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MRVLISGASIAGPVLAFWLAHYGFEVTVIERSPAPRKSGGHAVDLFKPAMDIIEMMGILDHVEAQSAGTE VLSIHREGKRLIDLPEVLIFSAVSERHVEIMRDDLSEILYGASAPSAEYIFGDSITALTDDGAGVRVAFD RASDRRFDLVIGADGLHSHVRGLVFGPESGYSHWLGQYLAVASIPNYLDLSDRALMYPQVDKIAGMYSAA QLSDARAFFLFRTPEPLDYHHRDVGRQKALLGEVYADVGWELPRMLAEVDATDTFYMDSITQLRMDTWSK GRITLVGDAGYCPGPAVGGSTSLAVVGAYVLAGEIAAAAGDHARAYPAYEAALREYVEVSRKLALTASGT LVPKSRLGLCTLVHGARILGHLPSSLTRSLSRLVAARRINIHDTFALRDYQGLISR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2678 | - | - | 100% (406) | hypothetical protein MAB_2678 |
| M. abscessus ATCC 19977 | MAB_0649c | - | 7e-66 | 36.95% (406) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_1431 | - | 1e-56 | 36.93% (352) | hypothetical protein MAB_1431 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 1e-59 | 39.88% (341) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 6e-15 | 26.19% (336) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 1e-73 | 43.82% (340) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4675 | - | 1e-119 | 53.62% (401) | membrane-associated oxidoreductase |
| M. avium 104 | MAV_0984 | - | 1e-117 | 54.32% (405) | hypothetical protein MAV_0984 |
| M. smegmatis MC2 155 | MSMEG_5719 | - | 1e-107 | 52.01% (398) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1880 | - | 8e-09 | 24.48% (335) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_0294 | - | 1e-115 | 52.12% (401) | membrane-associated oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 7e-15 | 27.71% (314) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4675|M.marinum_M -MR-ILISGASISGPVLAYWLSRYGFDVTVVERAPQLRKAGGHAVDLFRP
MUL_0294|M.ulcerans_Agy99 -MR-ILLSGASISGSVLAFWLSRYGFDVTVVERAPQLRKAGGHAVDLFRP
MAV_0984|M.avium_104 -MR-ILISGASIAGPVLAYWLTRYGFEVTVVERAPTLRKTGGHAVDLFRP
MSMEG_5719|M.smegmatis_MC2_155 -MK-VLISGASIAGPVLAYWLSRHGFEVTVVERSPVLRKTGGHAVDLFRP
MAB_2678|M.abscessus_ATCC_1997 -MR-VLISGASIAGPVLAFWLAHYGFEVTVIERSPAPRKSGGHAVDLFKP
Rv1260|M.tuberculosis_H37Rv -MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLR-PGGQAIDVRGP
Mb0590c|M.bovis_AF2122/97 -MK-VAISGAGVAGAALAHWLQRTGHTPTVIERAPKFR-TGGYMIDFWGV
Mflv_2621|M.gilvum_PYR-GCK MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG--AGSGISLWPN
Mvan_3960|M.vanbaalenii_PYR-1 MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLT--SGAGISIWPN
TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPP-AHVRSLGLHVR
: *.. :* * * * ::*: . :..
MMAR_4675|M.marinum_M SMEISAKMGVLSKIEALATGTETLTWY-REGAQRPVRVNLAKIFSATSDH
MUL_0294|M.ulcerans_Agy99 SMEISAKMGVLSKIEALATGTEILTWY-REGARRPVRVNLAKIFGATSDQ
MAV_0984|M.avium_104 AMEISAKMGVLPRIEDLATGTTRLTLY-REGRPQPSRIDLTKIYAASSDR
MSMEG_5719|M.smegmatis_MC2_155 AMEISERMGVLPEIEAHATGTTSMVVH-RPGTSRPARLDYLKVVGVISDR
MAB_2678|M.abscessus_ATCC_1997 AMDIIEMMGILDHVEAQSAGTEVLSIH-REG-KRLIDLPEVLIFSAVSER
Rv1260|M.tuberculosis_H37Rv ALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSP
Mb0590c|M.bovis_AF2122/97 GYQVAKRMGITDQIAAAGYHMEHVRSVGPTG-KVKADLGVDVFRRMVGDD
Mflv_2621|M.gilvum_PYR-GCK ALAALDQIGLGDSVRDAGGRVTAGAIRWRDG-TWVRRPSVRRIVDALGEP
Mvan_3960|M.vanbaalenii_PYR-1 ALAALDQIGLGDNVRQAGGRVTAGAIRWRDG-TWLRRPSAQRIVHALGEP
TH_1880|M.thermoresistible__bu SIEMLDQRGLLDRFLAHGQRHPVGGFFAAIAKPPAELDTAHGYVLGIRQP
. *: . .
MMAR_4675|M.marinum_M HVEIMRDDLSEIYYEASRNDAEYLFGDSITAISPDGR---VSFEHAAPRC
MUL_0294|M.ulcerans_Agy99 HVEIMRDDLSEIYYEASRHDTEYLFGDSITAISPDGR---VSFEQAAPRC
MAV_0984|M.avium_104 HVEIMRDDLSEVYYDAARDDVEYLFGDSITAIEPDGT---VTFEHCAPRT
MSMEG_5719|M.smegmatis_MC2_155 HIEIMRDDLSEIYFRAGRDDVEYLFGDTITSISPDGD---VTFEHHPPRR
MAB_2678|M.abscessus_ATCC_1997 HVEIMRDDLSEILYGASAPSAEYIFGDSITALTDDGAGVRVAFDRASDRR
Rv1260|M.tuberculosis_H37Rv DIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAARE
Mb0590c|M.bovis_AF2122/97 FTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTFERTAPRD
Mflv_2621|M.gilvum_PYR-GCK LVVVRRSRLTDILREALP-AGTVRTGLAATRVSVGASSVRITLSDGEVRE
Mvan_3960|M.vanbaalenii_PYR-1 LVVVRRSALTEILLDALP-PDTVQTGLSATALSIAAATARVTLSDGRTRE
TH_1880|M.thermoresistible__bu VTDRLLAEWAAER------GAVIRRGCAVVGLDQDAAGITVELADGSVQR
. : : : : :
MMAR_4675|M.marinum_M FDIVVGADGLHSNVRRLVFGEDAGHTQFLGGYLAVVSVPKGLAHDGEMVG
MUL_0294|M.ulcerans_Agy99 FDIVVGADGLHSNVRRLVFGEDAGHTQFLGGYLAVVSVPKGLAHDGEMVG
MAV_0984|M.avium_104 FDVVVGADGLHSNVRRLTFGDEAGLTRFLGGYLSVVSAPKTLVGPGEMVG
MSMEG_5719|M.smegmatis_MC2_155 FDVVVGADGLHSGVRRLVFGDNVSEN-FLAGYLSVVSVPKSLARDGEMTS
MAB_2678|M.abscessus_ATCC_1997 FDLVIGADGLHSHVRGLVFGPESGYSHWLGQYLAVASIPNYLDLSDRALM
Rv1260|M.tuberculosis_H37Rv FDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTW
Mb0590c|M.bovis_AF2122/97 FDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGYRPRD--ERS
Mflv_2621|M.gilvum_PYR-GCK SDAVVGADGVNSVLARTLNGPLRTRYVGYTAWRGIAAHP--------LDP
Mvan_3960|M.vanbaalenii_PYR-1 ADAVVGADGVNSMVARALNGPLPSRYVGYTAWRGVAAYR--------LDP
TH_1880|M.thermoresistible__bu ARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLS----ADPATVA
::*.** .* : .
MMAR_4675|M.marinum_M HVGPGRMAAVYTAAPLDDARLLFLFRTQEELQYHYRDVLRQKELLREAIA
MUL_0294|M.ulcerans_Agy99 HVGPGRMAAFYTAAPLDDAHLLFLFRTQEELRYHYRDVLRQKELLREAIA
MAV_0984|M.avium_104 HVGVGRFAGIYTADHLDDARAVFLFRSAAELAYDHRDTARQKELLREAFA
MSMEG_5719|M.smegmatis_MC2_155 FLKPGHMAAVYTADHLEDARAVFIFRPSRPLDYDHRDVERQKAQLRAAFE
MAB_2678|M.abscessus_ATCC_1997 YPQVDKIAGMYSAAQLSDARAFFLFRTPEPLDYHHRDVGRQKALLGEVYA
Rv1260|M.tuberculosis_H37Rv HYGDSTMAGVYSARNNTEARAALAFMDT-ELRIDYRDTEAQFAELQRRMA
Mb0590c|M.bovis_AF2122/97 YVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPG---VAPKDELRDQFG
Mflv_2621|M.gilvum_PYR-GCK ELGGETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAPGGEHAYLTAKVA
Mvan_3960|M.vanbaalenii_PYR-1 ALAGETMSAGTEVGHVPLGPDHTYWFATERTREGSRSAGGEHAYLTAKLA
TH_1880|M.thermoresistible__bu AVVAEVRKTQLRFGAMPLGDGVYRVIVPAEGVAGDRAEPTLDEFRRRLKA
MMAR_4675|M.marinum_M GMHPQVDLWLEELDRTPAFYFDSITQLQLDTWSRGRVTLVGDAGYCPGPA
MUL_0294|M.ulcerans_Agy99 GIHPQVDLWLEELDRTPAFYFDSITQLQLDTWSRGRVTLVGDAGYCPGPA
MAV_0984|M.avium_104 GMHDEVDGWLAETERTPTFYFDSITQLRTDRWSRRRVTLVGDAGYCPGPA
MSMEG_5719|M.smegmatis_MC2_155 HIAPEVDRWLDEVPRTPAFYFDAITQLEMTTWSRGRVTLVGDAGYCPGPA
MAB_2678|M.abscessus_ATCC_1997 DVGWELPRMLAEVDATDTFYMDSITQLRMDTWSKGRITLVGDAGYCPGPA
Rv1260|M.tuberculosis_H37Rv EDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALVGDAGYCCSPL
Mb0590c|M.bovis_AF2122/97 DVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLIGDAAGCISLL
Mflv_2621|M.gilvum_PYR-GCK DWADPIPRLVATTDPGDLLRNDLYDRARAARWSDGRAVLIGDAAHPMRPH
Mvan_3960|M.vanbaalenii_PYR-1 GWADPIPALLASTDPADVLRNDLYDRAQPRDWSRGPAVIVGDAAHPMRPH
TH_1880|M.thermoresistible__bu FAGTDFG-----AHTPRWLSRFGDATRLAERYRAGRVFLAGDAAHVHPPA
: : : ***.
MMAR_4675|M.marinum_M VGGSTSLSVLGAYILAGELAQAGGDYARA--FAAYEREMADPVSRSRAFA
MUL_0294|M.ulcerans_Agy99 VGGSTSLSVLGACILAGEPAQAGGDYARA--FAAYEREMADPVSRSHTFA
MAV_0984|M.avium_104 VGGSTSLAVLGAYVLAGELARADGDHLRA--FAAYELQMRESVRRSRSFA
MSMEG_5719|M.smegmatis_MC2_155 VGGSTSLAVYGAYVLAAEMVRAGEDYPAA--FDAYERTMLAPVVGSRKLA
MAB_2678|M.abscessus_ATCC_1997 VGGSTSLAVVGAYVLAGEIAAAAGDHARA--YPAYEAALREYVEVSRKLA
Rv1260|M.tuberculosis_H37Rv SGQGTSVALLGAYILAGELKAAGDDYQLG--FANYHAEFHGFVERNQWLV
Mb0590c|M.bovis_AF2122/97 GGEGTGLAITEAYVLAGELARAGGDHRRA--FDAYEKRLRPFIEGKQASA
Mflv_2621|M.gilvum_PYR-GCK LGQGGCQGIEDAAILA-RFLELADDVPTA--FERFEAFRKPRVGMLVREA
Mvan_3960|M.vanbaalenii_PYR-1 LGQGGCQGLEDAAILA-RFVGLSPDLPAA--FDRFGAFRRRRVRPLVRES
TH_1880|M.thermoresistible__bu GGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYHAERHPVAADVLNNT
* . .: * *. . . :
MMAR_4675|M.marinum_M SGVAVSLIPRSKAGVWALTHGAQLVSMLPGGLTKAVAKLNTKG-VRLYDS
MUL_0294|M.ulcerans_Agy99 SGVAVSLIPRSKAGVWALTHGAQLVSMLPGGLTKAVAKLNTKG-VRLYDS
MAV_0984|M.avium_104 RAAARGVIPGSRAGVWALTRGAQLVSAMPTSLARALAKLNTKG-VRMHDS
MSMEG_5719|M.smegmatis_MC2_155 RFNAKTVVPASGLGIRALVGVGQLISVLPVGLTRSLARLNDKG-VRLYDT
MAB_2678|M.abscessus_ATCC_1997 LTASGTLVPKSRLGLCTLVHGARILGHLPSSLTRSLSRLVAARRINIHDT
Rv1260|M.tuberculosis_H37Rv SDN----IPGG-------------------------APIPQEEFERIVHS
Mb0590c|M.bovis_AF2122/97 AKFIWFFRHPN-----------------------PIRPVVSQRCDAHDEL
Mflv_2621|M.gilvum_PYR-GCK QTLGRIVNVRPAVLSG--------LAGRATALIPERMVTAHLAWIAAGSA
Mvan_3960|M.vanbaalenii_PYR-1 AAIGRIVNLRPAFLSG--------VASRASALIPEWAVASHLASIAAGSA
TH_1880|M.thermoresistible__bu RAQMELMSPEPGPRAVRWLLAELMDFEEVNRYLTEKITAIGVRYHTMGDG
MMAR_4675|M.marinum_M MRFKEYAPPRPG--------------------------------------
MUL_0294|M.ulcerans_Agy99 MRFKEYAPPRPG--------------------------------------
MAV_0984|M.avium_104 MPVPDYAGSDV---------------------------------------
MSMEG_5719|M.smegmatis_MC2_155 MPLPQWPARLNG--------------------------------------
MAB_2678|M.abscessus_ATCC_1997 FALRDYQGLISR--------------------------------------
Rv1260|M.tuberculosis_H37Rv ITIKDY--------------------------------------------
Mb0590c|M.bovis_AF2122/97 RPAGDAVRRQRA--------------------------------------
Mflv_2621|M.gilvum_PYR-GCK FVLPTAADLAR---------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 FILPTAGDVGG---------------------------------------
TH_1880|M.thermoresistible__bu HGLLGRRMRDIPLTGGRLYARMHAGRGVLLDRTGTLSVSGWADRVDHIVD
MMAR_4675|M.marinum_M -------------------------------------------
MUL_0294|M.ulcerans_Agy99 -------------------------------------------
MAV_0984|M.avium_104 -------------------------------------------
MSMEG_5719|M.smegmatis_MC2_155 -------------------------------------------
MAB_2678|M.abscessus_ATCC_1997 -------------------------------------------
Rv1260|M.tuberculosis_H37Rv -------------------------------------------
Mb0590c|M.bovis_AF2122/97 -------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK -------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 -------------------------------------------
TH_1880|M.thermoresistible__bu PGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRWFGAPA