For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSANAPTSDDQGDLRDEQRLHGRLGPIGVVFMVVAAAAPLTVIGGNMPLGMGLGNGAGAPVGFLIAALVL LLFSIGFVAMTPYVPEAGAFFSYVTLGLGRRLGSGIAAVALIAYTAIQVGIYGYIGWAIDDTVRFYGGPE IPWPVYSFATLAIVAVLGYRHIELSAKVLGVALALEIGIVVLLDLVIVANPGPAGLTLSSFTPGVFTDGV LGIAVLFALTGFIGFEATAVFRDEARDPERTIPRATYAAVLIIGGFYALTCWAFVVAIGPDQVAEVAQRT LDGEANMLLDTTGDNLGRIGRDVVNVLLLTSLFACVLSFHNVIARYQFALARKGLLPKPLATVHPSHGSP SVSSLVQTATAAVIVAILAALGIDPLVGVFGSMAGVATVGMVLLMLTTSVAVLVFFARHADLASGRVWQT RIAPVLACLGLVGALLLVLTNFTLVTGGSATVSAILAAVPFVGLLAGAARRPRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1508 | - | - | 100% (474) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_3557 | - | e-123 | 49.68% (467) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_0499 | - | e-110 | 46.52% (445) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 7e-26 | 26.02% (442) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 1e-72 | 33.97% (468) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 7e-26 | 26.02% (442) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 1e-14 | 23.27% (447) | putative permease |
| M. abscessus ATCC 19977 | MAB_4350c | - | 1e-152 | 58.37% (454) | putative amino acid permease |
| M. marinum M | MMAR_3621 | rocE | 2e-26 | 26.92% (442) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 5e-25 | 26.02% (442) | amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 4e-14 | 24.67% (454) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 1e-26 | 26.92% (442) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | 2e-76 | 34.51% (452) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3621|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MSMEG_1508|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4350c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0605|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MMAR_3621|M.marinum_M ---------------------------MPATSIRLREQMLRRRPVGGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
TH_0471|M.thermoresistible__bu ----------------------------------MTDRLRVKSVEQSIAD
MSMEG_1508|M.smegmatis_MC2_155 -----------------------------------MSANAPTSDDQGDLR
MAB_4350c|M.abscessus_ATCC_199 -----------------------------------MTASKRACQGHGSAA
Mflv_1244|M.gilvum_PYR-GCK -----------------------------------MTESAERTAPGQTTP
Mvan_0605|M.vanbaalenii_PYR-1 -----------------------------------MAVRSDPPVHVAAEP
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVP--EAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVP--EAGPGVIVS
MMAR_3621|M.marinum_M AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP--EAGPAVIVS
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP--EAGPAVIVS
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVP--EAGPAVIVS
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTASTAGN-ITGPAISVS
MSMEG_1508|M.smegmatis_MC2_155 DE---QRLHGRLGPIGVVFMVVAAAAPLTVIGGNMPLGMGLGNGAGAPVG
MAB_4350c|M.abscessus_ATCC_199 ESDRPQKLDGQLGVIGIVLMVIAAAAPLTVIGGDGLLAIASGPGPGAPLG
Mflv_1244|M.gilvum_PYR-GCK TASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
Mvan_0605|M.vanbaalenii_PYR-1 -AEGHTLKRGAIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGNGLGTPAG
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK--IAGPFAPIA
.. : .: : : * .
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MMAR_3621|M.marinum_M FIIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
TH_0471|M.thermoresistible__bu FIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLIL
MSMEG_1508|M.smegmatis_MC2_155 FLIAALVLLLFSIGFVAMTPYVPEAGAFFSYVTLGLGRRLGSGIAAVALI
MAB_4350c|M.abscessus_ATCC_199 FLIAGLLLMAFAVGFVTMTPFVSEAGAFFSYITKGLGERWGLGAAFVALV
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
Mvan_0605|M.vanbaalenii_PYR-1 FAIATIVLSIFSVGFIALARHITAAGAFYTFVSRGWSRIPGLPAGVMSMF
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
: :* : :: : : *: : : .. . . .
Mb2347c|M.bovis_AF2122/97 EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
Rv2320c|M.tuberculosis_H37Rv EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
MMAR_3621|M.marinum_M EYGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MUL_1244|M.ulcerans_Agy99 EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVN
TH_0471|M.thermoresistible__bu EFSVAAAVVAKGWSSYLG----EVFEFAG-ATTRLGPITLDWG-------
MSMEG_1508|M.smegmatis_MC2_155 AY----TAIQVGIYGYIGWAIDDTVRFYGGPEIPWPVY------------
MAB_4350c|M.abscessus_ATCC_199 TY----TAIQVGMYGYMGWALNDLVTSYGGPELPWWLW------------
Mflv_1244|M.gilvum_PYR-GCK AY----IVFEASLIGIFAFFFQNFLSSQLGITIHWLVP------------
Mvan_0605|M.vanbaalenii_PYR-1 TY----MTMEAGLIGIFSVFADQAITSQFGIDLPWLVY------------
MLBr_01974|M.leprae_Br4923 TAS---IAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAV
. . . .
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MMAR_3621|M.marinum_M LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
TH_0471|M.thermoresistible__bu --ALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA
MSMEG_1508|M.smegmatis_MC2_155 --SFATLAIVAVLGYRHIELSAKVLGVALALEIGIVVLLDLVIVANPG-P
MAB_4350c|M.abscessus_ATCC_199 --AIVTLGLVAYLGYRNIELSSKVLGIALVLEIAVVLVTDAAIVFQGG-R
Mflv_1244|M.gilvum_PYR-GCK --ALLMLVLNSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGP
Mvan_0605|M.vanbaalenii_PYR-1 --AMIGVVVIATLSHWDISVAAKVLGAVLVAEIVMLTLTATASLMHH--P
MLBr_01974|M.leprae_Br4923 LLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSR
:. . . ..: : :
Mb2347c|M.bovis_AF2122/97 HLKDFVP---------------------------FGVAGIGSAAGTIFFS
Rv2320c|M.tuberculosis_H37Rv HLKDFVP---------------------------FGVAGIGSAAGTIFFS
MMAR_3621|M.marinum_M HLKDFAP---------------------------FGVAGVGAAAGTIFFS
MUL_1244|M.ulcerans_Agy99 HLKDFAP---------------------------FGVAGVGAAAGTIFFS
MAV_2087|M.avium_104 HLDDFAP---------------------------FGVAGVGTAAGTIFFS
TH_0471|M.thermoresistible__bu NYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFA
MSMEG_1508|M.smegmatis_MC2_155 AGLTLSS----------------------FTPGVFTDGVLGIAVLFALTG
MAB_4350c|M.abscessus_ATCC_199 DGISAYS----------------------FTPEAAASGPLGIAILFAFAG
Mflv_1244|M.gilvum_PYR-GCK DGFAIAET---------------LNPVGAFQPAAIAGASAGLGLFFAFWS
Mvan_0605|M.vanbaalenii_PYR-1 EGMSWTS----------------LNPATALSTNGVAGGVVGLGLLMAFWS
MLBr_01974|M.leprae_Br4923 SAYQPTTYS----------------LLGVTEIGKSTAASMTLATIVALYA
. : .
Mb2347c|M.bovis_AF2122/97 YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQ
Rv2320c|M.tuberculosis_H37Rv YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQ
MMAR_3621|M.marinum_M FIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQ
MUL_1244|M.ulcerans_Agy99 FIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQ
MAV_2087|M.avium_104 YIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQ
TH_0471|M.thermoresistible__bu FIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYT
MSMEG_1508|M.smegmatis_MC2_155 FIGFEATAVFRDEARDPERTIPRATYAAVLIIGGFYALTCWAFVVAIGPD
MAB_4350c|M.abscessus_ATCC_199 FMGFEATAVFRDEARQPERTIPRATYLSVAIIGVFYAVSCWAVVEAWGPA
Mflv_1244|M.gilvum_PYR-GCK WVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGPQ
Mvan_0605|M.vanbaalenii_PYR-1 WVGFESTAIYGEESKNPKKIVPQATMIAVIGIGVFYTFIAWGMIVGNGPT
MLBr_01974|M.leprae_Br4923 FTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDK
: *:: : :* *.: :.:. :: : .*
Mb2347c|M.bovis_AF2122/97 DFAEQ------ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMY
Rv2320c|M.tuberculosis_H37Rv DFAEQ------ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMY
MMAR_3621|M.marinum_M MFAGQ------EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMY
MUL_1244|M.ulcerans_Agy99 MFAGQ------EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMY
MAV_2087|M.avium_104 DFGGQ------QEAGLATILDHVTHGSWASTILAAGAVISIFSVTLVTMY
TH_0471|M.thermoresistible__bu ELRAAG-----ENANLATAFA-ANGIDWAAKVISIGALAGLTTVVIVLVL
MSMEG_1508|M.smegmatis_MC2_155 QVAEVAQRTLDGEANMLLDTTGDNLGRIGRDVVNVLLLTSLFACVLSFHN
MAB_4350c|M.abscessus_ATCC_199 NVKDVVQKSLDSGGNALLDTAEAYVGAVFRDIMQILLVTSLFACVLSFHN
Mflv_1244|M.gilvum_PYR-GCK QAVELAQ-SADTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMAFHN
Mvan_0605|M.vanbaalenii_PYR-1 KAVELS--SGPTPFDLIYAPTQQYLGQWAIVVFEWLMVGGSFACALAIHN
MLBr_01974|M.leprae_Br4923 IVATN----------HTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASF
:. : . :
Mb2347c|M.bovis_AF2122/97 GQTRILFAMGRDGL---LPARFAKVNPRTMTPVHNTVIVAIFASTLAAFI
Rv2320c|M.tuberculosis_H37Rv GQTRILFAMGRDGL---LPARFAKVNPRTMTPVHNTVIVAIFASTLAAFI
MMAR_3621|M.marinum_M GQTRILFAMGRDGL---LPARFAAVHPRFQTPVSNTVVVAIAAAVLAALV
MUL_1244|M.ulcerans_Agy99 GQTRILFAMGRDGL---LPARFAAVHPRFQTPVSNTVVVAIAAAVLAALV
MAV_2087|M.avium_104 GITRILFAMGRDGL---LPPRFARVNPRTMTPVNNTVIVAVAAATLAAFI
TH_0471|M.thermoresistible__bu GQTRVLFAMSRDGL---LPRPLSKTGPR-GTPVRITVLVGALVAIAASVF
MSMEG_1508|M.smegmatis_MC2_155 VIARYQFALARKGL---LPKPLATVHPSHGSPSVSSLVQTATAAVIVAIL
MAB_4350c|M.abscessus_ATCC_199 VIARYQFALANKGV---LPAPVGRVHPTERSPHISSALQSITAVAFVVLV
Mflv_1244|M.gilvum_PYR-GCK CASRYLYALGREGLSTGLQKTLGATHKTHGSPYIASFVQSGIALVLVLAF
Mvan_0605|M.vanbaalenii_PYR-1 SAARYLFAFGRDGL---LPRRLGAAHPKHASPYVASLAQSVFAAVVLIVC
MLBr_01974|M.leprae_Br4923 GAPRLWTALSDGRI---LPTRLS-SKNRFGVPIVAFGITAFLTLAFPLSL
.* *:. : * .. * .
Mb2347c|M.bovis_AF2122/97 PLDS----------LADMVSIGTLTAFSVVAVGVIVLR---VREPDLPR-
Rv2320c|M.tuberculosis_H37Rv PLDS----------LADMVSIGTLTAFSVVAVGVIVLR---VREPDLPR-
MMAR_3621|M.marinum_M PLNR----------LADMVSIGTLTAFIVVSVGVIILR---VREPALPR-
MUL_1244|M.ulcerans_Agy99 PLNR----------LADMVSIGTLTAFIVVSVGVIILR---VREPALPR-
MAV_2087|M.avium_104 PLQN----------LADMVSIGTLTAFVVVSVGVIVLR---VREPDLPR-
TH_0471|M.thermoresistible__bu PVGN----------LEEMVNIGTLFAFALVSAGVIVLR---RTRPDLKR-
MSMEG_1508|M.smegmatis_MC2_155 AALGIDPLVGVFGSMAGVATVGMVLLMLTTSVAVLVFFARHA-DLASGR-
MAB_4350c|M.abscessus_ATCC_199 AAVGLDPMVQVFSSMAGISTVGMLMLLILTSVAVPLFFSRDD-SARAGR-
Mflv_1244|M.gilvum_PYR-GCK FFAGMDPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFHFHKNHPSSAH-
Mvan_0605|M.vanbaalenii_PYR-1 AISGSDPYAVLFVLVAILATLCLLTVQTMSSIATVVYFHVKKQHPETAN-
MLBr_01974|M.leprae_Br4923 RFDSLN--------LTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKR
: : : . . . .
Mb2347c|M.bovis_AF2122/97 -GFKVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVAVIFYLMWGR
Rv2320c|M.tuberculosis_H37Rv -GFKVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVAVIFYLMWGR
MMAR_3621|M.marinum_M -GFWVPGYPVTPILSILACGYLLYSLHWYTWIAFGGWVGIALIFYLFWGR
MUL_1244|M.ulcerans_Agy99 -GFWVPGYPVTPILSILACGYLLYSLHWYTWIAFGGWVGIALIFYLFWGR
MAV_2087|M.avium_104 -GFRVPGYPVTPVLSIMACGYILASLHWYTWIAFSGWVLLALIFYFVWGR
TH_0471|M.thermoresistible__bu -GFRVPFVPWLPLAAIAACLWLMLNLTGLTWVRFLGWMALGLVLYFFYGR
MSMEG_1508|M.smegmatis_MC2_155 -VWQTRIAPVLACLGLVGALLLVLTNFTLVTGGS------ATVSAILAAV
MAB_4350c|M.abscessus_ATCC_199 -VLTTYVAPIVATIGLSASVYLVLKNFTLVTDQS------TVISTVLAAL
Mflv_1244|M.gilvum_PYR-GCK -WFKTFLAPLTGGIGMLYVVYLLWEHKESAAGAASGTLLFKLTPWIVVGV
Mvan_0605|M.vanbaalenii_PYR-1 -WWRTLAAPVIGGAGMVYVIYLMASNMSAAAGTASESLFFKMIPYILLTL
MLBr_01974|M.leprae_Br4923 NVFTDKVLPITAVVVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGI
* . .
Mb2347c|M.bovis_AF2122/97 HHSALNEEVP------------------------
Rv2320c|M.tuberculosis_H37Rv HHSALNEEVP------------------------
MMAR_3621|M.marinum_M HHSRLNAPALHDNPTGEER---------------
MUL_1244|M.ulcerans_Agy99 HHSRLNAPALHDNPTGEER---------------
MAV_2087|M.avium_104 HHSALNDAAVD--PSGQER---------------
TH_0471|M.thermoresistible__bu HHSMLGRGMTDISARRTG----------------
MSMEG_1508|M.smegmatis_MC2_155 PFVGLLAGAARRP---RD----------------
MAB_4350c|M.abscessus_ATCC_199 PIAALIYGLVQKKGVHRR----------------
Mflv_1244|M.gilvum_PYR-GCK FAFGAAMALYFKFKDKRRYELIGRIVYDDSEVRD
Mvan_0605|M.vanbaalenii_PYR-1 LFGSIAVALYLRKARPDLYARIGSTVFDDKPTD-
MLBr_01974|M.leprae_Br4923 PAVAYLHYYRTSGIK-------------------