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VKVLISGASIAGPVLAYWLSRHGFEVTVVERSPVLRKTGGHAVDLFRPAMEISERMGVLPEIEAHATGTT SMVVHRPGTSRPARLDYLKVVGVISDRHIEIMRDDLSEIYFRAGRDDVEYLFGDTITSISPDGDVTFEHH PPRRFDVVVGADGLHSGVRRLVFGDNVSENFLAGYLSVVSVPKSLARDGEMTSFLKPGHMAAVYTADHLE DARAVFIFRPSRPLDYDHRDVERQKAQLRAAFEHIAPEVDRWLDEVPRTPAFYFDAITQLEMTTWSRGRV TLVGDAGYCPGPAVGGSTSLAVYGAYVLAAEMVRAGEDYPAAFDAYERTMLAPVVGSRKLARFNAKTVVP ASGLGIRALVGVGQLISVLPVGLTRSLARLNDKGVRLYDTMPLPQWPARLNG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5719 | - | - | 100% (402) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3318 | - | 4e-58 | 39.22% (385) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3039 | - | 1e-47 | 36.21% (406) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 2e-45 | 35.71% (350) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 7e-10 | 24.50% (400) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 7e-64 | 43.20% (331) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2678 | - | 1e-107 | 52.01% (398) | hypothetical protein MAB_2678 |
| M. marinum M | MMAR_4675 | - | 1e-143 | 63.48% (397) | membrane-associated oxidoreductase |
| M. avium 104 | MAV_0984 | - | 1e-143 | 64.23% (397) | hypothetical protein MAV_0984 |
| M. thermoresistible (build 8) | TH_4641 | - | 4e-05 | 26.01% (346) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0294 | - | 1e-137 | 61.96% (397) | membrane-associated oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 7e-15 | 26.04% (338) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4675|M.marinum_M -----MR-ILISGASISGPVLAYWLSRYGFDVTVVERAPQLRKAGGHAVD
MUL_0294|M.ulcerans_Agy99 -----MR-ILLSGASISGSVLAFWLSRYGFDVTVVERAPQLRKAGGHAVD
MAV_0984|M.avium_104 -----MR-ILISGASIAGPVLAYWLTRYGFEVTVVERAPTLRKTGGHAVD
MSMEG_5719|M.smegmatis_MC2_155 -----MK-VLISGASIAGPVLAYWLSRHGFEVTVVERSPVLRKTGGHAVD
MAB_2678|M.abscessus_ATCC_1997 -----MR-VLISGASIAGPVLAFWLAHYGFEVTVIERSPAPRKSGGHAVD
Rv1260|M.tuberculosis_H37Rv -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLR-PGGQAID
Mb0590c|M.bovis_AF2122/97 -----MK-VAISGAGVAGAALAHWLQRTGHTPTVIERAPKFR-TGGYMID
Mflv_2621|M.gilvum_PYR-GCK ----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG--AGSGIS
Mvan_5278|M.vanbaalenii_PYR-1 -----MK-VVIVGAGMGGMSAAIALRQIGIDTVVYERVTENK-PVGAAIS
TH_4641|M.thermoresistible__bu MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPA-TTSRANF
: : **. * * * * : :: . .
MMAR_4675|M.marinum_M LFRPSMEISAKMGVLSKIEALATGTETLTWY-REGAQRPVRVNLAKIFSA
MUL_0294|M.ulcerans_Agy99 LFRPSMEISAKMGVLSKIEALATGTEILTWY-REGARRPVRVNLAKIFGA
MAV_0984|M.avium_104 LFRPAMEISAKMGVLPRIEDLATGTTRLTLY-REGRPQPSRIDLTKIYAA
MSMEG_5719|M.smegmatis_MC2_155 LFRPAMEISERMGVLPEIEAHATGTTSMVVH-RPGTSRPARLDYLKVVGV
MAB_2678|M.abscessus_ATCC_1997 LFKPAMDIIEMMGILDHVEAQSAGTEVLSIH-REGK-RLIDLPEVLIFSA
Rv1260|M.tuberculosis_H37Rv VRGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGP
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGK-VKADLGVDVFRRM
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGT-WVRRPSVRRIVDA
Mvan_5278|M.vanbaalenii_PYR-1 VWSNGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMHPLIEQ
TH_4641|M.thermoresistible__bu LHARGSEVLDRLGALGGLPERS--VRAMQITTHLGGEPVMRMQFGDPGMR
. . :*
MMAR_4675|M.marinum_M TSDHHVEIMRDDLSEIYY-EASRNDAEYLFGDSITAIS--PDGR---VSF
MUL_0294|M.ulcerans_Agy99 TSDQHVEIMRDDLSEIYY-EASRHDTEYLFGDSITAIS--PDGR---VSF
MAV_0984|M.avium_104 SSDRHVEIMRDDLSEVYY-DAARDDVEYLFGDSITAIE--PDGT---VTF
MSMEG_5719|M.smegmatis_MC2_155 ISDRHIEIMRDDLSEIYF-RAGRDDVEYLFGDTITSIS--PDGD---VTF
MAB_2678|M.abscessus_ATCC_1997 VSERHVEIMRDDLSEILY-GASAPSAEYIFGDSITALT--DDGAGVRVAF
Rv1260|M.tuberculosis_H37Rv VNSPDIELLRDDLVELLY-GATQPSVEYLFDDSISTLQ--DDGDSVRVTF
Mb0590c|M.bovis_AF2122/97 VGDDFTSLPRGDLAAAIY-TTIEDQVETIFDDSIATID--EHRDGVRLTF
Mflv_2621|M.gilvum_PYR-GCK LGEPLVVVRRSRLTDILR-EALP-AGTVRTGLAATRVS--VGASSVRITL
Mvan_5278|M.vanbaalenii_PYR-1 VGQRPYPIARAELQLMLM-KAYG-IDDINFGMKMVGVENDTAGSAAKATF
TH_4641|M.thermoresistible__bu TAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLR--QDASTVTAGI
: : : . : :
MMAR_4675|M.marinum_M EHAAPRCFDIVVGADGLHSNVRR---------------------LVFG-E
MUL_0294|M.ulcerans_Agy99 EQAAPRCFDIVVGADGLHSNVRR---------------------LVFG-E
MAV_0984|M.avium_104 EHCAPRTFDVVVGADGLHSNVRR---------------------LTFG-D
MSMEG_5719|M.smegmatis_MC2_155 EHHPPRRFDVVVGADGLHSGVRR---------------------LVFG-D
MAB_2678|M.abscessus_ATCC_1997 DRASDRRFDLVIGADGLHSHVRG---------------------LVFG-P
Rv1260|M.tuberculosis_H37Rv ERAAAREFDLVIGADGLHSNVRR---------------------LVFG-P
Mb0590c|M.bovis_AF2122/97 ERTAPRDFDLVIGADGLHSNVRR---------------------LVFG-P
Mflv_2621|M.gilvum_PYR-GCK SDGEVRESDAVVGADGVNSVLAR---------------------TLNG-P
Mvan_5278|M.vanbaalenii_PYR-1 ADGTTVSADVIIGADGAGSITRE---------------------YVLGGP
TH_4641|M.thermoresistible__bu GGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYLDWRLD
::*.** *
MMAR_4675|M.marinum_M DAGHTQFLGGYLAVVSVPKGLAHDGEMVGHVGPGRMAAVYTAAPLDDARL
MUL_0294|M.ulcerans_Agy99 DAGHTQFLGGYLAVVSVPKGLAHDGEMVGHVGPGRMAAFYTAAPLDDAHL
MAV_0984|M.avium_104 EAGLTRFLGGYLSVVSAPKTLVGPGEMVGHVGVGRFAGIYTADHLDDARA
MSMEG_5719|M.smegmatis_MC2_155 NVSEN-FLAGYLSVVSVPKSLARDGEMTSFLKPGHMAAVYTADHLEDARA
MAB_2678|M.abscessus_ATCC_1997 ESGYSHWLGQYLAVASIPNYLDLSDRALMYPQVDKIAGMYSAAQLSDARA
Rv1260|M.tuberculosis_H37Rv EEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEARA
Mb0590c|M.bovis_AF2122/97 ERDFEHYLGCKVAACVVDGYRPRD--ERSYVLYNTVDRQLARFALRGDRT
Mflv_2621|M.gilvum_PYR-GCK LRTRYVGYTAWRGIAAHP--------LDPELGGETLGPGTQVGHVPLGPD
Mvan_5278|M.vanbaalenii_PYR-1 VSRRYAGYVNYNGLVSTDDAIGPATEWTTYVGDGKRVSVMPVSDDR----
TH_4641|M.thermoresistible__bu RSGTTGWIHPDGMVGAMPMPDGLWRIIAYDPGPGDLDQGALERLLYERTG
MMAR_4675|M.marinum_M LFLFRTQEELQYHYRDVLRQKELLR---------EAIAGMHPQVDLWLEE
MUL_0294|M.ulcerans_Agy99 LFLFRTQEELRYHYRDVLRQKELLR---------EAIAGIHPQVDLWLEE
MAV_0984|M.avium_104 VFLFRSAAELAYDHRDTARQKELLR---------EAFAGMHDEVDGWLAE
MSMEG_5719|M.smegmatis_MC2_155 VFIFRPSRPLDYDHRDVERQKAQLR---------AAFEHIAPEVDRWLDE
MAB_2678|M.abscessus_ATCC_1997 FFLFRTPEPLDYHHRDVGRQKALLG---------EVYADVGWELPRMLAE
Rv1260|M.tuberculosis_H37Rv ALAFMDT-ELRIDYRDTEAQFAELQ---------RRMAEDGWVRAQLLHY
Mb0590c|M.bovis_AF2122/97 MFLFVFRAEHDNPG---VAPKDELR---------DQFGDVGWESRDILAA
Mflv_2621|M.gilvum_PYR-GCK HTYWFATERTAEGGSAPGGEHAYLT---------AKVADWADPIPRLVAT
Mvan_5278|M.vanbaalenii_PYR-1 FYFFFDVVEPQGSPYEEGRVREVLR---------AHFAGWTPGVQTLIDT
TH_4641|M.thermoresistible__bu HRVKVTGTVWQSEFRVHRRLADTYRRGRVFIAGDAAHAHAPFGGQGMLTG
:
MMAR_4675|M.marinum_M LDRTPAFYFDSITQLQ-------LDTWSRGR----VTLVGDAGYCPGPAV
MUL_0294|M.ulcerans_Agy99 LDRTPAFYFDSITQLQ-------LDTWSRGR----VTLVGDAGYCPGPAV
MAV_0984|M.avium_104 TERTPTFYFDSITQLR-------TDRWSRRR----VTLVGDAGYCPGPAV
MSMEG_5719|M.smegmatis_MC2_155 VPRTPAFYFDAITQLE-------MTTWSRGR----VTLVGDAGYCPGPAV
MAB_2678|M.abscessus_ATCC_1997 VDATDTFYMDSITQLR-------MDTWSKGR----ITLVGDAGYCPGPAV
Rv1260|M.tuberculosis_H37Rv MRSAPDFYFDEMSQIL-------MDRWSRGR----VALVGDAGYCCSPLS
Mb0590c|M.bovis_AF2122/97 LDDVEDLYFDVVSQIR-------MDRWSRGR----VLLIGDAAGCISLLG
Mflv_2621|M.gilvum_PYR-GCK TDPGDLLRNDLYDRAR-------AARWSDGR----AVLIGDAAHPMRPHL
Mvan_5278|M.vanbaalenii_PYR-1 LDPLATNRVEILDLDP-------FHTWVKGR----VAVLGDAAHNTTPDI
TH_4641|M.thermoresistible__bu LGDAENLAFKLALVIRGYAGPALLDTYEAERRPLATEVLRNTSAATKLNI
. : * :: ::.
MMAR_4675|M.marinum_M GGSTS------LSVLGAYILAGELAQAGGDYARAFAAYEREMADPVSRSR
MUL_0294|M.ulcerans_Agy99 GGSTS------LSVLGACILAGEPAQAGGDYARAFAAYEREMADPVSRSH
MAV_0984|M.avium_104 GGSTS------LAVLGAYVLAGELARADGDHLRAFAAYELQMRESVRRSR
MSMEG_5719|M.smegmatis_MC2_155 GGSTS------LAVYGAYVLAAEMVRAGEDYPAAFDAYERTMLAPVVGSR
MAB_2678|M.abscessus_ATCC_1997 GGSTS------LAVVGAYVLAGEIAAAAGDHARAYPAYEAALREYVEVSR
Rv1260|M.tuberculosis_H37Rv GQGTS------VALLGAYILAGELKAAGDDYQLGFANYHAEFHGFVERNQ
Mb0590c|M.bovis_AF2122/97 GEGTG------LAITEAYVLAGELARAGGDHRRAFDAYEKRLRPFIEGKQ
Mflv_2621|M.gilvum_PYR-GCK GQGGC------QGIEDAAILARFLELAD-DVPTAFERFEAFRKPRVGMLV
Mvan_5278|M.vanbaalenii_PYR-1 GQGGC------SAMEDAIALQWAFKDHPDDVHAALAAYQSARTERAADLV
TH_4641|M.thermoresistible__bu ADRGVGRFLRDRVVLPLLALPSVQRRLTYQTSQLWVTYRGGPLAPRTVSM
. : * : :.
MMAR_4675|M.marinum_M AFASGVAVSLIPRSKAGVWALTHGAQLVSMLPGGLTKAVAKLNTKG-VRL
MUL_0294|M.ulcerans_Agy99 TFASGVAVSLIPRSKAGVWALTHGAQLVSMLPGGLTKAVAKLNTKG-VRL
MAV_0984|M.avium_104 SFARAAARGVIPGSRAGVWALTRGAQLVSAMPTSLARALAKLNTKG-VRM
MSMEG_5719|M.smegmatis_MC2_155 KLARFNAKTVVPASGLGIRALVGVGQLISVLPVGLTRSLARLNDKG-VRL
MAB_2678|M.abscessus_ATCC_1997 KLALTASGTLVPKSRLGLCTLVHGARILGHLPSSLTRSLSRLVAARRINI
Rv1260|M.tuberculosis_H37Rv WLVSDN----IPGG-------------------------APIPQEEFERI
Mb0590c|M.bovis_AF2122/97 ASAAKFIWFFRHPN-----------------------PIRPVVSQRCDAH
Mflv_2621|M.gilvum_PYR-GCK REAQTLGRIVNVRPAVLSG--------LAGRATALIPERMVTAHLAWIAA
Mvan_5278|M.vanbaalenii_PYR-1 LRARKRCDVTHAKDP----------QVTSRWYDELRNEDGTNIIRGIVGN
TH_4641|M.thermoresistible__bu TTPRPGDRVPDQRCVRDDGHISRLYEQLGGRWAVLEPGSGRHHREGPGLL
MMAR_4675|M.marinum_M YDSMRFK-EYAPPRPG----------------------------------
MUL_0294|M.ulcerans_Agy99 YDSMRFK-EYAPPRPG----------------------------------
MAV_0984|M.avium_104 HDSMPVP-DYAGSDV-----------------------------------
MSMEG_5719|M.smegmatis_MC2_155 YDTMPLP-QWPARLNG----------------------------------
MAB_2678|M.abscessus_ATCC_1997 HDTFALR-DYQGLISR----------------------------------
Rv1260|M.tuberculosis_H37Rv VHSITIK-DY----------------------------------------
Mb0590c|M.bovis_AF2122/97 DELRPAG-DAVRRQRA----------------------------------
Mflv_2621|M.gilvum_PYR-GCK GSAFVLP-TAADLAR-----------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 IVGGPLT-PVTAATEG----------------------------------
TH_4641|M.thermoresistible__bu GTAHTFLGEYVVGLRGAEMRGCDAFLVRPDGHLAWRGRDATDLADWLKSA
MMAR_4675|M.marinum_M -------
MUL_0294|M.ulcerans_Agy99 -------
MAV_0984|M.avium_104 -------
MSMEG_5719|M.smegmatis_MC2_155 -------
MAB_2678|M.abscessus_ATCC_1997 -------
Rv1260|M.tuberculosis_H37Rv -------
Mb0590c|M.bovis_AF2122/97 -------
Mflv_2621|M.gilvum_PYR-GCK -------
Mvan_5278|M.vanbaalenii_PYR-1 -------
TH_4641|M.thermoresistible__bu LTVGRVR