMEVTT
Mvan_3173|M.vanbaalenii_PYR-1 ALLARGTALIDEAYA---APEVTRDAAAQASLTVAAAKALAQQDAVEIAG
MSMEG_3668|M.smegmatis_MC2_155 ALLARGTAIIDAGQS---EAELSRDTAAEASLTVAAAKALAQEYAVEIAS
TH_3393|M.thermoresistible__bu ALLGEAARAVDAAT-----ADLTEDTAAAASIAVATAKVAAERAALRAST
MAB_1422c|M.abscessus_ATCC_199 ATVLAAADAIEAATATLRDGVPDAQLAQEAQVAVAKAKVHIDAVALDAAT
MAV_3422|M.avium_104 ALVRNAAAELAPALQAARDTGIDPELEAAASIAAARVKVAIQEPALRAAS
: .: . . * * . *: :
Mb3302c|M.bovis_AF2122/97 DAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR---
Rv3274c|M.tuberculosis_H37Rv DAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR---
MLBr_00737|M.leprae_Br4923 DAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR---
MMAR_1262|M.marinum_M DAVQLFGGAGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR---
MUL_2626|M.ulcerans_Agy99 DAVQLFGGAGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR---
Mflv_4743|M.gilvum_PYR-GCK DAVQLFGGAGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLK---
Mvan_3173|M.vanbaalenii_PYR-1 AIFELTGTSGTDGAVNLDRHWRNVRVHSLHDPARWKYVHLGNHTLHDTRP
MSMEG_3668|M.smegmatis_MC2_155 GIFELTGASGTDSAVNLDRHWRNVRTHSLHDPARWKYVHLGNHTLHGTRP
TH_3393|M.thermoresistible__bu ALFELGGTRSATVSANLSRFWRDARTHTLHDPTRWKLHHIGRYLLSGTRP
MAB_1422c|M.abscessus_ATCC_199 KLLDLGGASAASRTRNLDRHWRNIRTISLHNPVHYKARVIGQNLLHGTPL
MAV_3422|M.avium_104 RVFDAGGASAVQASALLDRHWRNLRTLFSHNPTVYKARVLGDVVVNGAAL
.: * . :.* *: : :: . : :
Mb3302c|M.bovis_AF2122/97 -------
Rv3274c|M.tuberculosis_H37Rv -------
MLBr_00737|M.leprae_Br4923 -------
MMAR_1262|M.marinum_M -------
MUL_2626|M.ulcerans_Agy99 -------
Mflv_4743|M.gilvum_PYR-GCK -------
Mvan_3173|M.vanbaalenii_PYR-1 PRLGLIL
MSMEG_3668|M.smegmatis_MC2_155 PRLGLVL
TH_3393|M.thermoresistible__bu PRHGQL-
MAB_1422c|M.abscessus_ATCC_199 PANAYF-
MAV_3422|M.avium_104 PDTSFF-