For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MNQPDLSAAPLRRADSEMENLAEKIALTAREMSAEIDRDRRLPDELVARLGEAGLLRATMPREVQAAELA PGPALRCAEAVARGDASAGWCVSIAITSALLVAYLPASSRDEMFGAGRSVAAGVWAPRGKAKSVDGGVVV SGRWPFCSGINHADMMFAGCFVEGQPVPSVVALPKDDLRALDTWHTLGLRGTGSHDCVAEEVFVPADRVF SVFDGPSIDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGDKKGLGAKRTLAERSATQTAVATAE AALGAARALFYEAIDSAWQASHNPDPVPVALRNRLRLAATHAARTSADVVRIMYDLAGSSAIYDGSPLQR RFRDAFTATAHFQVNEASRELPGRVLLGQHCDTSML
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1556 | - | - | 100% (386) | dehydrogenase |
| M. marinum M | MMAR_3457 | - | 7e-41 | 32.96% (361) | hypothetical protein MMAR_3457 |
| M. marinum M | MMAR_3433 | - | 1e-35 | 29.61% (358) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3121c | - | 1e-179 | 83.24% (376) | hypothetical protein Mb3121c |
| M. gilvum PYR-GCK | Mflv_3440 | - | 4e-39 | 32.69% (361) | acyl-CoA dehydrogenase type 2 |
| M. tuberculosis H37Rv | Rv3094c | - | 1e-179 | 83.24% (376) | hypothetical protein Rv3094c |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-06 | 21.73% (382) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0075 | - | 9e-38 | 31.00% (371) | putative hydroxylase |
| M. avium 104 | MAV_2166 | - | 6e-40 | 28.49% (372) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2077 | - | 3e-36 | 27.37% (369) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_2929 | - | 4e-37 | 30.33% (366) | PUTATIVE acyl-CoA dehydrogenase, C- domain protein |
| M. ulcerans Agy99 | MUL_3474 | - | 0.0 | 96.46% (396) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3194 | - | 3e-39 | 31.87% (364) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1556|M.marinum_M -----------MNQPDLSAAPLRRADSEMENLAEKIALTAREMSAEIDRD
MUL_3474|M.ulcerans_Agy99 MTEPPSLPGVLMNQPDLSAAPLRRADSEMEDLAEKIALTAREMSAEIDRD
Mb3121c|M.bovis_AF2122/97 -----------MNQ----------SETEIEILAEKIARWARARSAEIERD
Rv3094c|M.tuberculosis_H37Rv -----------MNQ----------SETEIEILAEKIARWARARSAEIERD
Mflv_3440|M.gilvum_PYR-GCK --------------------------MTAVEQAHALRDVVGAHAAESEQL
Mvan_3194|M.vanbaalenii_PYR-1 ----------------------------MVERARGMRDLVRAQAAESEQI
MSMEG_2077|M.smegmatis_MC2_155 ----------------MTISVSGAAAATTSAITDEFVTRLAERAREAEEL
TH_2929|M.thermoresistible__bu ---------------------MSATAAQTAEITAEFVQRLAERAAEADEL
MAV_2166|M.avium_104 ----------------------MVEHHPLHGITDEFVARLGERAEEAERL
MAB_0075|M.abscessus_ATCC_1997 ------------MEGQRGGRTIVAMTERVIDRINDLAEQLREQAWEAEKL
MLBr_00737|M.leprae_Br4923 ------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQR
: : :.
MMAR_1556|M.marinum_M RRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAG
MUL_3474|M.ulcerans_Agy99 RRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAG
Mb3121c|M.bovis_AF2122/97 RRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAG
Rv3094c|M.tuberculosis_H37Rv RRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAG
Mflv_3440|M.gilvum_PYR-GCK RTLAPAVVDAMWSSGLMSAFNPSAAGGSEPTFAEMIETWIEMAWQDGSFG
Mvan_3194|M.vanbaalenii_PYR-1 RTMTPAIVEAMWSTGLMSAFNPAPAGGVEPSFAEMIETWIEMAWQDGSFG
MSMEG_2077|M.smegmatis_MC2_155 RRLPDATMTDLAASGFTELLTPARFGGQQADFPALLDPVRRMAHGCASSA
TH_2929|M.thermoresistible__bu RRLPAATIDDLTASGFTELLVPARYGGRQAEFPALLDPVRRMAHGCTSSA
MAV_2166|M.avium_104 RRLPAATVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMAQGCASSA
MAB_0075|M.abscessus_ATCC_1997 GRLPDETAKMLKAAGLIRLLQPQKYGGYEAHPREFAETVMTTAALDPASG
MLBr_00737|M.leprae_Br4923 ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS
:. : : : * . * : .
MMAR_1556|M.marinum_M WCVSIAITSALLVA----------YLPASSRDEMFGAG--RSVAAGVWAP
MUL_3474|M.ulcerans_Agy99 WCVSIAITSALLVA----------YLPASSRDEMFGAG--RSVAAGVWAP
Mb3121c|M.bovis_AF2122/97 WCVSIAITSALLVA----------YLPARSREEMFGGG--RGVAAGVWAP
Rv3094c|M.tuberculosis_H37Rv WCVSIAITSALLVA----------YLPARSREEMFGGG--RGVAAGVWAP
Mflv_3440|M.gilvum_PYR-GCK WVGIANFPSSFAAAS---------YLPDSGFAEVFTANDNRVTMGGQFFP
Mvan_3194|M.vanbaalenii_PYR-1 WVGIANLPSSFAAAT---------YLPDGGFAEVFTANHNRVTMGGQFFP
MSMEG_2077|M.smegmatis_MC2_155 WTIGFLALHNWMLA----------LFGEQAQAEAYATR--PFLAPAPLAP
TH_2929|M.thermoresistible__bu WTIGFFALHNWMLA----------LFDEQAQQEVFADR--PVLAPAPLAP
MAV_2166|M.avium_104 WTLGFYALHNWMLS----------LFDPQAQREVFASG--PVLAPAPLAP
MAB_0075|M.abscessus_ATCC_1997 WICGVVGVHPWQVA----------FADSRVAEEMWGEDQ-DIWMASPYAP
MLBr_00737|M.leprae_Br4923 LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAA
. .
MMAR_1556|M.marinum_M RGKAKSVDGG--VVVSGRWPFCSGINHADMMFAGCFVEGQ----------
MUL_3474|M.ulcerans_Agy99 RGKAKSVDGG--VVVSGRWPFCSGINHADMMFAGCFVEGQ----------
Mb3121c|M.bovis_AF2122/97 RGTARSVDGG--VVVSGRWPFCSGINHADIMFAGCFVDDR----------
Rv3094c|M.tuberculosis_H37Rv RGTARSVDGG--VVVSGRWPFCSGINHADIMFAGCFVDDR----------
Mflv_3440|M.gilvum_PYR-GCK NGQGVAVDGG--YRLTGAWSFGSGTGHAEYVAAGFFPMVDGEMRWAGEGI
Mvan_3194|M.vanbaalenii_PYR-1 NGQGHAVDGG--YRLTGSWSFGSGTGHAEYVAAGFLPMVDGEIRWAGDGV
MSMEG_2077|M.smegmatis_MC2_155 NGRGLPTEGG--VRLSGRWSWATGVMHANWIMVGALCGPDD--------A
TH_2929|M.thermoresistible__bu TGRGLPVDGG--VRLTGRWSWATGVMHANWVLVGALCGPED--------A
MAV_2166|M.avium_104 TGRATPADGG--VRLTGRWSWATGAMDADWLIVGALIERTD--------R
MAB_0075|M.abscessus_ATCC_1997 TGVAKPVDGG--YIFNGRWQFSSGTDHCDWIILGAMLGDADG--TPIMPP
MLBr_00737|M.leprae_Br4923 SMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKG-----ANG
. .* ..* : :. .. .
MMAR_1556|M.marinum_M PVPSVVALPKDDLRALDTWHTLGLRGTGSHDCVAEEVFVPADRVFSVFDG
MUL_3474|M.ulcerans_Agy99 PVPSVVALPKDDLRALDTWHTLGLCGTGSHDCVAEEVFVPADRVFSVFDG
Mb3121c|M.bovis_AF2122/97 QVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDG
Rv3094c|M.tuberculosis_H37Rv QVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDG
Mflv_3440|M.gilvum_PYR-GCK PDMQVAVVPRDQVSFKDGWHVQGLRGTGSYDYAIDDVFVPHDRTFALFTR
Mvan_3194|M.vanbaalenii_PYR-1 PDMQVAVVPRAEVSFKDGWHVQGLKGTGSYDYSIDDVFVPHDRTFALFTR
MSMEG_2077|M.smegmatis_MC2_155 IYPALALLPASDIEVVDVWHTDGMRATGSNDVVVTDAFVPEHRLVSVIDV
TH_2929|M.thermoresistible__bu IYPALALLPAADVTVEDTWHTVGMRATGSADVVVTEAFVPEHRLLRVTDI
MAV_2166|M.avium_104 IDPALVVVPAGQVEVVDTWHTAGMRGTGSHDVVIADVFVPEHRLVAVADI
MAB_0075|M.abscessus_ATCC_1997 KMLHMILPRADYQIVEDSWNVVGLRGTGSKDIIVNDAFVPSYRVMDGDQV
MLBr_00737|M.leprae_Br4923 ISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEP--
: : *: .: : : . :* * .
MMAR_1556|M.marinum_M PS--------IDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGDK
MUL_3474|M.ulcerans_Agy99 PT--------IDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGDK
Mb3121c|M.bovis_AF2122/97 PI--------VDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGK
Rv3094c|M.tuberculosis_H37Rv PI--------VDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGK
Mflv_3440|M.gilvum_PYR-GCK EPK------RGSSPAGRMGMMPVTAAGHAAWALGVAKSMLDDVAELAATK
Mvan_3194|M.vanbaalenii_PYR-1 EPR------RGSSPATRMGMMPVTAAGHAAWALGVAKSMLDDVSELAATK
MSMEG_2077|M.smegmatis_MC2_155 YTGTAPGAKVHDAATYRWPMVPALALLAAMPALGSAERAVEIYAQRLSER
TH_2929|M.thermoresistible__bu YAGTTPGAALHDAAAYRWPMVPALALLAAMPALGSAERVTDLFAERLGHR
MAV_2166|M.avium_104 YGGTAPGAREHAAATYRWPMVPALALTAAMPVLGAAERVVQLFADRLGER
MAB_0075|M.abscessus_ATCC_1997 IDGTAQRDAGMTDTLYRMPWSTMFPLGISSAVIGIAEGALAAHLEYQRER
MLBr_00737|M.leprae_Br4923 ----------GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
. .:* *. :
MMAR_1556|M.marinum_M KGLGAKRTLAERSATQTAVATAEAALGAARALFYEAIDSAWQASHNPD--
MUL_3474|M.ulcerans_Agy99 KGLGAKRTLAERSATQTAVATAEAALGAARALFYEAIDSAWQASHNPDPV
Mb3121c|M.bovis_AF2122/97 KGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAE--
Rv3094c|M.tuberculosis_H37Rv KGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAE--
Mflv_3440|M.gilvum_PYR-GCK FRMSDMASLASRPTFQKDLAHHVAAWRAARLLVLDAFTGAEGAVAAGA--
Mvan_3194|M.vanbaalenii_PYR-1 FRMSDMAALASRPTFQKGLAHHVAAWRAARLLVLDAFGTAEAAVAGGD--
MSMEG_2077|M.smegmatis_MC2_155 VIAYEGVKQKDKPAAVAHLGEARVRLRALRGLLADTVGEIEDTVTAGD--
TH_2929|M.thermoresistible__bu VIAYEGVAQRDKPIAQAHLGRARVRLRALHGLLADTVGQIQQLVAAGD--
MAV_2166|M.avium_104 VLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRIEAIVAGGD--
MAB_0075|M.abscessus_ATCC_1997 VGAQG-TAVKDDPYVLFAIGEAAADINAARQEILANVDKIWGIVDSGK--
MLBr_00737|M.leprae_Br4923 KQFGESISTFQS--IQFMLADMAMKVEAARLIVYAAAARAERGEPDLG--
. . * : .
MMAR_1556|M.marinum_M --------PVPVALRNRLRLAATHAARTSADVVRIMYDLAGSSAIYDGSP
MUL_3474|M.ulcerans_Agy99 PVPVPVPVPVPVALRNRLRLAATHAARTSADVVRTMYDLAGSSAIYDGSP
Mb3121c|M.bovis_AF2122/97 --------AVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAP
Rv3094c|M.tuberculosis_H37Rv --------AVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAP
Mflv_3440|M.gilvum_PYR-GCK --------ELTPTMRADMRVAAVFATDTARGCAEWAHLAAGTTSIREGSR
Mvan_3194|M.vanbaalenii_PYR-1 --------DLTPTLRADMRVAAVFATDTARACAEWAHLVAGTSSIREGSR
MSMEG_2077|M.smegmatis_MC2_155 --------PVSREVRAQARLAAAHIVRESRAVIALLLASSGASAHFLDNP
TH_2929|M.thermoresistible__bu --------PVPRPVRADARLAAAHIVHESRAIIGDLLAASGASVQFLSHP
MAV_2166|M.avium_104 --------RVSRSVRAEARLAAARTVHESRAIIADVTEASGASAHFLSSP
MAB_0075|M.abscessus_ATCC_1997 --------EVSFADRAAGRRTQVRAAWRAVMAVDQIFSRSGGNAMRLDKP
MLBr_00737|M.leprae_Br4923 ---------------FISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFP
: : * .
MMAR_1556|M.marinum_M LQRRFRDAFTATAHFQVN-EASRELPGRVLLGQHCDTSML---
MUL_3474|M.ulcerans_Agy99 LQRRFRDAFTATAHFQVN-EASRELPGRVLLGQHCDTSML---
Mb3121c|M.bovis_AF2122/97 LQRRFRDAFTATAHFQVN-EASRELPGRVLLDQPADVSML---
Rv3094c|M.tuberculosis_H37Rv LQRRFRDAFTATAHFQVN-EASRELPGRVLLDQPADVSML---
Mflv_3440|M.gilvum_PYR-GCK LERAFRDIYTGTQHAFIS-EKVAIDAAQVWLGVVEDQFGL---
Mvan_3194|M.vanbaalenii_PYR-1 LERAFRDVYTGTQHAFIS-EKVAIDAAQVWLGVVEDQFGL---
MSMEG_2077|M.smegmatis_MC2_155 LQRISRDVGVLSGHVIFDHDTSCELAGALSIGMKISPIAMI--
TH_2929|M.thermoresistible__bu MQRFQRDVDVLAGHVVFDYDTSRELAGALELGLKVSPLAMI--
MAV_2166|M.avium_104 MQRAKRDVDIAAGHVVFDYDTSRELAGALAIGAKISPISMI--
MAB_0075|M.abscessus_ATCC_1997 LQRYWRDAHTGLAHAIHVPSTVFHASALSSLGIEPQGPLRSMI
MLBr_00737|M.leprae_Br4923 VERFMRDAKITQIYEGTN-QIQRVVMSRALLR-----------
::* ** : . . :