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MSLHTAVSLPGSAPHPDVITDLLGRISADHRRRLDDGGHEPPSLGVELVKAHRVGAAPLDRDLGGWGLST EEFFDLVMALGEADPDLAHILRVHFSVVEELQRAPRRPNAERWIAVVADGGLIGGVTSEQSTNQVGGQTY DTRLIRTDDGRLILRGRKYYSTGAQYSDHLRVSAQGDDGAPVGAIIPADRVGVVHTDDWDGIGQRHTGSG TTVLDDVVVHDDELFPLGTKVGVDRPRGALLQLYLHAIAAGILRSLRTDAVALVRGRQRSYTFATEASPT ADPQLLQVVGEIDAVAYAASAVVRSAARELGVALQAARAGGFDHELEHRASVAAARVKVAIEEPALRAAG RIFDVGGASAIRASANLDRHWRNLRTLFSHNPTVYKARVLGDVAVNHAPLPDSSFF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3259 | - | - | 100% (406) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5001 | - | 6e-77 | 41.13% (389) | pesticide degrading monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4084 | - | 1e-71 | 41.94% (372) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3121c | - | 2e-09 | 27.16% (243) | hypothetical protein Mb3121c |
| M. gilvum PYR-GCK | Mflv_4548 | - | 1e-08 | 24.79% (359) | acyl-CoA dehydrogenase type 2 |
| M. tuberculosis H37Rv | Rv3094c | - | 2e-09 | 27.16% (243) | hypothetical protein Rv3094c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1422c | - | 1e-74 | 40.91% (396) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1556 | - | 2e-07 | 24.58% (240) | dehydrogenase |
| M. avium 104 | MAV_3422 | - | 1e-153 | 69.59% (388) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3393 | - | 2e-38 | 33.53% (337) | PUTATIVE Acyl-CoA dehydrogenase, type 2, C-terminal domain |
| M. ulcerans Agy99 | MUL_3474 | - | 3e-05 | 23.14% (242) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 9e-31 | 29.64% (361) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3259|M.smegmatis_MC2_155 ----------MSLHTAVSLPGSAPHPDVITDLLGRISADHRRR--LDDGG
MAV_3422|M.avium_104 ------------MPVAFHRQDTPAGAAAVQPVLAEIAADYRLR--LADGG
MAB_1422c|M.abscessus_ATCC_199 ----------MTSAPSVLEIRALPGTDTYRNLLAQVAEGARDRD-LDD--
TH_3393|M.thermoresistible__bu ---------VTEPLTMARIVDTAEALAVAARLSGSFAAEASTR----DAE
Mvan_3173|M.vanbaalenii_PYR-1 -----MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAER----ERA
Mb3121c|M.bovis_AF2122/97 -----------MNQ----------SETEIEILAEKIARWARARSAEIERD
Rv3094c|M.tuberculosis_H37Rv -----------MNQ----------SETEIEILAEKIARWARARSAEIERD
MMAR_1556|M.marinum_M -----------MNQPDLSAAPLRRADSEMENLAEKIALTAREMSAEIDRD
MUL_3474|M.ulcerans_Agy99 MTEPPSLPGVLMNQPDLSAAPLRRADSEMEDLAEKIALTAREMSAEIDRD
Mflv_4548|M.gilvum_PYR-GCK ------------------------MSERVLDRLNELAGQFKEQAVEAEKL
.: :
MSMEG_3259|M.smegmatis_MC2_155 HEPPSLGVELVKAHRVGAAPLDRDLGGWGLSTEEFFDLVMALGEADPDLA
MAV_3422|M.avium_104 TEPPLRGLKLVRDHRLGALRLARELGGAGYTAPEFFDYLVALAAADPDLA
MAB_1422c|M.abscessus_ATCC_199 -ENPFDQVRLLKEAGFGRLRIPTELGGAGLSVRQLFSAIIDVAQADPIVA
TH_3393|M.thermoresistible__bu RLLPYEQVCELKRSGLLTLSVPAEHGGLDVPATVLAEVFRLLAHGDPSVA
Mvan_3173|M.vanbaalenii_PYR-1 GAVLTPQLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAVG
Mb3121c|M.bovis_AF2122/97 RRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAG
Rv3094c|M.tuberculosis_H37Rv RRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAG
MMAR_1556|M.marinum_M RRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAG
MUL_3474|M.ulcerans_Agy99 RRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAG
Mflv_4548|M.gilvum_PYR-GCK GKLPDATVKSMKSIGSIRLLQPKKHGGLEVHPREFAETVMATAALDPAAG
: : . . * .
MSMEG_3259|M.smegmatis_MC2_155 HILRVHFSVVEELQRAPRRPNAERWIAVVADGGLIGGVTSEQSTNQVGGQ
MAV_3422|M.avium_104 HILRIHYALVEELQVTPRRPGSDRWIAVVAEGGLIGGANAEQSQKSVGGN
MAB_1422c|M.abscessus_ATCC_199 HIFRTHFWFVEERLRTLADPVSAAWLTKVNEGNLFANAFSEKGSLAVGSL
TH_3393|M.thermoresistible__bu QIPHSHFTFLEVLRLQGTERQRGFFYGLVLEGALFANAQSERG--PHPID
Mvan_3173|M.vanbaalenii_PYR-1 QLLLSHFVVAQAISGLGHTQPAPRIYADLLAGAQLGNASAERGT-AHALD
Mb3121c|M.bovis_AF2122/97 WCVSIAITSALLVAYLPARSREEMFGGGR---GVAAGVWAPRGT------
Rv3094c|M.tuberculosis_H37Rv WCVSIAITSALLVAYLPARSREEMFGGGR---GVAAGVWAPRGT------
MMAR_1556|M.marinum_M WCVSIAITSALLVAYLPASSRDEMFGAGR---SVAAGVWAPRGK------
MUL_3474|M.ulcerans_Agy99 WCVSIAITSALLVAYLPASSRDEMFGAGR---SVAAGVWAPRGK------
Mflv_4548|M.gilvum_PYR-GCK WVNGVVGVHPYQLAYADPKVGEEIWADDID--TWVASPYAPQG-------
.. : :.
MSMEG_3259|M.smegmatis_MC2_155 TYDTRLIRTDDGRLILRGRKYYSTGAQYSDHLRVSAQGDDG---------
MAV_3422|M.avium_104 HRDTRLVTTPDG-LRLRGRKFYSTGAQFSDYLRITAQDDDG---------
MAB_1422c|M.abscessus_ATCC_199 VFNTRLLPVGDA-YRLNGEKFYSTGTLFADYLTVTATTDRD---------
TH_3393|M.thermoresistible__bu VDTTVLLRRGAGDYLLTGRKFYSTGALFADWIVVRASVPADAADAPTAAT
Mvan_3173|M.vanbaalenii_PYR-1 RRTTVTRRD--GHWVLNGTKYYATGTLGATWIAVAARIEGRENGD-----
Mb3121c|M.bovis_AF2122/97 ------ARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDR---------
Rv3094c|M.tuberculosis_H37Rv ------ARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDR---------
MMAR_1556|M.marinum_M ------AKSVDGGVVVSGRWPFCSGINHADMMFAGCFVEGQ---------
MUL_3474|M.ulcerans_Agy99 ------AKSVDGGVVVSGRWPFCSGINHADMMFAGCFVEGQ---------
Mflv_4548|M.gilvum_PYR-GCK -----VAVPTDGGYIFTGRWQFSSGTDACDWIILGAMVGDAKGVP---LM
. . * :.:* . : .
MSMEG_3259|M.smegmatis_MC2_155 -APVGAIIPADRVGVVHTDDWDGIGQRHTGSGTTVLDDVVVHDD------
MAV_3422|M.avium_104 -APTAVVIPVDRAGVEHLDDWDGIGQRQTGSGTTVFNDVAVADD------
MAB_1422c|M.abscessus_ATCC_199 -SVASVIVPGDRDGVRLVDDWDGFGQRRTGTGTTIFSQVDVAAD------
TH_3393|M.thermoresistible__bu PKAVAFVPRHAPGLTV-IDDWDGMGQRTTASGSVTLDEVRVPAD------
Mvan_3173|M.vanbaalenii_PYR-1 -TATAFVRPDQEGVTLDLESWSAFGQRGTASGEVRLNNVVVDDD------
Mb3121c|M.bovis_AF2122/97 --QVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPAD------
Rv3094c|M.tuberculosis_H37Rv --QVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPAD------
MMAR_1556|M.marinum_M --PVPSVVALPKDDLRALDTWHTLGLRGTGSHDCVAEEVFVPAD------
MUL_3474|M.ulcerans_Agy99 --PVPSVVALPKDDLRALDTWHTLGLCGTGSHDCVAEEVFVPAD------
Mflv_4548|M.gilvum_PYR-GCK PPQMLHMILPRKDYQIVDDSWDVVGLRGTGSKDVIVDGAFVPTYRTMDGM
: : * .* *.: . . *
MSMEG_3259|M.smegmatis_MC2_155 ELFPLG--TKVGVDRP-----RGALLQLYLHAIAAGILRSLRTDAVALVR
MAV_3422|M.avium_104 EVFPLG--STIGVNRA-----RGALVQLYLHAVAAGILRSLTEDAAALVR
MAB_1422c|M.abscessus_ATCC_199 EILSETPYDAAPVPTT-----QYASLQLYILAIVAGVLRAVVDDGEALLR
TH_3393|M.thermoresistible__bu HVV----PFTPIFRRPTV---YGARAQLWHAALDVGIATAALEEG-VRLA
Mvan_3173|M.vanbaalenii_PYR-1 LLIDEGPPPDPITADPSV---LGAFDQALHAAIDIGIARAALEDGAVFVR
Mb3121c|M.bovis_AF2122/97 RVFSVF--DGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAG
Rv3094c|M.tuberculosis_H37Rv RVFSVF--DGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAG
MMAR_1556|M.marinum_M RVFSVF--DGPSIDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAG
MUL_3474|M.ulcerans_Agy99 RVFSVF--DGPTIDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAG
Mflv_4548|M.gilvum_PYR-GCK KVMDGSAQIEAGMTEPLYKMPWSTMFPLGISSATIGICEGALAAHLDYQR
:. . : * .
MSMEG_3259|M.smegmatis_MC2_155 GRQRS---YTFATEASPTADPQLLQVVGEIDAVAYAASAVVRSAARELGV
MAV_3422|M.avium_104 GRRRT---YTFASADTPTADPQLLQIVGEIDAVAYTAHALVRNAAAELAP
MAB_1422c|M.abscessus_ATCC_199 SRQRN---FSHALTERPVDDPLLQRTLGELSATAFAAEATVLAAADAIEA
TH_3393|M.thermoresistible__bu ARARP---HFESGAPVATDDPTLIQSAGEVAVTVRAAQALLGEAARAVDA
Mvan_3173|M.vanbaalenii_PYR-1 TRSRPWKEALDAGIERADQEPHVVRRFGELTARLYALEALLARGTALIDE
Mb3121c|M.bovis_AF2122/97 GKKGLG--STRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHD
Rv3094c|M.tuberculosis_H37Rv GKKGLG--STRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHD
MMAR_1556|M.marinum_M DKKGLG--AKRTLAERSATQTAVATAEAALGAARALFYEAIDSAWQASHN
MUL_3474|M.ulcerans_Agy99 DKKGLG--AKRTLAERSATQTAVATAEAALGAARALFYEAIDSAWQASHN
Mflv_4548|M.gilvum_PYR-GCK ERVGAN---GTAIKDDPYVMYAIGDAAAEIEASRNTLLSNVDRVYDIVDS
: : . . : . :
MSMEG_3259|M.smegmatis_MC2_155 ALQAARAGGFDHELEHRASVAAARVKVAIEEPALRAAGRIFDVGGASAIR
MAV_3422|M.avium_104 ALQAARDTGIDPELEAAASIAAARVKVAIQEPALRAASRVFDAGGASAVQ
MAB_1422c|M.abscessus_ATCC_199 ATATLRDGVPDAQLAQEAQVAVAKAKVHIDAVALDAATKLLDLGGASAAS
TH_3393|M.thermoresistible__bu ATAD-----LTEDTAAAASIAVATAKVAAERAALRASTALFELGGTRSAT
Mvan_3173|M.vanbaalenii_PYR-1 AYAAP---EVTRDAAAQASLTVAAAKALAQQDAVEIAGAIFELTGTSGTD
Mb3121c|M.bovis_AF2122/97 AE----------AVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIY
Rv3094c|M.tuberculosis_H37Rv AE----------AVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIY
MMAR_1556|M.marinum_M PD----------PVPVALRNRLRLAATHAARTSADVVRIMYDLAGSSAIY
MUL_3474|M.ulcerans_Agy99 PDPVPVPVPVPVPVPVALRNRLRLAATHAARTSADVVRTMYDLAGSSAIY
Mflv_4548|M.gilvum_PYR-GCK GR----------EVTFETRAAVRRSQIKAVWRAVAAVDQIFARSGGNALR
: : * .
MSMEG_3259|M.smegmatis_MC2_155 ASANLDRHWRNLRT---LFSHNPTVYKARVLGDVAVNHAPLPDSSFF-
MAV_3422|M.avium_104 ASALLDRHWRNLRT---LFSHNPTVYKARVLGDVVVNGAALPDTSFF-
MAB_1422c|M.abscessus_ATCC_199 RTRNLDRHWRNIRT---ISLHNPVHYKARVIGQNLLHGTPLPANAYF-
TH_3393|M.thermoresistible__bu VSANLSRFWRDART---HTLHDPTRWKLHHIGRYLLSGTRPPRHGQL-
Mvan_3173|M.vanbaalenii_PYR-1 GAVNLDRHWRNVRV---HSLHDPARWKYVHLGNHTLHDTRPPRLGLIL
Mb3121c|M.bovis_AF2122/97 DNAPLQRRFRDAFT---ATAHFQVNEASRELPGRVLLDQPADVSML--
Rv3094c|M.tuberculosis_H37Rv DNAPLQRRFRDAFT---ATAHFQVNEASRELPGRVLLDQPADVSML--
MMAR_1556|M.marinum_M DGSPLQRRFRDAFT---ATAHFQVNEASRELPGRVLLGQHCDTSML--
MUL_3474|M.ulcerans_Agy99 DGSPLQRRFRDAFT---ATAHFQVNEASRELPGRVLLGQHCDTSML--
Mflv_4548|M.gilvum_PYR-GCK MDKPLQRYWRDAHAGVAHAIHVPGTVYHASALSSLGVDPQGPLRAMI-
*.* :*: . *