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MSEVVDDRPGSDAPPGSEKLRGNLGIPAIVLMVVAAAAPLSTIGGNVPIGMALGDTTGIPVAFVVAGVIF LLFSASFVAMSKYVTDAGAFYAYIQRGLGRAAGTGAAVLALPAYMCTLLGVSAYDGVILGGLIERFGGPQ IPWWILTALVLAAVAWLGYRDIDLSAKVLGVFLVSEVAILVVLDLVIVLRGGEQGITGDSFTPQGLAGGV GIALLYALWGFVGVEATSVFRDEAKDPDRTVPRATYWAVGIVASFYAFSSWALIEGNGGHDAIQVAKDDP DNFMVNTAQQYLGMLGRDLTTLFWFVSVFACALAFHNITARYAFVLGQNNVFPKQLGKVHHRFGAPSNAS LAVTVASFVIMAILAGLGLDPVLQIFGPLGGVGVLALAILWLLTTISVVIFFRRRGGATRIVVLASAATL ALGAGLVLIVSNLPLVVGGSPTLAVILGIAPVVVFGIGMVLSRRATGTLSEAKSE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0499 | - | - | 100% (475) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_1508 | - | e-110 | 46.52% (445) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_3557 | - | e-110 | 43.55% (473) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 3e-17 | 24.75% (408) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 8e-59 | 30.44% (473) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 3e-17 | 24.75% (408) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 2e-10 | 22.67% (375) | putative permease |
| M. abscessus ATCC 19977 | MAB_4350c | - | 1e-104 | 41.18% (459) | putative amino acid permease |
| M. marinum M | MMAR_2243 | - | 1e-17 | 25.98% (408) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_2087 | - | 8e-18 | 23.43% (397) | amino acid transporter |
| M. thermoresistible (build 8) | TH_4382 | - | 2e-11 | 22.48% (467) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 2e-16 | 24.40% (332) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | 4e-65 | 32.87% (432) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MSMEG_0499|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4350c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0605|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2243|M.marinum_M --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MSMEG_0499|M.smegmatis_MC2_155 -----------------------------------MSEVVDDRPGSDAPP
MAB_4350c|M.abscessus_ATCC_199 -----------------------------------MTASKRACQGHGSAA
Mflv_1244|M.gilvum_PYR-GCK -----------------------------------MTESAERTAPGQTTP
Mvan_0605|M.vanbaalenii_PYR-1 -----------------------------------MAVRSDPPVHVAAEP
MMAR_2243|M.marinum_M ------------------------------------------------MS
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAG--PGVIVS
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAG--PGVIVS
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVPEAG--PAVIVS
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVPEAG--PAVIVS
MSMEG_0499|M.smegmatis_MC2_155 GSE---KLRGNLGIPAIVLMVVAAAAPLSTIGGNVPIGMALGDTTGIPVA
MAB_4350c|M.abscessus_ATCC_199 ESDRPQKLDGQLGVIGIVLMVIAAAAPLTVIGGDGLLAIASGPGPGAPLG
Mflv_1244|M.gilvum_PYR-GCK TASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
Mvan_0605|M.vanbaalenii_PYR-1 -AEGHTLKRGAIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGNGLGTPAG
MMAR_2243|M.marinum_M QPTGEPRLRRALGVAGLVAFGLAYIDPLAMFDTFGVVSQTTHG--HVPTA
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVGDILGTGIYALVGDVAGEVGG--AAWLP
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAG--PFAPIA
.* : : :
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLG----------EAV
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLG----------EAV
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLG----------EAV
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLG----------EVV
MSMEG_0499|M.smegmatis_MC2_155 FVVAGVIFLLFSASFVAMSKYVTDAGAFYAYIQRGLG----------RAA
MAB_4350c|M.abscessus_ATCC_199 FLIAGLLLMAFAVGFVTMTPFVSEAGAFFSYITKGLG----------ERW
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLG----------RVM
Mvan_0605|M.vanbaalenii_PYR-1 FAIATIVLSIFSVGFIALARHITAAGAFYTFVSRGWS----------RIP
MMAR_2243|M.marinum_M YVVTFVAMLFTAASYAVLVHAYPSAGSAYTFARRSFG----------GNV
TH_4382|M.thermoresistible__bu FLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGI---------QFV
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
: :: : : .. : .
Mb2347c|M.bovis_AF2122/97 AMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDT
Rv2320c|M.tuberculosis_H37Rv AMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDT
MUL_1244|M.ulcerans_Agy99 AMGVASCLLLEYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDE
MAV_2087|M.avium_104 AMGVAACLLLEYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDA
MSMEG_0499|M.smegmatis_MC2_155 GTGAAVLALPAYMCTLLGVSAYDGVILGGLIERFGGPQIPWWILTALVLA
MAB_4350c|M.abscessus_ATCC_199 GLGAAFVALVTYTAIQVGMYGYMGWALNDLVTSYGGPELPWWLWAIVTLG
Mflv_1244|M.gilvum_PYR-GCK GMASGLIITLAYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVPALLMLV
Mvan_0605|M.vanbaalenii_PYR-1 GLPAGVMSMFTYMTMEAGLIGIFSVFADQAITSQFGIDLPWLVYAMIGVV
MMAR_2243|M.marinum_M GFLTGWALMLDYLLLPLVNYLLIGIYLNAQFP-----AVPAPVFCLAAIA
TH_4382|M.thermoresistible__bu TFLVAFIVMCSGITSASTASRFFAANLEVGLGQEWG-RLGVAGVALLFMA
MLBr_01974|M.leprae_Br4923 TASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAVLLA
. :
Mb2347c|M.bovis_AF2122/97 HPG----WVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFM
Rv2320c|M.tuberculosis_H37Rv HPG----WVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFM
MUL_1244|M.ulcerans_Agy99 RPGEAAGYLNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFV
MAV_2087|M.avium_104 QPG----YVNLPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFG
MSMEG_0499|M.smegmatis_MC2_155 AVA----WLGYRDIDLSAKVLGVFLVSEVAILVVLDLVIVLRGG-EQGIT
MAB_4350c|M.abscessus_ATCC_199 LVA----YLGYRNIELSSKVLGIALVLEIAVVLVTDAAIVFQGG-RDGIS
Mflv_1244|M.gilvum_PYR-GCK LNS----ILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGFA
Mvan_0605|M.vanbaalenii_PYR-1 VIA----TLSHWDISVAAKVLGAVLVAEIVMLTLTATASLMHH--PEGMS
MMAR_2243|M.marinum_M LVT----TVNIVGVVIMNRLNFALVGLQLAFVLVFITVSLLYLRDHPDAS
TH_4382|M.thermoresistible__bu LLA----MVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGADV
MLBr_01974|M.leprae_Br4923 INIFG--NLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSRS
: :
Mb2347c|M.bovis_AF2122/97 IIAFSAYSADHLKDFVPFGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDP
Rv2320c|M.tuberculosis_H37Rv IIAFSAYSADHLKDFVPFGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDP
MUL_1244|M.ulcerans_Agy99 ILALTAYDTNHLKDFAPFGVAGVGAAAGTIFFSFIGLDAVSTAGEEVRNP
MAV_2087|M.avium_104 ILAFTAFDMHHLDDFAPFGVAGVGTAAGTIFFSYIGLDAVSTAGDEVTNP
MSMEG_0499|M.smegmatis_MC2_155 GDS-------FTPQGLAGG-VGIALLY--ALWGFVGVEATSVFRDEAKDP
MAB_4350c|M.abscessus_ATCC_199 AYS-------FTPEAAASGPLGIAILF--AFAGFMGFEATAVFRDEARQP
Mflv_1244|M.gilvum_PYR-GCK IAETLNPVGAFQPAAIAGASAGLGLFF--AFWSWVGFESTAMYGEESKDP
Mvan_0605|M.vanbaalenii_PYR-1 WTS-LNPATALSTNGVAGGVVGLGLLM--AFWSWVGFESTAIYGEESKNP
MMAR_2243|M.marinum_M LLQP-----LYSAGFRGGDILGGAAVV---ALSFVGFDAVSTMAEEARNP
TH_4382|M.thermoresistible__bu DFTR---VVAFETTTDKSVFLAVSAATSLAFFAMVGFEDSVNMAEETRDP
MLBr_01974|M.leprae_Br4923 AYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMNTP
. . *.: :* *
Mb2347c|M.bovis_AF2122/97 QKTMPRALIAALVVVTGVYVLVALAALGTQP------WQDFAEQETAGLA
Rv2320c|M.tuberculosis_H37Rv QKTMPRALIAALVVVTGVYVLVALAALGTQP------WQDFAEQETAGLA
MUL_1244|M.ulcerans_Agy99 QQSVPRALIAALFVVTGVYVLVAFAALGTQP------WQMFAGQEEAGLA
MAV_2087|M.avium_104 QKTMPRALIAALLTVTGVYVFVALAALGTQP------WQDFGGQQEAGLA
MSMEG_0499|M.smegmatis_MC2_155 DRTVPRATYWAVGIVASFYAFSSWALIEGNG---GHDAIQVAKDDPDNFM
MAB_4350c|M.abscessus_ATCC_199 ERTIPRATYLSVAIIGVFYAVSCWAVVEAWGPANVKDVVQKSLDSGGNAL
Mflv_1244|M.gilvum_PYR-GCK KRIIPRATMIAVLGVGIFYVFVSWMAIAGTGP-QQAVELAQSADTSSEIF
Mvan_0605|M.vanbaalenii_PYR-1 KKIVPQATMIAVIGIGVFYTFIAWGMIVGNGP-TKAVELS-SGPTPFDLI
MMAR_2243|M.marinum_M RRTVPLAIILTVLIGGATFLSVSYCATLVEP-------DYRAITTPNSAA
TH_4382|M.thermoresistible__bu VVIFPRALLTGLGIAGAVYVVVAIVAVALVP-------VGTLQASDVPLV
MLBr_01974|M.leprae_Br4923 DRTLPKAIPLTILTVGVIYILALVVAMLLGS----------DKIVATNHT
.* * : :
Mb2347c|M.bovis_AF2122/97 IILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGL---
Rv2320c|M.tuberculosis_H37Rv IILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGL---
MUL_1244|M.ulcerans_Agy99 TILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGL---
MAV_2087|M.avium_104 TILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGL---
MSMEG_0499|M.smegmatis_MC2_155 VNTAQQYLGMLGRDLTTLFWFVSVFACALAFHNITARYAFVLGQNNV---
MAB_4350c|M.abscessus_ATCC_199 LDTAEAYVGAVFRDIMQILLVTSLFACVLSFHNVIARYQFALANKGV---
Mflv_1244|M.gilvum_PYR-GCK FAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLYALGREGLSTG
Mvan_0605|M.vanbaalenii_PYR-1 YAPTQQYLGQWAIVVFEWLMVGGSFACALAIHNSAARYLFAFGRDGL---
MMAR_2243|M.marinum_M LQIVVSAGGHSLQTFFIIAYMCACSAAALSSQVSVTRILYAMGRDGVLP-
TH_4382|M.thermoresistible__bu EVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRV---
MLBr_01974|M.leprae_Br4923 VKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRI---
. . . . : .* :. :
Mb2347c|M.bovis_AF2122/97 LPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDS----------LAD
Rv2320c|M.tuberculosis_H37Rv LPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDS----------LAD
MUL_1244|M.ulcerans_Agy99 LPARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNR----------LAD
MAV_2087|M.avium_104 LPPRFARVNPRTMTPVNNTVIVAVAAATLAAFIPLQN----------LAD
MSMEG_0499|M.smegmatis_MC2_155 FPKQLGKVHHRFGAPSNASLAVTVASFVIMAILAGLGLDPVLQIFGPLGG
MAB_4350c|M.abscessus_ATCC_199 LPAPVGRVHPTERSPHISSALQSITAVAFVVLVAAVGLDPMVQVFSSMAG
Mflv_1244|M.gilvum_PYR-GCK LQKTLGATHKTHGSPYIASFVQSGIALVLVLAFFFAGMDPYIHMYTLLAI
Mvan_0605|M.vanbaalenii_PYR-1 LPRRLGAAHPKHASPYVASLAQSVFAAVVLIVCAISGSDPYAVLFVLVAI
MMAR_2243|M.marinum_M -RAVFGRISRRFRTPIGAALVVSAVS-TLALIADLET----------MAS
TH_4382|M.thermoresistible__bu LPPVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFADS---TAIAVLGG
MLBr_01974|M.leprae_Br4923 LPTRLSSKN-RFGVPIVAFGITAFLTLAFPLSLRFDSLN--------LTG
.. * : : . :
Mb2347c|M.bovis_AF2122/97 MVSIGTLTAFSVVAVGVIVLRVREPDLPRGFK--VPGYPVTPVLSVLACG
Rv2320c|M.tuberculosis_H37Rv MVSIGTLTAFSVVAVGVIVLRVREPDLPRGFK--VPGYPVTPVLSVLACG
MUL_1244|M.ulcerans_Agy99 MVSIGTLTAFIVVSVGVIILRVREPALPRGFW--VPGYPVTPILSILACG
MAV_2087|M.avium_104 MVSIGTLTAFVVVSVGVIVLRVREPDLPRGFR--VPGYPVTPVLSIMACG
MSMEG_0499|M.smegmatis_MC2_155 VGVLALAILWLLTTISVVIFFR-RRGGATRIV--VLAS-----AATLALG
MAB_4350c|M.abscessus_ATCC_199 ISTVGMLMLLILTSVAVPLFFS-RDDSARAGR--VLTTYVAPIVATIGLS
Mflv_1244|M.gilvum_PYR-GCK LGTMAILIVQSLCAFSVVAYFHFHKNHPSSAH--WFKTFLAPLTGGIGML
Mvan_0605|M.vanbaalenii_PYR-1 LATLCLLTVQTMSSIATVVYFHVKKQHPETAN--WWRTLAAPVIGGAGMV
MMAR_2243|M.marinum_M IVSFGALAAFTLVHLAVTKHFLIDQRRRGWRS--WALYAAMPAVGVVLTG
TH_4382|M.thermoresistible__bu TTSLLLLAVFAMVNVAVLVLRRDESRDPVVARRHFRTPTFLPVVGFVASL
MLBr_01974|M.leprae_Br4923 LAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVVVSA
. : .. .
Mb2347c|M.bovis_AF2122/97 YILASLHWYTWLAFSGWVA---VAVIFYLMWGRHHSALNEEVP-------
Rv2320c|M.tuberculosis_H37Rv YILASLHWYTWLAFSGWVA---VAVIFYLMWGRHHSALNEEVP-------
MUL_1244|M.ulcerans_Agy99 YLLYSLHWYTWIAFGGWVG---IALIFYLFWGRHHSRLNAPALHDNPTGE
MAV_2087|M.avium_104 YILASLHWYTWIAFSGWVL---LALIFYFVWGRHHSALNDAAVD--PSGQ
MSMEG_0499|M.smegmatis_MC2_155 AGLVLIVSNLPLVVGGS------PTLAVILGIAPVVVFGIGMVLSRRATG
MAB_4350c|M.abscessus_ATCC_199 ASVYLVLKNFTLVTDQS------TVISTVLAALPIAALIYGLVQKKGVHR
Mflv_1244|M.gilvum_PYR-GCK YVVYLLWEHKESAAGAASGTLLFKLTPWIVVGVFAFGAAMALYFKFKDKR
Mvan_0605|M.vanbaalenii_PYR-1 YVIYLMASNMSAAAGTASESLFFKMIPYILLTLLFGSIAVALYLRKARPD
MMAR_2243|M.marinum_M WLWTSLSVGAFAIGFAWLG---IGTSYLAVLTRGFRKPAPAVDFDADAAP
TH_4382|M.thermoresistible__bu YLVTPLSGRPAQQYLLSVVLIVIGVLLFGVTMAINRQLGIPTRAVGDPAK
MLBr_01974|M.leprae_Br4923 GLMVSFDYRSIFLTRGGPN--YFSISLIAITFIGIPAVAYLHYYRTSGIK
. .
Mb2347c|M.bovis_AF2122/97 -----------------
Rv2320c|M.tuberculosis_H37Rv -----------------
MUL_1244|M.ulcerans_Agy99 ER---------------
MAV_2087|M.avium_104 ER---------------
MSMEG_0499|M.smegmatis_MC2_155 TLSEAKSE---------
MAB_4350c|M.abscessus_ATCC_199 R----------------
Mflv_1244|M.gilvum_PYR-GCK RYELIGRIVYDDSEVRD
Mvan_0605|M.vanbaalenii_PYR-1 LYARIGSTVFDDKPTD-
MMAR_2243|M.marinum_M IQTEIDLTKEGTLQ---
TH_4382|M.thermoresistible__bu MVLPPD-----------
MLBr_01974|M.leprae_Br4923 -----------------