For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGYQVT GLDISPTALTTAKRRASDAGVDVKFAVGDATKLTGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRP GATLLLSCFSNAMPPDEEWPRSTVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRG S*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1377c | - | - | 100% (212) | PUTATIVE TRANSFERASE |
| M. tuberculosis H37Rv | Rv2675c | - | 4e-30 | 39.09% (197) | hypothetical protein Rv2675c |
| M. tuberculosis H37Rv | Rv0560c | - | 2e-28 | 36.36% (187) | benzoquinone methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1412c | - | 1e-127 | 100.00% (212) | putative transferase |
| M. gilvum PYR-GCK | Mflv_1324 | - | 2e-31 | 38.62% (189) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00130 | - | 8e-08 | 33.33% (99) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_0867c | - | 3e-40 | 45.95% (185) | putative transferase |
| M. marinum M | MMAR_2193 | - | 8e-92 | 74.76% (210) | NodS-like (sam)-dependent methyltransferase |
| M. avium 104 | MAV_3570 | - | 2e-34 | 41.12% (197) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3041 | - | 2e-74 | 63.89% (216) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 2e-30 | 36.08% (194) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3309 | - | 8e-30 | 40.64% (187) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 5e-31 | 35.78% (218) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1324|M.gilvum_PYR-GCK ------MA----------EVMDWDSAYRGEGE-FEGEP----PWNIGEPQ
TH_1722|M.thermoresistible__bu ------MATEDPGTGDPTDTIDWDSVYRQEAPGFDGPP----PWNIGEPQ
Rv1377c|M.tuberculosis_H37Rv ------MPG-----------IDFDALYRGESPGEGLPPITTPPWDTKAPK
Mb1412c|M.bovis_AF2122/97 ------MPG-----------IDFDALYRGESPGEGLPPITTPPWDTKAPK
MMAR_2193|M.marinum_M --------------------MDFDALYRGESPRPGVAPMTTPPWDTKAPK
MSMEG_3041|M.smegmatis_MC2_155 ------MTGP------TGSEFDFDALYRGESPAEGVPPITSVPWDTKAPK
MAV_3570|M.avium_104 ------MTASF----DPADPARFEEMYRDQRTSHGLP--AATPWDIGGPQ
MUL_3309|M.ulcerans_Agy99 ------MTAP-----DPTDPTRFEEMYRDQRVAHGLP--AATPWDIGGPQ
MAB_0867c|M.abscessus_ATCC_199 ------MGAP--------TQNIFEDLYRDSLHEGGP----IVPWDSKDAK
Mvan_1888|M.vanbaalenii_PYR-1 ------MDLT-------PRLSRFDEFYKNQTP----------PWVIGEPQ
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDP
: * *
Mflv_1324|M.gilvum_PYR-GCK PELAALWRD------------------GRFRSEVLDAGCGHAELSLALAA
TH_1722|M.thermoresistible__bu PELAALHRA------------------GAFRSDVLDAGCGHAEISMALAA
Rv1377c|M.tuberculosis_H37Rv DNVIGWHTG------------------GWVHGDVLDIGCGLGDNAIYLAR
Mb1412c|M.bovis_AF2122/97 DNVIGWHTG------------------GWVHGDVLDIGCGLGDNAIYLAR
MMAR_2193|M.marinum_M ENVIAWQAG------------------GWVHGDVLDIGCGLGDNAIYLAA
MSMEG_3041|M.smegmatis_MC2_155 ENVVAWEQA------------------GLVHGHVLDIGCGLGDNAIYLAQ
MAV_3570|M.avium_104 PVVRQLVAL------------------GAVKGEVLDPGTGPGHHAIYYAS
MUL_3309|M.ulcerans_Agy99 PVVEQLVAL------------------GAVKGEVLDPGTGPGHHAIYYAS
MAB_0867c|M.abscessus_ATCC_199 PRIKELALL------------------GAIRGDVLDIGCGLGDNAIYLAQ
Mvan_1888|M.vanbaalenii_PYR-1 QAIVELEQA------------------GLIGGRVLDVGCGTGEHTILLAR
MLBr_00130|M.leprae_Br4923 PMALPLEASDEPNRAHINLYHRTATQVNLSGKRILEVSCGHGGGASYLTR
. :*: . * . : :
Mflv_1324|M.gilvum_PYR-GCK DGY--TVTGVDISPTAMAAASAAAAERGLSEKASFVAADITALSGFDGRF
TH_1722|M.thermoresistible__bu DGY--TVVGIDLSPTAIAAANRTAQERGLAT-ASFVQGDITDFGGYDGRF
Rv1377c|M.tuberculosis_H37Rv NGY--QVTGLDISPTALTTAKRRASDAGVDV--KFAVGDATKLTGYTGAF
Mb1412c|M.bovis_AF2122/97 NGY--QVTGLDISPTALTTAKRRASDAGVDV--KFAVGDATKLTGYTGAF
MMAR_2193|M.marinum_M HGH--PVTGLDISPTALITAARRADDAGVHV--TFAVADATKLDGYTDAF
MSMEG_3041|M.smegmatis_MC2_155 QGY--RVTALDISPTALITAERRAADAGVDV--TFAVADATRLDGYDDVF
MAV_3570|M.avium_104 QGF--SATGIDGSAAAIERARANARTAGVSV--NFELADATKLDGFDGRF
MUL_3309|M.ulcerans_Agy99 KGY--SATGIDGSATAIERARDNAAKAGVSV--NFQVADATRLEGLDNRF
MAB_0867c|M.abscessus_ATCC_199 QGF--NVTGLDFAPSAIEQAKGRAAAAGVAV--DFQVADATTLDGWDARF
Mvan_1888|M.vanbaalenii_PYR-1 AGY--DVLGIDGAPTAVEQARRNAEAQGVDA--RFELADALHLG-PDPTY
MLBr_00130|M.leprae_Br4923 ALHPASYTGLDLNPAGIKLCQKRHQLPGLEF----VRGDAENLPFDNESF
. .:* .:.: . *: .* : :
Mflv_1324|M.gilvum_PYR-GCK STVVDSTLFHSLP--VESRAGYLESVHRAARPGAGFFVLVFAKGAFPADT
TH_1722|M.thermoresistible__bu NTIIDSTLFHSIP--VQARDGYLRSIHRAAAPGARYFALVFAKGAFPEEM
Rv1377c|M.tuberculosis_H37Rv DTVIDCGMFHCLD--DDGKRSYAASVHRATRPGATLLLSCFSN--AMPPD
Mb1412c|M.bovis_AF2122/97 DTVIDCGMFHCLD--DDGKRSYAASVHRATRPGATLLLSCFSN--AMPPD
MMAR_2193|M.marinum_M DTVIDSGMFHCLD--DEGKRSYAAAVHRATRPGATLLMSCFCD--ANPPN
MSMEG_3041|M.smegmatis_MC2_155 DTVVDSGMFHCLS--DDAKGSYAAAVHRATRAGATLLLGAFSD--ANLQH
MAV_3570|M.avium_104 DTVVDCAFYHVFATEPELRSSYARALHRATKPGARLYMFEFGE--HDVNG
MUL_3309|M.ulcerans_Agy99 DTVVDCAFYHTFGTAPELQRSYVQALWRATKPGARLYMYEFGA--HQVNG
MAB_0867c|M.abscessus_ATCC_199 DTVIDSGVYHCFD--AEGHTEYASALHRATRPGARWYIWCFAQ--GAVHG
Mvan_1888|M.vanbaalenii_PYR-1 DTIVDSALFHIFD--DADRATYVRSLHAATRPGSVVHLLALSD--SGR--
MLBr_00130|M.leprae_Br4923 DVVINIEASHCYP----HFPRFLAEVVRVLRPGGHLAYADLRPSNKVGEW
..::: * : : . .*. :
Mflv_1324|M.gilvum_PYR-GCK EQGP--NEVSEIELREAVS-PYWTIDDIRPALIHTNVPKLPGMPPPPLDM
TH_1722|M.thermoresistible__bu EQGPGPNPVDEDELREAVS-KYWEIDEIRPAFIHANMP--PDVPGVESFD
Rv1377c|M.tuberculosis_H37Rv EEW-PRSTVSEQTLRDVLGGAGWDIESLEPATVR---REL----------
Mb1412c|M.bovis_AF2122/97 EEW-PRSTVSEQTLRDVLGGAGWDIESLEPATVR---REL----------
MMAR_2193|M.marinum_M EQQ-PRPAVPEQTLRDVLGGAGWEIAALDPVTVN---RQLGGS-------
MSMEG_3041|M.smegmatis_MC2_155 DNW-QAAWVSEDTLRSSLDDGGWDITSLTTETIRVPGAALAGSGDEG---
MAV_3570|M.avium_104 FK--MMRSLSENDFRDVLPAAGWEISYLGPTTYQVNLSAETIQMMAARNP
MUL_3309|M.ulcerans_Agy99 LT--AIRSLPEENFREMLPLGGWEITYLGPTTYRTTVSMETLETMAARNP
MAB_0867c|M.abscessus_ATCC_199 VPTPFQNGQRAEEIEQVLTTSGWSVLQINPTT----MSAPKAEFLNAIRG
Mvan_1888|M.vanbaalenii_PYR-1 ---GFGPEVSEHTIRAAFG-AGWEVEALTETTYRGVVIDAHTEALNLP--
MLBr_00130|M.leprae_Br4923 EVDFANSRLQQLSQREINAEVLRGIASNSQKSRDLVDRHLPAFLRFAGRE
. :
Mflv_1324|M.gilvum_PYR-GCK LD------------------DRGHLRMQAFLLSAHKEP-
TH_1722|M.thermoresistible__bu TD------------------EKGRTKLPAFLLSAHKA--
Rv1377c|M.tuberculosis_H37Rv --------------------DGTEVEMAFWNVRAQRRGS
Mb1412c|M.bovis_AF2122/97 --------------------DGTEVEMAFWNVRAQRRGS
MMAR_2193|M.marinum_M --------------------DGQPIKLAFWYVRARRQN-
MSMEG_3041|M.smegmatis_MC2_155 --------------------GADEFDAAFFLVQAQRR--
MAV_3570|M.avium_104 DMADEAAKLLERFRAMEPWLQAGRVHAPFWEVHATRVD-
MUL_3309|M.ulcerans_Agy99 EVADQVGPLVERFKTIQPWLTDGIAHVPFWEVHATRPD-
MAB_0867c|M.abscessus_ATCC_199 SYRGDP-AVLDR---LDQDVTDPLLHVPVYTVIAERM--
Mvan_1888|M.vanbaalenii_PYR-1 --------------------AGTVVDEPAWSARIRRL--
MLBr_00130|M.leprae_Br4923 FIGVQG-------TQLSRYLEGGELSYRMYSFAKD----
: