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TRSALISGAGIAGPALAFWLTEAGWEVTVIERAKQLRSSGYPIDIRGAAVEAVDRMGLLQQITANRYQHP LMDFLTPGGRRLARLDMGEVLNDPDAGDIEITRGALTRIFFEASAGRADYVFGDTITGLSPTDAGVDVTF GHRDPQTFDVVIGADGIHSNVRALSFGAENQYLRHLGPYVAIWDIPTEMIAPGTGYMYSHPGRTVGIERT FDSAATRAFLTFVHPSPGSVNRHDISEVAAELRRAFAEDRWRTAEIIDTLLDADDVFFDTASQVRLNRWS TGRIGLVGDAAYAPAFLSGQGTSLAVAGAYVLASELVRHDQPEKAFSAYEHRMRHFVVRNQNLALRTDGT VLSRTRGQLLRRNIVVAMTPWLHRVGLDRLLRTERREATTDLSLPDNDLRRSPSRQT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3318 | - | - | 100% (408) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5719 | - | 4e-58 | 39.22% (385) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_1980 | - | 4e-57 | 37.12% (396) | hypothetical protein MSMEG_1980 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 7e-51 | 36.68% (349) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 8e-12 | 25.29% (348) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 1e-56 | 36.81% (345) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2678 | - | 1e-60 | 38.20% (356) | hypothetical protein MAB_2678 |
| M. marinum M | MMAR_2185 | - | 3e-57 | 38.04% (347) | oxidoreductase |
| M. avium 104 | MAV_1408 | - | 2e-59 | 39.14% (350) | hypothetical protein MAV_1408 |
| M. thermoresistible (build 8) | TH_1880 | - | 8e-07 | 26.83% (164) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_1770 | - | 2e-57 | 38.04% (347) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 3e-11 | 25.23% (333) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2185|M.marinum_M MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIR-PGGQTVDLRG
MUL_1770|M.ulcerans_Agy99 MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIR-PGGQTVDLRG
Rv1260|M.tuberculosis_H37Rv --MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLR-PGGQAIDVRG
MAV_1408|M.avium_104 --MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPR-PGGQAIDVRG
MAB_2678|M.abscessus_ATCC_1997 ---MRVLISGASIAGPVLAFWLAHYGFEVTVIERSPAPRKSGGHAVDLFK
Mb0590c|M.bovis_AF2122/97 ---MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFR-TGGYMIDFWG
MSMEG_3318|M.smegmatis_MC2_155 -MTRSALISGAGIAGPALAFWLTEAGWEVTVIERAKQLR-SSGYPIDIRG
Mflv_2621|M.gilvum_PYR-GCK -MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG--AGSGISLWP
Mvan_5278|M.vanbaalenii_PYR-1 ---MKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENK-PVGAAISVWS
TH_1880|M.thermoresistible__bu --VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPP-AHVRSLGLHV
: *.. * * * * : * :..
MMAR_2185|M.marinum_M AGRLVIERMGLLEQMRQRSLRQRGIAWIRADG-RRRAEMPVE----AFHG
MUL_1770|M.ulcerans_Agy99 AGRLVIERMGLLEQMRQRSLRQRGIAWIRADG-RRRAEMPVE----AFHG
Rv1260|M.tuberculosis_H37Rv PALDVLERMGLLAAAQEHKTRIRGASFVDRDG-NELFRDTES---TPTGG
MAV_1408|M.avium_104 PALGVLERMGLLAAAAKRRTQIRGSSVVDRDG-NELSRDTEAAISGPTGG
MAB_2678|M.abscessus_ATCC_1997 PAMDIIEMMGILDHVEAQSAGTEVLS-IHREG-KRLIDLPEV----LIFS
Mb0590c|M.bovis_AF2122/97 VGYQVAKRMGITDQIAAAGYHMEHVRSVGPTG-KVKADLGVD----VFRR
MSMEG_3318|M.smegmatis_MC2_155 AAVEAVDRMGLLQQITANRYQHPLMDFLTPGG-RRLARLDMG----EVLN
Mflv_2621|M.gilvum_PYR-GCK NALAALDQIGLGDSVRDAGGRVTAGAIRWRDG-TWVRRPSVR----RIVD
Mvan_5278|M.vanbaalenii_PYR-1 NGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMH----PLIE
TH_1880|M.thermoresistible__bu RSIEMLDQRGLLDRFLAHGQRHPVGGFFAAIA-----KPPAE------LD
. . *:
MMAR_2185|M.marinum_M NGPVSELEILRGDLAAVLYRAT-AAGTDYRFGTRITDLAPSGDAVQARLS
MUL_1770|M.ulcerans_Agy99 NGPVSELEILRGDLAAVLYRAT-AAGTDYRFGTRITDLAPSGDAVQARLS
Rv1260|M.tuberculosis_H37Rv PVNSPDIELLRDDLVELLYGAT-QPSVEYLFDDSISTLQDDGDSVRVTFE
MAV_1408|M.avium_104 PIEGPDIELLRDDLVELLYGAS-QWTAEYLFDDTITALDDRGAAVRVSFE
MAB_2678|M.abscessus_ATCC_1997 AVSERHVEIMRDDLSEILYGAS-APSAEYIFGDSITALTDDGAGVRVAFD
Mb0590c|M.bovis_AF2122/97 MVGDDFTSLPRGDLAAAIYTTI-EDQVETIFDDSIATIDEHRDGVRLTFE
MSMEG_3318|M.smegmatis_MC2_155 DPDAGDIEITRGALTRIFFEAS-AGRADYVFGDTITGLSPTDAGVDVTFG
Mflv_2621|M.gilvum_PYR-GCK ALGEPLVVVRRSRLTDILREAL-PAG-TVRTGLAATRVSVGASSVRITLS
Mvan_5278|M.vanbaalenii_PYR-1 QVGQRPYPIARAELQLMLMKAYGIDDINFGMKMVGVENDTAGSAAKATFA
TH_1880|M.thermoresistible__bu TAHGYVLGIRQPVTDRLLAEWAAERGAVIRRGCAVVGLDQDAAGITVELA
: : : . :
MMAR_2185|M.marinum_M DGTTVRADLVVGADGPHSGVRRLAFG-PEEQFARPLGGYNAWFSAPDTVG
MUL_1770|M.ulcerans_Agy99 DGTTVRADLVVGADGPHSGVRRLAFG-PEEQFARPLGGYNAWFSAPDTVG
Rv1260|M.tuberculosis_H37Rv RAAAREFDLVIGADGLHSNVRRLVFG-PEEQFVKRLGTHAAIFTVPNFLE
MAV_1408|M.avium_104 RAAPRDFDLVIGADGLHSNVRRLVFG-PEDEFIERLGTHAAIFTVPNFLG
MAB_2678|M.abscessus_ATCC_1997 RASDRRFDLVIGADGLHSHVRGLVFG-PESGYSHWLGQYLAVASIPNYLD
Mb0590c|M.bovis_AF2122/97 RTAPRDFDLVIGADGLHSNVRRLVFG-PERDFEHYLGCKVAACVVDGYRP
MSMEG_3318|M.smegmatis_MC2_155 HRDPQTFDVVIGADGIHSNVRALSFG-AENQYLRHLGPYVAIWDIPTEMI
Mflv_2621|M.gilvum_PYR-GCK DGEVRESDAVVGADGVNSVLARTLNG-PLR--TRYVG-YTAWRGIAAHPL
Mvan_5278|M.vanbaalenii_PYR-1 DGTTVSADVIIGADGAGSITREYVLGGPVSRRYAGYVNYNGLVSTDDAIG
TH_1880|M.thermoresistible__bu DGSVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLSADPAT
::*.** *
MMAR_2185|M.marinum_M LNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAP-IRYDRGDLDAQR
MUL_1770|M.ulcerans_Agy99 LNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAP-IRYDRGDLDAQR
Rv1260|M.tuberculosis_H37Rv LDYWQTWHYGDSTMAG-VYSARNNTEARAALAFMDTE-LRIDYRDTEAQF
MAV_1408|M.avium_104 LDYWQMWHYGDSTMAG-VYSARDNAEARAMLGFMDAE-LRLDYRDTEAQF
MAB_2678|M.abscessus_ATCC_1997 LSDRALMYPQVDKIAG-MYSAAQLSDARAFFLFRTPEPLDYHHRDVGRQK
Mb0590c|M.bovis_AF2122/97 RDERSYVLY--NTVDR-QLARFALRGDRTMFLFVFRA--EHDNPGVAPK-
MSMEG_3318|M.smegmatis_MC2_155 APGTGYMYSHPGRTVG-IERTFDSAATRAFLTFVHPSPGSVNRHDISEVA
Mflv_2621|M.gilvum_PYR-GCK DPELGGETLGPGTQVG-----HVPLGPDHTYWFATER-TAEGGSAPGGEH
Mvan_5278|M.vanbaalenii_PYR-1 PATEWTTYVGDGKRVS-----VMPVSDDRFYFFFDVVEPQGSPYEEGRVR
TH_1880|M.thermoresistible__bu VAAVVAEVRKTQLRFG-----AMPLGDGVYRVIVPAEGVAGDR--AEPTL
:
MMAR_2185|M.marinum_M DLLAARFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAWSRGRVTLVGD
MUL_1770|M.ulcerans_Agy99 DLLAACFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAWSRGRVTLVGD
Rv1260|M.tuberculosis_H37Rv AELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALVGD
MAV_1408|M.avium_104 AELERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIKMDRWSRGRVALVGD
MAB_2678|M.abscessus_ATCC_1997 ALLGEVYADVGWELPRMLAEVDATDTFYMDSITQLRMDTWSKGRITLVGD
Mb0590c|M.bovis_AF2122/97 DELRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLIGD
MSMEG_3318|M.smegmatis_MC2_155 AELRRAFAEDRWRTAEIIDTLLDADDVFFDTASQVRLNRWSTGRIGLVGD
Mflv_2621|M.gilvum_PYR-GCK AYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRARAARWSDGRAVLIGD
Mvan_5278|M.vanbaalenii_PYR-1 EVLRAHFAGWTPGVQTLIDTLDPLATNRVEILDLDPFHTWVKGRVAVLGD
TH_1880|M.thermoresistible__bu DEFRRRLKAFAG--TDFGAHTPRWLSRFGDATR--LAERYRAGRVFLAGD
: : : : ** : **
MMAR_2185|M.marinum_M AGYCASPLSGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYETV
MUL_1770|M.ulcerans_Agy99 AGYCASPLSGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYETV
Rv1260|M.tuberculosis_H37Rv AGYCCSPLSGQGTSVALLGAYILAGELKAAGDD------YQLGFANYHAE
MAV_1408|M.avium_104 AGYCCSPLSGQGTSVALLGAYILAGELKAAGED------HEAGFANYHRE
MAB_2678|M.abscessus_ATCC_1997 AGYCPGPAVGGSTSLAVVGAYVLAGEIAAAAGD------HARAYPAYEAA
Mb0590c|M.bovis_AF2122/97 AAGCISLLGGEGTGLAITEAYVLAGELARAGGD------HRRAFDAYEKR
MSMEG_3318|M.smegmatis_MC2_155 AAYAPAFLSGQGTSLAVAGAYVLASELVRHDQP-------EKAFSAYEHR
Mflv_2621|M.gilvum_PYR-GCK AAHPMRPHLGQGGCQGIEDAAILARFLELADDVP-------TAFERFEAF
Mvan_5278|M.vanbaalenii_PYR-1 AAHNTTPDIGQGGCSAMEDAIALQWAFKDHPDD------VHAALAAYQSA
TH_1880|M.thermoresistible__bu AAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGG----WAPDGLLDTYHAE
*. * . .: * * : :.
MMAR_2185|M.marinum_M LRPYVANCQDLPNSIDRFLPMSES--------EIRSNAAAMKYMQRWPFR
MUL_1770|M.ulcerans_Agy99 LRPYVANCQDLPNSIDRFLPMSES--------EIRSNAAAMKYMQRWPFR
Rv1260|M.tuberculosis_H37Rv FHGFVERNQWLVSDN-----IPG----------GAPIP-------QEEFE
MAV_1408|M.avium_104 FADYVQRNQWLVVDN-----IPG----------GAPIP-------QEVFE
MAB_2678|M.abscessus_ATCC_1997 LREYVEVSRKLALTASGTL-VPKSRLGLCTLVHGARILGHLPSSLTRSLS
Mb0590c|M.bovis_AF2122/97 LRPFIEGKQASAAKFIWFFRHPN---------PIRPVVSQR----CDAHD
MSMEG_3318|M.smegmatis_MC2_155 MRHFVVRNQNLALRTDGTVLSRTRG----QLLRRNIVVAMTPWLHRVGLD
Mflv_2621|M.gilvum_PYR-GCK RKPRVGMLVREAQTLGRIVNVRPAVLSG---LAGRATALIPERMVTAHLA
Mvan_5278|M.vanbaalenii_PYR-1 RTERAADLVLRARKRCDVTHAKDPQ------VTSRWYDELRNEDGTNIIR
TH_1880|M.thermoresistible__bu RHPVAADVLNNTRAQMELMSPEPGPRAVRWLLAELMDFEEVNRYLTEKIT
MMAR_2185|M.marinum_M FFAERKWFTIAESIELPRYPRLP---------------------------
MUL_1770|M.ulcerans_Agy99 FFAERKWFTIAESIELPRYPRLP---------------------------
Rv1260|M.tuberculosis_H37Rv RIVHS--------ITIKDY-------------------------------
MAV_1408|M.avium_104 RIVAS--------ITLKDY-------------------------------
MAB_2678|M.abscessus_ATCC_1997 RLVAARRINIHDTFALRDYQGLISR-------------------------
Mb0590c|M.bovis_AF2122/97 ELRPAG-------DAVRRQRA-----------------------------
MSMEG_3318|M.smegmatis_MC2_155 RLLRTERREATTDLSLPDNDLRRSPSRQT---------------------
Mflv_2621|M.gilvum_PYR-GCK WIAAGSAFVLPTAADLAR--------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 GIVGNIVGGPLTPVTAATEG------------------------------
TH_1880|M.thermoresistible__bu AIGVRYHTMGDGHGLLGRRMRDIPLTGGRLYARMHAGRGVLLDRTGTLSV
:
MMAR_2185|M.marinum_M --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MAB_2678|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3318|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1880|M.thermoresistible__bu SGWADRVDHIVDPGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRW
MMAR_2185|M.marinum_M -----
MUL_1770|M.ulcerans_Agy99 -----
Rv1260|M.tuberculosis_H37Rv -----
MAV_1408|M.avium_104 -----
MAB_2678|M.abscessus_ATCC_1997 -----
Mb0590c|M.bovis_AF2122/97 -----
MSMEG_3318|M.smegmatis_MC2_155 -----
Mflv_2621|M.gilvum_PYR-GCK -----
Mvan_5278|M.vanbaalenii_PYR-1 -----
TH_1880|M.thermoresistible__bu FGAPA