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TEPPSLPGVLMNQPDLSAAPLRRADSEMEDLAEKIALTAREMSAEIDRDRRLPDELVARLGEAGLLRATM PREVQAAELAPGPALRCAEAVARGDASAGWCVSIAITSALLVAYLPASSRDEMFGAGRSVAAGVWAPRGK AKSVDGGVVVSGRWPFCSGINHADMMFAGCFVEGQPVPSVVALPKDDLRALDTWHTLGLCGTGSHDCVAE EVFVPADRVFSVFDGPTIDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGDKKGLGAKRTLAERS ATQTAVATAEAALGAARALFYEAIDSAWQASHNPDPVPVPVPVPVPVPVALRNRLRLAATHAARTSADVV RTMYDLAGSSAIYDGSPLQRRFRDAFTATAHFQVNEASRELPGRVLLGQHCDTSML*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3474 | - | - | 100% (407) | dehydrogenase |
| M. ulcerans Agy99 | MUL_2707 | - | 7e-32 | 28.26% (368) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4141 | - | 1e-28 | 28.17% (355) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3121c | - | 1e-176 | 80.83% (386) | hypothetical protein Mb3121c |
| M. gilvum PYR-GCK | Mflv_3440 | - | 4e-37 | 31.81% (371) | acyl-CoA dehydrogenase type 2 |
| M. tuberculosis H37Rv | Rv3094c | - | 1e-176 | 80.83% (386) | hypothetical protein Rv3094c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0075 | - | 3e-35 | 30.45% (381) | putative hydroxylase |
| M. marinum M | MMAR_1556 | - | 0.0 | 96.46% (396) | dehydrogenase |
| M. avium 104 | MAV_2767 | - | 1e-37 | 31.56% (377) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2077 | - | 1e-32 | 26.39% (379) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_2929 | - | 4e-35 | 30.05% (376) | PUTATIVE acyl-CoA dehydrogenase, C- domain protein |
| M. vanbaalenii PYR-1 | Mvan_3194 | - | 2e-36 | 31.02% (374) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3440|M.gilvum_PYR-GCK --------------------------MTAVEQAHALRDVVGAHAAESEQL
Mvan_3194|M.vanbaalenii_PYR-1 ----------------------------MVERARGMRDLVRAQAAESEQI
MAV_2767|M.avium_104 ------------------MTSIADTDDRVVALARGMRDLVQDQAAESERM
Mb3121c|M.bovis_AF2122/97 -----------MNQ----------SETEIEILAEKIARWARARSAEIERD
Rv3094c|M.tuberculosis_H37Rv -----------MNQ----------SETEIEILAEKIARWARARSAEIERD
MUL_3474|M.ulcerans_Agy99 MTEPPSLPGVLMNQPDLSAAPLRRADSEMEDLAEKIALTAREMSAEIDRD
MMAR_1556|M.marinum_M -----------MNQPDLSAAPLRRADSEMENLAEKIALTAREMSAEIDRD
MSMEG_2077|M.smegmatis_MC2_155 ----------------MTISVSGAAAATTSAITDEFVTRLAERAREAEEL
TH_2929|M.thermoresistible__bu ---------------------MSATAAQTAEITAEFVQRLAERAAEADEL
MAB_0075|M.abscessus_ATCC_1997 ------------MEGQRGGRTIVAMTERVIDRINDLAEQLREQAWEAEKL
: : * :.
Mflv_3440|M.gilvum_PYR-GCK RTLAPAVVDAMWSSGLMSAFNPSAAGGSEPTFAEMIETWIEMAWQDGSFG
Mvan_3194|M.vanbaalenii_PYR-1 RTMTPAIVEAMWSTGLMSAFNPAPAGGVEPSFAEMIETWIEMAWQDGSFG
MAV_2767|M.avium_104 RTLTPAIVDAMWASGLMSAFNTIEAGGVEPSFTEMIETWIEMAWQDGSFG
Mb3121c|M.bovis_AF2122/97 RRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAG
Rv3094c|M.tuberculosis_H37Rv RRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAG
MUL_3474|M.ulcerans_Agy99 RRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAG
MMAR_1556|M.marinum_M RRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAG
MSMEG_2077|M.smegmatis_MC2_155 RRLPDATMTDLAASGFTELLTPARFGGQQADFPALLDPVRRMAHGCASSA
TH_2929|M.thermoresistible__bu RRLPAATIDDLTASGFTELLVPARYGGRQAEFPALLDPVRRMAHGCTSSA
MAB_0075|M.abscessus_ATCC_1997 GRLPDETAKMLKAAGLIRLLQPQKYGGYEAHPREFAETVMTTAALDPASG
:. : :*: . . : * : .
Mflv_3440|M.gilvum_PYR-GCK WVGIANFPSSFAAASYLPDSGFAEVFTANDNRVTMGGQFFPNGQGVAVDG
Mvan_3194|M.vanbaalenii_PYR-1 WVGIANLPSSFAAATYLPDGGFAEVFTANHNRVTMGGQFFPNGQGHAVDG
MAV_2767|M.avium_104 WVGIANLPSSFAAAAYLPDDGFAEVFTAHDNHVTMGGQFFPNGQGAAVDG
Mb3121c|M.bovis_AF2122/97 WC-VSIAITSALLVAYLPARSREEMFGG--GRGVAAGVWAPRGTARSVDG
Rv3094c|M.tuberculosis_H37Rv WC-VSIAITSALLVAYLPARSREEMFGG--GRGVAAGVWAPRGTARSVDG
MUL_3474|M.ulcerans_Agy99 WC-VSIAITSALLVAYLPASSRDEMFGA--GRSVAAGVWAPRGKAKSVDG
MMAR_1556|M.marinum_M WC-VSIAITSALLVAYLPASSRDEMFGA--GRSVAAGVWAPRGKAKSVDG
MSMEG_2077|M.smegmatis_MC2_155 WT-IGFLALHNWMLALFGEQAQAEAYAT--RPFLAPAPLAPNGRGLPTEG
TH_2929|M.thermoresistible__bu WT-IGFFALHNWMLALFDEQAQQEVFAD--RPVLAPAPLAPTGRGLPVDG
MAB_0075|M.abscessus_ATCC_1997 WI-CGVVGVHPWQVAFADSRVAEEMWGE-DQDIWMASPYAPTGVAKPVDG
* . : * : . * * . ..:*
Mflv_3440|M.gilvum_PYR-GCK GYRLTGAWSFGSGTGHAEYVAAGFFPMVDGEMRWAGEGIPDMQVAVVPRD
Mvan_3194|M.vanbaalenii_PYR-1 GYRLTGSWSFGSGTGHAEYVAAGFLPMVDGEIRWAGDGVPDMQVAVVPRA
MAV_2767|M.avium_104 GYLVSGAWNFGSGIGHSQYVAAGFLPMDDGEMRWISEGFPEMRVAVIPRE
Mb3121c|M.bovis_AF2122/97 GVVVSGRWPFCSGINHADIMFAGCFVD----------DRQVPSVVALNKD
Rv3094c|M.tuberculosis_H37Rv GVVVSGRWPFCSGINHADIMFAGCFVD----------DRQVPSVVALNKD
MUL_3474|M.ulcerans_Agy99 GVVVSGRWPFCSGINHADMMFAGCFVE----------GQPVPSVVALPKD
MMAR_1556|M.marinum_M GVVVSGRWPFCSGINHADMMFAGCFVE----------GQPVPSVVALPKD
MSMEG_2077|M.smegmatis_MC2_155 GVRLSGRWSWATGVMHANWIMVGALCG--------PDDAIYPALALLPAS
TH_2929|M.thermoresistible__bu GVRLTGRWSWATGVMHANWVLVGALCG--------PEDAIYPALALLPAA
MAB_0075|M.abscessus_ATCC_1997 GYIFNGRWQFSSGTDHCDWIILGAMLGDADG--TPIMPPKMLHMILPRAD
* ..* * : :* *.: : * : :
Mflv_3440|M.gilvum_PYR-GCK QVSFKDGWHVQGLRGTGSYDYAIDDVFVPHDRTFALFTREPKRGS-----
Mvan_3194|M.vanbaalenii_PYR-1 EVSFKDGWHVQGLKGTGSYDYSIDDVFVPHDRTFALFTREPRRGS-----
MAV_2767|M.avium_104 QISFDDGWYVQGLKGTGSYDYSARDVFVPAARTFELFTRAPFRGA-----
Mb3121c|M.bovis_AF2122/97 ELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDR------
Rv3094c|M.tuberculosis_H37Rv ELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDR------
MUL_3474|M.ulcerans_Agy99 DLRALDTWHTLGLCGTGSHDCVAEEVFVPADRVFSVFDGPTIDR------
MMAR_1556|M.marinum_M DLRALDTWHTLGLRGTGSHDCVAEEVFVPADRVFSVFDGPSIDR------
MSMEG_2077|M.smegmatis_MC2_155 DIEVVDVWHTDGMRATGSNDVVVTDAFVPEHRLVSVIDVYTGTAPGAKVH
TH_2929|M.thermoresistible__bu DVTVEDTWHTVGMRATGSADVVVTEAFVPEHRLLRVTDIYAGTTPGAALH
MAB_0075|M.abscessus_ATCC_1997 YQIVEDSWNVVGLRGTGSKDIIVNDAFVPSYRVMDGDQVIDGTAQRDAGM
* * . *: .*** * :.*** * .
Mflv_3440|M.gilvum_PYR-GCK -SPAGRMGMMPVTAAGHAAWALGVAKSMLDDVAELAATKFRMSDMASLAS
Mvan_3194|M.vanbaalenii_PYR-1 -SPATRMGMMPVTAAGHAAWALGVAKSMLDDVSELAATKFRMSDMAALAS
MAV_2767|M.avium_104 -SPATRMGLMPVTAAGHASWALGVAKSMLDDVQELAATKFRMSDMASLAS
Mb3121c|M.bovis_AF2122/97 --PLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAE
Rv3094c|M.tuberculosis_H37Rv --PLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAE
MUL_3474|M.ulcerans_Agy99 --PLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGDKKGLGAKRTLAE
MMAR_1556|M.marinum_M --PLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGDKKGLGAKRTLAE
MSMEG_2077|M.smegmatis_MC2_155 DAATYRWPMVPALALLAAMPALGSAERAVEIYAQRLSERVIAYEGVKQKD
TH_2929|M.thermoresistible__bu DAAAYRWPMVPALALLAAMPALGSAERVTDLFAERLGHRVIAYEGVAQRD
MAB_0075|M.abscessus_ATCC_1997 TDTLYRMPWSTMFPLGISSAVIGIAEGALAAHLEYQRER-VGAQGTAVKD
. * . . .:* *. : : .
Mflv_3440|M.gilvum_PYR-GCK RPTFQKDLAHHVAAWRAARLLVLDAFTGAEGAVAAGA----------ELT
Mvan_3194|M.vanbaalenii_PYR-1 RPTFQKGLAHHVAAWRAARLLVLDAFGTAEAAVAGGD----------DLT
MAV_2767|M.avium_104 RPTFQKGLAHHRAAWRAARLLVLDAFTTAEAAVAAGQ----------ELT
Mb3121c|M.bovis_AF2122/97 RSATQAAAATAESALGAARALFYEVIEAAWQVSHDAE----------AVP
Rv3094c|M.tuberculosis_H37Rv RSATQAAAATAESALGAARALFYEVIEAAWQVSHDAE----------AVP
MUL_3474|M.ulcerans_Agy99 RSATQTAVATAEAALGAARALFYEAIDSAWQASHNPDPVPVPVPVPVPVP
MMAR_1556|M.marinum_M RSATQTAVATAEAALGAARALFYEAIDSAWQASHNPD----------PVP
MSMEG_2077|M.smegmatis_MC2_155 KPAAVAHLGEARVRLRALRGLLADTVGEIEDTVTAGD----------PVS
TH_2929|M.thermoresistible__bu KPIAQAHLGRARVRLRALHGLLADTVGQIQQLVAAGD----------PVP
MAB_0075|M.abscessus_ATCC_1997 DPYVLFAIGEAAADINAARQEILANVDKIWGIVDSGK----------EVS
. . * : . . :.
Mflv_3440|M.gilvum_PYR-GCK PTMRADMRVAAVFATDTARGCAEWAHLAAGTTSIREGSRLERAFRDIYTG
Mvan_3194|M.vanbaalenii_PYR-1 PTLRADMRVAAVFATDTARACAEWAHLVAGTSSIREGSRLERAFRDVYTG
MAV_2767|M.avium_104 PALRADMRVAAVYATDTARGCAEWAHLVAGTSSIREGSRLERAFRDIYTG
Mb3121c|M.bovis_AF2122/97 VTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTA
Rv3094c|M.tuberculosis_H37Rv VTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTA
MUL_3474|M.ulcerans_Agy99 VALRNRLRLAATHAARTSADVVRTMYDLAGSSAIYDGSPLQRRFRDAFTA
MMAR_1556|M.marinum_M VALRNRLRLAATHAARTSADVVRIMYDLAGSSAIYDGSPLQRRFRDAFTA
MSMEG_2077|M.smegmatis_MC2_155 REVRAQARLAAAHIVRESRAVIALLLASSGASAHFLDNPLQRISRDVGVL
TH_2929|M.thermoresistible__bu RPVRADARLAAAHIVHESRAIIGDLLAASGASVQFLSHPMQRFQRDVDVL
MAB_0075|M.abscessus_ATCC_1997 FADRAAGRRTQVRAAWRAVMAVDQIFSRSGGNAMRLDKPLQRYWRDAHTG
* * : . . : :* . . ::* ** .
Mflv_3440|M.gilvum_PYR-GCK TQHAFIS-EKVAIDAAQVWLGVVEDQFGL---
Mvan_3194|M.vanbaalenii_PYR-1 TQHAFIS-EKVAIDAAQVWLGVVEDQFGL---
MAV_2767|M.avium_104 TQHAFIS-EKVAIDVAQIWLGIIEDQPGL---
Mb3121c|M.bovis_AF2122/97 TAHFQVN-EASRELPGRVLLDQPADVSML---
Rv3094c|M.tuberculosis_H37Rv TAHFQVN-EASRELPGRVLLDQPADVSML---
MUL_3474|M.ulcerans_Agy99 TAHFQVN-EASRELPGRVLLGQHCDTSML---
MMAR_1556|M.marinum_M TAHFQVN-EASRELPGRVLLGQHCDTSML---
MSMEG_2077|M.smegmatis_MC2_155 SGHVIFDHDTSCELAGALSIGMKISPIAMI--
TH_2929|M.thermoresistible__bu AGHVVFDYDTSRELAGALELGLKVSPLAMI--
MAB_0075|M.abscessus_ATCC_1997 LAHAIHVPSTVFHASALSSLGIEPQGPLRSMI
* . . :. .