For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSERVLDRLNELAGQFKEQAVEAEKLGKLPDATVKSMKSIGSIRLLQPKKHGGLEVHPREFAETVMATAA LDPAAGWVNGVVGVHPYQLAYADPKVGEEIWADDIDTWVASPYAPQGVAVPTDGGYIFTGRWQFSSGTDA CDWIILGAMVGDAKGVPLMPPQMLHMILPRKDYQIVDDSWDVVGLRGTGSKDVIVDGAFVPTYRTMDGMK VMDGSAQIEAGMTEPLYKMPWSTMFPLGISSATIGICEGALAAHLDYQRERVGANGTAIKDDPYVMYAIG DAAAEIEASRNTLLSNVDRVYDIVDSGREVTFETRAAVRRSQIKAVWRAVAAVDQIFARSGGNALRMDKP LQRYWRDAHAGVAHAIHVPGTVYHASALSSLGVDPQGPLRAMI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4548 | - | - | 100% (393) | acyl-CoA dehydrogenase type 2 |
| M. gilvum PYR-GCK | Mflv_1463 | - | 4e-84 | 40.46% (388) | acyl-CoA dehydrogenase type 2 |
| M. gilvum PYR-GCK | Mflv_4461 | - | 6e-35 | 28.21% (358) | acyl-CoA dehydrogenase type 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3601c | - | 2e-80 | 39.02% (387) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3570c | - | 4e-80 | 39.02% (387) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0075 | - | 1e-180 | 74.05% (393) | putative hydroxylase |
| M. marinum M | MMAR_5065 | - | 1e-78 | 39.47% (375) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_3020 | - | 0.0 | 78.68% (394) | pigment production hydroxylase |
| M. smegmatis MC2 155 | MSMEG_2892 | - | 0.0 | 83.21% (393) | pigment production hydroxylase |
| M. thermoresistible (build 8) | TH_3059 | - | 0.0 | 79.64% (393) | PUTATIVE pigment production hydroxylase |
| M. ulcerans Agy99 | MUL_4141 | - | 2e-78 | 39.47% (375) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2892 | - | 0.0 | 80.41% (393) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2892|M.smegmatis_MC2_155 ------------MTKR----VIDGIAELADQLREQAVEAERIGKLTDTTV
TH_3059|M.thermoresistible__bu ------------MTKR----VIDGIAELADQLREQSIEAERIGKLTDQTV
Mvan_2892|M.vanbaalenii_PYR-1 ------------MTQR----VIDSLAEFAEQLRGQAEEAEKIGKLTDDTV
MAV_3020|M.avium_104 ------------MSER----VIDRVMAMADQLRDQAAEAEQLGRLTDDTV
Mflv_4548|M.gilvum_PYR-GCK ------------MSER----VLDRLNELAGQFKEQAVEAEKLGKLPDATV
MAB_0075|M.abscessus_ATCC_1997 MEGQRGGRTIVAMTER----VIDRINDLAEQLREQAWEAEKLGRLPDETA
Mb3601c|M.bovis_AF2122/97 ---------MTSIQQRDAQSVLAAIDDLLPEIRDRAQATEDLRRLPDETV
Rv3570c|M.tuberculosis_H37Rv ---------MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETV
MMAR_5065|M.marinum_M ---------MTTIQQRDAQSVLAAIDDLLPQLRERAQATEDLRRLPDETV
MUL_4141|M.ulcerans_Agy99 ---------MTTIQQRDAQSVLAAIDDLLPQLRERAQATEDLRRLPDETV
: :* *: : : ::: :: :* : :*.* *.
MSMEG_2892|M.smegmatis_MC2_155 KTMKQVGSIRLLQPKKHGGLEVHPREFAETVMATAALDPSAGWINGVVGV
TH_3059|M.thermoresistible__bu KIMKKLGSIRLLQPKKHGGLEVHPREFAETVMATAALDPSAGWINGVVGV
Mvan_2892|M.vanbaalenii_PYR-1 KTMKQIGSIRLLQPKKHGGMEVHPREFAETVMATAALDPSAGWINGVVGV
MAV_3020|M.avium_104 KLMKGAGLIRLLQTKQYQGFEVHPREFAETVMATAALDPAAGWIVGVVGV
Mflv_4548|M.gilvum_PYR-GCK KSMKSIGSIRLLQPKKHGGLEVHPREFAETVMATAALDPAAGWVNGVVGV
MAB_0075|M.abscessus_ATCC_1997 KMLKAAGLIRLLQPQKYGGYEAHPREFAETVMTTAALDPASGWICGVVGV
Mb3601c|M.bovis_AF2122/97 KALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGV
Rv3570c|M.tuberculosis_H37Rv KALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGV
MMAR_5065|M.marinum_M QALEDVGFFTLLQPEQWGGLQCDPTLFYEATRRLASACGSTGWVSSIIGV
MUL_4141|M.ulcerans_Agy99 QALEDVGFFTLLQPEQWGGLQCDPTLFYEATRRLASACGSTGWVSSIIGV
: :. * : ***.:: * : .* * *:. *: ::**: .::**
MSMEG_2892|M.smegmatis_MC2_155 HPYQLAYADPRVGEEIWAQDVDTWVASPYAPQGVAVPVDGGYIFNGRWQF
TH_3059|M.thermoresistible__bu HPYQLAYADPRVAEEIWAEDVDTWIASPYAPQGVARPVDGGYLFNGRWQF
Mvan_2892|M.vanbaalenii_PYR-1 HPYQLAYADPRVGAEIWADDVDTWVASPYAPQGVATPVDGGYLFNGRWQF
MAV_3020|M.avium_104 HPYQLAYADPKVAAEVWADDVDTWMASPYAPQGVAKPVNGGYIFNGRWQF
Mflv_4548|M.gilvum_PYR-GCK HPYQLAYADPKVGEEIWADDIDTWVASPYAPQGVAVPTDGGYIFTGRWQF
MAB_0075|M.abscessus_ATCC_1997 HPWQVAFADSRVAEEMWGEDQDIWMASPYAPTGVAKPVDGGYIFNGRWQF
Mb3601c|M.bovis_AF2122/97 HNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNW
Rv3570c|M.tuberculosis_H37Rv HNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNW
MMAR_5065|M.marinum_M HNWHLALFDQLAQEEVWGSDPKTRISSSYAPMGAGVVVDGGYLVNGSWNW
MUL_4141|M.ulcerans_Agy99 HNWHLALFDQLAQEEVWGSDPKTRISSSYAPMGAGVVVDGGYLVNGSWNW
* :::* * . *:*..* . ::*.*** *.. .:***:..* *::
MSMEG_2892|M.smegmatis_MC2_155 SSGTDHCDWIILG-AMVGDADGTPLMPPQMLHMILPRKDYEIVDDSWDVV
TH_3059|M.thermoresistible__bu SSGTDHCDWIILG-AMVGDADGTPVTPPRMLHMILPRKDYEIVEDSWDVV
Mvan_2892|M.vanbaalenii_PYR-1 SSGTDHCDWIFLG-AMIGDAEGKPLMPPQMLHMILPRKDYEIVEDSWDVV
MAV_3020|M.avium_104 SSGTDHCDWIILG-AMLGDEQGVPLMPPQMLHMILPRKDYEIVEDSWNVV
Mflv_4548|M.gilvum_PYR-GCK SSGTDACDWIILG-AMVGDAKGVPLMPPQMLHMILPRKDYQIVDDSWDVV
MAB_0075|M.abscessus_ATCC_1997 SSGTDHCDWIILG-AMLGDADGTPIMPPKMLHMILPRADYQIVEDSWNVV
Mb3601c|M.bovis_AF2122/97 SSGCDHASWTFVGGPVIKDGR-----PVDFGSFLIPRSEYEI-KDVWYVV
Rv3570c|M.tuberculosis_H37Rv SSGCDHASWTFVGGPVIKDGR-----PVDFGSFLIPRSEYEI-KDVWYVV
MMAR_5065|M.marinum_M SSGCDHATWCFAGGPVIKDGR-----PVDFGSFLIPRTEYRI-DDVWHVV
MUL_4141|M.ulcerans_Agy99 SSGCDHGTWCFAGGPVIKDGR-----PVDFGSFLIPRTEYRI-DDVWHVV
*** * * : * .:: * * : :::** :*.* .* * **
MSMEG_2892|M.smegmatis_MC2_155 GLRGTGSKDVIVKDAFVPAYRTMDGMKVMDGTAQREAGMTEPLYLMPWST
TH_3059|M.thermoresistible__bu GLRGTGSKDVIVKDAFVPAYRTMDGMKVMDGTAQREAGMTEPLYLMPWST
Mvan_2892|M.vanbaalenii_PYR-1 GLRGTGSKDVIVRDAFVPAYRTMDAMKVMDGTAQREAGMTETLYLMPWST
MAV_3020|M.avium_104 GLRGTGSKDVIVKDAFVPSYRTMDATKVMDGTAQREAGMTEPLYLMPWST
Mflv_4548|M.gilvum_PYR-GCK GLRGTGSKDVIVDGAFVPTYRTMDGMKVMDGSAQIEAGMTEPLYKMPWST
MAB_0075|M.abscessus_ATCC_1997 GLRGTGSKDIIVNDAFVPSYRVMDGDQVIDGTAQRDAGMTDTLYRMPWST
Mb3601c|M.bovis_AF2122/97 GLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGT
Rv3570c|M.tuberculosis_H37Rv GLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGT
MMAR_5065|M.marinum_M GLRGTGSNTVVVKDVFVPRHRFLSYKAMNDHTAGGLQTNTAPVYKMPWGT
MUL_4141|M.ulcerans_Agy99 GLRGTGSNTVVVKDVFVPRHRFLSYKAMNDHTAGGLQTNTAPVYKMPWGT
*******: ::* ..*** :* :. : * :* : .:* ***.*
MSMEG_2892|M.smegmatis_MC2_155 MFPLGISSATIGIAEGALAAALDYQRQRVNS--SGVAVKDDPYVMYAIGE
TH_3059|M.thermoresistible__bu MFPLGISSATIGIAEGALAAALDYQRRRVNS--SGVAVKDDPYVMYAIGE
Mvan_2892|M.vanbaalenii_PYR-1 MFPLGISSATIGIAEGALAAALDYQRERVNS--SGVAIKDDPYVMYAIGE
MAV_3020|M.avium_104 MFPLGISAATIGIAEGALAAHLDYQRSRVGA--TGTAIKDDPYVMYAIGE
Mflv_4548|M.gilvum_PYR-GCK MFPLGISSATIGICEGALAAHLDYQRERVGA--NGTAIKDDPYVMYAIGD
MAB_0075|M.abscessus_ATCC_1997 MFPLGISSAVIGIAEGALAAHLEYQRERVGA--QGTAVKDDPYVLFAIGE
Mb3601c|M.bovis_AF2122/97 MHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAE
Rv3570c|M.tuberculosis_H37Rv MHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAE
MMAR_5065|M.marinum_M MHPTTITAPIVGMAYGAYDAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAE
MUL_4141|M.ulcerans_Agy99 MHPTTITAPIVGMAYGAYDAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAE
*.* *::. :*:. ** * :::* ** : * ****:. *.:
MSMEG_2892|M.smegmatis_MC2_155 AAADINAARQELLANADRIYDMVAAGKEVSFEDRAAGRRTQIRAVWRAVS
TH_3059|M.thermoresistible__bu AAADINAARQELLANADRIYDIVASGAEVSFEDRAAGRRTQVRAVWRAVS
Mvan_2892|M.vanbaalenii_PYR-1 AAADINAARQEILANADRIYDMVDAGKEVSFQDRAAGRRTQVRAVWRAVS
MAV_3020|M.avium_104 AAADINAARQELLANADRIYDIVASGKEVSFVDRAAGRRTQVRAVWRAVS
Mflv_4548|M.gilvum_PYR-GCK AAAEIEASRNTLLSNVDRVYDIVDSGREVTFETRAAVRRSQIKAVWRAVA
MAB_0075|M.abscessus_ATCC_1997 AAADINAARQEILANVDKIWGIVDSGKEVSFADRAAGRRTQVRAAWRAVM
Mb3601c|M.bovis_AF2122/97 AASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIA
Rv3570c|M.tuberculosis_H37Rv AASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIA
MMAR_5065|M.marinum_M AASDIDAAWRQLMGNVGDEYALLSAGKEIPFDLRTRARRDQVRATGRSIA
MUL_4141|M.ulcerans_Agy99 AASDIDAAWRQLMGNVGDEYALLSAGKEIPFDLRTRARRDQVRATGRSIA
**::*:*: . ::.*.. : :: :* *:.* *: ** *::*. *::
MSMEG_2892|M.smegmatis_MC2_155 AVDEIFARCGGNAARMDKPLQRYWRDVHVGQAHAIHVPGTVYHASALSSL
TH_3059|M.thermoresistible__bu AVDEIFARCGGNAARMDQPLQRFWRDVHVAQAHAIHSPGTVYHASALSSL
Mvan_2892|M.vanbaalenii_PYR-1 AVDEVFARCGGNGTRMDKPLQRYWRDVHVGQAHAIHVPGTVFHASALSSL
MAV_3020|M.avium_104 AVDEIFARSGGNAARMDKPLQRYWRDVHVGQMHAIHVPGTTYHASALSSI
Mflv_4548|M.gilvum_PYR-GCK AVDQIFARSGGNALRMDKPLQRYWRDAHAGVAHAIHVPGTVYHASALSSL
MAB_0075|M.abscessus_ATCC_1997 AVDQIFSRSGGNAMRLDKPLQRYWRDAHTGLAHAIHVPSTVFHASALSSL
Mb3601c|M.bovis_AF2122/97 SIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEF
Rv3570c|M.tuberculosis_H37Rv SIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEF
MMAR_5065|M.marinum_M SIDRLFEASGATALANDAPIQRFWRDAHAGRVHAANDPERAYVIFGNNEF
MUL_4141|M.ulcerans_Agy99 SIDRLFEASGATALANDAPIQRFWRDAHAGRVHAANDPERAYVIFGNNEF
::*.:* .*... : *:**:***.*.. ** : * .: . .:
MSMEG_2892|M.smegmatis_MC2_155 GVDP-QGPLRAMI
TH_3059|M.thermoresistible__bu GVEP-QGPLRAMI
Mvan_2892|M.vanbaalenii_PYR-1 GVDP-QGPLRAMI
MAV_3020|M.avium_104 GIDPPEGPLRALI
Mflv_4548|M.gilvum_PYR-GCK GVDP-QGPLRAMI
MAB_0075|M.abscessus_ATCC_1997 GIEP-QGPLRSMI
Mb3601c|M.bovis_AF2122/97 GLPP----GDTMV
Rv3570c|M.tuberculosis_H37Rv GLPP----GDTMV
MMAR_5065|M.marinum_M GLPA----GDTMV
MUL_4141|M.ulcerans_Agy99 GLPA----GDTMV
*: . :::