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MAVRSDPPVHVAAEPAEGHTLKRGAIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGNGLGTPAGFAIATI VLSIFSVGFIALARHITAAGAFYTFVSRGWSRIPGLPAGVMSMFTYMTMEAGLIGIFSVFADQAITSQFG IDLPWLVYAMIGVVVIATLSHWDISVAAKVLGAVLVAEIVMLTLTATASLMHHPEGMSWTSLNPATALST NGVAGGVVGLGLLMAFWSWVGFESTAIYGEESKNPKKIVPQATMIAVIGIGVFYTFIAWGMIVGNGPTKA VELSSGPTPFDLIYAPTQQYLGQWAIVVFEWLMVGGSFACALAIHNSAARYLFAFGRDGLLPRRLGAAHP KHASPYVASLAQSVFAAVVLIVCAISGSDPYAVLFVLVAILATLCLLTVQTMSSIATVVYFHVKKQHPET ANWWRTLAAPVIGGAGMVYVIYLMASNMSAAAGTASESLFFKMIPYILLTLLFGSIAVALYLRKARPDLY ARIGSTVFDDKPTD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | - | 100% (504) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_5564 | - | e-133 | 47.23% (487) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_2078 | - | e-123 | 45.00% (520) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 4e-16 | 20.87% (412) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 1e-135 | 47.84% (487) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 4e-16 | 20.87% (412) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 7e-07 | 19.25% (239) | putative permease |
| M. abscessus ATCC 19977 | MAB_0950c | - | 1e-138 | 47.36% (511) | putative amino acid permease family protein |
| M. marinum M | MMAR_0869 | - | 5e-21 | 25.58% (430) | amino acid permease |
| M. avium 104 | MAV_2087 | - | 8e-16 | 21.14% (402) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_3821 | - | 0.0 | 81.33% (482) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 9e-13 | 22.12% (443) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 9e-16 | 23.24% (327) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 ----------------------------------------------MPTT
Rv2320c|M.tuberculosis_H37Rv ----------------------------------------------MPTT
MUL_1244|M.ulcerans_Agy99 ----------------------------------------------MPAT
MAV_2087|M.avium_104 --------------------------------------------------
Mvan_0605|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3821|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0950c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 SMSLRELMLRRRPVSGAPVASGASGNLKR---------------------
Rv2320c|M.tuberculosis_H37Rv SMSLRELMLRRRPVSGAPVASGASGNLKR---------------------
MUL_1244|M.ulcerans_Agy99 SIRLREQMLRRRPAGGAPVAEGAAGSLKR---------------------
MAV_2087|M.avium_104 ------------------MAPGTADHLRR---------------------
Mvan_0605|M.vanbaalenii_PYR-1 ----MAVRSDP--PVHVAAEPAEGHTLKRG--------------------
MSMEG_3821|M.smegmatis_MC2_155 --MAMAVEFDQGTGAGSTAPRDNSATLKRG--------------------
Mflv_1244|M.gilvum_PYR-GCK ----MTESAER-TAPGQTTPTASVQRLKRN--------------------
MAB_0950c|M.abscessus_ATCC_199 ----MSDTID--PPVGTTTEPDSMQRLKPN--------------------
MMAR_0869|M.marinum_M ----------------MAVTTGARSELQK---------------------
TH_4382|M.thermoresistible__bu --------------MSGTRTEQAQPELRR---------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
*
Mb2347c|M.bovis_AF2122/97 ----------SFGTFQLTMFGVGATIGTGIFFVLAQAVP--EAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv ----------SFGTFQLTMFGVGATIGTGIFFVLAQAVP--EAGPGVIVS
MUL_1244|M.ulcerans_Agy99 ----------SFGTFELTMFGVGSTVGTGIFFVLAEAVP--EAGPAVIVS
MAV_2087|M.avium_104 ----------GIGTFQLTMFGVGSTIGTGIFFVMSQAVP--EAGPAVIVS
Mvan_0605|M.vanbaalenii_PYR-1 ----------AIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGNGLGTPAG
MSMEG_3821|M.smegmatis_MC2_155 ----------AIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGNGLGAPGG
Mflv_1244|M.gilvum_PYR-GCK ----------AVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
MAB_0950c|M.abscessus_ATCC_199 ----------AVGLIGVLFMAVATAAPITAMVGNVPMAVGFGNGAYAPAG
MMAR_0869|M.marinum_M ----------ALGQRSAVLFGLAYMTPIIVLGIFGVIAE--RSKGASAGS
TH_4382|M.thermoresistible__bu ----------VLGPGLLLLFIVGDILGTGIYALVGDVAG--EVGGAAWLP
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK--IAGPFAPIA
.* :: :
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLG-EAVAMVVAACLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLG-EAVAMVVAACLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLG-EAVAMGVASCLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLG-EVVAMGVAACLL
Mvan_0605|M.vanbaalenii_PYR-1 FAIATIVLSIFSVGFIALARHITAAGAFYTFVSRGWS-RIPGLPAGVMSM
MSMEG_3821|M.smegmatis_MC2_155 FLIATVVLTIFSIGFVALARHITAAGAFYTFVSRAWS-RIPGLAAGVMPA
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLG-RVMGMASGLIIT
MAB_0950c|M.abscessus_ATCC_199 YLVATIVLTLFAIGYAAMSRHIVATGAFYGYISHGLG-RVVGLGSGFLIT
MMAR_0869|M.marinum_M YLLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALD-ARVGFMVGWAVL
TH_4382|M.thermoresistible__bu FLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVM
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFG-HRIGIYVGVTHA
: :* : . : .. : . : .
Mb2347c|M.bovis_AF2122/97 LEYGVATAAVAVGWS------GYVNKLLSNLFGFQMPHVLSAAPWDTHPG
Rv2320c|M.tuberculosis_H37Rv LEYGVATAAVAVGWS------GYVNKLLSNLFGFQMPHVLSAAPWDTHPG
MUL_1244|M.ulcerans_Agy99 LEYGVATAAVAVGLS------GYVNKLLHNVFGFQLPQALSEAPWDERPG
MAV_2087|M.avium_104 LEYGVATAAVSVNWS------GYLNKLLSNVVGFQLPHALSAAPWDAQPG
Mvan_0605|M.vanbaalenii_PYR-1 FTYMTMEAGLIGIFS------VFADQAITSQFGIDLPWLVYAMIGVVVIA
MSMEG_3821|M.smegmatis_MC2_155 FTYMTMEAGLVGIFS------AFADQAFSMQFGIDLPWEVYAVIGLVAIA
Mflv_1244|M.gilvum_PYR-GCK LAYIVFEASLIGIFA------FFFQNFLSSQLGITIHWLVPALLMLVLNS
MAB_0950c|M.abscessus_ATCC_199 LAYMVFEASLVGIFS------FFANDLFQTFFQVDVPWVVFAVAMLATNA
MMAR_0869|M.marinum_M LDYLFLPLVIWLIGG------SYLQDRFP-----TVPFWTWIVGFAALTT
TH_4382|M.thermoresistible__bu CSGITSASTASRFFA------ANLEVGLGQEWG-RLGVAGVALLFMALLA
MLBr_01974|M.leprae_Br4923 ITASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAVLL
:
Mb2347c|M.bovis_AF2122/97 ----WVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIA
Rv2320c|M.tuberculosis_H37Rv ----WVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIA
MUL_1244|M.ulcerans_Agy99 EAAGYLNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILA
MAV_2087|M.avium_104 ----YVNLPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILA
Mvan_0605|M.vanbaalenii_PYR-1 TLSHWDISVAAKVLGAVLVAEIVMLTLTATASLMHH--PEGMSWTS-LNP
MSMEG_3821|M.smegmatis_MC2_155 ALSHFDISVAAKVLGVVLVAEIIMLSMTAIAGLVHH--PDGMSFTS-LNP
Mflv_1244|M.gilvum_PYR-GCK ILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGFAIAETLNP
MAB_0950c|M.abscessus_ATCC_199 VLTYFDLNLAARVLGVFLVTEILMLSLLALSVLFAGGGPQGWSWGS-LNP
MMAR_0869|M.marinum_M VLNLIGLKVADRAN--FILMTFQLLILAFFVALTIGYLVGDSRSLLSLTP
TH_4382|M.thermoresistible__bu MVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGADVDFTRVVA
MLBr_01974|M.leprae_Br4923 AINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSRSA
: : .
Mb2347c|M.bovis_AF2122/97 FSAYS---ADHLKDFVPFGVAG--IGSAAGTIFFSYIGLDAVSTAGDEVK
Rv2320c|M.tuberculosis_H37Rv FSAYS---ADHLKDFVPFGVAG--IGSAAGTIFFSYIGLDAVSTAGDEVK
MUL_1244|M.ulcerans_Agy99 LTAYD---TNHLKDFAPFGVAG--VGAAAGTIFFSFIGLDAVSTAGEEVR
MAV_2087|M.avium_104 FTAFD---MHHLDDFAPFGVAG--VGTAAGTIFFSYIGLDAVSTAGDEVT
Mvan_0605|M.vanbaalenii_PYR-1 ATALS-----------TNGVAGGVVGLGLLMAFWSWVGFESTAIYGEESK
MSMEG_3821|M.smegmatis_MC2_155 VTALS-----------VNNVAGGVVGLGLLMAFWSWVGFESTAIYGEESK
Mflv_1244|M.gilvum_PYR-GCK VGAFQ-----------PAAIAGASAGLGLFFAFWSWVGFESTAMYGEESK
MAB_0950c|M.abscessus_ATCC_199 LNGFHDLGGVVQGPAGPLAVAG-SAGVGLFFAFWSWVGFESSAMYAEESK
MMAR_0869|M.marinum_M FTGNG-------------GFTA--ITAGAAVAAYSFLGFDAVSTLTEETH
TH_4382|M.thermoresistible__bu FETTT------------DKSVFLAVSAATSLAFFAMVGFEDSVNMAEETR
MLBr_01974|M.leprae_Br4923 YQPTTYS---LLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMN
. . :: *:: :*
Mb2347c|M.bovis_AF2122/97 DPQKTMPRALIAALVVVTGVYVLVALAALG-TQPWQDFAEQ----ETAGL
Rv2320c|M.tuberculosis_H37Rv DPQKTMPRALIAALVVVTGVYVLVALAALG-TQPWQDFAEQ----ETAGL
MUL_1244|M.ulcerans_Agy99 NPQQSVPRALIAALFVVTGVYVLVAFAALG-TQPWQMFAGQ----EEAGL
MAV_2087|M.avium_104 NPQKTMPRALIAALLTVTGVYVFVALAALG-TQPWQDFGGQ----QEAGL
Mvan_0605|M.vanbaalenii_PYR-1 NPKKIVPQATMIAVIGIGVFYTFIAWGMIVGNGPTKAVELS-SGPTPFDL
MSMEG_3821|M.smegmatis_MC2_155 NPKRIVPLATMIAVIGIGVFYTFISWGVVVGNGPDKAVELA-SGPAPFDL
Mflv_1244|M.gilvum_PYR-GCK DPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGPQQAVELAQSADTSSEI
MAB_0950c|M.abscessus_ATCC_199 NPKKIIPIAIVTSVVGVGLFYVLVSWLAIVGTGPENAVALAQDSSTAGNI
MMAR_0869|M.marinum_M DAERTIPRAIVLIALIGGAIFVTVAYVVSLVAPGSSFPDAD-------SL
TH_4382|M.thermoresistible__bu DPVVIFPRALLTGLGIAGAVYVVVAIVAVALVPVGTLQASD------VPL
MLBr_01974|M.leprae_Br4923 TPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATNH---------
. .* * .:
Mb2347c|M.bovis_AF2122/97 AIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP
Rv2320c|M.tuberculosis_H37Rv AIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP
MUL_1244|M.ulcerans_Agy99 ATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLP
MAV_2087|M.avium_104 ATILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLP
Mvan_0605|M.vanbaalenii_PYR-1 IYAPTQQYLGQWAIVVFEWLMVGGSFACALAIHNSAARYLFAFGRDGLLP
MSMEG_3821|M.smegmatis_MC2_155 LYVPTAEYLGPWAVTVFEWLVVGGSFACALAIHNSAARYLFAFGRDGLLW
Mflv_1244|M.gilvum_PYR-GCK FFAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLYALGREGLST
MAB_0950c|M.abscessus_ATCC_199 FFGPVQSHLGVWAVNLFKVLLMTGSFACGMAFHNCAARYLYALGRENVIP
MMAR_0869|M.marinum_M SEGVARTIGGNLFAAVFLAALIIGQFTSGLAAQAAVSRLLYAMGRDGVLP
TH_4382|M.thermoresistible__bu VEVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRVLP
MLBr_01974|M.leprae_Br4923 TVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRILP
. :: : . : .* .:. :
Mb2347c|M.bovis_AF2122/97 ---ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDS------------
Rv2320c|M.tuberculosis_H37Rv ---ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDS------------
MUL_1244|M.ulcerans_Agy99 ---ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNR------------
MAV_2087|M.avium_104 ---PRFARVNPRTMTPVNNTVIVAVAAATLAAFIPLQN------------
Mvan_0605|M.vanbaalenii_PYR-1 ---RRLGAAHPKHASPYVASLAQSVFAAVVLIVCAISGSDPYAVLFVLVA
MSMEG_3821|M.smegmatis_MC2_155 ---HRLGEAHPRHRSPWVASLAQSAFAAVLLVVCSLTKSDPYADLFVLVA
Mflv_1244|M.gilvum_PYR-GCK GLQKTLGATHKTHGSPYIASFVQSGIALVLVLAFFFAGMDPYIHMYTLLA
MAB_0950c|M.abscessus_ATCC_199 GMRKTIGSTHSTHGSPHVAGFVQTAFATVVVLFFAATGRDPYTGLYGLMA
MMAR_0869|M.marinum_M --RRVFGVVSAKFHTPMFNIMLTGAVGMAAILLSVATS------------
TH_4382|M.thermoresistible__bu ---PVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFADS------TAIA
MLBr_01974|M.leprae_Br4923 ----TRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLN----------
*
Mb2347c|M.bovis_AF2122/97 -LADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPGYP--VTPVLSV
Rv2320c|M.tuberculosis_H37Rv -LADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPGYP--VTPVLSV
MUL_1244|M.ulcerans_Agy99 -LADMVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPGYP--VTPILSI
MAV_2087|M.avium_104 -LADMVSIGTLTAFVVVSVGVIVLRVREPDLPRGFRVPGYP--VTPVLSI
Mvan_0605|M.vanbaalenii_PYR-1 ILATLCLLTVQTMSSIATVVYFHVKKQHPETANWWRTLAAP--VIGGAGM
MSMEG_3821|M.smegmatis_MC2_155 ILATLLLLIVQTMCSVATVVYFHVKKQHPETASWWRTLLAP--IIGGAGM
Mflv_1244|M.gilvum_PYR-GCK ILGTMAILIVQSLCAFSVVAYFHFHKNHPSSAHWFKTFLAP--LTGGIGM
MAB_0950c|M.abscessus_ATCC_199 LLGTTAILIVQALTAFAVISYFHVLRHHPETAHWFRTLVAP--LLGGLGM
MMAR_0869|M.marinum_M --TSFINFGAFTAFTLVNVSVVVYFVR--ERGAGLPRWRYL--VLPVIGA
TH_4382|M.thermoresistible__bu VLGGTTSLLLLAVFAMVNVAVLVLRRDESRDPVVARRHFRTPTFLPVVGF
MLBr_01974|M.leprae_Br4923 -LTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAV
: . : . . .
Mb2347c|M.bovis_AF2122/97 LACGYILAS-----------------LHWYTWLAFSGWVAVAVIFYLMWG
Rv2320c|M.tuberculosis_H37Rv LACGYILAS-----------------LHWYTWLAFSGWVAVAVIFYLMWG
MUL_1244|M.ulcerans_Agy99 LACGYLLYS-----------------LHWYTWIAFGGWVGIALIFYLFWG
MAV_2087|M.avium_104 MACGYILAS-----------------LHWYTWIAFSGWVLLALIFYFVWG
Mvan_0605|M.vanbaalenii_PYR-1 VYVIYLMASNMSAAAGTASESLFFKMIPYILLTLLFGSIAVALYLRKARP
MSMEG_3821|M.smegmatis_MC2_155 LYVIYLMTSNMQAAAGTASDTLFFKLIPYAVVGLTLGSMLLALYWRKARP
Mflv_1244|M.gilvum_PYR-GCK LYVVYLLWEHKESAAGAASGTLLFKLTPWIVVGVFAFGAAMALYFKFKDK
MAB_0950c|M.abscessus_ATCC_199 VYVVYLLAKHASFAAGTASNDWVFTAIPWVVAAAGIGGIALALTLKYTAP
MMAR_0869|M.marinum_M AVDIYLLAH-----------------LASDALIVGLSWAAIGFLYLLWLT
TH_4382|M.thermoresistible__bu VASLYLVTPLSG------------RPAQQYLLSVVLIVIGVLLFGVTMAI
MLBr_01974|M.leprae_Br4923 VVSAGLMVS-------------------FDYRSIFLTRGGPNYFSISLIA
::
Mb2347c|M.bovis_AF2122/97 RHHSALNEEVP-----------
Rv2320c|M.tuberculosis_H37Rv RHHSALNEEVP-----------
MUL_1244|M.ulcerans_Agy99 RHHSRLNAPALHDNPTGEER--
MAV_2087|M.avium_104 RHHSALNDAAVD--PSGQER--
Mvan_0605|M.vanbaalenii_PYR-1 DLYARIGSTVFDDK-----PTD
MSMEG_3821|M.smegmatis_MC2_155 DLYDRIGSTIFDDREPVREPAN
Mflv_1244|M.gilvum_PYR-GCK RRYELIGRIVYDDSE----VRD
MAB_0950c|M.abscessus_ATCC_199 HRYDDLGRTVLEEAH----ER-
MMAR_0869|M.marinum_M RGLTRQPPDLAGAAERG-----
TH_4382|M.thermoresistible__bu NRQLGIPTRAVGDPAKMVLPPD
MLBr_01974|M.leprae_Br4923 ITFIGIPAVAYLHYYRTSGIK-