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SETTTVPESLGEPSSPRQLRGNLGVTAIVFMVVAAAAPLGVIGGVVPLGLAAGNGAGFPATFIASTLVLL LFAVGFTAMTPYVDEAGAFFSYLRQALGFPAGIGIAFVALVSYVALEAGVYGLLGPAGASVVELLGGPAL PWWLFAAAAFALTTYLGYRNIELSSRVLGVLLTAEIAIVLVLDLVIVARGGDHGLSSGIVSPGAIFSGSL GIGLLFAIISYVGFEATAIFRDEARAPERTIPRATYAALILIGVFYAVTSWALISGWGDDAAVARATDNG DTFLGDTAQRYIGVVGADIITVLYFTSLFACILAFHNVASRYVFALSQRDVLPASLSVPHSRHGSPHAAS LWISGAVALSVLLAVLFGLDPAAQFYTWFAGTTTVGIVVLMTATSVAVLVFFARDRRGQSLWRVRIAPAL GLIGLVGALVLILSNLSDLVGGSSVLAWVIVVLLVTAFAAGVVVGARVGGRAAPDRTPRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3557 | - | - | 100% (481) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_1508 | - | e-123 | 49.68% (467) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_0499 | - | e-110 | 43.55% (473) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0535 | gabP | 5e-18 | 26.09% (437) | GABA permease GabP |
| M. gilvum PYR-GCK | Mflv_1244 | - | 6e-65 | 32.58% (488) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv0522 | gabP | 5e-18 | 26.09% (437) | GABA permease GabP |
| M. leprae Br4923 | MLBr_01974 | - | 5e-11 | 21.77% (372) | putative permease |
| M. abscessus ATCC 19977 | MAB_4350c | - | 1e-118 | 48.70% (460) | putative amino acid permease |
| M. marinum M | MMAR_0869 | - | 5e-22 | 22.89% (415) | amino acid permease |
| M. avium 104 | MAV_4626 | - | 2e-20 | 25.52% (435) | gaba permease |
| M. thermoresistible (build 8) | TH_4382 | - | 8e-14 | 23.14% (471) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_2787 | - | 9e-18 | 25.33% (379) | hypothetical protein MUL_2787 |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | 6e-66 | 31.36% (491) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0535|M.bovis_AF2122/97 --------------------------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_3557|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4350c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0605|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MUL_2787|M.ulcerans_Agy99 --------------------------------------------------
Mb0535|M.bovis_AF2122/97 --------------------------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_3557|M.smegmatis_MC2_155 -----------------------------------MSETTTVPESLG---
MAB_4350c|M.abscessus_ATCC_199 -----------------------------------MTASKRACQGHGSAA
Mflv_1244|M.gilvum_PYR-GCK -----------------------------------MTESAERTAPGQTTP
Mvan_0605|M.vanbaalenii_PYR-1 -----------------------------------MAVRSDPPVHVAAEP
MMAR_0869|M.marinum_M -----------------------------------------------MAV
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MUL_2787|M.ulcerans_Agy99 ----------------------MGHLDADKKTNHQPIEGDCVSQGEATSV
Mb0535|M.bovis_AF2122/97 ------------------MIAIGGVIGAGLFVGSGVVIRATG------PA
Rv0522|M.tuberculosis_H37Rv ------------------MIAIGGVIGAGLFVGSGVVIRATG------PA
MAV_4626|M.avium_104 -MAGTSQLRQGLSQRQLSMIALGGVIGAGLFVGSGVVIKDTG------PA
MSMEG_3557|M.smegmatis_MC2_155 EPSSPRQLRGNLGVTAIVFMVVAAAAPLGVIGGVVPLGLAAGN----GAG
MAB_4350c|M.abscessus_ATCC_199 ESDRPQKLDGQLGVIGIVLMVIAAAAPLTVIGGDGLLAIASGP----GPG
Mflv_1244|M.gilvum_PYR-GCK TASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGN----GSH
Mvan_0605|M.vanbaalenii_PYR-1 -AEGHTLKRGAIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGN----GLG
MMAR_0869|M.marinum_M TTGARSELQKALGQRSAVLFGLAYMTPIIVLGIFGVIAERSK------GA
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVGDILGTGIYALVGDVAGEVG------GA
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAG------PF
MUL_2787|M.ulcerans_Agy99 AVEGKGLKGGAVGLLSSVVIGTASTAPAYSLAATLGLIVASRGELLCGVK
.: :
Mb0535|M.bovis_AF2122/97 AFLTYALCGALIVLVMRMLGEMAAANPSTGAFADYAAKALGGWAG-FSVG
Rv0522|M.tuberculosis_H37Rv AFLTYALCGALIVLVMRMLGEMAAANPSTGAFADYAAKALGGWAG-FSVG
MAV_4626|M.avium_104 AFLTYALCGLLIVLVMRMLGEMAAANPSTGSFADYAAAALGRWAG-FSVA
MSMEG_3557|M.smegmatis_MC2_155 FPATFIASTLVLLLFAVGFTAMTPYVDEAGAFFSYLRQALGFPAG-IGIA
MAB_4350c|M.abscessus_ATCC_199 APLGFLIAGLLLMAFAVGFVTMTPFVSEAGAFFSYITKGLGERWG-LGAA
Mflv_1244|M.gilvum_PYR-GCK APAGYLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMG-MASG
Mvan_0605|M.vanbaalenii_PYR-1 TPAGFAIATIVLSIFSVGFIALARHITAAGAFYTFVSRGWSRIPG-LPAG
MMAR_0869|M.marinum_M SAGSYLLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVG-FMVG
TH_4382|M.thermoresistible__bu AWLPFLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVA
MLBr_01974|M.leprae_Br4923 APIAYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGV
MUL_2787|M.ulcerans_Agy99 APAIVLLSFIPMYMIAVAYQELNKAEPDCGTTFTWASRAFGPVTG-WLGG
. . : . .
Mb0535|M.bovis_AF2122/97 WLYWYFWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTA-------
Rv0522|M.tuberculosis_H37Rv WLYWYFWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTA-------
MAV_4626|M.avium_104 WLYWYFWVIVVGFEAVAGGKVLNYWFHAPLWVLSLGLMLLMTA-------
MSMEG_3557|M.smegmatis_MC2_155 FVALVSYVALEAGVYGLLGPAGASVVELLGGPALPWWLFAAAA-------
MAB_4350c|M.abscessus_ATCC_199 FVALVTYTAIQVGMYGYMGWALNDLVTSYGGPELPWWLWAIVT-------
Mflv_1244|M.gilvum_PYR-GCK LIITLAYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVPALLM-------
Mvan_0605|M.vanbaalenii_PYR-1 VMSMFTYMTMEAGLIGIFSVFADQAITSQFGIDLPWLVYAMIG-------
MMAR_0869|M.marinum_M WAVLLDYLFLPLVIWLIGGSYLQDRFP-----TVPFWTWIVGF-------
TH_4382|M.thermoresistible__bu FIVMCSGITSASTASRFFAANLEVGLGQEWG-RLGVAGVALLF-------
MLBr_01974|M.leprae_Br4923 THAITASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTL-------
MUL_2787|M.ulcerans_Agy99 WGIIAADVIVMANLAQIAGAYSFTFVGELGWQSASNLAHSTLWSTVAGVA
. .
Mb0535|M.bovis_AF2122/97 -TNLVSVSSFGEFEFWFAGVK-----VATIVGFLVLGTAFAFGLLPGH--
Rv0522|M.tuberculosis_H37Rv -TNLVSVSSFGEFEFWFAGVK-----VATIVGFLVLGTAFAFGLLPGH--
MAV_4626|M.avium_104 -TNLFSVSSFGEFEFWFAGIK-----VATIVIFLVVGAAYVIGLVPGH--
MSMEG_3557|M.smegmatis_MC2_155 -FALTTYLGYRNIELSSRVLG-----VLLTAEIAIVLVLDLVIVARGG--
MAB_4350c|M.abscessus_ATCC_199 -LGLVAYLGYRNIELSSKVLG-----IALVLEIAVVLVTDAAIVFQGG--
Mflv_1244|M.gilvum_PYR-GCK -LVLNSILTYFDVNLTAKVLG-----VFLITEIFMLALGAVAVAVKGGGP
Mvan_0605|M.vanbaalenii_PYR-1 -VVVIATLSHWDISVAAKVLG-----AVLVAEIVMLTLTATASLMHH--P
MMAR_0869|M.marinum_M -AALTTVLNLIGLKVADRANF-----ILMTFQLLILAFFVALTIGYLVG-
TH_4382|M.thermoresistible__bu -MALLAMVNLRGVGESVRLNV-----LLTIVEISGLLLVIFVGLWAFTGG
MLBr_01974|M.leprae_Br4923 -TFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQ
MUL_2787|M.ulcerans_Agy99 WIVVMTCICYRGTDVSARMQY-----VLLSVELVVLVALAAVALARVYTN
: : :
Mb0535|M.bovis_AF2122/97 --GMDFSNLSAHGGFFP--------DGVG--AVFAAIVVAIFSMTGTEVV
Rv0522|M.tuberculosis_H37Rv --GMDFSNLSAHGGFFP--------DGVG--AVFAAIVVAIFSMTGTEVV
MAV_4626|M.avium_104 --HDGLTNLVSHGGFFP--------RGVG--AVFAAIVVVIFSMVGAEIV
MSMEG_3557|M.smegmatis_MC2_155 ------DHGLSSGIVSP--------GAIFSGSLGIGLLFAIISYVGFEAT
MAB_4350c|M.abscessus_ATCC_199 ------RDGISAYSFTP--------EAAASGPLGIAILFAFAGFMGFEAT
Mflv_1244|M.gilvum_PYR-GCK DGFAIAETLNPVGAFQP--------AAIAGASAGLGLFFAFWSWVGFEST
Mvan_0605|M.vanbaalenii_PYR-1 EGMSWTS-LNPATALST--------NGVAGGVVGLGLLMAFWSWVGFEST
MMAR_0869|M.marinum_M ----DSRSLLSLTPFTG--------NGGFT-AITAGAAVAAYSFLGFDAV
TH_4382|M.thermoresistible__bu GADVDFTRVVAFETTTD--------KSVFL-AVSAATSLAFFAMVGFEDS
MLBr_01974|M.leprae_Br4923 HVNNYVTSRSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESI
MUL_2787|M.ulcerans_Agy99 HGDVGSLRPSLSWLWPS--------GLDFGTQMAPALLITIFIYWGFDTA
. .. * :
Mb0535|M.bovis_AF2122/97 TIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILP--------W
Rv0522|M.tuberculosis_H37Rv TIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILP--------W
MAV_4626|M.avium_104 TVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVFLLVAILP--------W
MSMEG_3557|M.smegmatis_MC2_155 AIFRDEARAPERTIPRATYAALILIGVFYAVTSWALISGWG---DDAAVA
MAB_4350c|M.abscessus_ATCC_199 AVFRDEARQPERTIPRATYLSVAIIGVFYAVSCWAVVEAWGPANVKDVVQ
Mflv_1244|M.gilvum_PYR-GCK AMYGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGP-QQAVELA
Mvan_0605|M.vanbaalenii_PYR-1 AIYGEESKNPKKIVPQATMIAVIGIGVFYTFIAWGMIVGNGP-TKAVELS
MMAR_0869|M.marinum_M STLTEETHDAERTIPRAIVLIALIGGAIFVTVAYVVSLVAP--------G
TH_4382|M.thermoresistible__bu VNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVALVP-------VG
MLBr_01974|M.leprae_Br4923 ANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGS---------
MUL_2787|M.ulcerans_Agy99 VACNDETDDPGRTLGRAAVISTFLLLATYAVVTVASIAFAG-VGVDGIGL
* . . :* :
Mb0535|M.bovis_AF2122/97 NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLF
Rv0522|M.tuberculosis_H37Rv NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLF
MAV_4626|M.avium_104 DSVELGASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNSGLYTASRMLF
MSMEG_3557|M.smegmatis_MC2_155 RATDNGDTFLGDTAQRYIGVVGADIITVLYFTSLFACILAFHNVASRYVF
MAB_4350c|M.abscessus_ATCC_199 KSLDSGGNALLDTAEAYVGAVFRDIMQILLVTSLFACVLSFHNVIARYQF
Mflv_1244|M.gilvum_PYR-GCK QSADTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLY
Mvan_0605|M.vanbaalenii_PYR-1 -SGPTPFDLIYAPTQQYLGQWAIVVFEWLMVGGSFACALAIHNSAARYLF
MMAR_0869|M.marinum_M SSFPDADSLSEGVARTIGGNLFAAVFLAALIIGQFTSGLAAQAAVSRLLY
TH_4382|M.thermoresistible__bu TLQASDVPLVEVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIY
MLBr_01974|M.leprae_Br4923 -DKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWT
MUL_2787|M.ulcerans_Agy99 GNPDNSNDVFAAVGPALFGDGVLGKIGLLLLSASILTSASASTQTTILPT
: . . .
Mb0535|M.bovis_AF2122/97 VLAARQE-----APAQLVKVNRR-GVPTFAIMGSSVVGFLCVIMAWVSP-
Rv0522|M.tuberculosis_H37Rv VLAARQE-----APAQLVKVNRR-GVPTFAIMGSSVVGFLCVIMAWVSP-
MAV_4626|M.avium_104 VLAERGE-----APARLVRLSGR-GVPHIAILCSSAVGFLCVVMARVAP-
MSMEG_3557|M.smegmatis_MC2_155 ALSQRDV-----LPASLSVPHSRHGSPHAASLWISGAVALSVLLAVLFGL
MAB_4350c|M.abscessus_ATCC_199 ALANKGV-----LPAPVGRVHPTERSPHISSALQSITAVAFVVLVAAVGL
Mflv_1244|M.gilvum_PYR-GCK ALGREGLSTG--LQKTLGATHKTHGSPYIASFVQSGIALVLVLAFFFAGM
Mvan_0605|M.vanbaalenii_PYR-1 AFGRDGL-----LPRRLGAAHPKHASPYVASLAQSVFAAVVLIVCAISGS
MMAR_0869|M.marinum_M AMGRDGVLP----RRVFGVVSAKFHTPMFNIMLTGAVGMAAILLSVATS-
TH_4382|M.thermoresistible__bu GMARQRV-----LPPVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFAD
MLBr_01974|M.leprae_Br4923 ALSDGRI------LPTRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSL
MUL_2787|M.ulcerans_Agy99 ARTTLSMAVYKALPASFAKIHPRYLTPTVSTIAMGAVSILFYVLFTLVSR
* .
Mb0535|M.bovis_AF2122/97 ---ATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVR--MWLF
Rv0522|M.tuberculosis_H37Rv ---ATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVR--MWLF
MAV_4626|M.avium_104 ---NTVFLFLLNSSGAIILFVYWLIALSQIVLRRRTPAERLSVK--MWFF
MSMEG_3557|M.smegmatis_MC2_155 DPAAQFYTWFAGTTTVGIVVLMTATSVAVLVFFARD---RRGQS--LWRV
MAB_4350c|M.abscessus_ATCC_199 DPMVQVFSSMAGISTVGMLMLLILTSVAVPLFFSRDD-SARAGR--VLTT
Mflv_1244|M.gilvum_PYR-GCK DPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFHFHKNHPSSAH--WFKT
Mvan_0605|M.vanbaalenii_PYR-1 DPYAVLFVLVAILATLCLLTVQTMSSIATVVYFHVKKQHPETAN--WWRT
MMAR_0869|M.marinum_M ----------TSFINFGAFTAFTLVNVSVVVYFVRER--GAGLP--RWRY
TH_4382|M.thermoresistible__bu ---STAIAVLGGTTSLLLLAVFAMVNVAVLVLRRDESRDPVVARRHFRTP
MLBr_01974|M.leprae_Br4923 N--------LTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTD
MUL_2787|M.ulcerans_Agy99 N----LLSALIGSVGLVIAFYYGLTGYACAHYYRATLTKSLRNFVMRGVV
:
Mb0535|M.bovis_AF2122/97 PGLS--IVTVTGIVAVLARMAFDYAARS----------------------
Rv0522|M.tuberculosis_H37Rv PGLS--IVTVTGIVAVLARMAFDYAARS----------------------
MAV_4626|M.avium_104 PVLS--VLTLAGITAVLVQMAFDATARS----------------------
MSMEG_3557|M.smegmatis_MC2_155 RIAP--ALGLIGLVGALVLILSNLSDLVGGSS---------------VLA
MAB_4350c|M.abscessus_ATCC_199 YVAP--IVATIGLSASVYLVLKNFTLVTDQST---------------VIS
Mflv_1244|M.gilvum_PYR-GCK FLAP--LTGGIGMLYVVYLLWEHKESAAGAASGTLLF---------KLTP
Mvan_0605|M.vanbaalenii_PYR-1 LAAP--VIGGAGMVYVIYLMASNMSAAAGTASESLFF---------KMIP
MMAR_0869|M.marinum_M LVLP--VIGAAVDIYLLAHLASDALIVG----------------------
TH_4382|M.thermoresistible__bu TFLP--VVGFVASLYLVTPLSGRPAQQYLLS-----------------VV
MLBr_01974|M.leprae_Br4923 KVLP--ITAVVVSAGLMVSFDYRSIFLTRGGP-----------------N
MUL_2787|M.ulcerans_Agy99 PLTGGVVLTVVFIFGLIEYAKRDWLVENGHNVTIFGFGAVAVVGVGSMLL
:
Mb0535|M.bovis_AF2122/97 QLWLSLLSWAVVVGCYLVTTLVRRPLNRPW--------------------
Rv0522|M.tuberculosis_H37Rv QLWLSLLSWAVVVGCYLVTTLVRRPLNRPW--------------------
MAV_4626|M.avium_104 QLWLSLLSWAVVVALYFVARSRGRVAAR----------------------
MSMEG_3557|M.smegmatis_MC2_155 WVIVVLLVTAFAAGVVVGARVGGRAAPDRTPRA-----------------
MAB_4350c|M.abscessus_ATCC_199 TVLAALPIAALIYGLVQKKGVHRR--------------------------
Mflv_1244|M.gilvum_PYR-GCK WIVVGVFAFGAAMALYFKFKDKRRYELIGRIVYDDSEVRD----------
Mvan_0605|M.vanbaalenii_PYR-1 YILLTLLFGSIAVALYLRKARPDLYARIGSTVFDDKPTD-----------
MMAR_0869|M.marinum_M ---LSWAAIGFLYLLWLTRGLTRQPPDLAGAAERG---------------
TH_4382|M.thermoresistible__bu LIVIGVLLFGVTMAINRQLGIPTRAVGDPAKMVLPPD-------------
MLBr_01974|M.leprae_Br4923 YFSISLIAITFIGIPAVAYLHYYRTSGIK---------------------
MUL_2787|M.ulcerans_Agy99 GVVVMLIWWAISPGFFRGRTLRRHSADLLLEPAVSPPAHLALPDSGDMQT
Mb0535|M.bovis_AF2122/97 --------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------
MAV_4626|M.avium_104 --------------------------------
MSMEG_3557|M.smegmatis_MC2_155 --------------------------------
MAB_4350c|M.abscessus_ATCC_199 --------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------
Mvan_0605|M.vanbaalenii_PYR-1 --------------------------------
MMAR_0869|M.marinum_M --------------------------------
TH_4382|M.thermoresistible__bu --------------------------------
MLBr_01974|M.leprae_Br4923 --------------------------------
MUL_2787|M.ulcerans_Agy99 VIAADLSNLPAGETAVNPQTGQHLTKDTSGAS