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LSRIEEGAFERELNHTSPVDAFAMIQEARLGALRIPADLGGYGIGLVTFFEFLMRLATVDPNVAHALRAH YVFVDERLFEFRRGQERLWLDHIVAGDLFGNANTELTAKQAAGLEPSRFQARLSADGDEYRLNGTKFYST GSLYCQWVVVSAVNDAGAVVRAIVPTNRDGVRIDDDWDGIGQRLTASGTAVFDNVRVYTHEVFIRQAGHV DGYGSPMAQLYLTAVTAGILEAINRDAVTVLRGRTRTFAHGVGSSAKDDPLLQHVVGQLASDAFAGRAVV LEAARALADAAETVMADGVGDKSLLEAAKMACAKAKVTIENLVSRSGWQLFDVAGASATLRTKNLDRHWR NARTIASHNPVLYKTRALGDYLVNGNPLPRGSAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4084 | - | - | 100% (385) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4391 | - | 5e-76 | 40.15% (391) | acyl-CoA dehydrogenase-family protein |
| M. smegmatis MC2 155 | MSMEG_5001 | - | 1e-75 | 40.15% (391) | pesticide degrading monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3601c | - | 6e-09 | 24.42% (389) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5011 | - | 1e-13 | 23.20% (362) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0752c | fadE9 | 4e-09 | 23.55% (361) | acyl-CoA dehydrogenase FADE9 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-09 | 23.19% (345) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1422c | - | 8e-85 | 43.30% (388) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4034 | fadE | 6e-11 | 22.35% (349) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_3422 | - | 1e-72 | 41.03% (368) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3721 | - | 3e-44 | 36.71% (286) | PUTATIVE putative acyl-CoA dehydrogenase family protein |
| M. ulcerans Agy99 | MUL_4141 | - | 8e-09 | 24.62% (390) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 2e-29 | 29.40% (398) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3601c|M.bovis_AF2122/97 ---------MTSIQQRDAQSVLAAIDDLLPEIRDRAQATEDL--RRLPDE
MUL_4141|M.ulcerans_Agy99 ---------MTTIQQRDAQSVLAAIDDLLPQLRERAQATEDL--RRLPDE
MSMEG_4084|M.smegmatis_MC2_155 ---------------------------MLSRIEEGAFERELN--HTSPVD
MAB_1422c|M.abscessus_ATCC_199 ------MTSAPSVLEIRALPGTDTYRNLLAQVAEGARDRDLD--DENPFD
MAV_3422|M.avium_104 --------MPVAFHRQDTPAGAAAVQPVLAEIAADYRLRLADGGTEPPLR
TH_3721|M.thermoresistible__bu ---------VPYFDEQRFEALAAEFRPVFDRIRAGAVQRERD--RELPFE
Mflv_5011|M.gilvum_PYR-GCK ---------MDYFGLDDDDRVIAETAAAFAEKRLAPHALEWDETHHFPVD
Rv0752c|M.tuberculosis_H37Rv -----------MFVLNDDERVIVETAAAFAGKRLAPHALEWDAAKHFPVD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MMAR_4034|M.marinum_M --------MTAPQVSDEDFAQILAQTRHFVRSVVLPREQQILDEDRVPED
Mvan_3173|M.vanbaalenii_PYR-1 -MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAERERAG--AVLTP
Mb3601c|M.bovis_AF2122/97 TVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIV
MUL_4141|M.ulcerans_Agy99 TVQALEDVGFFTLLQPEQWGGLQCDPTLFYEATRRLASACGSTGWVSSII
MSMEG_4084|M.smegmatis_MC2_155 AFAMIQEARLGALRIPADLGGYGIGLVTFFEFLMRLATVDPNVAHALRAH
MAB_1422c|M.abscessus_ATCC_199 QVRLLKEAGFGRLRIPTELGGAGLSVRQLFSAIIDVAQADPIVAHIFRTH
MAV_3422|M.avium_104 GLKLVRDHRLGALRLARELGGAGYTAPEFFDYLVALAAADPDLAHILRIH
TH_3721|M.thermoresistible__bu QIGWLKAAGFGAVRLPVSAGGRGATIPELTRLLIELSTADSNITQALRGH
Mflv_5011|M.gilvum_PYR-GCK VLREAAELGMAAIYCGEDAGGSGLRRIDAVRIFEKLSTADPTVAAFLSIH
Rv0752c|M.tuberculosis_H37Rv VLREAAELGMAAIYCRDDVGGSGLRRLDGVRIFEQLAIADPVTAAFLSIH
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MMAR_4034|M.marinum_M LRDQAKQMGLFGYAIPPQWGGLGLNLVQDVELAMELGYTSLAVRSMFGTN
Mvan_3173|M.vanbaalenii_PYR-1 QLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAVGQLLLSH
: ** :. .
Mb3601c|M.bovis_AF2122/97 G-VHNWHLALFDQRAQEEVWGEDPSTR----------ISSSYAPMGAG--
MUL_4141|M.ulcerans_Agy99 G-VHNWHLALFDQLAQEEVWGSDPKTR----------ISSSYAPMGAG--
MSMEG_4084|M.smegmatis_MC2_155 Y-VFVDERLFEFRRGQERLWLDHIVAGDLFGNANTELTAKQAAGLEPSRF
MAB_1422c|M.abscessus_ATCC_199 F-WFVEERLRTLADPVSAAWLTKVNEGNLFANA---FSEKGSLAVGSLVF
MAV_3422|M.avium_104 Y-ALVEELQVTPRRPGSDRWIAVVAEGGLIGGAN---AEQSQKSVGGNHR
TH_3721|M.thermoresistible__bu F-AFAEDRLVAAPGPGRDRWWQRFAAGDLAGNAW---TEIGDVVLGEANT
Mflv_5011|M.gilvum_PYR-GCK N-MCAWMVDSFGTEEQRKLWVPKLASMDAIASYC---LTEPGAGSDASAL
Rv0752c|M.tuberculosis_H37Rv N-MCAWMIDSFGTDEQRKDWIPRLATMGVIASYC---LTEPGAGSDAGAL
MLBr_00737|M.leprae_Br4923 K-LGTMGLILRGSEELKKQVLPSLAAEGAMASYA---LSEREAGSDAASM
MMAR_4034|M.marinum_M NGIAGQVLVGFGTDEQKARWLEPIASGDVVASFA---LTEPGAGSSPAGL
Mvan_3173|M.vanbaalenii_PYR-1 F-VVAQAISGLGHTQPAPRIYADLLAGAQLGNAS-----AERGTAHALDR
Mb3601c|M.bovis_AF2122/97 ----VVVDG----GYLVNGSWNWSSGCDHASWTFVGGPVIKD---GRPVD
MUL_4141|M.ulcerans_Agy99 ----VVVDG----GYLVNGSWNWSSGCDHGTWCFAGGPVIKD---GRPVD
MSMEG_4084|M.smegmatis_MC2_155 QARLSADGD----EYRLNGTKFYSTGSLYCQWVVVSAV-NDA---GA-VV
MAB_1422c|M.abscessus_ATCC_199 NTRLLPVGD----AYRLNGEKFYSTGTLFADYLTVTAT-TDR---DS-VA
MAV_3422|M.avium_104 DTRLVTTPD----GLRLRGRKFYSTGAQFSDYLRITAQ-DDD---GA-PT
TH_3721|M.thermoresistible__bu KVAPSGDPG----TFVVNGQKFYSTGSIFADWIDLYAQRTDT---GE-FV
Mflv_5011|M.gilvum_PYR-GCK RTKAVRSGD----EYVLDGVKQFISGAGTSDVYIVMARTGSD--GPKGIS
Rv0752c|M.tuberculosis_H37Rv STRAVRHGSGKGGDYVLDGVKQFISGAAASDVYVVMARTGAE--GPRGVS
MLBr_00737|M.leprae_Br4923 RTRAKADGD----DWILNGFKCWITNGGKSTWYTVMAVTDPDK-GANGIS
MMAR_4034|M.marinum_M RTKAVRDGD----DWLITGQKRFITNAPVADLFVVFARTRPASDKSPGIA
Mvan_3173|M.vanbaalenii_PYR-1 RTTVTRRDG----HWVLNGTKYYATGTLGATWIAVAARIEGRE--NGDTA
. : * : :. .
Mb3601c|M.bovis_AF2122/97 FGSFLIPRSEYEIKDV-WYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMN
MUL_4141|M.ulcerans_Agy99 FGSFLIPRTEYRIDDV-WHVVGLRGTGSNTVVVKDVFVPRHRFLSYKAMN
MSMEG_4084|M.smegmatis_MC2_155 RAIVPTNRDGVRIDDD-WDGIGQRLTASGTAVFDNVRVYTHEVFIR----
MAB_1422c|M.abscessus_ATCC_199 SVIVPGDRDGVRLVDD-WDGFGQRRTGTGTTIFSQVDVAADEILSETPY-
MAV_3422|M.avium_104 AVVIPVDRAGVEHLDD-WDGIGQRQTGSGTTVFNDVAVADDEVFPLG---
TH_3721|M.thermoresistible__bu IAAVDAHADGVTHADD-WDGFGQRTTGSGTSTYRDVRVPAENLIPFA---
Mflv_5011|M.gilvum_PYR-GCK AFVVPKDTPGLSFGTD-EVKMGWNAQPTRQVILEGARVPADALLGGPDG-
Rv0752c|M.tuberculosis_H37Rv AFIVEKGTPGLSFGAP-EAKMGWHAQPTAQVVLDGVRVPAEAMLGGADG-
MLBr_00737|M.leprae_Br4923 AFIVHKDDEGFSIGPK-EKKLGIKGSPTTELYFDKCRIPGDRIIGEP---
MMAR_4034|M.marinum_M VFLVPAQSAGVEVGAK-DAKMGQEGAWTADVSFTDVRVDDAALVGGS---
Mvan_3173|M.vanbaalenii_PYR-1 TAFVRPDQEGVTLDLESWSAFGQRGTASGEVRLNNVVVDDDLLIDEGPP-
. .* . : : ..
Mb3601c|M.bovis_AF2122/97 DHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQG--K
MUL_4141|M.ulcerans_Agy99 DHTAGGLQTNTAPVYKMPWGTMHPTTITAPIVGMAYGAYDAHVEHQG--K
MSMEG_4084|M.smegmatis_MC2_155 -------QAGHVDGYGSPMAQLYLTAVTAGILEAINRDAVTVLRGR---T
MAB_1422c|M.abscessus_ATCC_199 -------DAAPVPTTQYASLQLYILAIVAGVLRAVVDDGEALLRSR---Q
MAV_3422|M.avium_104 -------STIGVNRARGALVQLYLHAVAAGILRSLTEDAAALVRGR---R
TH_3721|M.thermoresistible__bu ----------TRFRYQTAFYQLFHLATLAGIAHAATAELAQRVRGR---T
Mflv_5011|M.gilvum_PYR-GCK -----EGTGFGIAMKGLNGGRINIAACSLGGAQAAYDKTVSYLADR----
Rv0752c|M.tuberculosis_H37Rv -----EGAGFGIAMSGLNGGRLNIAACSLGGAQAAFDKAGAYVRDR----
MLBr_00737|M.leprae_Br4923 ------GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR----
MMAR_4034|M.marinum_M -----EDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVAYASTA----
Mvan_3173|M.vanbaalenii_PYR-1 -----PDPITADPSVLGAFDQALHAAIDIGIARAALEDGAVFVRTRSRPW
:
Mb3601c|M.bovis_AF2122/97 RVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGK
MUL_4141|M.ulcerans_Agy99 RVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLMGNVGDEYALLSAGK
MSMEG_4084|M.smegmatis_MC2_155 RTFAHGVGSSAKDDPLLQHVVGQLASDAFAGRAVVLEAARALADAAETVM
MAB_1422c|M.abscessus_ATCC_199 RNFSHALTERPVDDPLLQRTLGELSATAFAAEATVLAAADAIEAATATLR
MAV_3422|M.avium_104 RTYTFASADTPTADPQLLQIVGEIDAVAYTAHALVRNAAAELAPALQAAR
TH_3721|M.thermoresistible__bu RTFSHGNAPRYAADPQIQQVVGEVMAAAFAAEAIALRAAEDXX-------
Mflv_5011|M.gilvum_PYR-GCK ----QAFGGSLLDEPTIRFTLADMATGLETSRALLWRAATALDNDH----
Rv0752c|M.tuberculosis_H37Rv ----QAFGGSLLDEPTVRFTLADMATGLQTSRMLLWRAASALDDDD----
MLBr_00737|M.leprae_Br4923 ----KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGE----
MMAR_4034|M.marinum_M ----TQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSG-----
Mvan_3173|M.vanbaalenii_PYR-1 KEALDAGIERADQEPHVVRRFGELTARLYALEALLARGTALIDEAYAAPE
..: : .
Mb3601c|M.bovis_AF2122/97 -------EIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPI
MUL_4141|M.ulcerans_Agy99 -------EIPFDLRTRARRDQVRATGRSIASIDRLFEASGATALANDAPI
MSMEG_4084|M.smegmatis_MC2_155 ADGVGDKSLLEAAKMACAKAKVTIENLVSRSGWQLFDVAGASATLRTKNL
MAB_1422c|M.abscessus_ATCC_199 -DGVPDAQLAQEAQVAVAKAKVHIDAVALDAATKLLDLGGASAASRTRNL
MAV_3422|M.avium_104 -DTGIDPELEAAASIAAARVKVAIQEPALRAASRVFDAGGASAVQASALL
TH_3721|M.thermoresistible__bu ----------------------------------XRRRSSAAPPRRRTRP
Mflv_5011|M.gilvum_PYR-GCK ----------PDRVELCAMAKRYVTDACFEVADQALQLHGGYGYLREYGL
Rv0752c|M.tuberculosis_H37Rv ----------ADKVELCAMAKRYVTDTCFEVADQALQLHGGYGYLREYGL
MLBr_00737|M.leprae_Br4923 ----------PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPV
MMAR_4034|M.marinum_M ----------ADRRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPV
Mvan_3173|M.vanbaalenii_PYR-1 VTR----DAAAQASLTVAAAKALAQQDAVEIAGAIFELTGTSGTDGAVNL
.
Mb3601c|M.bovis_AF2122/97 QRFWRDAHAGRVHAAND-PERAYVIFGNHEFGLPPGDTMV
MUL_4141|M.ulcerans_Agy99 QRFWRDAHAGRVHAAND-PERAYVIFGNNEFGLPAGDTMV
MSMEG_4084|M.smegmatis_MC2_155 DRHWRNARTIASHNPVLYKTRALGDYLVNGNPLPRGSAF-
MAB_1422c|M.abscessus_ATCC_199 DRHWRNIRTISLHNPVHYKARVIGQNLLHGTPLPANAYF-
MAV_3422|M.avium_104 DRHWRNLRTLFSHNPTVYKARVLGDVVVNGAALPDTSFF-
TH_3721|M.thermoresistible__bu RSCWDATRSSSVCVPRSRPPRCTSPWAPRPMSG-------
Mflv_5011|M.gilvum_PYR-GCK EKIVRDLRVHRILEGTNEIMRVVIGRSAASRARAS-----
Rv0752c|M.tuberculosis_H37Rv EKIVRDLRVHRILEGTNEIMRLVIGRAEAARFRATV----
MLBr_00737|M.leprae_Br4923 ERFMRDAKITQIYEGTNQIQRVVMSRALLR----------
MMAR_4034|M.marinum_M ERIYRDVRLLRLYEGTSEIQQLIIGSNLIKAANR------
Mvan_3173|M.vanbaalenii_PYR-1 DRHWRNVRVHSLHDPARWKYVHLGNHTLHDTRPPRLGLIL
: