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M. marinum M MMAR_4034 (fadE)

annotation: acyl-CoA dehydrogenase FadE
coordinates: 4973331 - 4974494
length: 387

MTAPQVSDEDFAQILAQTRHFVRSVVLPREQQILDEDRVPEDLRDQAKQMGLFGYAIPPQWGGLGLNLVQ
DVELAMELGYTSLAVRSMFGTNNGIAGQVLVGFGTDEQKARWLEPIASGDVVASFALTEPGAGSSPAGLR
TKAVRDGDDWLITGQKRFITNAPVADLFVVFARTRPASDKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGA
WTADVSFTDVRVDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVAYASTATQGGVTIG
SFQLVQAMLADQQTGVLAGRALVRDAARMWVSGADRRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMRG
VPVERIYRDVRLLRLYEGTSEIQQLIIGSNLIKAANR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. marinum M MMAR_4034 fadE - 100% (387) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_4161 fadE3 2e-56 35.81% (377) acyl-CoA dehydrogenase FadE3
M. marinum M MMAR_0455 fadE3_2 2e-56 35.81% (377) acyl-CoA dehydrogenase FadE3_2

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0221c fadE3 8e-57 36.05% (380) acyl-CoA dehydrogenase FADE3
M. gilvum PYR-GCK Mflv_4370 - 0.0 82.08% (385) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv2500c fadE19 8e-54 34.70% (366) acyl-CoA dehydrogenase
M. leprae Br4923 MLBr_00737 fadE25 9e-50 32.63% (377) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_1188c - 6e-55 35.88% (379) acyl-CoA dehydrogenase
M. avium 104 MAV_1571 - 0.0 85.64% (383) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_2205 - 0.0 81.87% (386) putative acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_3736 - 0.0 83.63% (391) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_4024 fadE3 1e-56 35.81% (377) acyl-CoA dehydrogenase FadE3
M. vanbaalenii PYR-1 Mvan_1974 - 0.0 82.78% (389) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb0221c|M.bovis_AF2122/97           -MRN-------------------------ELNDDEAMLVATVRAFIDRDV
MUL_4024|M.ulcerans_Agy99           MMNND--------------------SPDSQLDEDEAMLVATVRAFIDRDV
MMAR_4034|M.marinum_M               -MT-----------------------APQVSDEDFAQILAQTRHFVRSVV
MAV_1571|M.avium_104                -MTSA--------------------EVAEVSEQDFGEILAQTRQFVRTAV
MSMEG_2205|M.smegmatis_MC2_155      -MTGTVTDG---------------QSAAEVGDEDFEEILAQARSFIRNAV
TH_3736|M.thermoresistible__bu      -MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAV
Mflv_4370|M.gilvum_PYR-GCK          -MASPPANAAEAG-----------IPSAEVNDEDFQAILAATREFVRTAV
Mvan_1974|M.vanbaalenii_PYR-1       ------------------------MSTAEVGDEDFRQILAQTRQFVRTAV
MLBr_00737|M.leprae_Br4923          ----------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEI
MAB_1188c|M.abscessus_ATCC_199      ---------------------------MFNLTEEQREIWNTAREFADIHI
Rv2500c|M.tuberculosis_H37Rv        ------------------MTTTTTTISGGILPKEYQDLRDTVADFARTVV
                                                                    .:   :      :    :

Mb0221c|M.bovis_AF2122/97           KPTVREVEHANSYPEAWIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQ
MUL_4024|M.ulcerans_Agy99           RPSVREVEHANTYPQAWIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQ
MMAR_4034|M.marinum_M               LPREQQILDEDRVPEDLRDQAKQMGLFGYAIPPQWGGLGLNLVQDVELAM
MAV_1571|M.avium_104                VPREQEILDGDRVPDDLRDQAKKMGLFGYAIPQQWGGLGLNLMQDVELAM
MSMEG_2205|M.smegmatis_MC2_155      VPRENEILATDKVPDDIREQAKNMGLFGYAIPQQWGGLGLNLAQDVELAM
TH_3736|M.thermoresistible__bu      VPRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGGLGLDLAQDVELAM
Mflv_4370|M.gilvum_PYR-GCK          VPREQEILSTDQVPDDLREQTKSMGLFGYAIPQEWGGLGLNLAQDVELAM
Mvan_1974|M.vanbaalenii_PYR-1       VPREQEILTTDRVPDELREQAKSMGLFGYAIPQEWGGLGLDLTQDVELAM
MLBr_00737|M.leprae_Br4923          APHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIE
MAB_1188c|M.abscessus_ATCC_199      APHALDWDRDKYFPVEIFPKAAALGMGGIYVNPDVGGSGLTRLDASLIFE
Rv2500c|M.tuberculosis_H37Rv        APVSAKHDAEHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLE
                                     *   .       *          *: .  .    **          :  

Mb0221c|M.bovis_AF2122/97           ELARGWMSLAGAMGG-HTVVAKLLTLFGTEEQRRTYLPPMASGELRATMA
MUL_4024|M.ulcerans_Agy99           ELARGWMSLAGAMGG-HTVVAKLLMLFGTDEQKSTYLPAMATGELRATMA
MMAR_4034|M.marinum_M               ELGYTSLAVRSMFGTNNGIAGQVLVGFGTDEQKARWLEPIASGDVVASFA
MAV_1571|M.avium_104                ELGYTSLALRSMFGTNNGIAGQVLVGFGTEAQKARWLEPMAAGDVVASFA
MSMEG_2205|M.smegmatis_MC2_155      EFGYTSLALRSMFGTNNGIAGQVLVGFGTDEQKQQWLEGIASGEVVASFA
TH_3736|M.thermoresistible__bu      ELGYTSLALRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEVVASFA
Mflv_4370|M.gilvum_PYR-GCK          ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFA
Mvan_1974|M.vanbaalenii_PYR-1       ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKSTWLERIASGEVVASFA
MLBr_00737|M.leprae_Br4923          EVARVDASASLIPAVNK-LGTMGLILRGSEELKKQVLPSLAAEGAMASYA
MAB_1188c|M.abscessus_ATCC_199      AMATGCSAVSAFISIHN-MAAWMIDEFGDEEQRRRWLPSMCTMETIGAYC
Rv2500c|M.tuberculosis_H37Rv        ELGKVDQSVAITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFG
                                     ..    :          :    :   * :  :   *  : :    .   

Mb0221c|M.bovis_AF2122/97           LTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWISNARR--SGLFAV
MUL_4024|M.ulcerans_Agy99           LTEPGGGSDLQNMSTTAMADGPDQ---LLITGAKTWISNARR--SGLIAL
MMAR_4034|M.marinum_M               LTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPV--ADLFVV
MAV_1571|M.avium_104                LTEPGAGSNPAGLRTKAVADGD----NWVISGQKRFITNAPV--ANLFVV
MSMEG_2205|M.smegmatis_MC2_155      LTEPGAGSNPAGLRTKAVRDGS----DWVINGQKRFITNAPT--AGLFVV
TH_3736|M.thermoresistible__bu      LTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPV--ADLFVV
Mflv_4370|M.gilvum_PYR-GCK          LTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPN--ADLFVT
Mvan_1974|M.vanbaalenii_PYR-1       LTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPN--ANLFVT
MLBr_00737|M.leprae_Br4923          LSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGK--STWYTV
MAB_1188c|M.abscessus_ATCC_199      LTEPECGSDAAALRTSAIRQGD----EYVLNGVKQFISGAGA--ADLYVV
Rv2500c|M.tuberculosis_H37Rv        LTEPGAGSDAGSTRTTARLEGD----EWIINGSKQFITNSGTDITSLVTV
                                    *:*   **.     : *  :*       ::.* * :*:..    :   . 

Mb0221c|M.bovis_AF2122/97           LCKTDPN--ATPRHQGMSIVLVEPG-PGLTVSRDLPKLGYKGVESCELSF
MUL_4024|M.ulcerans_Agy99           LCKTDPH--ATPRHHGISIVLVEPG-PGLNISADLPKLGYKGVEACELSF
MMAR_4034|M.marinum_M               FARTRP---ASDKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSF
MAV_1571|M.avium_104                FARTRP---ADDQGPGIAVFLVPADAAGVQIGAKDAKMGQEGAWTADVSF
MSMEG_2205|M.smegmatis_MC2_155      FARTRP---ADADGAGIAVFLVPADTPGVEVGPKDAKMGQEGAWTADVNF
TH_3736|M.thermoresistible__bu      FARSRP---ADERGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTF
Mflv_4370|M.gilvum_PYR-GCK          FARSRP---ADDKGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNF
Mvan_1974|M.vanbaalenii_PYR-1       FARSRP---ADDKGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNF
MLBr_00737|M.leprae_Br4923          MAVTDP----DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYF
MAB_1188c|M.abscessus_ATCC_199      MARTG-----GPGPRGISTIVVPKGTPGLSFGAPERKMGWHAQPTAQVVF
Rv2500c|M.tuberculosis_H37Rv        TAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTF
                                     . :            :: .:*     *. .     *:* ..  :  : *

Mb0221c|M.bovis_AF2122/97           DNLRVPVSAILGGAMGQGFSQMMKGLETGRIQVAARALGVATAALEDSLA
MUL_4024|M.ulcerans_Agy99           DNYRAPTSAILGGQPGQGFSQMMKGLETGRIQVAARALGVASAALDDALA
MMAR_4034|M.marinum_M               TDVRVDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVA
MAV_1571|M.avium_104                DDVRVGGDALIGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVS
MSMEG_2205|M.smegmatis_MC2_155      TDVRVPAAALVGGSEDVGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
TH_3736|M.thermoresistible__bu      TDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
Mflv_4370|M.gilvum_PYR-GCK          TDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDESVA
Mvan_1974|M.vanbaalenii_PYR-1       TDVRVPDAALVGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVT
MLBr_00737|M.leprae_Br4923          DKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
MAB_1188c|M.abscessus_ATCC_199      EDVRVPVANRIG-EEGIGFTIAMRGLNGGRLNIASCSLGGARSALEKVIE
Rv2500c|M.tuberculosis_H37Rv        ADARVPRENLLG-ARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVK
                                     . .      :*   . *:   :  *   *  :.: : * *  .::  : 

Mb0221c|M.bovis_AF2122/97           YAQQRESFGRPIWQHQAVGNYLADMATKLTAARQLTRYAAERYDSGQR-C
MUL_4024|M.ulcerans_Agy99           YAQQRHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYDSGQR-C
MMAR_4034|M.marinum_M               YASTATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSGAD-R
MAV_1571|M.avium_104                YASTATQGGTPIGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGED-R
MSMEG_2205|M.smegmatis_MC2_155      YAATATQGGQPIGNFQLVQAMIADQQTGVMAGRALVRDAAQKWVTGED-R
TH_3736|M.thermoresistible__bu      YAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAARKWVSGED-R
Mflv_4370|M.gilvum_PYR-GCK          YAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQD-R
Mvan_1974|M.vanbaalenii_PYR-1       YAATATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETARQWVTGED-R
MLBr_00737|M.leprae_Br4923          YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDL
MAB_1188c|M.abscessus_ATCC_199      YLRTRKAFGEELIKFQALQFRLADMATELEAARTMVWRAAAAVTEGDPRA
Rv2500c|M.tuberculosis_H37Rv        YANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP-F
                                    *       *  :  .* :   :*       ..*     :*     *    

Mb0221c|M.bovis_AF2122/97           DMEAGMAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMILG
MUL_4024|M.ulcerans_Agy99           DMEAGMAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMIVG
MMAR_4034|M.marinum_M               RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRDVRLLRLY
MAV_1571|M.avium_104                RVAPSAAKLYCTEMAGRVADLAVQVHGGSGYMRGVPVERIYRDVRLLRLY
MSMEG_2205|M.smegmatis_MC2_155      RIAPSAAKLYCTEMAGTVADLAVQIHGGTGYMREVPVERIYREVRLLRLY
TH_3736|M.thermoresistible__bu      RVAPSAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRDVRLLRLY
Mflv_4370|M.gilvum_PYR-GCK          RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLY
Mvan_1974|M.vanbaalenii_PYR-1       RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLY
MLBr_00737|M.leprae_Br4923          GFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIY
MAB_1188c|M.abscessus_ATCC_199      AELCAMAKRIATDVGFTVANEALQLHGGYGYLAEYGIEKIVRDLRVHQIL
Rv2500c|M.tuberculosis_H37Rv        KKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIG
                                        . :*  .:: .   :  * ::.** *:     : :  *:  :  : 

Mb0221c|M.bovis_AF2122/97           EGTNEIQRNVIAGQLVARGGI-------
MUL_4024|M.ulcerans_Agy99           EGTNEIQRNVIARQLIARGGI-------
MMAR_4034|M.marinum_M               EGTSEIQQLIIGSNLIKAANR-------
MAV_1571|M.avium_104                EGTSEIQRLIIGSNLVKAAQRATTTKER
MSMEG_2205|M.smegmatis_MC2_155      EGTSEIQRLIIGGGLVKAAQRQL-----
TH_3736|M.thermoresistible__bu      EGTSEIQRLIIGGGLVKAAQRQTN----
Mflv_4370|M.gilvum_PYR-GCK          EGTSEIQKLIIGGGLVKGAKGK------
Mvan_1974|M.vanbaalenii_PYR-1       EGTSEIQRLIIGGGLVKGAKAR------
MLBr_00737|M.leprae_Br4923          EGTNQIQRVVMSRALLR-----------
MAB_1188c|M.abscessus_ATCC_199      EGTNEIMRVIVSRKLIEQGLPA------
Rv2500c|M.tuberculosis_H37Rv        EGTTEVQLMLIARSLGLQ----------
                                    ***.::   ::.  *

species	id	gene	e-value	identity (len)	annotation
M. marinum M	MMAR_4034	fadE	-	100% (387)	acyl-CoA dehydrogenase FadE
M. marinum M	MMAR_4161	fadE3	2e-56	35.81% (377)	acyl-CoA dehydrogenase FadE3
M. marinum M	MMAR_0455	fadE3_2	2e-56	35.81% (377)	acyl-CoA dehydrogenase FadE3_2