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M. thermoresistible (build 8) TH_3393 (-)

annotation: Acyl-CoA dehydrogenase, type 2, C-terminal domain
coordinates: 1392128 - 1393348
length: 407

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_3393 - - 100% (407) Acyl-CoA dehydrogenase, type 2, C-terminal domain
M. thermoresistible (build 8) TH_3721 - 2e-36 35.22% (301) PUTATIVE putative acyl-CoA dehydrogenase family protein
M. thermoresistible (build 8) TH_3059 - 3e-18 27.73% (375) PUTATIVE pigment production hydroxylase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3302c fadE25 2e-14 23.61% (377) acyl-CoA dehydrogenase FADE25
M. gilvum PYR-GCK Mflv_4548 - 2e-16 25.39% (386) acyl-CoA dehydrogenase type 2
M. tuberculosis H37Rv Rv3274c fadE25 2e-14 23.61% (377) acyl-CoA dehydrogenase FADE25
M. leprae Br4923 MLBr_00737 fadE25 2e-14 23.94% (376) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_1422c - 4e-53 37.34% (391) putative acyl-CoA dehydrogenase
M. marinum M MMAR_4030 - 2e-15 25.70% (358) acyl-CoA dehydrogenase
M. avium 104 MAV_3422 - 3e-40 34.27% (356) acyl-CoA dehydrogenase domain-containing protein
M. smegmatis MC2 155 MSMEG_2650 - 1e-166 72.93% (399) acyl-CoA dehydrogenase
M. ulcerans Agy99 MUL_3895 - 5e-16 26.54% (358) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_3173 - 1e-65 39.37% (414) acyl-CoA dehydrogenase type 2

CLUSTAL 2.0.9 multiple sequence alignment


TH_3393|M.thermoresistible__bu      -----VTEPLTMARIVDTAEALAVAARLSGSFAAEASTRDAER--LLPYE
MSMEG_2650|M.smegmatis_MC2_155      ------MTATSATRIGSAKDALIEAARLSAVFAEGAGARDADR--RLPHD
Mvan_3173|M.vanbaalenii_PYR-1       -MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAERERAG--AVLTP
MAB_1422c|M.abscessus_ATCC_199      ------MTSAPSVLEIRALPGTDTYRNLLAQVAEGARDRDLD--DENPFD
MAV_3422|M.avium_104                ------MPVAFHRQDT--PAGAAAVQPVLAEIAADYRLRLADGGTEPPLR
Mb3302c|M.bovis_AF2122/97           MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
Rv3274c|M.tuberculosis_H37Rv        MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MMAR_4030|M.marinum_M               MTKLAQT-----LGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHE
MUL_3895|M.ulcerans_Agy99           MTKLAQT-----LGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHE
Mflv_4548|M.gilvum_PYR-GCK          ----------------MSERVLDRLNELAGQFKEQAVEAEKLG--KLPDA
                                                                                      

TH_3393|M.thermoresistible__bu      QVCELKRSGLLTLSVPAEHGGLDVPATVLAEVFRLLAHGDPSVAQIPHSH
MSMEG_2650|M.smegmatis_MC2_155      EIRALKESGLLAITVPVAHGGIDMPSTVLAEVIRLLSHGDSSIGQIPHSH
Mvan_3173|M.vanbaalenii_PYR-1       QLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAVGQLLLSH
MAB_1422c|M.abscessus_ATCC_199      QVRLLKEAGFGRLRIPTELGGAGLSVRQLFSAIIDVAQADPIVAHIFRTH
MAV_3422|M.avium_104                GLKLVRDHRLGALRLARELGGAGYTAPEFFDYLVALAAADPDLAHILRIH
Mb3302c|M.bovis_AF2122/97           ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
Rv3274c|M.tuberculosis_H37Rv        ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
MLBr_00737|M.leprae_Br4923          ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MMAR_4030|M.marinum_M               IVEQMRSIGLFGLMIPEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH
MUL_3895|M.ulcerans_Agy99           IVEQTRSIGLFGLMIPEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH
Mflv_4548|M.gilvum_PYR-GCK          TVKSMKSIGSIRLLQPKKHGGLEVHPREFAETVMATAALDPAAGWVNGVV
                                     :          :  .   **           .   :      . :    

TH_3393|M.thermoresistible__bu      FTFLEVLRLQGTERQRGFFYGLVLE-GALFANAQSERG-PHPIDVDTTVL
MSMEG_2650|M.smegmatis_MC2_155      FTFLEALRLQGTESQRAFFYGLVLD-GALFANAQAERG-PHPTDVDTTTL
Mvan_3173|M.vanbaalenii_PYR-1       FVVAQAISGLGHTQPAPRIYADLLA-GAQLGNASAERGTAHALDRRTTVT
MAB_1422c|M.abscessus_ATCC_199      FWFVEERLRTLADPVSAAWLTKVNE-GNLFANAFSEKGSLAVGSLVFNTR
MAV_3422|M.avium_104                YALVEELQVTPRRPGSDRWIAVVAE-GGLIGGANAEQSQKSVGGNHRDTR
Mb3302c|M.bovis_AF2122/97           KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
Rv3274c|M.tuberculosis_H37Rv        KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
MLBr_00737|M.leprae_Br4923          KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
MMAR_4030|M.marinum_M               FIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRA
MUL_3895|M.ulcerans_Agy99           FIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRA
Mflv_4548|M.gilvum_PYR-GCK          GVHPYQLAYADPKVGEEIWADDIDT---WVASPYAPQG-----------V
                                                          :       . . :               

TH_3393|M.thermoresistible__bu      LRRGAGDYLLTGRKFYSTGALFADWIVVRASVPADAADAPTAATPKAVAF
MSMEG_2650|M.smegmatis_MC2_155      RPAGDG-YVLSGRKFYSTGALFADWILVRASLSDGSVTVPTASTPKAVAF
Mvan_3173|M.vanbaalenii_PYR-1       RR--DGHWVLNGTKYYATGTLGATWIAVAARIEG------RENGDTATAF
MAB_1422c|M.abscessus_ATCC_199      LLPVGDAYRLNGEKFYSTGTLFADYLTVTATTDR---------DSVASVI
MAV_3422|M.avium_104                LVTTPDGLRLRGRKFYSTGAQFSDYLRITAQDDD---------GAPTAVV
Mb3302c|M.bovis_AF2122/97           KADGD-HWILNGAKCWITNGGKSTWYTVMAVTDP-----DRGANGISAFM
Rv3274c|M.tuberculosis_H37Rv        KADGD-HWILNGAKCWITNGGKSTWYTVMAVTDP-----DRGANGISAFM
MLBr_00737|M.leprae_Br4923          KADGD-DWILNGFKCWITNGGKSTWYTVMAVTDP-----DKGANGISAFI
MMAR_4030|M.marinum_M               TRGADGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGA---AQPHRNLTAFL
MUL_3895|M.ulcerans_Agy99           TRGADGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGA---AQPHRNLTAFL
Mflv_4548|M.gilvum_PYR-GCK          AVPTDGGYIFTGRWQFSSGTDACDWIILGAMVGDAKG-VPLMPPQMLHMI
                                             : *   : :.   .    : .                   .

TH_3393|M.thermoresistible__bu      VPRHA------PGLTV-IDDWDGMGQRTTASGSVTLDEVRVPAD------
MSMEG_2650|M.smegmatis_MC2_155      VPRDA------AGVTI-VDDWDGMGQRTTASGTVTLDDVQVPAE------
Mvan_3173|M.vanbaalenii_PYR-1       VRPDQ------EGVTLDLESWSAFGQRGTASGEVRLNNVVVDDD------
MAB_1422c|M.abscessus_ATCC_199      VPGDR------DGVRL-VDDWDGFGQRRTGTGTTIFSQVDVAAD------
MAV_3422|M.avium_104                IPVDR------AGVEH-LDDWDGIGQRQTGSGTTVFNDVAVADD------
Mb3302c|M.bovis_AF2122/97           VHKDD------EGFTV-GPKERKLGIKGSPTTELYFENCRIPGD------
Rv3274c|M.tuberculosis_H37Rv        VHKDD------EGFTV-GPKERKLGIKGSPTTELYFENCRIPGD------
MLBr_00737|M.leprae_Br4923          VHKDD------EGFSI-GPKEKKLGIKGSPTTELYFDKCRIPGD------
MMAR_4030|M.marinum_M               VEKPTGFGEVLPGLTI-PGKIDKLGYKGIDTTELIFDGYRATAD------
MUL_3895|M.ulcerans_Agy99           VEKPTGFGEVLPGLTI-PGKIDKLGYKGIDTTEVIFDGYRATAD------
Mflv_4548|M.gilvum_PYR-GCK          LPRKD--------YQIVDDSWDVVGLRGTGSKDVIVDGAFVPTYRTMDGM
                                    :                  .   .* :   :    ..             

TH_3393|M.thermoresistible__bu      HVV----PFTPIFRRPTVYGARAQLW---HAALDVGIATAALEEG-VRLA
MSMEG_2650|M.smegmatis_MC2_155      HVV----PFTAIFTEPTVYGSRAQLL---HTAIDVGIATAALDEG-VRQA
Mvan_3173|M.vanbaalenii_PYR-1       LLIDEGPPPDPITADPSVLGAFDQAL---HAAIDIGIARAALEDGAVFVR
MAB_1422c|M.abscessus_ATCC_199      EIL--SETPYDAAPVPTTQYASLQLY---ILAIVAGVLRAVVDDGEALLR
MAV_3422|M.avium_104                EVF--PLG--STIGVNRARGALVQLY---LHAVAAGILRSLTEDAAALVR
Mb3302c|M.bovis_AF2122/97           RIIG---EPGTGFKTALATLDHTRPT---IGAQAVGIAQGALDAAIAYTK
Rv3274c|M.tuberculosis_H37Rv        RIIG---EPGTGFKTALATLDHTRPT---IGAQAVGIAQGALDAAIAYTK
MLBr_00737|M.leprae_Br4923          RIIG---EPGTGFKTALATLDHTRPT---IGAQAVGIAQGALDAAIVYTK
MMAR_4030|M.marinum_M               DILGG--TPGQGFFQMMDGIEVGRVN---VSARACGVGLRAFELAVRYAQ
MUL_3895|M.ulcerans_Agy99           DILGG--TPGQGFFPMMDGIEVGRVN---VSARACGVGLRAFELAVRYAQ
Mflv_4548|M.gilvum_PYR-GCK          KVMDGSAQIEAGMTEPLYKMPWSTMFPLGISSATIGICEGALAAHLDYQR
                                     :.                            :   *:             

TH_3393|M.thermoresistible__bu      ARARP---HFESGAPVATDDPTLIQSAGEVAVTVRAAQALLGEAARAVDA
MSMEG_2650|M.smegmatis_MC2_155      ARARP---HFESKVASVADDPTVVQAAGELAVTVRSAQALLAEAARQVDA
Mvan_3173|M.vanbaalenii_PYR-1       TRSRPWKEALDAGIERADQEPHVVRRFGELTARLYALEALLARGTALIDE
MAB_1422c|M.abscessus_ATCC_199      SRQRN---FSHALTERPVDDPLLQRTLGELSATAFAAEATVLAAADAIEA
MAV_3422|M.avium_104                GRRRT---YTFASADTPTADPQLLQIVGEIDAVAYTAHALVRNAAAELAP
Mb3302c|M.bovis_AF2122/97           DRKQFG--------ESISTFQAVQFMLADMAMKVEAARLMVYSAAARAER
Rv3274c|M.tuberculosis_H37Rv        DRKQFG--------ESISTFQAVQFMLADMAMKVEAARLMVYSAAARAER
MLBr_00737|M.leprae_Br4923          DRKQFG--------ESISTFQSIQFMLADMAMKVEAARLIVYAAAARAER
MMAR_4030|M.marinum_M               QRHTFG--------KPIAEHQAISFQLAEMATKVEAAHLMMVHAARLKDS
MUL_3895|M.ulcerans_Agy99           QRHTFG--------KPIAEHQAISFQLAEMATKVEAAHLMMVHAARLKDS
Mflv_4548|M.gilvum_PYR-GCK          ERVGAN-------GTAIKDDPYVMYAIGDAAAEIEASRNTLLSNVDRVYD
                                     *                    :    .:      : .  :   .     

TH_3393|M.thermoresistible__bu      ATAD-----LTEDTAAAASIAVATAKVAAERAALRASTALFELGGTRSAT
MSMEG_2650|M.smegmatis_MC2_155      ARAD-----LTDETAAAASIAVAVAKVAAVRASLDASSALFELGGTRSAS
Mvan_3173|M.vanbaalenii_PYR-1       AYAAP---EVTRDAAAQASLTVAAAKALAQQDAVEIAGAIFELTGTSGTD
MAB_1422c|M.abscessus_ATCC_199      ATATLRDGVPDAQLAQEAQVAVAKAKVHIDAVALDAATKLLDLGGASAAS
MAV_3422|M.avium_104                ALQAARDTGIDPELEAAASIAAARVKVAIQEPALRAASRVFDAGGASAVQ
Mb3302c|M.bovis_AF2122/97           GEPDLG-------------FISAASKCFASDVAMEVTTDAVQLFGGAGYT
Rv3274c|M.tuberculosis_H37Rv        GEPDLG-------------FISAASKCFASDVAMEVTTDAVQLFGGAGYT
MLBr_00737|M.leprae_Br4923          GEPDLG-------------FISAASKCFASDIAMEVTTDAVQLFGGAGYT
MMAR_4030|M.marinum_M               GERND--------------VAAGMAKYLASEYCSEVTQQSFRIHGGYGYS
MUL_3895|M.ulcerans_Agy99           GERND--------------VAAGMAKYLASEYCSEVTQQSFRIHGGYGYS
Mflv_4548|M.gilvum_PYR-GCK          IVDSGR------EVTFETRAAVRRSQIKAVWRAVAAVDQIFARSGGNALR
                                                             :      .       .   *  .  

TH_3393|M.thermoresistible__bu      VSANLSRFWRDART---HTLHDPTRWKLHHIGRYLLSGTRPPRHGQL-
MSMEG_2650|M.smegmatis_MC2_155      AGGNLSRYWRDART---HTLHDSTRWKLRHIGRYTLSGTKPPRHSQI-
Mvan_3173|M.vanbaalenii_PYR-1       GAVNLDRHWRNVRV---HSLHDPARWKYVHLGNHTLHDTRPPRLGLIL
MAB_1422c|M.abscessus_ATCC_199      RTRNLDRHWRNIRT---ISLHNPVHYKARVIGQNLLHGTPLPANAYF-
MAV_3422|M.avium_104                ASALLDRHWRNLRT---LFSHNPTVYKARVLGDVVVNGAALPDTSFF-
Mb3302c|M.bovis_AF2122/97           TDFPVERFMRDAKI---TQIYEGTNQIQRVVMSRALLR----------
Rv3274c|M.tuberculosis_H37Rv        TDFPVERFMRDAKI---TQIYEGTNQIQRVVMSRALLR----------
MLBr_00737|M.leprae_Br4923          SDFPVERFMRDAKI---TQIYEGTNQIQRVVMSRALLR----------
MMAR_4030|M.marinum_M               KEYEIERLMRDAPF---LLIGEGTSEIQKSIISKRLLHEYRE------
MUL_3895|M.ulcerans_Agy99           KEYEIERLMRDAPF---LLIGEGTSEIQKSIISKRLLHEYRE------
Mflv_4548|M.gilvum_PYR-GCK          MDKPLQRYWRDAHAGVAHAIHVPGTVYHASALSSLGVDPQGPLRAMI-
                                        :.*  *:

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_3393	-	-	100% (407)	Acyl-CoA dehydrogenase, type 2, C-terminal domain
M. thermoresistible (build 8)	TH_3721	-	2e-36	35.22% (301)	PUTATIVE putative acyl-CoA dehydrogenase family protein
M. thermoresistible (build 8)	TH_3059	-	3e-18	27.73% (375)	PUTATIVE pigment production hydroxylase