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MAVTTGARSELQKALGQRSAVLFGLAYMTPIIVLGIFGVIAERSKGASAGSYLLATVAMLFTAQSYGVMA RHFPVAGSAYTYVRKALDARVGFMVGWAVLLDYLFLPLVIWLIGGSYLQDRFPTVPFWTWIVGFAALTTV LNLIGLKVADRANFILMTFQLLILAFFVALTIGYLVGDSRSLLSLTPFTGNGGFTAITAGAAVAAYSFLG FDAVSTLTEETHDAERTIPRAIVLIALIGGAIFVTVAYVVSLVAPGSSFPDADSLSEGVARTIGGNLFAA VFLAALIIGQFTSGLAAQAAVSRLLYAMGRDGVLPRRVFGVVSAKFHTPMFNIMLTGAVGMAAILLSVAT STSFINFGAFTAFTLVNVSVVVYFVRERGAGLPRWRYLVLPVIGAAVDIYLLAHLASDALIVGLSWAAIG FLYLLWLTRGLTRQPPDLAGAAERG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0869 | - | - | 100% (445) | amino acid permease |
| M. marinum M | MMAR_2243 | - | 1e-85 | 39.16% (429) | cationic amino acid transport integral membrane protein |
| M. marinum M | MMAR_3621 | rocE | 4e-35 | 28.20% (461) | cationic amino acid transport integral membrane protein RocE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 2e-36 | 26.65% (454) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_4722 | - | 4e-31 | 26.60% (470) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 2e-36 | 26.65% (454) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 8e-20 | 25.36% (422) | putative permease |
| M. abscessus ATCC 19977 | MAB_3842 | - | 3e-33 | 27.19% (456) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_2087 | - | 2e-31 | 27.03% (455) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_0446 | - | 1e-102 | 45.89% (438) | putrescine importer |
| M. thermoresistible (build 8) | TH_0471 | - | 3e-27 | 28.69% (488) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 3e-34 | 27.98% (461) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 4e-34 | 26.50% (468) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0869|M.marinum_M --------------------------------------------------
MSMEG_0446|M.smegmatis_MC2_155 --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MAB_3842|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4722|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MMAR_0869|M.marinum_M ----------------------------------------------MAVT
MSMEG_0446|M.smegmatis_MC2_155 ----------------------------------------------MSST
Mb2347c|M.bovis_AF2122/97 --------------------------MPTTSMSLRELMLRRRPVSGAPVA
Rv2320c|M.tuberculosis_H37Rv --------------------------MPTTSMSLRELMLRRRPVSGAPVA
MUL_1244|M.ulcerans_Agy99 --------------------------MPATSIRLREQMLRRRPAGGAPVA
MAV_2087|M.avium_104 ------------------------------------------------MA
MAB_3842|M.abscessus_ATCC_1997 --------------------------MAPSSPSLAQQLLRRRPTSGAPTA
Mflv_4722|M.gilvum_PYR-GCK --------------------------MTQEPVTQAPGRLRLKSVEQSIAD
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------MVQEPGAQTVGRRRTKSVEQSIAD
TH_0471|M.thermoresistible__bu ----------------------------------MTDRLRVKSVEQSIAD
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MMAR_0869|M.marinum_M TG-ARSELQKALGQRSAVLFGLAYMTPIIVLGIFGVIAE-RSKGASAGSY
MSMEG_0446|M.smegmatis_MC2_155 AEVAEGHLKRALGLPSLVLFGLVYMVPLTVFTTYGIVTQ-TSGGRVPLSY
Mb2347c|M.bovis_AF2122/97 SGASG-NLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSF
Rv2320c|M.tuberculosis_H37Rv SGASG-NLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSF
MUL_1244|M.ulcerans_Agy99 EGAAG-SLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
MAV_2087|M.avium_104 PGTAD-HLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVP-EAGPAVIVSF
MAB_3842|M.abscessus_ATCC_1997 HGAGG-HLKQSMGTFQLTMIGVGATVGTGIFFILAESVP-KAGPAVMASF
Mflv_4722|M.gilvum_PYR-GCK TDEPGTKLRKDLNWWDLTVFGVSVVIGAGIFTITASTAANITGPAISLSF
Mvan_1740|M.vanbaalenii_PYR-1 TDEPSTRLRKELNWWDLTVFGVSVVIGAGIFTITASTAANITGPAISLSF
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSF
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK-IAGPFAPIAY
:. . .::*: :: . : ::
MMAR_0869|M.marinum_M LLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVGFMVGWAVLLD
MSMEG_0446|M.smegmatis_MC2_155 LVTLAAMVFTARSYARMSVAYPVAGSAYTYTQKSFGAPVGFLAGWSLLLD
Mb2347c|M.bovis_AF2122/97 IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
Rv2320c|M.tuberculosis_H37Rv IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MAB_3842|M.abscessus_ATCC_1997 LVAGLAAGLAALCYAELASAVPVSGSSFSYAYTTLGELAAMVVAACLLLE
Mflv_4722|M.gilvum_PYR-GCK IFAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
Mvan_1740|M.vanbaalenii_PYR-1 IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
TH_0471|M.thermoresistible__bu IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
.: . * . : **:::: ::. . . :
MMAR_0869|M.marinum_M YLFLPLVIWLIGG-SYLQ-----------DRFPTVPFWT-----------
MSMEG_0446|M.smegmatis_MC2_155 YLFLPMINYLVIG-LYLS-----------AAIPAIPAWV-----------
Mb2347c|M.bovis_AF2122/97 YGVATAAVAVGWS-GYVNKLLSNLFGFQMPHVLSAAPWD-THPG----WV
Rv2320c|M.tuberculosis_H37Rv YGVATAAVAVGWS-GYVNKLLSNLFGFQMPHVLSAAPWD-THPG----WV
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLS-GYVNKLLHNVFGFQLPQALSEAPWD-ERPGEAAGYL
MAV_2087|M.avium_104 YGVATAAVSVNWS-GYLNKLLSNVVGFQLPHALSAAPWD-AQPG----YV
MAB_3842|M.abscessus_ATCC_1997 YGVSAAAVAVGWS-QYLDKLLVNLFGWHLPHAISAAPWDSADPAAPHPWL
Mflv_4722|M.gilvum_PYR-GCK FAVAAAVVAKGWS-SYLG----TVFGFAG-GTAEVAGFD----------L
Mvan_1740|M.vanbaalenii_PYR-1 FAVAAAVVAKGWS-SYLG----TVFGFAG-GTTEVAGFQ----------L
TH_0471|M.thermoresistible__bu FSVAAAVVAKGWS-SYLG----EVFEFAG-ATTRLGPIT----------L
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLT-----------
. :
MMAR_0869|M.marinum_M --WIVGFAALTTVLNLIGLKVADRANFILMTFQLLILAFFVALTIGYLVG
MSMEG_0446|M.smegmatis_MC2_155 --FILIAIAIVTVLNIVGIVSVARANFVIIAVQAIFIVAFLILATSKVFS
Mb2347c|M.bovis_AF2122/97 NLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSA
Rv2320c|M.tuberculosis_H37Rv NLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSA
MUL_1244|M.ulcerans_Agy99 NLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDT
MAV_2087|M.avium_104 NLPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDM
MAB_3842|M.abscessus_ATCC_1997 NLPAVLLIIMCAILLIRGTSESALVNTVMVLLKLAVLSVFAIIAFTAFHA
Mflv_4722|M.gilvum_PYR-GCK DWGALVIIAIVTAILAMGTKLSASVSLAITALKVSVVLLVVIVGAFYIKM
Mvan_1740|M.vanbaalenii_PYR-1 DWGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVIVGAFYIKA
TH_0471|M.thermoresistible__bu DWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKA
MLBr_01974|M.leprae_Br4923 ---FLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIIT
: . : * .. : : .
MMAR_0869|M.marinum_M DSRSLLSLTPFTGNG---------------------GFTAITAGAAVAAY
MSMEG_0446|M.smegmatis_MC2_155 YG-TVDLAAPFTGDGTA------------------PGFSPVLAGAAILCL
Mb2347c|M.bovis_AF2122/97 DHLKDFVP---------------------------FGVAGIGSAAGTIFF
Rv2320c|M.tuberculosis_H37Rv DHLKDFVP---------------------------FGVAGIGSAAGTIFF
MUL_1244|M.ulcerans_Agy99 NHLKDFAP---------------------------FGVAGVGAAAGTIFF
MAV_2087|M.avium_104 HHLDDFAP---------------------------FGVAGVGTAAGTIFF
MAB_3842|M.abscessus_ATCC_1997 GNFSDFAP---------------------------FGVSGIGAAAGTIFF
Mflv_4722|M.gilvum_PYR-GCK ENFSPFIPAPEPGEAGGTGAEQSLFSLMTGAEGSHYGWYGLLAGASIVFF
Mvan_1740|M.vanbaalenii_PYR-1 ENFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVLAGASIVFF
TH_0471|M.thermoresistible__bu ANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFF
MLBr_01974|M.leprae_Br4923 QHVNNYVTSRSAYQPTTYSLLG-------VTEIGKSTAASMTLATIVALY
: .:
MMAR_0869|M.marinum_M SFLGFDAVSTLTEETHDAERTIPRAIVLIALIGGAIFVTVAYVVSLVAPG
MSMEG_0446|M.smegmatis_MC2_155 SFLGFDAVSTLSEEAKDPKRTVPRAIMIATLASGLIFVVLSYVAQVVFPS
Mb2347c|M.bovis_AF2122/97 SYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPW
Rv2320c|M.tuberculosis_H37Rv SYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPW
MUL_1244|M.ulcerans_Agy99 SFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPW
MAV_2087|M.avium_104 SYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPW
MAB_3842|M.abscessus_ATCC_1997 TYVGLDTVSTAGEEVKDPQRTMPRALIAALLIVTAFYLVVALAALGAQPW
Mflv_4722|M.gilvum_PYR-GCK AFIGFDIVATTAEETKVPQRDVPRGILASLGIVTVLYVAVAIVLSGMVSY
Mvan_1740|M.vanbaalenii_PYR-1 AFIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAVVLTGMVSY
TH_0471|M.thermoresistible__bu AFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHY
MLBr_01974|M.leprae_Br4923 AFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGS-
:: *:: ::. :* ..: :.:.: .:: .
MMAR_0869|M.marinum_M SSFPDADSLSEGVART--IGGNLFAAVFLAALIIGQFTSGLAAQAAVSRL
MSMEG_0446|M.smegmatis_MC2_155 NEFSDVDSGSLDVMMT--AGGNFLQVFFTAAYVAGATGSAITSQASVARI
Mb2347c|M.bovis_AF2122/97 QDFAEQETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRI
Rv2320c|M.tuberculosis_H37Rv QDFAEQETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRI
MUL_1244|M.ulcerans_Agy99 QMFAGQEEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRI
MAV_2087|M.avium_104 QDFGGQQEAGLATILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRI
MAB_3842|M.abscessus_ATCC_1997 KEFEGQ-SAGLALILDKVTGSTSASTFLAAGAVISIFSITLVSMYGQTRI
Mflv_4722|M.gilvum_PYR-GCK KDLRDA-ESPNLATAFSLNGVDWAAKVISIGALAGLTTVVIVLVLGQTRV
Mvan_1740|M.vanbaalenii_PYR-1 TELRDA-ETQNLATAFSLNGVDWAAKVISIGALAGLTTVVIVLVLGQTRV
TH_0471|M.thermoresistible__bu TELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIVLVLGQTRV
MLBr_01974|M.leprae_Br4923 ---DKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRL
.: . : . :. . .*:
MMAR_0869|M.marinum_M LYAMGRDGVLPRRVFGVVSAKFHTPMFNIMLTGAVGM-AAILLSVATSTS
MSMEG_0446|M.smegmatis_MC2_155 LYAMGRDGVLPRPFFGHVSPRFSTPVYAILAVAVISL-LAIVIDLGILAS
Mb2347c|M.bovis_AF2122/97 LFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFAST-LAAFIPLDSLAD
Rv2320c|M.tuberculosis_H37Rv LFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFAST-LAAFIPLDSLAD
MUL_1244|M.ulcerans_Agy99 LFAMGRDGLLPARFAAVHPRFQTPVSNTVVVAIAAAV-LAALVPLNRLAD
MAV_2087|M.avium_104 LFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAAT-LAAFIPLQNLAD
MAB_3842|M.abscessus_ATCC_1997 LFAIGRDGLLPSVFAQVNPRTLTPVNNTIIVAVVVGF-MAAFVPLDSLAN
Mflv_4722|M.gilvum_PYR-GCK LFAMSRDGLLPRQLAKTGEH-GTPVRITLLVGAVVAV-TATVFPIDKLEE
Mvan_1740|M.vanbaalenii_PYR-1 LFAMSRDGLLPRQLAKTGEH-GTPVRITLIVGAVVAV-TATVFPIGKLEE
TH_0471|M.thermoresistible__bu LFAMSRDGLLPRPLSKTGPR-GTPVRITVLVGALVAI-AASVFPVGNLEE
MLBr_01974|M.leprae_Br4923 WTALSDGRILPTRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLTG
*:. . :** . : . : .
MMAR_0869|M.marinum_M FINFGAFTAFTLVNVSVVV-YFVRERG-AGLPRWRYL--VLPVIGAAVDI
MSMEG_0446|M.smegmatis_MC2_155 VISFGALVAFSAVNLSVIKHYFVDHRERAGAQAINSL--VLPLIGFALTV
Mb2347c|M.bovis_AF2122/97 MVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPGYP--VTPVLSVLACG
Rv2320c|M.tuberculosis_H37Rv MVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPGYP--VTPVLSVLACG
MUL_1244|M.ulcerans_Agy99 MVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPGYP--VTPILSILACG
MAV_2087|M.avium_104 MVSIGTLTAFVVVSVGVIVLRVREPDLPRGFRVPGYP--VTPVLSIMACG
MAB_3842|M.abscessus_ATCC_1997 MVSIGTLTAFIVVSIGVIILRVREPELPRAFRVPGYP--VTPVLSVIACG
Mflv_4722|M.gilvum_PYR-GCK MVNIGTLFAFVLVSAGVIVLRRTRPDLKRGFRTPWVP--VLPILSIIACV
Mvan_1740|M.vanbaalenii_PYR-1 MVNIGTLFAFVLVSAGVLVLRRTRPDLKRGFRTPWVP--LLPILAIAACV
TH_0471|M.thermoresistible__bu MVNIGTLFAFALVSAGVIVLRRTRPDLKRGFRVPFVP--WLPLAAIAACL
MLBr_01974|M.leprae_Br4923 LAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVVVSA
. :. : * * .:. *: .
MMAR_0869|M.marinum_M YLLAHLASDALIVGLS---WAAIGFLYLLWLTRGLTRQPPDLAGAAERG-
MSMEG_0446|M.smegmatis_MC2_155 WLWFSLDGLALIIGLC---WLAIGFVWLAGVTRGFQRPTPVLDMKE----
Mb2347c|M.bovis_AF2122/97 YILASLHWYTWLAFSG---WVAVAVIFYLMWGRHHSALNEEVP-------
Rv2320c|M.tuberculosis_H37Rv YILASLHWYTWLAFSG---WVAVAVIFYLMWGRHHSALNEEVP-------
MUL_1244|M.ulcerans_Agy99 YLLYSLHWYTWIAFGG---WVGIALIFYLFWGRHHSRLNAPALHDNPTGE
MAV_2087|M.avium_104 YILASLHWYTWIAFSG---WVLLALIFYFVWGRHHSALNDAAVD--PSGQ
MAB_3842|M.abscessus_ATCC_1997 YILFSLPWITWIAFGA---WVAIVLVFYLVWGRHHSALNDLPSDPAELSE
Mflv_4722|M.gilvum_PYR-GCK WLMLNLTGLTWIRFSV---WMAIGVVLYFVYGRRHSLVARRQRERAGLHT
Mvan_1740|M.vanbaalenii_PYR-1 WLMLNLTGLTWIRFLI---WMAIGVVVYFLYGRRHSLVGRRMG-------
TH_0471|M.thermoresistible__bu WLMLNLTGLTWVRFLG---WMALGLVLYFFYGRHHSMLGRGMTDISARRT
MLBr_01974|M.leprae_Br4923 GLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK--
: : : . : : .:
MMAR_0869|M.marinum_M ----
MSMEG_0446|M.smegmatis_MC2_155 ----
Mb2347c|M.bovis_AF2122/97 ----
Rv2320c|M.tuberculosis_H37Rv ----
MUL_1244|M.ulcerans_Agy99 ER--
MAV_2087|M.avium_104 ER--
MAB_3842|M.abscessus_ATCC_1997 KEPV
Mflv_4722|M.gilvum_PYR-GCK DTP-
Mvan_1740|M.vanbaalenii_PYR-1 ----
TH_0471|M.thermoresistible__bu G---
MLBr_01974|M.leprae_Br4923 ----