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TADAPARPRNALRLMFDPVFGALFWGKIFSVVAVWTHGIVAAIVMYDATRSAVMVGMVGVAQFLPQLILS PTSGKWADVGNPARQILLGRLMCIAGSGSTAAWMALAPDLTGNAVAVPVLVGATLVGFGFVIGGPAMQSV VPNLIREGELATAMALNSIPMTIGRILGPPIGAYLAAHLGAAAGFAISAGLHVIFAVFLVLVTFPTRPKL DPDGDYRVRAALRHVWRDRPLLLALLAVSTVGFASDPSITLTPSMAEDLGGGTQLVGALSASFGVGAAVG MIVLAVLRGRIASERVSSVGLFLLTAGSALLAAATEAPVALIGFAIAGLGFGWSMTGLSTVVQERAPEEL RGRIMALWLVGFLGSRPFAAALLGGAADVFNVRVAFLIAAAATFALALAARPATMSAPIPASV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1329 | - | - | 100% (414) | major facilitator superfamily protein MFS_1, putative |
| M. smegmatis MC2 155 | MSMEG_0357 | - | 3e-25 | 25.83% (391) | transmembrane transport protein |
| M. smegmatis MC2 155 | MSMEG_6390 | - | 8e-25 | 27.48% (404) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 9e-14 | 25.68% (366) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1033 | - | 1e-158 | 68.05% (410) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1258c | - | 9e-14 | 25.68% (366) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0880 | - | 1e-23 | 24.82% (407) | hypothetical protein MAB_0880 |
| M. marinum M | MMAR_4182 | - | 2e-13 | 26.84% (313) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 4e-11 | 24.04% (366) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_1753 | - | 1e-165 | 70.42% (409) | major facilitator superfamily protein MFS_1, putative |
| M. ulcerans Agy99 | MUL_0354 | - | 5e-07 | 30.16% (189) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_5800 | - | 1e-169 | 73.67% (414) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1033|M.gilvum_PYR-GCK ---------MIQSPSRPAPVTSLPARGAFGLMFDRVFGALFWGKMFAVVA
Mvan_5800|M.vanbaalenii_PYR-1 -------------MTAEATAARLPARNALGLMFDPVFGALFWGKIFAVVA
MSMEG_1329|M.smegmatis_MC2_155 -------------MTADAPAR---PRNALRLMFDPVFGALFWGKIFSVVA
TH_1753|M.thermoresistible__bu -------VSTSPATTTTAATDPAPPRGALGLMFDPVFGGLFWGKILSVVA
Mb1288c|M.bovis_AF2122/97 ----------------------------MRNSNRGPAFLILFATLMAAAG
Rv1258c|M.tuberculosis_H37Rv ----------------------------MRNSNRGPAFLILFATLMAAAG
MMAR_4182|M.marinum_M ----------------------------MRNSSRGPAFLILFATLAACAG
MAV_1406|M.avium_104 --------------------------------------MILFATLLATAG
MAB_0880|M.abscessus_ATCC_1997 ---------------------MADRGGIFVSLRTRNYRLWISGQMVSLIG
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
.
Mflv_1033|M.gilvum_PYR-GCK VWTHGLVAAIVMYDATR-SALMVGLVGVAQFFPQLILAPTSGKWADTGNP
Mvan_5800|M.vanbaalenii_PYR-1 VWTHGIVAAIVMYDATR-SALMVGMVGVVQFAPQLILSPTSGKWADTGNP
MSMEG_1329|M.smegmatis_MC2_155 VWTHGIVAAIVMYDATR-SAVMVGMVGVAQFLPQLILSPTSGKWADVGNP
TH_1753|M.thermoresistible__bu VWTHGIVAAITMFNATG-SAVMVGLVGVAQFGPQLILTPISGKWADVGNQ
Mb1288c|M.bovis_AF2122/97 DGVSIVAFPWLVLQREG-SAGQASIVASATMLPLLFATLVAGTAVDYFGR
Rv1258c|M.tuberculosis_H37Rv DGVSIVAFPWLVLQREG-SAGQASIVASATMLPLLFATLVAGTAVDYFGR
MMAR_4182|M.marinum_M NGISIVAFPWLVLEREG-SAGQASIVAGAITLPLLFSTLVAGTAVDYFGR
MAV_1406|M.avium_104 TGISIVAFPWLALQHRH-SATDASIVAAAMTLPLVLATLIAGTAVDFFGR
MAB_0880|M.abscessus_ATCC_1997 TWMQRVAQDWLVLDLSHGNAFLLGVVMALQFGPTLLLSVWGGMLADRYDK
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
. . .: * . .
Mflv_1033|M.gilvum_PYR-GCK ARQ--------ILLGRVFCVIGSG--SIAVWMFAEPGLQGVAV-------
Mvan_5800|M.vanbaalenii_PYR-1 ARQ--------ILLGRVLCVAGSG--SIAAWMFVQPGLTGLAA-------
MSMEG_1329|M.smegmatis_MC2_155 ARQ--------ILLGRLMCIAGSG--STAAWMALAPDLTGNAV-------
TH_1753|M.thermoresistible__bu ARQ--------ILLGRLLCTAGSG--LIAAWLFLSPHMQGVAV-------
Mb1288c|M.bovis_AF2122/97 RRV--------SMVADALSGAAVAGVPLVAWGYGGDAVNVLVL-------
Rv1258c|M.tuberculosis_H37Rv RRV--------SMVADALSGAAVAGVPLVAWGYGGDAVNVLVL-------
MMAR_4182|M.marinum_M RPV--------SMVSDALSGSAVAIVPLIAWAFGDDAVSVAVL-------
MAV_1406|M.avium_104 RRV--------SLVCDWLSGAAVTAVPLTAWIFGAAAIDVAEL-------
MAB_0880|M.abscessus_ATCC_1997 RRM--------LMLTQALM-------ALFALTVGLLQVTGLVR-------
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
: . . .
Mflv_1033|M.gilvum_PYR-GCK -------------------------------------------AIPILIG
Mvan_5800|M.vanbaalenii_PYR-1 -------------------------------------------AVPVLLG
MSMEG_1329|M.smegmatis_MC2_155 -------------------------------------------AVPVLVG
TH_1753|M.thermoresistible__bu -------------------------------------------AVPILIG
Mb1288c|M.bovis_AF2122/97 -------------------------------------------AVLAALA
Rv1258c|M.tuberculosis_H37Rv -------------------------------------------AVLAALA
MMAR_4182|M.marinum_M -------------------------------------------AALGACS
MAV_1406|M.avium_104 -------------------------------------------AVLAFCA
MAB_0880|M.abscessus_ATCC_1997 -------------------------------------------IWHVMAV
MUL_0354|M.ulcerans_Agy99 GVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAGVLVGMAEARSVAALLVG
Mflv_1033|M.gilvum_PYR-GCK TTLVGIGFVVGGPAMQSIVPTLIRNGELPTAMALN--SLPMTVGRVIGPA
Mvan_5800|M.vanbaalenii_PYR-1 TTLVGFGFVVGGPAMQSIVPNLIRAGELPTAMALN--SIPMTIGRIIGPA
MSMEG_1329|M.smegmatis_MC2_155 ATLVGFGFVIGGPAMQSVVPNLIREGELATAMALN--SIPMTIGRILGPP
TH_1753|M.thermoresistible__bu TTLVGFGFVVGGPAMQSIVPSLIRPGELSTAMALN--SLPMTVGRIAGPA
Mb1288c|M.bovis_AF2122/97 AAFGPAGMTARDSMLPEAAARAGWS--LDRINGAY--EAILNLAFIVGPA
Rv1258c|M.tuberculosis_H37Rv AAFGPAGMTARDSMLPEAAARAGWS--LDRINGAY--EAILNLAFIVGPA
MMAR_4182|M.marinum_M ATFDPAGITARQSMLPEAAARAGWS--LDRINSSY--EAILNLAFVVGPG
MAV_1406|M.avium_104 AAFDPAGMTARQSMLPEAAARAGWS--LDRTNSSY--EAMLNLAFIVGPG
MAB_0880|M.abscessus_ATCC_1997 AFAMGCAAAIEAPTRQSFTIEMVGPEHLPNAVGLN--SMVFNLAGIIGPA
MUL_0354|M.ulcerans_Agy99 AMITGVVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGRAITGG
: . ..:.
Mflv_1033|M.gilvum_PYR-GCK AGAYLAAHVGPATAFTVSAVLHLVFAMFLLAVRFPAPPQ-----RRPGAD
Mvan_5800|M.vanbaalenii_PYR-1 AGAYLAAHIGPATAFAVSTVLHLVFAFFLLAVRFPAPPE-----RRAGTD
MSMEG_1329|M.smegmatis_MC2_155 IGAYLAAHLGAAAGFAISAGLHVIFAVFLVLVTFPTRPK-----LDPDGD
TH_1753|M.thermoresistible__bu VGAYIAASFGAPTAFAVSCVLHLLFALILVALPFPAQTP-----QPAGTD
Mb1288c|M.bovis_AF2122/97 IGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLV
Rv1258c|M.tuberculosis_H37Rv IGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLV
MMAR_4182|M.marinum_M IGGLMIATVGGITTMWITAGAFGLSLLAIGALRLEGAGRPHHETRPDGLV
MAV_1406|M.avium_104 LGGLLIATLGGINTMWVTAGCFALSFLAIGALRLEGAGKPPRATRPVGLV
MAB_0880|M.abscessus_ATCC_1997 TSGVLIGLIGTGWVFLLNFVSFIAVGIALWRMRPGELHS---SEPIPAAK
MUL_0354|M.ulcerans_Agy99 VGGLLAAWSGVPVLFWINAVACALLALVAARCIPATAHRP--PVAPAVHV
.. : . * : :. .
Mflv_1033|M.gilvum_PYR-GCK YRVRAAVRYVLADRPL-LLALLAVTTVGIVSDPSITLAPSMADELGGGAA
Mvan_5800|M.vanbaalenii_PYR-1 YRVRVAVRYVLRDRPL-LLALVAVTTVGIVSDPSITLTPSMADELGGGAS
MSMEG_1329|M.smegmatis_MC2_155 YRVRAALRHVWRDRPL-LLALLAVSTVGFASDPSITLTPSMAEDLGGGTQ
TH_1753|M.thermoresistible__bu YRVRTALRHVWRDRPL-LLALLAVTTVGFASDPSITLAPSLADNLGGGSE
Mb1288c|M.bovis_AF2122/97 SGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQ-PV
Rv1258c|M.tuberculosis_H37Rv SGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQ-PV
MMAR_4182|M.marinum_M SGVTQGLRFVWNLRVLRALALIDLTVTALYLPMESVLFPTYFSDRQQ-PA
MAV_1406|M.avium_104 TGIAEGVRFVWNLRVLRTLGLIDLAVTALYLPMESVLFPKYFADQHQ-PA
MAB_0880|M.abscessus_ATCC_1997 GQLRQGFSYVWRRRDLFMIMLTVFLVSTFGLNFSLTLAVLARETFGRGAE
MUL_0354|M.ulcerans_Agy99 RAAHNSYRRAFSDGRLVLLFASSLATLTAVRGLYATVPMLMADSGLGAGE
. . * : . . .:
Mflv_1033|M.gilvum_PYR-GCK MVGTLSAVFGVGAALGMGSLAVLRGRIASAYVSSIGMVALT-----LGSA
Mvan_5800|M.vanbaalenii_PYR-1 LVGTLSAVFGVGAAVGMTALALLRGRIGSAVVSSIGMAALA-----AGSA
MSMEG_1329|M.smegmatis_MC2_155 LVGALSASFGVGAAVGMIVLAVLRGRIASERVSSVGLFLLT-----AGSA
TH_1753|M.thermoresistible__bu LVGALSAAFGIGAAAGMATLALLRGRLASARVSVIGLWLLG-----AGSL
Mb1288c|M.bovis_AF2122/97 QLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLG-----LASM
Rv1258c|M.tuberculosis_H37Rv QLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLG-----LASM
MMAR_4182|M.marinum_M QLGSVLVALSLGSLVGALGYGMLSNYVSRRTIMLTAVLTLG-----AATT
MAV_1406|M.avium_104 QLGWALMALALGGVAGALGYAVLSARLRRRTAVLTATLTFG-----ATTA
MAB_0880|M.abscessus_ATCC_1997 SYGLLSTALAIGTLLGAT-FAARRTKKVRMTLFYGAAMAFG-----LSEV
MUL_0354|M.ulcerans_Agy99 FGWAQVANAAAGIGLTPVITPWLGRKVAARINPRLDILAIAGGWTALTMA
. * :
Mflv_1033|M.gilvum_PYR-GCK VLAVGMQSWIAYTGFALAGFGFGCAMTGLSTVVQERAPEELRGRIMALWL
Mvan_5800|M.vanbaalenii_PYR-1 ILAVAMEPWVALTGFAVSGFGFGCAMTGLSTVVQERAPEELRGRIMALWL
MSMEG_1329|M.smegmatis_MC2_155 LLAAATEAPVALIGFAIAGLGFGWSMTGLSTVVQERAPEELRGRIMALWL
TH_1753|M.thermoresistible__bu VLALSTVTAVALAGFVVAGVGFGWAMTGLSTVVQERAPDELRGRIMALWL
Mb1288c|M.bovis_AF2122/97 VIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMT
Rv1258c|M.tuberculosis_H37Rv VIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMT
MMAR_4182|M.marinum_M GIALLPPLPVILVLCALIGVVYGPIQPIYNYVMQTRAPHYLRGRVVGVMT
MAV_1406|M.avium_104 GIAVLPPLPVILGLCAVTGVVYGPIQPIYNFVMQTRAPHHLRGRVVGVMA
MAB_0880|M.abscessus_ATCC_1997 VVSVMPTYLSVALALVPAGLLALTFTTSAMNIIQLSVDSQLRGRVMGIYM
MUL_0354|M.ulcerans_Agy99 GAALAHTTFGFAIAVAASAAGEIAWFVIAVGTVHRIAPPASGGRYHGIWS
: . . :: . ** .:
Mflv_1033|M.gilvum_PYR-GCK VGFLGSRPIAAAVLGGTADLTNVFVAFAVASGLALVVTVLCRPSKLVDLR
Mvan_5800|M.vanbaalenii_PYR-1 VGFLGSRPIAAAVLGGTADVLSVYAAFAVAAALSLAVTLLCRPAKLVGPI
MSMEG_1329|M.smegmatis_MC2_155 VGFLGSRPFAAALLGGAADVFNVRVAFLIAAAATFALALAARPATMSAPI
TH_1753|M.thermoresistible__bu VGFLGSRPIAAAVLGGTADTISVAAAFALAALSVAVIAVLCRPATLGRPA
Mb1288c|M.bovis_AF2122/97 SLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALREL
Rv1258c|M.tuberculosis_H37Rv SLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALREL
MMAR_4182|M.marinum_M SLAYAAGPLGLLLAGPVADAAGLKVAFFALALPIAITGLMCIRLPSLREL
MAV_1406|M.avium_104 GLTYAAGPLGLLVAGPLADAAGLKATFLTLAVPILAIGVVACGLPSLREL
MAB_0880|M.abscessus_ATCC_1997 VAFLGGTPLGSPLVGWLADLHGGRMPLLVGGLVSAAAGLVCATYLHRHPC
MUL_0354|M.ulcerans_Agy99 MTLAIASVVAPIVSSCSLTHGGHRLVALVTVTVGLAGAALCLPLNRSGDV
. .. : . . .
Mflv_1033|M.gilvum_PYR-GCK ---------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 PD-------------------------------
MSMEG_1329|M.smegmatis_MC2_155 PASV-----------------------------
TH_1753|M.thermoresistible__bu PFEPVPVGGGSTGADRARSNMVVTNPAEL----
Mb1288c|M.bovis_AF2122/97 DLAPQADIDRPVGSAQ-----------------
Rv1258c|M.tuberculosis_H37Rv DLAPQADIDRPVGSAQ-----------------
MMAR_4182|M.marinum_M DHAPTQDISETSLL-------------------
MAV_1406|M.avium_104 DRAPQFADDPGA---------------------
MAB_0880|M.abscessus_ATCC_1997 PVVAGEVPEADDMVPPAPAATPVCEPTPLARRS
MUL_0354|M.ulcerans_Agy99 GVRDSQYTAVAAAA-------------------