For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQLPIMANRRWAPHTRRQSGRA TSTCSSLMRFSASESRAHSRFECYTLVRWSIRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKI AGPFAPIAYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAITASIAWGVLASS FVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGL WTIITQHVNNYVTSRSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMNTPDRTL PKAIPLTILTVGVIYILALVVAMLLGSDKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFG APRLWTALSDGRILPTRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLTGLAVIARFIQFIIVPIA LFALARSRTTNSVYVKRNVFTDKVLPITAVVVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAV AYLHYYRTSGIK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01974 | - | - | 100% (572) | putative permease |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 6e-13 | 22.17% (397) | putative L-asparagine permease |
| M. leprae Br4923 | MLBr_01304 | ansP1 | 1e-12 | 22.22% (396) | putative L-asparagine permease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2001c | - | 0.0 | 77.06% (462) | permease |
| M. gilvum PYR-GCK | Mflv_4722 | - | 6e-26 | 24.44% (446) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1979c | - | 0.0 | 76.84% (462) | permease |
| M. abscessus ATCC 19977 | MAB_3599c | - | 4e-26 | 24.63% (475) | putative amino acid permease |
| M. marinum M | MMAR_3621 | rocE | 4e-28 | 24.39% (410) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 1e-24 | 23.51% (404) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1412 | - | 2e-25 | 23.59% (407) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 2e-24 | 24.19% (434) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 9e-28 | 24.39% (410) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 3e-26 | 23.76% (442) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4722|M.gilvum_PYR-GCK --------------------------------------MTQEPVTQAPGR
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------MVQEPGAQTVGR
TH_0471|M.thermoresistible__bu ----------------------------------------------MTDR
MAB_3599c|M.abscessus_ATCC_199 --------------------------------------------MPGSGL
MMAR_3621|M.marinum_M ---------------------------------------MPATSIRLREQ
MUL_1244|M.ulcerans_Agy99 ---------------------------------------MPATSIRLREQ
MAV_2087|M.avium_104 --------------------------------------------------
MSMEG_1412|M.smegmatis_MC2_155 ---------------------------------------MSAPPTSMAGQ
Mb2001c|M.bovis_AF2122/97 --------------------------------------------------
Rv1979c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mflv_4722|M.gilvum_PYR-GCK LRLKSVEQSIADTD------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 RRTKSVEQSIADTD------------------------------------
TH_0471|M.thermoresistible__bu LRVKSVEQSIADTD------------------------------------
MAB_3599c|M.abscessus_ATCC_199 WRTKSVEQSIADTD------------------------------------
MMAR_3621|M.marinum_M MLRRRPVGGAPVAE------------------------------------
MUL_1244|M.ulcerans_Agy99 MLRRRPAGGAPVAE------------------------------------
MAV_2087|M.avium_104 -----------MAP------------------------------------
MSMEG_1412|M.smegmatis_MC2_155 MMRRRPVIGAPVAH------------------------------------
Mb2001c|M.bovis_AF2122/97 ---MVG----PRTR------------------------------------
Rv1979c|M.tuberculosis_H37Rv ---MVG----PRTR------------------------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
:
Mflv_4722|M.gilvum_PYR-GCK --EPGTKLRKDLNWWDLTVFGVSVVIGAGIFTITASTAANITGPAISLSF
Mvan_1740|M.vanbaalenii_PYR-1 --EPSTRLRKELNWWDLTVFGVSVVIGAGIFTITASTAANITGPAISLSF
TH_0471|M.thermoresistible__bu --EPDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSF
MAB_3599c|M.abscessus_ATCC_199 --EPETKLRRDLTWWDLTVFGVSVVIGAGIFTVTASTAANVTGPAISLSF
MMAR_3621|M.marinum_M --GAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
MUL_1244|M.ulcerans_Agy99 --GAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
MAV_2087|M.avium_104 --GTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVP-EAGPAVIVSF
MSMEG_1412|M.smegmatis_MC2_155 --GASDHLKRSIGTFQLTLFGVGATVGTGIFLVLQEAVP-EAGPAVLVSF
Mb2001c|M.bovis_AF2122/97 -----GYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIG-LAGPFAPMAY
Rv1979c|M.tuberculosis_H37Rv -----GYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIG-LAGPFAPMAY
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK-IAGPFAPIAY
: .:.::*:. :*:*** .. :** :::
Mflv_4722|M.gilvum_PYR-GCK IFAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
Mvan_1740|M.vanbaalenii_PYR-1 IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
TH_0471|M.thermoresistible__bu IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
MAB_3599c|M.abscessus_ATCC_199 IMAAIGCGLAAMCYAEFASTIPVAGSAYTFSYATFGEFAAWILGWDLILE
MMAR_3621|M.marinum_M IIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MSMEG_1412|M.smegmatis_MC2_155 VLAGVAAGLSALCYAEMASAVPVSGSTYSYAYTTMGEFVAMGVAACLLLE
Mb2001c|M.bovis_AF2122/97 VLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAIT
Rv1979c|M.tuberculosis_H37Rv VLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAIT
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
:*.: ..: *: * * : . *::*::: :::*. . :. :
Mflv_4722|M.gilvum_PYR-GCK FAVAAAVVAKGWSSYLG----TVFGFAG-GTAEVAGFDLDWG--------
Mvan_1740|M.vanbaalenii_PYR-1 FAVAAAVVAKGWSSYLG----TVFGFAG-GTTEVAGFQLDWG--------
TH_0471|M.thermoresistible__bu FSVAAAVVAKGWSSYLG----EVFEFAG-ATTRLGPITLDWG--------
MAB_3599c|M.abscessus_ATCC_199 FSVGAATVAKGWSSYLS----TVFGLSS-GAVHLGAVKIDWG--------
MMAR_3621|M.marinum_M YGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLNL
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLNL
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVNL
MSMEG_1412|M.smegmatis_MC2_155 YGVSMSATSIGWGGYLNQLLDDVFGFRIPQALTSAPWGENPG----IMNL
Mb2001c|M.bovis_AF2122/97 ASIAWGVLASFFVSTLLR---VAFPDKAWADAEQLFSVKTLT--------
Rv1979c|M.tuberculosis_H37Rv ASIAWGVLASFFVSTLLR---VAFPDKAWADAEQLFSVKTLT--------
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLR---VAFPEKIWADNDELISVKTLT--------
.:. .. : . : ..
Mflv_4722|M.gilvum_PYR-GCK -ALVIIAIVTAILAMGTKLSASVSLAITALKVSVVLLVVIVGAFYIKMEN
Mvan_1740|M.vanbaalenii_PYR-1 -ALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVIVGAFYIKAEN
TH_0471|M.thermoresistible__bu -ALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAAN
MAB_3599c|M.abscessus_ATCC_199 -ALLIVSVLTVLLAVGTKLSSRVSLVITTIKVLVVLLVIIVGAFFIKTAN
MMAR_3621|M.marinum_M PAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTNH
MUL_1244|M.ulcerans_Agy99 PAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTNH
MAV_2087|M.avium_104 PAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMHH
MSMEG_1412|M.smegmatis_MC2_155 TATLLIVMCGLLLIRGASESALVNTIMVIIKLAVLALFVAVAFTAFTTDH
Mb2001c|M.bovis_AF2122/97 -FLGFIGVLLAINLFGNRAIKWANGTSTVGKAFALSAFIVGGLWIITTQH
Rv1979c|M.tuberculosis_H37Rv -FLGFIGVLLAINLFGNRAIKWANGTSTVGKAFALSAFIVGGLWIITTQH
MLBr_01974|M.leprae_Br4923 -FLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQH
:: . : * .. . * .: . . :
Mflv_4722|M.gilvum_PYR-GCK FSPFIPAPEPGEAGGTGAEQSLFSLMTGAEGSHYGWYGLLAGASIVFFAF
Mvan_1740|M.vanbaalenii_PYR-1 FSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVLAGASIVFFAF
TH_0471|M.thermoresistible__bu YTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFAF
MAB_3599c|M.abscessus_ATCC_199 YTPFIPPAEAGSSSRQGLDQSLFSFVAGGSGSQYGWFGVLAGASIVFFAF
MMAR_3621|M.marinum_M LKDFAP---------------------------FGVAGVGAAAGTIFFSF
MUL_1244|M.ulcerans_Agy99 LKDFAP---------------------------FGVAGVGAAAGTIFFSF
MAV_2087|M.avium_104 LDDFAP---------------------------FGVAGVGTAAGTIFFSY
MSMEG_1412|M.smegmatis_MC2_155 FAGFWD---------------------------KGFAGITAAAGSIFFTF
Mb2001c|M.bovis_AF2122/97 VNNYATAWS-------AYSATPYSLLGVAEIGKGTFSSMALATIVALYAF
Rv1979c|M.tuberculosis_H37Rv VNNYATAWS-------AYSATPYSLLGVAEIGKGTFSSMALATIVALYAF
MLBr_01974|M.leprae_Br4923 VNNYVTSRS-------AYQPTTYSLLGVTEIGKSTAASMTLATIVALYAF
: .: .: ::::
Mflv_4722|M.gilvum_PYR-GCK IGFDIVATTAEETKVPQRDVPRGILASLGIVTVLYVAVAIVLSGMVSYKD
Mvan_1740|M.vanbaalenii_PYR-1 IGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAVVLTGMVSYTE
TH_0471|M.thermoresistible__bu IGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYTE
MAB_3599c|M.abscessus_ATCC_199 IGFDVVATTAEETRNPQKDVPRGIIASLVIVTVLYVAVTVVLSGMVKYSD
MMAR_3621|M.marinum_M IGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQM
MUL_1244|M.ulcerans_Agy99 IGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQM
MAV_2087|M.avium_104 IGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQD
MSMEG_1412|M.smegmatis_MC2_155 IGLDAVSTAGDEVKNPQKTMPRAILGALVVVASVYILVAFAGLGTQSADE
Mb2001c|M.bovis_AF2122/97 TGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSNKI
Rv1979c|M.tuberculosis_H37Rv TGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSNKI
MLBr_01974|M.leprae_Br4923 TGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKI
*:: ::.:.:* *:: :.:.: :: * :*: . .
Mflv_4722|M.gilvum_PYR-GCK LRDA--ESPNLATAFS--LNGVDWAAKVISIGALAGLTTVVIVLVLGQTR
Mvan_1740|M.vanbaalenii_PYR-1 LRDA--ETQNLATAFS--LNGVDWAAKVISIGALAGLTTVVIVLVLGQTR
TH_0471|M.thermoresistible__bu LRAAG-ENANLATAFA--ANGIDWAAKVISIGALAGLTTVVIVLVLGQTR
MAB_3599c|M.abscessus_ATCC_199 LRVAD-SHPNLSTAFH--LNGVDWAAKVIAVGALAGLTTVVMVLMLGQIR
MMAR_3621|M.marinum_M FAGQE--EAGLATILDNVTHS-AWASTVLAMGAVISIFTVTLVTMYGQTR
MUL_1244|M.ulcerans_Agy99 FAGQE--EAGLATILDNVTHS-AWASTVLAMGAVISIFTVTLVTMYGQTR
MAV_2087|M.avium_104 FGGQQ--EAGLATILDHVTHG-SWASTILAAGAVISIFSVTLVTMYGITR
MSMEG_1412|M.smegmatis_MC2_155 FGSEEQSEAGLAVILTNILHGQTWASTILSFGAVISIFSVTLVVMYGQTR
Mb2001c|M.bovis_AF2122/97 AASGD--TVKLAAAIGN-----ATFRTIIVVGALISMFGINVAASFGAPR
Rv1979c|M.tuberculosis_H37Rv AASDD--TVKLAAAIGN-----ATFRTIIVVGALISMFGINVAASFGAPR
MLBr_01974|M.leprae_Br4923 VATNH--TVKLAAAVGN-----NTFRTIIVVGALVSMFGINVAASFGAPR
*:. . .:: **: .: : :. * *
Mflv_4722|M.gilvum_PYR-GCK VLFAMSRDGLLPRQLAKTGEH-GTPVRITLLVGAVVAVTATV-FPIDKLE
Mvan_1740|M.vanbaalenii_PYR-1 VLFAMSRDGLLPRQLAKTGEH-GTPVRITLIVGAVVAVTATV-FPIGKLE
TH_0471|M.thermoresistible__bu VLFAMSRDGLLPRPLSKTGPR-GTPVRITVLVGALVAIAASV-FPVGNLE
MAB_3599c|M.abscessus_ATCC_199 VIFAMCRDGLLPRELARTGSH-GTPIRITLIVGFLVAVAASL-TPIEGLE
MMAR_3621|M.marinum_M ILFAMGRDGLLPARFAAVHPRFQTPVSNTVVVAIAAAVLAAL-VPLNRLA
MUL_1244|M.ulcerans_Agy99 ILFAMGRDGLLPARFAAVHPRFQTPVSNTVVVAIAAAVLAAL-VPLNRLA
MAV_2087|M.avium_104 ILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAATLAAF-IPLQNLA
MSMEG_1412|M.smegmatis_MC2_155 ILFAMGRDGLLPSMFARVNSHTMTPINNTIVVALVTGTLAGF-VPLDYLW
Mb2001c|M.bovis_AF2122/97 LWTALADSGVLPTRLSRKNQYDVPMVSFAITASLALAFPLALRFDNLHLT
Rv1979c|M.tuberculosis_H37Rv LWTALADSGVLPTRLSRKNQYDVPMVSFAITASLALAFPLALRFDNLHLT
MLBr_01974|M.leprae_Br4923 LWTALSDGRILPTRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLT
: *: . :** :: . : : . . . *
Mflv_4722|M.gilvum_PYR-GCK EMVNIGTLFAFVLVSAGVIVLRRTRPDLKRGFRTPWVP--VLPILSIIAC
Mvan_1740|M.vanbaalenii_PYR-1 EMVNIGTLFAFVLVSAGVLVLRRTRPDLKRGFRTPWVP--LLPILAIAAC
TH_0471|M.thermoresistible__bu EMVNIGTLFAFALVSAGVIVLRRTRPDLKRGFRVPFVP--WLPLAAIAAC
MAB_3599c|M.abscessus_ATCC_199 EIVNVGTLFAFVLVSAGVIVLRRSRPDLPRSFRTPGVP--WLPIVAIVAC
MMAR_3621|M.marinum_M DMVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPGYP--VTPILSILAC
MUL_1244|M.ulcerans_Agy99 DMVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPGYP--VTPILSILAC
MAV_2087|M.avium_104 DMVSIGTLTAFVVVSVGVIVLRVREPDLPRGFRVPGYP--VTPVLSIMAC
MSMEG_1412|M.smegmatis_MC2_155 DLVSIGTLVAFIVVSAGVVLLRVREPDLPRSFKVPGYP--VTPVLSIIAC
Mb2001c|M.bovis_AF2122/97 GLAVIARFVQFIIVPIALIALARSQAVEHAAVRRNAFTDKVLPLVAIVVS
Rv1979c|M.tuberculosis_H37Rv GLAVIARFVQFIIVPIALIALARSQAVEHAAVRRNAFTDKVLPLVAIVVS
MLBr_01974|M.leprae_Br4923 GLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVVVS
:. :. : * :*. .:. * .. . . *: :: ..
Mflv_4722|M.gilvum_PYR-GCK VWLMLNLTGLTWIRFSV---WMAIGVVLYFVYGRRHSLVA----------
Mvan_1740|M.vanbaalenii_PYR-1 VWLMLNLTGLTWIRFLI---WMAIGVVVYFLYGRRHSLVG----------
TH_0471|M.thermoresistible__bu LWLMLNLTGLTWVRFLG---WMALGLVLYFFYGRHHSMLG----------
MAB_3599c|M.abscessus_ATCC_199 GWLMLNLAVRTWLFALS---WMVIGVIVYFAYSRKHSVLG----------
MMAR_3621|M.marinum_M GYLLYSLHWYTWIAFGG---WVGIALIFYLFWGRHHSRLN----------
MUL_1244|M.ulcerans_Agy99 GYLLYSLHWYTWIAFGG---WVGIALIFYLFWGRHHSRLN----------
MAV_2087|M.avium_104 GYILASLHWYTWIAFSG---WVLLALIFYFVWGRHHSALN----------
MSMEG_1412|M.smegmatis_MC2_155 LFVLYGLPAVTWLWFSV---WVGAVLLFYLLWGRRHSALNDGGDGYIPGA
Mb2001c|M.bovis_AF2122/97 VGLAVSYDYRCIFLVRGGPNYFSIALIVITFIVVPAMAYLH---------
Rv1979c|M.tuberculosis_H37Rv VGLAVSYDYRCIFLVRGGPNYFSIALIVITFVVVPAMAYLH---------
MLBr_01974|M.leprae_Br4923 AGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLH---------
: . . :. ::
Mflv_4722|M.gilvum_PYR-GCK -RRQRERAGLHTDTP-
Mvan_1740|M.vanbaalenii_PYR-1 -RRMG-----------
TH_0471|M.thermoresistible__bu -RGMTDISARRTG---
MAB_3599c|M.abscessus_ATCC_199 -LRVDVEQ--------
MMAR_3621|M.marinum_M APALHDNPTGEER---
MUL_1244|M.ulcerans_Agy99 APALHDNPTGEER---
MAV_2087|M.avium_104 DAAVD--PSGQER---
MSMEG_1412|M.smegmatis_MC2_155 AAGEDDVMTGHPEDRA
Mb2001c|M.bovis_AF2122/97 YYRIIRRVGDRPSTR-
Rv1979c|M.tuberculosis_H37Rv YYRIIRRVGDRPSTR-
MLBr_01974|M.leprae_Br4923 YYRTSGIK--------