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MHPGTVSTPLSSSSSVVDSALTHQDRHETTFPVVNPATEEVLADVADLDGAAAVAALDNAVAAQRSWAAT TPQQRSDVLMRAYTLMIQRTEDLALLMTLEMGKPLPESRGEVAYAAEFFRWFAGEAVRLDGSVMLAPDGQ SRLIVTHRPVGPCLLITPWNFPLAMGTRKIGPALAAGCTCLVKPAEQTPLSMLALLGILREAGVPDGVVS VITTADPGATMAPLLADPRVRKLSFTGSTEVGRYLLAQCAPTVKRTSMELGGNAPFIVFDDADPEEAAAG ALIAKMRNIGQACTAANRIYVQRGIADAFTEALTTKLTALRMGPGVEPGVDVGPLIDPDAVAKADRLVTD ARKRGATVRLGGEVPDGTGYFYPPSVLTDVPDESDMMRTEIFAPVAAIATFETEQEVITRANDSEFGLVA YLYTNDTRRGWRVSEQLETGMVGLNRPVVSTPAAPFGGVKQSGIGREGGFAGIEEFMETKYIGAAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4418 | - | - | 100% (486) | succinate-semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4208 | - | e-154 | 59.47% (454) | putative succinate-semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 8e-80 | 36.58% (462) | gamma-aminobutyraldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 6e-73 | 37.74% (461) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1858 | - | 1e-145 | 55.07% (454) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. tuberculosis H37Rv | Rv2858c | aldC | 6e-73 | 37.74% (461) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-68 | 34.14% (454) | succinic semialdehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 2e-83 | 38.70% (460) | aldehyde dehydrogenase NAD dependent |
| M. avium 104 | MAV_2101 | - | 6e-86 | 39.91% (466) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2488 | - | 1e-159 | 60.35% (454) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
| M. thermoresistible (build 8) | TH_4137 | - | 1e-120 | 48.37% (461) | PUTATIVE putative [NADP+] succinate-semialdehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 9e-82 | 38.04% (460) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4876 | - | 1e-144 | 55.51% (454) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1858|M.gilvum_PYR-GCK MDNSAVEALLASVPTGLWIGGEEREGTS--TFDVLDPSDDTVLTSVADAT
Mvan_4876|M.vanbaalenii_PYR-1 MDTS---ALLKSVPTGLWIGGEERQGTS--TFSVLDPSDDEVLATVADAT
MSMEG_2488|M.smegmatis_MC2_155 MTEHEN-RVVSGVQKRLFIDGKWVDATDGATFDVLDPATGEVLCAVADAS
MAB_4418|M.abscessus_ATCC_1997 MHPGTVSTPLSSSSSVVDSALTHQDRHET-TFPVVNPATEEVLADVADLD
TH_4137|M.thermoresistible__bu ----------------MYIDGEWQSAASGKTFASINPANGAVLDSVPDGE
Mb2883c|M.bovis_AF2122/97 --------MSTTQ--------------------LINPATEEVLASVDHTD
Rv2858c|M.tuberculosis_H37Rv --------MSTTQ--------------------LINPATEEVLASVDHTD
MAV_2101|M.avium_104 --------MSTTIP-------------------VFNPSTEEQIAEVPDSD
MMAR_3556|M.marinum_M --------MTTTVSVAGSWINGAAHSTGGRQHAVINPATQETIAELALAT
MUL_2789|M.ulcerans_Agy99 --------MTTTVSVAGSWINGAAHSTGGRQHAVINPATQETIAELALAT
MLBr_02573|M.leprae_Br4923 -----------------------------MSIATINPATGETVKTFTPTT
.:*: : .
Mflv_1858|M.gilvum_PYR-GCK ADDARAALDAACAVQAE--WAGTAPRKRGEILRSVFETITARADDIAALM
Mvan_4876|M.vanbaalenii_PYR-1 ADDARDALDAACAVQGE--WAATPARKRGEILRSVFETITARADDIAALM
MSMEG_2488|M.smegmatis_MC2_155 PQDGRAALDAAVAAQPE--FAALPPRERADMLTGAFELLHERIDDLALLM
MAB_4418|M.abscessus_ATCC_1997 GAAAVAALDNAVAAQRS--WAATTPQQRSDVLMRAYTLMIQRTEDLALLM
TH_4137|M.thermoresistible__bu REDARRAIDAAAAALPD--WRSRTAYERAEVLVEAHRIMLERRDDLAELM
Mb2883c|M.bovis_AF2122/97 ANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAALE
Rv2858c|M.tuberculosis_H37Rv ANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAALE
MAV_2101|M.avium_104 QAAVDAAVARARETFESGVWRKAPASHRANVLFRAARIIEERKDELAALE
MMAR_3556|M.marinum_M PADVDRAVVAARRALPQ--WAGVTPAERSAVLAKLADLLEQRAPELIAEE
MUL_2789|M.ulcerans_Agy99 PADVDHAVVAARRALPQ--WAGVTTAERSAVLAELADLLEQRAPELIAEE
MLBr_02573|M.leprae_Br4923 QDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALM
*: * : . .*. : . :
Mflv_1858|M.gilvum_PYR-GCK TLEMGKVLAESKG-EVTYGAEFFRWFAEEAVRIDGRYTAAPA-------G
Mvan_4876|M.vanbaalenii_PYR-1 TLEMGKVFAESKG-EVTYGAEFFRWFAEEAVRIEGRYTPAPA-------G
MSMEG_2488|M.smegmatis_MC2_155 TLEMGKPLAEARG-EITYAAEFFRHFAAEAVRIDGGYQTAPA-------G
MAB_4418|M.abscessus_ATCC_1997 TLEMGKPLPESRG-EVAYAAEFFRWFAGEAVRLDGSVMLAPD-------G
TH_4137|M.thermoresistible__bu TREQGKPLRMART-EVGYAADFLLWFAEEAKRVYGEVIPSAR-------A
Mb2883c|M.bovis_AF2122/97 VANSGHPI-VSAEWEAGHVRDVLAFYAASPERLSGRQIPVAG----GVDV
Rv2858c|M.tuberculosis_H37Rv VANSGHPI-VSAEWEAGHVRDVLAFYAASPERLSGRQIPVAG----GVDV
MAV_2101|M.avium_104 SQDNGMNL-TAAGHIIPVSVDMLKYYAGWVGKIHGESANLVSDGLLGTWE
MMAR_3556|M.marinum_M VCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEYS-----ADH
MUL_2789|M.ulcerans_Agy99 VCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEYS-----ADH
MLBr_02573|M.leprae_Br4923 TLEMGKTLQSAKD-EAMKCAKGFRYYAEKAETLLADEPAEAA-----AVG
: * : : . : :* : .
Mflv_1858|M.gilvum_PYR-GCK TGRILVTKQAVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETP
Mvan_4876|M.vanbaalenii_PYR-1 TGRILVTKQAVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETP
MSMEG_2488|M.smegmatis_MC2_155 GSRFLIARQPVGPCLLITPWNFPMAMGTRKLGPAIAAGCTSVIKPAHQTP
MAB_4418|M.abscessus_ATCC_1997 QSRLIVTHRPVGPCLLITPWNFPLAMGTRKIGPALAAGCTCLVKPAEQTP
TH_4137|M.thermoresistible__bu DQRFIVLAQPVGVCAAITPWNYPISMLTRKLAPALAAGCTSVLKPAEQTP
Mb2883c|M.bovis_AF2122/97 TFN-----EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTP
Rv2858c|M.tuberculosis_H37Rv TFN-----EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTP
MAV_2101|M.avium_104 TYHTFTQLEPVGVVGLIIPWNGPFFVAMLKVAPALAAGCSAVLKPAEETP
MMAR_3556|M.marinum_M TSS--IRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTP
MUL_2789|M.ulcerans_Agy99 TSS--IRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTP
MLBr_02573|M.leprae_Br4923 ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVP
..:* : *** *: **: ** ::* : .*
Mflv_1858|M.gilvum_PYR-GCK LTMLLLAKLMADAGLPKGVLSVLPTTSPGPVTETLIDDGRLRKLTFTGST
Mvan_4876|M.vanbaalenii_PYR-1 LTMLLLAKLMAEAGLPKGVLSVLPTSNPGAVTEALINDGRLRKLTFTGST
MSMEG_2488|M.smegmatis_MC2_155 LSMLALMDILSEVGVPAGAVNCVTAMDAGGVMEPLIRSGLARKLSFTGST
MAB_4418|M.abscessus_ATCC_1997 LSMLALLGILREAGVPDGVVSVITTADPGATMAPLLADPRVRKLSFTGST
TH_4137|M.thermoresistible__bu LCAVETFKVFADAGVPAGVVNLVTCSDPEPVADELLGDPRVRKISFTGST
Mb2883c|M.bovis_AF2122/97 LTTMRLGELAVEAGLDEDLLQVLPGKG-TVVGERFVTHPDIRKIVFTGST
Rv2858c|M.tuberculosis_H37Rv LTTMRLGELAVEAGLDEDLLQVLPGKG-TVVGERFVTHPDIRKIVFTGST
MAV_2101|M.avium_104 LTALKLEEIFREAGLPDGVLNVITGYG-ETTGAALTAHPDVDKISFTGST
MMAR_3556|M.marinum_M LTTLTLARLAAEAGLPDGVLNVVTGLG-ADVGAALAAHPGVDLVTFTGST
MUL_2789|M.ulcerans_Agy99 LTTLTLARLAAEAGLPDGVLNVVTGLG-ADVGAALAAHPGVDLVTFTGST
MLBr_02573|M.leprae_Br4923 QCALYLADVIARGGFPEDCFQTLLISA--NGVEAILRDPRVAAATLTGSE
: : *. . .. : : :***
Mflv_1858|M.gilvum_PYR-GCK GVGKALVKQSADKLLRTSMELGGNAPFVVFDDADVDAAVDGAILAKMRNG
Mvan_4876|M.vanbaalenii_PYR-1 GVGKALVKQSADKLLRTSMELGGNAPFIVFDDADVDAAVDGAILAKMRNG
MSMEG_2488|M.smegmatis_MC2_155 KVGRMLLEQCAEKILRTSLELGGNAPLIVFEDADLDEAVEGAILAKMRNM
MAB_4418|M.abscessus_ATCC_1997 EVGRYLLAQCAPTVKRTSMELGGNAPFIVFDDADPEEAAAGALIAKMRNI
TH_4137|M.thermoresistible__bu EVGRMIASRAGATMKRVSMELGGHAPFLVFPDADPEHAAKGGAAVKFLNT
Mb2883c|M.bovis_AF2122/97 EVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNA
Rv2858c|M.tuberculosis_H37Rv EVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNA
MAV_2101|M.avium_104 EVGRLIVKAAAGNLKRLTLELGGKSPLIMFDDANLDKAIMGAGMGLLAGS
MMAR_3556|M.marinum_M AVGRKVMAAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAGALINS
MUL_2789|M.ulcerans_Agy99 AVGRKVMAAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAGAVINS
MLBr_02573|M.leprae_Br4923 PAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNN
.*: : .. :**** . ::: ..: : * . . .
Mflv_1858|M.gilvum_PYR-GCK GEACTAANRIHVANAVREEFTDKFVKRMSEFTLGKGLDEKSTLGPLINAK
Mvan_4876|M.vanbaalenii_PYR-1 GEACTAANRIHVANAVREEFTEKFVKRMSEFTLGKGLDEKSTLGPLINAK
MSMEG_2488|M.smegmatis_MC2_155 GEACTAANRLFVHSSVIDEFGRRLAERMAEMPVGRGTEDGVRVGPLIDEA
MAB_4418|M.abscessus_ATCC_1997 GQACTAANRIYVQRGIADAFTEALTTKLTALRMGPGVEPGVDVGPLIDPD
TH_4137|M.thermoresistible__bu GQACICPNRFIVHRSIAEPFIATLRARIEKLVPGDGLAAGTTVGPLIDEV
Mb2883c|M.bovis_AF2122/97 GQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRA
Rv2858c|M.tuberculosis_H37Rv GQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRA
MAV_2101|M.avium_104 GQNCSCTSRIYVQRGIYDQVVEGLAEFAMMLPMGGSDDPNSVLGPLISEK
MMAR_3556|M.marinum_M GQDCTAATRAIVARELYHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLA
MUL_2789|M.ulcerans_Agy99 GQDCTAATRAIVARELCHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLA
MLBr_02573|M.leprae_Br4923 GQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATES
*: * . .* . : . . . . * :***
Mflv_1858|M.gilvum_PYR-GCK QVATVTELVSDAVSRGATVAVGGVAPGGP----GNFYPATVLTDVPADAR
Mvan_4876|M.vanbaalenii_PYR-1 QVATVTELVSDAVSRGATVAVGGVAPGGP----GNFYPATVLTDVPADAR
MSMEG_2488|M.smegmatis_MC2_155 ALQKVTSLVDDAVKRGATVLTGGSAPSGP----GFFYPPTVLSGVPRDAE
MAB_4418|M.abscessus_ATCC_1997 AVAKADRLVTDARKRGATVRLGGEVPDGT----GYFYPPSVLTDVPDESD
TH_4137|M.thermoresistible__bu ALKKMQRQVDDAVDKGAKLELGGSRLQGPAFDNGHFYAPTILTGVTPDML
Mb2883c|M.bovis_AF2122/97 HRDKVAGYVPD----DAPVAFRGTAPAGR----GFWFPPTVLTPKRGD-R
Rv2858c|M.tuberculosis_H37Rv HRDKVAGYVPD----DAPVAFRGTAPAGR----GFWFPPTVLTPKRGD-R
MAV_2101|M.avium_104 QRQRVEGIVNDGVAAGAKVITGGKPMDRK----GYFYEATIITNTTPDMR
MMAR_3556|M.marinum_M HRDRVADIVAKAPAQGARIVVGGRIPDLA----GAFYLPTLLADVGEQSQ
MUL_2789|M.ulcerans_Agy99 HRDRVADILAKAPAQGARIVVGGRIPDLA----GAFYLPTLLADVGEQSQ
MLBr_02573|M.leprae_Br4923 GRAQVEQQVDAAAAAGAVIRCGGKRPDRP----GWFYPPTVITDITKDMA
: .* : * * :: .:::: :
Mflv_1858|M.gilvum_PYR-GCK ILKEEVFGPVAPIAGFDTEEEGIAAANDTEYGLAAYVYTQSLDRALRVAE
Mvan_4876|M.vanbaalenii_PYR-1 ILKEEVFGPVAPIAGFDTEEEGIAAANDTEYGLAAYVYTQSLDRALRVAE
MSMEG_2488|M.smegmatis_MC2_155 MVGQEIFGPVAPLTPFDTEEEAVAAANDTEYGLVSYVFTNDLRRALRVAE
MAB_4418|M.abscessus_ATCC_1997 MMRTEIFAPVAAIATFETEQEVITRANDSEFGLVAYLYTNDTRRGWRVSE
TH_4137|M.thermoresistible__bu ICSEETFGPIAPVMVFDDEDEAIAMANSTEYGLAGYIYTRDISRAIRVGE
Mb2883c|M.bovis_AF2122/97 TVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVAR
Rv2858c|M.tuberculosis_H37Rv TVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVAR
MAV_2101|M.avium_104 LIREEIFGPVGCVIPFDDEDEVIAAANDTHYGLAGAIWTENLSRAHRVVN
MMAR_3556|M.marinum_M AYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASR
MUL_2789|M.ulcerans_Agy99 AYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASR
MLBr_02573|M.leprae_Br4923 LYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFID
* *.*: : : : ** : :** . :* . . :
Mflv_1858|M.gilvum_PYR-GCK GIESGMVGVNRGVISDPAAPFGGIKESGFGREGGTEGIEEYLDTKYIALT
Mvan_4876|M.vanbaalenii_PYR-1 NIESGMVGVNRGVISDAAAPFGGIKESGFGREGGTEGIEEYLDTKYIALT
MSMEG_2488|M.smegmatis_MC2_155 ALETGMVGLNQGIVSNPAAPFGGIKESGLGREGGAVGIDEFLETKYVGIK
MAB_4418|M.abscessus_ATCC_1997 QLETGMVGLNRPVVSTPAAPFGGVKQSGIGREGGFAGIEEFMETKYIGAA
TH_4137|M.thermoresistible__bu ALDFGMIGINDINPTSAAVPFGGIKQSGLGREGARAGIEEYLDTKVLGIA
Mb2883c|M.bovis_AF2122/97 AVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIA
Rv2858c|M.tuberculosis_H37Rv AVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIA
MAV_2101|M.avium_104 ELRAGQIWVNSALAADPSMPISGHKQSGWGGERGRKGIEAYFNTKAVYIG
MMAR_3556|M.marinum_M EISAGCVWINDHIPIVSEMPHGGVAASGFGKDMSEYSFEEYLTIKHVMSD
MUL_2789|M.ulcerans_Agy99 EISAGCVWINDHIPIVSEMPHGGVAASGFGNDMSEYSFDEYLTIKHVMSD
MLBr_02573|M.leprae_Br4923 NIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA
: * : :* * .* ** * : . . : * :
Mflv_1858|M.gilvum_PYR-GCK K-----------------
Mvan_4876|M.vanbaalenii_PYR-1 R-----------------
MSMEG_2488|M.smegmatis_MC2_155 M-----------------
MAB_4418|M.abscessus_ATCC_1997 V-----------------
TH_4137|M.thermoresistible__bu L-----------------
Mb2883c|M.bovis_AF2122/97 VGEEM-------------
Rv2858c|M.tuberculosis_H37Rv VGEEM-------------
MAV_2101|M.avium_104 L-----------------
MMAR_3556|M.marinum_M ITGVAEKPWHRTIFSTRI
MUL_2789|M.ulcerans_Agy99 ITGVAEKPWHRTIFSTRI
MLBr_02573|M.leprae_Br4923 ------------------