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MTESAERTAPGQTTPTASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAGYLVAT IVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITLAYIVFEASLIGIFAFFFQNFLSSQL GITIHWLVPALLMLVLNSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGFAIAETLNPVG AFQPAAIAGASAGLGLFFAFWSWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTG PQQAVELAQSADTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLYALGREGLSTGLQ KTLGATHKTHGSPYIASFVQSGIALVLVLAFFFAGMDPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFH FHKNHPSSAHWFKTFLAPLTGGIGMLYVVYLLWEHKESAAGAASGTLLFKLTPWIVVGVFAFGAAMALYF KFKDKRRYELIGRIVYDDSEVRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1244 | - | - | 100% (513) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_2651 | - | 7e-21 | 28.15% (437) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_4427 | - | 8e-15 | 24.32% (407) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 1e-20 | 23.53% (408) | cationic amino acid transport integral membrane protein RocE |
| M. tuberculosis H37Rv | Rv2320c | rocE | 1e-20 | 23.53% (408) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 1e-11 | 25.00% (240) | putative permease |
| M. abscessus ATCC 19977 | MAB_0950c | - | 1e-179 | 60.04% (513) | putative amino acid permease family protein |
| M. marinum M | MMAR_3621 | rocE | 2e-20 | 23.11% (437) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 1e-20 | 23.31% (472) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_0279 | - | 0.0 | 83.10% (509) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 6e-13 | 24.57% (460) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 5e-20 | 23.85% (499) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_5564 | - | 0.0 | 92.13% (508) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 -------------------------------------------------M
Rv2320c|M.tuberculosis_H37Rv -------------------------------------------------M
MMAR_3621|M.marinum_M -------------------------------------------------M
MUL_1244|M.ulcerans_Agy99 -------------------------------------------------M
MAV_2087|M.avium_104 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5564|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0279|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0950c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 PTTSMSLRELMLRRRPVSGAPVASGASGNLKR------------------
Rv2320c|M.tuberculosis_H37Rv PTTSMSLRELMLRRRPVSGAPVASGASGNLKR------------------
MMAR_3621|M.marinum_M PATSIRLREQMLRRRPVGGAPVAEGAAGSLKR------------------
MUL_1244|M.ulcerans_Agy99 PATSIRLREQMLRRRPAGGAPVAEGAAGSLKR------------------
MAV_2087|M.avium_104 ---------------------MAPGTADHLRR------------------
Mflv_1244|M.gilvum_PYR-GCK --------MTESAERTAPGQTTPTASVQRLKRN-----------------
Mvan_5564|M.vanbaalenii_PYR-1 -----------MTEDVVPRQTAPTDSVQRLKRN-----------------
MSMEG_0279|M.smegmatis_MC2_155 -----------MTEQSVAGSENAAHDIQRLKRN-----------------
MAB_0950c|M.abscessus_ATCC_199 ---------MSDTIDPPVGTTTEPDSMQRLKPN-----------------
TH_4382|M.thermoresistible__bu -----------------MSGTRTEQAQPELRR------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
:
Mb2347c|M.bovis_AF2122/97 ----------SFGTFQLTMFGVG--ATIGTGIFFVLAQAVPEAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv ----------SFGTFQLTMFGVG--ATIGTGIFFVLAQAVPEAGPGVIVS
MMAR_3621|M.marinum_M ----------SFGTFELTMFGVG--STVGTGIFFVLAEAVPEAGPAVIVS
MUL_1244|M.ulcerans_Agy99 ----------SFGTFELTMFGVG--STVGTGIFFVLAEAVPEAGPAVIVS
MAV_2087|M.avium_104 ----------GIGTFQLTMFGVG--STIGTGIFFVMSQAVPEAGPAVIVS
Mflv_1244|M.gilvum_PYR-GCK ----------AVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
Mvan_5564|M.vanbaalenii_PYR-1 ----------AVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
MSMEG_0279|M.smegmatis_MC2_155 ----------AVGTVGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
MAB_0950c|M.abscessus_ATCC_199 ----------AVGLIGVLFMAVATAAPITAMVGNVPMAVGFGNGAYAPAG
TH_4382|M.thermoresistible__bu ----------VLGPGLLLLFIVG--DILGTGIYALVGDVAGEVGGAAWLP
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN--SIIGAGIFMTPGEVIKIAGPFAPIA
.* : :: : : : : . * .
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MMAR_3621|M.marinum_M FIIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
Mvan_5564|M.vanbaalenii_PYR-1 YLVATVVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGGIITM
MSMEG_0279|M.smegmatis_MC2_155 YFVATVVLGLFAIGYATMAKHITATGAFYGYISHGLGRIVGMAAGGLITM
MAB_0950c|M.abscessus_ATCC_199 YLVATIVLTLFAIGYAAMSRHIVATGAFYGYISHGLGRVVGLGSGFLITL
TH_4382|M.thermoresistible__bu FLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVM
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
: :* : : *. .. * :* . :
Mb2347c|M.bovis_AF2122/97 EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
Rv2320c|M.tuberculosis_H37Rv EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
MMAR_3621|M.marinum_M EYGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MUL_1244|M.ulcerans_Agy99 EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVN
Mflv_1244|M.gilvum_PYR-GCK AYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVPALLMLVLNS----ILT
Mvan_5564|M.vanbaalenii_PYR-1 AYVVFEASLIGIFAFFFQNFLSSQFGFDIHWLIPALLMLALNC----ILT
MSMEG_0279|M.smegmatis_MC2_155 AYVVFEASLIGIFSFFFQNFLDSQLGIHIHWIIPALLMLATNA----ILT
MAB_0950c|M.abscessus_ATCC_199 AYMVFEASLVGIFSFFANDLFQTFFQVDVPWVVFAVAMLATNA----VLT
TH_4382|M.thermoresistible__bu CSGITSASTAS---RFFAANLEVGLGQEWGRLGVAGVALLFMA------L
MLBr_01974|M.leprae_Br4923 TASIAWGVLAS---SFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAV
: . : : .
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MMAR_3621|M.marinum_M LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
Mflv_1244|M.gilvum_PYR-GCK YFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGFAIAETLNPVGA
Mvan_5564|M.vanbaalenii_PYR-1 YFDVNLTAKVLGVFLVTEIVMLSLGAIAVAVKGGGPDGFAVGEILNPVGA
MSMEG_0279|M.smegmatis_MC2_155 YFDVNLTAKVLGVFLVTEIVMLALGAVAVLFRGGGPDGFAVNEILNPAGA
MAB_0950c|M.abscessus_ATCC_199 YFDLNLAARVLGVFLVTEILMLSLLALSVLFAGGGPQGWSWGS-LNPLNG
TH_4382|M.thermoresistible__bu LAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGADVDFTRV
MLBr_01974|M.leprae_Br4923 LLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSR
: : . : .: : . *
Mb2347c|M.bovis_AF2122/97 HLKDFVPFG-----------VAGIGSAAGTIFFSYIGLDAVSTAGDEVKD
Rv2320c|M.tuberculosis_H37Rv HLKDFVPFG-----------VAGIGSAAGTIFFSYIGLDAVSTAGDEVKD
MMAR_3621|M.marinum_M HLKDFAPFG-----------VAGVGAAAGTIFFSFIGLDAVSTAGEEVRN
MUL_1244|M.ulcerans_Agy99 HLKDFAPFG-----------VAGVGAAAGTIFFSFIGLDAVSTAGEEVRN
MAV_2087|M.avium_104 HLDDFAPFG-----------VAGVGTAAGTIFFSYIGLDAVSTAGDEVTN
Mflv_1244|M.gilvum_PYR-GCK FQPAA-IAG------------ASAGLGLFFAFWSWVGFESTAMYGEESKD
Mvan_5564|M.vanbaalenii_PYR-1 FQPAA-IAG------------ASAGLGLFFAFWSWVGFESTAMYGEESKD
MSMEG_0279|M.smegmatis_MC2_155 FSPATGIVG------------ASAGLGLFFAFWSWVGFESTAMYGEESRN
MAB_0950c|M.abscessus_ATCC_199 FHDLGGVVQGPAGPLA---VAGSAGVGLFFAFWSWVGFESSAMYAEESKN
TH_4382|M.thermoresistible__bu VAFETTTDKS---------VFLAVSAATSLAFFAMVGFEDSVNMAEETRD
MLBr_01974|M.leprae_Br4923 SAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMNT
. . ::: *:: .:*
Mb2347c|M.bovis_AF2122/97 PQKTMPRALIAALVVVTGVYVLVALAALG-TQPWQDFAEQETAG----LA
Rv2320c|M.tuberculosis_H37Rv PQKTMPRALIAALVVVTGVYVLVALAALG-TQPWQDFAEQETAG----LA
MMAR_3621|M.marinum_M PQQSVPRALIAALFVVTGVYVLVAFAALG-TQPWQMFAGQEEAG----LA
MUL_1244|M.ulcerans_Agy99 PQQSVPRALIAALFVVTGVYVLVAFAALG-TQPWQMFAGQEEAG----LA
MAV_2087|M.avium_104 PQKTMPRALIAALLTVTGVYVFVALAALG-TQPWQDFGGQQEAG----LA
Mflv_1244|M.gilvum_PYR-GCK PKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGPQQAVELAQSADTSSEIF
Mvan_5564|M.vanbaalenii_PYR-1 PKRIIPRATMIAVLGVGLFYVFVSWMAIAGTGPKQAVELAQSADTSSEIF
MSMEG_0279|M.smegmatis_MC2_155 PKRIIPRATMIAVLGVGVFYVFISWMAIAGTGPQQSIELAQDANTASEIF
MAB_0950c|M.abscessus_ATCC_199 PKKIIPIAIVTSVVGVGLFYVLVSWLAIVGTGPENAVALAQDSSTAGNIF
TH_4382|M.thermoresistible__bu PVVIFPRALLTGLGIAGAVYVVVAIVAVA----LVPVGTLQASDVP--LV
MLBr_01974|M.leprae_Br4923 PDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATN---------HT
* .* * : . .*:. *:
Mb2347c|M.bovis_AF2122/97 IILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP-
Rv2320c|M.tuberculosis_H37Rv IILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP-
MMAR_3621|M.marinum_M TILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLP-
MUL_1244|M.ulcerans_Agy99 TILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLP-
MAV_2087|M.avium_104 TILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLP-
Mflv_1244|M.gilvum_PYR-GCK FAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLYALGREGLSTG
Mvan_5564|M.vanbaalenii_PYR-1 FAPVRTTYGEWAITLFNILLVSGSFACGMAFHNCASRYLYALGREGLSTR
MSMEG_0279|M.smegmatis_MC2_155 FAPVRDTYGEWAITVFNILLVTGSFACGMAFHNCASRYLYALGREGLSRG
MAB_0950c|M.abscessus_ATCC_199 FGPVQSHLGVWAVNLFKVLLMTGSFACGMAFHNCAARYLYALGRENVIPG
TH_4382|M.thermoresistible__bu EVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRVLP-
MLBr_01974|M.leprae_Br4923 VKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRILP-
. :: : . : .* .:. :
Mb2347c|M.bovis_AF2122/97 --ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDSL--ADMVSIGTLT
Rv2320c|M.tuberculosis_H37Rv --ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDSL--ADMVSIGTLT
MMAR_3621|M.marinum_M --ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNRL--ADMVSIGTLT
MUL_1244|M.ulcerans_Agy99 --ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNRL--ADMVSIGTLT
MAV_2087|M.avium_104 --PRFARVNPRTMTPVNNTVIVAVAAATLAAFIPLQNL--ADMVSIGTLT
Mflv_1244|M.gilvum_PYR-GCK LQKTLGATHKTHGSPYIASFVQSGIALVLVLAFFFAGM--DPYIHMYTLL
Mvan_5564|M.vanbaalenii_PYR-1 LQDTLGATHKTHGSPHIASFVQTGITLVLILAFFAAGM--DPYIHMYTLL
MSMEG_0279|M.smegmatis_MC2_155 LQKTLGATHPTHGSPYIASFVQSAIALVIVLSFLFAGM--DPYVHMYTLL
MAB_0950c|M.abscessus_ATCC_199 MRKTIGSTHSTHGSPHVAGFVQTAFATVVVLFFAATGR--DPYTGLYGLM
TH_4382|M.thermoresistible__bu --PVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFAD--STAIAVLGGT
MLBr_01974|M.leprae_Br4923 ---TRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLTGLAVIARFI
: * . : : . . :
Mb2347c|M.bovis_AF2122/97 AFSVVAVGVIVLRVR-------------EPDLPRGFKVPGYPVTPVLSVL
Rv2320c|M.tuberculosis_H37Rv AFSVVAVGVIVLRVR-------------EPDLPRGFKVPGYPVTPVLSVL
MMAR_3621|M.marinum_M AFIVVSVGVIILRVR-------------EPALPRGFWVPGYPVTPILSIL
MUL_1244|M.ulcerans_Agy99 AFIVVSVGVIILRVR-------------EPALPRGFWVPGYPVTPILSIL
MAV_2087|M.avium_104 AFVVVSVGVIVLRVR-------------EPDLPRGFRVPGYPVTPVLSIM
Mflv_1244|M.gilvum_PYR-GCK AILGTMAILIVQSLCAFSVVAYFHFHKNHPSSAHWFKTFLAPLTGGIGML
Mvan_5564|M.vanbaalenii_PYR-1 AILGTMAILIVQSLCAFSVIAYFHFHKNHPSSAHWFKTFLAPLLGGIGML
MSMEG_0279|M.smegmatis_MC2_155 AILGTMAILIVQSLCAFSVISYFHIHKNHPESKHWFKTLVAPGLGGLGML
MAB_0950c|M.abscessus_ATCC_199 ALLGTTAILIVQALTAFAVISYFHVLRHHPETAHWFRTLVAPLLGGLGMV
TH_4382|M.thermoresistible__bu TSLLLLAVFAMVNVAVLVLRR--DESRDPVVARRHFRTP--TFLPVVGFV
MLBr_01974|M.leprae_Br4923 QFIIVPIALFALARS-----------RTTNSVYVKRNVFTDKVLPITAVV
. . ..:
Mb2347c|M.bovis_AF2122/97 ACGYILAS-----------------LHWYTWLAFSGWVAVAVIFYLMWGR
Rv2320c|M.tuberculosis_H37Rv ACGYILAS-----------------LHWYTWLAFSGWVAVAVIFYLMWGR
MMAR_3621|M.marinum_M ACGYLLYS-----------------LHWYTWIAFGGWVGIALIFYLFWGR
MUL_1244|M.ulcerans_Agy99 ACGYLLYS-----------------LHWYTWIAFGGWVGIALIFYLFWGR
MAV_2087|M.avium_104 ACGYILAS-----------------LHWYTWIAFSGWVLLALIFYFVWGR
Mflv_1244|M.gilvum_PYR-GCK YVVYLLWEHKESAAGAASGTLLFKLTPWIVVGVFAFGAAMALYFKFKDKR
Mvan_5564|M.vanbaalenii_PYR-1 YVVYLLWEHKESAAGAASGTLLFKLTPWIVVGLFALGAAMALYFKFNDKR
MSMEG_0279|M.smegmatis_MC2_155 YVVYLLWEHKDTAAGTASGTLLFKLTPWIVVSVFVLGAALATYFKLRDPR
MAB_0950c|M.abscessus_ATCC_199 YVVYLLAKHASFAAGTASNDWVFTAIPWVVAAAGIGGIALALTLKYTAPH
TH_4382|M.thermoresistible__bu ASLYLVTPLSGRP-----------AQQYLLSVVLIVIGVLLFGVTMAINR
MLBr_01974|M.leprae_Br4923 VSAGLMVS------------------FDYRSIFLTRGGPNYFSISLIAIT
:: .
Mb2347c|M.bovis_AF2122/97 HHSALNEEVP----------
Rv2320c|M.tuberculosis_H37Rv HHSALNEEVP----------
MMAR_3621|M.marinum_M HHSRLNAPALHDNPTGEER-
MUL_1244|M.ulcerans_Agy99 HHSRLNAPALHDNPTGEER-
MAV_2087|M.avium_104 HHSALNDAAVD--PSGQER-
Mflv_1244|M.gilvum_PYR-GCK RYELIGRIVYDDSEVRD---
Mvan_5564|M.vanbaalenii_PYR-1 RYELIGRIVYDDSEIRD---
MSMEG_0279|M.smegmatis_MC2_155 RYGLIGRIVYDEAVERD---
MAB_0950c|M.abscessus_ATCC_199 RYDDLGRTVLEEAHER----
TH_4382|M.thermoresistible__bu QLGIPTRAVGDPAKMVLPPD
MLBr_01974|M.leprae_Br4923 FIGIPAVAYLHYYRTSGIK-