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IQSPSRPAPVTSLPARGAFGLMFDRVFGALFWGKMFAVVAVWTHGLVAAIVMYDATRSALMVGLVGVAQF FPQLILAPTSGKWADTGNPARQILLGRVFCVIGSGSIAVWMFAEPGLQGVAVAIPILIGTTLVGIGFVVG GPAMQSIVPTLIRNGELPTAMALNSLPMTVGRVIGPAAGAYLAAHVGPATAFTVSAVLHLVFAMFLLAVR FPAPPQRRPGADYRVRAAVRYVLADRPLLLALLAVTTVGIVSDPSITLAPSMADELGGGAAMVGTLSAVF GVGAALGMGSLAVLRGRIASAYVSSIGMVALTLGSAVLAVGMQSWIAYTGFALAGFGFGCAMTGLSTVVQ ERAPEELRGRIMALWLVGFLGSRPIAAAVLGGTADLTNVFVAFAVASGLALVVTVLCRPSKLVDLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1033 | - | - | 100% (417) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_5163 | - | 5e-31 | 27.53% (385) | protein of unknown function DUF894, DitE |
| M. gilvum PYR-GCK | Mflv_2728 | - | 6e-10 | 26.36% (387) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 5e-09 | 21.32% (394) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv1258c | - | 5e-09 | 21.32% (394) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0880 | - | 2e-23 | 23.37% (398) | hypothetical protein MAB_0880 |
| M. marinum M | MMAR_0333 | - | 3e-16 | 25.57% (395) | hypothetical protein MMAR_0333 |
| M. avium 104 | MAV_0138 | - | 4e-07 | 27.20% (261) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_1329 | - | 1e-158 | 68.05% (410) | major facilitator superfamily protein MFS_1, putative |
| M. thermoresistible (build 8) | TH_1753 | - | 1e-158 | 71.43% (399) | major facilitator superfamily protein MFS_1, putative |
| M. ulcerans Agy99 | MUL_0501 | - | 2e-06 | 22.03% (463) | integral membrane drug efflux protein |
| M. vanbaalenii PYR-1 | Mvan_5800 | - | 0.0 | 82.51% (406) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1033|M.gilvum_PYR-GCK -----MIQSPSRPAPVTSLPARGAFGLMFDRVFGALFWGKMFAVVAVWTH
Mvan_5800|M.vanbaalenii_PYR-1 ---------MTAEATAARLPARNALGLMFDPVFGALFWGKIFAVVAVWTH
MSMEG_1329|M.smegmatis_MC2_155 ---------MTADAPAR---PRNALRLMFDPVFGALFWGKIFSVVAVWTH
TH_1753|M.thermoresistible__bu ---VSTSPATTTTAATDPAPPRGALGLMFDPVFGGLFWGKILSVVAVWTH
Mb1288c|M.bovis_AF2122/97 --------------------MRNSN---RGPAF-LILFATLMAAAGDGVS
Rv1258c|M.tuberculosis_H37Rv --------------------MRNSN---RGPAF-LILFATLMAAAGDGVS
MAB_0880|M.abscessus_ATCC_1997 -----------------MADRGGIFVSLRTRNYRLWISGQMVSLIGTWMQ
MAV_0138|M.avium_104 -------MMSSNVRAARNRPGRTDPQPPTGAPLFVGVLGLLLATGWVANH
MMAR_0333|M.marinum_M ------------------MALAATRKLVRDPQLRRLMAVCATFLTSNSAH
MUL_0501|M.ulcerans_Agy99 MLSTAMDEAHCTPAEVAPPDTRTGTSSPGEHVYPDRLDAGLLRIAGVCVL
.
Mflv_1033|M.gilvum_PYR-GCK GLVAAIVMYDA------------TRSALMVGLVGVAQFFPQLILAPTSGK
Mvan_5800|M.vanbaalenii_PYR-1 GIVAAIVMYDA------------TRSALMVGMVGVVQFAPQLILSPTSGK
MSMEG_1329|M.smegmatis_MC2_155 GIVAAIVMYDA------------TRSAVMVGMVGVAQFLPQLILSPTSGK
TH_1753|M.thermoresistible__bu GIVAAITMFNA------------TGSAVMVGLVGVAQFGPQLILTPISGK
Mb1288c|M.bovis_AF2122/97 IVAFPWLVLQR------------EGSAGQASIVASATMLPLLFATLVAGT
Rv1258c|M.tuberculosis_H37Rv IVAFPWLVLQR------------EGSAGQASIVASATMLPLLFATLVAGT
MAB_0880|M.abscessus_ATCC_1997 RVAQDWLVLDLS-----------HGNAFLLGVVMALQFGPTLLLSVWGGM
MAV_0138|M.avium_104 FVGLMPAISDRD-----------HLATTTLDGIFGIYALGLLPGLLVGGR
MMAR_0333|M.marinum_M GVLLTVFAFSV-------------GGAATVGVVTLVRMLPSALLAPLAAT
MUL_0501|M.ulcerans_Agy99 ASLMSVLDATVVGIAQRTFIIEFDSTQAVVAWTMTGYTLALATVIPVAGW
..
Mflv_1033|M.gilvum_PYR-GCK WADTGNPARQILLGRVFCVIGSG--SIAVWMFAEPGLQGVAVAIPILIGT
Mvan_5800|M.vanbaalenii_PYR-1 WADTGNPARQILLGRVLCVAGSG--SIAAWMFVQPGLTGLAAAVPVLLGT
MSMEG_1329|M.smegmatis_MC2_155 WADVGNPARQILLGRLMCIAGSG--STAAWMALAPDLTGNAVAVPVLVGA
TH_1753|M.thermoresistible__bu WADVGNQARQILLGRLLCTAGSG--LIAAWLFLSPHMQGVAVAVPILIGT
Mb1288c|M.bovis_AF2122/97 AVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAA
Rv1258c|M.tuberculosis_H37Rv AVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAA
MAB_0880|M.abscessus_ATCC_1997 LADRYDKRRMLMLTQALM-------ALFALTVGLLQVTGLVRIWHVMAVA
MAV_0138|M.avium_104 TSDALGRRPVALTG------------SAAALVGTVAMLLSQHSPALFAGR
MMAR_0333|M.marinum_M LATSPRPQVHLAIGVGARG-------MTTIATVIVVVSGAPLGVVLVVLG
MUL_0501|M.ulcerans_Agy99 AADRFGTKRLWMGS------------VLAFALGSLLCALAPNILSLIFFR
.
Mflv_1033|M.gilvum_PYR-GCK TLVGIGFVVGGPAMQSIVPTLIRNGELPTAMALNSLPMTVGRVIGPAAGA
Mvan_5800|M.vanbaalenii_PYR-1 TLVGFGFVVGGPAMQSIVPNLIRAGELPTAMALNSIPMTIGRIIGPAAGA
MSMEG_1329|M.smegmatis_MC2_155 TLVGFGFVIGGPAMQSVVPNLIREGELATAMALNSIPMTIGRILGPPIGA
TH_1753|M.thermoresistible__bu TLVGFGFVVGGPAMQSIVPSLIRPGELSTAMALNSLPMTVGRIAGPAVGA
Mb1288c|M.bovis_AF2122/97 AFGPAGMTARDSMLPEAAARAGWS--LDRINGAYEAILNLAFIVGPAIGG
Rv1258c|M.tuberculosis_H37Rv AFGPAGMTARDSMLPEAAARAGWS--LDRINGAYEAILNLAFIVGPAIGG
MAB_0880|M.abscessus_ATCC_1997 FAMGCAAAIEAPTRQSFTIEMVGPEHLPNAVGLNSMVFNLAGIIGPATSG
MAV_0138|M.avium_104 LIVGLGVGLAISAGTAWASDLRGPAGAATAGAVLTAGFAVGPFAGGVL--
MMAR_0333|M.marinum_M VDSLMSAAVRSLHAALVVRLATSVAEAATANAATGVLLYASALAGPALAG
MUL_0501|M.ulcerans_Agy99 VLQGVGGGMLMPLGFIILTRAAGPKRLGRLMAAIGIPMLLGPIGGPILGG
. . : . . *
Mflv_1033|M.gilvum_PYR-GCK YLAAHVGPATAFTVSAVLHLVFAMFLLAVRFPAP-----PQRRPGADYRV
Mvan_5800|M.vanbaalenii_PYR-1 YLAAHIGPATAFAVSTVLHLVFAFFLLAVRFPAP-----PERRAGTDYRV
MSMEG_1329|M.smegmatis_MC2_155 YLAAHLGAAAGFAISAGLHVIFAVFLVLVTFPTR-----PKLDPDGDYRV
TH_1753|M.thermoresistible__bu YIAASFGAPTAFAVSCVLHLLFALILVALPFPAQ-----TPQPAGTDYRV
Mb1288c|M.bovis_AF2122/97 LMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGI
Rv1258c|M.tuberculosis_H37Rv LMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGI
MAB_0880|M.abscessus_ATCC_1997 VLIGLIGTGWVFLLNFVSFIAVGIALWRMRPGELHS---SEPIPAAKGQL
MAV_0138|M.avium_104 AWAGPSGVRASFALAAAILALAAFAVVAAPQPSP-----VTAPADPDGEE
MMAR_0333|M.marinum_M VMLAFVGVGWALTLPAALFVVGALTALRITVAPIDDMPDTGGARPSGGVA
MUL_0501|M.ulcerans_Agy99 WLISSFGWHWIFLVNLPIG-LAAFALAAITFPADRPVPSESFDVIGVLLL
. * : : .
Mflv_1033|M.gilvum_PYR-GCK RAAVRYVLA-----------------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 RVAVRYVLR-----------------------------------------
MSMEG_1329|M.smegmatis_MC2_155 RAALRHVWR-----------------------------------------
TH_1753|M.thermoresistible__bu RTALRHVWR-----------------------------------------
Mb1288c|M.bovis_AF2122/97 AEGLRFVWN-----------------------------------------
Rv1258c|M.tuberculosis_H37Rv AEGLRFVWN-----------------------------------------
MAB_0880|M.abscessus_ATCC_1997 RQGFSYVWR-----------------------------------------
MAV_0138|M.avium_104 TADAAPQGI-----------------------------------------
MMAR_0333|M.marinum_M RVQLRAVGAGFRAIIE----------------------------------
MUL_0501|M.ulcerans_Agy99 SPGLAAFLLALSLIPDRGTVADRYVLIPVIAGLSLIGGFAWHAWHRADHP
Mflv_1033|M.gilvum_PYR-GCK --------DRPL-LLALLAVTTVGIVSDPSITLAPSMADELGGGAAMVGT
Mvan_5800|M.vanbaalenii_PYR-1 --------DRPL-LLALVAVTTVGIVSDPSITLTPSMADELGGGASLVGT
MSMEG_1329|M.smegmatis_MC2_155 --------DRPL-LLALLAVSTVGFASDPSITLTPSMAEDLGGGTQLVGA
TH_1753|M.thermoresistible__bu --------DRPL-LLALLAVTTVGFASDPSITLAPSLADNLGGGSELVGA
Mb1288c|M.bovis_AF2122/97 --------LRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWA
Rv1258c|M.tuberculosis_H37Rv --------LRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWA
MAB_0880|M.abscessus_ATCC_1997 --------RRDLFMIMLTVFLVSTFGLNFSLTLAVLARETFGRGAESYGL
MAV_0138|M.avium_104 --------SRALSWAMPLAPWVFASATLGFVTIPGRLHTALAAPVAAGTA
MMAR_0333|M.marinum_M -------SRPAAAAATLFLLTTTLLDGFWYVASAPLAADQFGLGPSGVTT
MUL_0501|M.ulcerans_Agy99 LIDLHLFNNSVVTQANLTLLAFAAAYFGSSLLIPTYLQQVLHQTPMQSGL
Mflv_1033|M.gilvum_PYR-GCK LSAVFGVGAALGMGSLAVLRGRIASAYVSSIGMVALTLGSAVLAV-----
Mvan_5800|M.vanbaalenii_PYR-1 LSAVFGVGAAVGMTALALLRGRIGSAVVSSIGMAALAAGSAILAV-----
MSMEG_1329|M.smegmatis_MC2_155 LSASFGVGAAVGMIVLAVLRGRIASERVSSVGLFLLTAGSALLAA-----
TH_1753|M.thermoresistible__bu LSAAFGIGAAAGMATLALLRGRLASARVSVIGLWLLGAGSLVLAL-----
Mb1288c|M.bovis_AF2122/97 LMAIAG-GGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAF-----
Rv1258c|M.tuberculosis_H37Rv LMAIAG-GGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAF-----
MAB_0880|M.abscessus_ATCC_1997 LSTALAIGTLLGAT-FAARRTKKVRMTLFYGAAMAFGLSEVVVSV-----
MAV_0138|M.avium_104 TLIVNGVSGAVQVLARALRWGPQAGTAGAVLAALGYAVAAAAPST-----
MMAR_0333|M.marinum_M IMTIYGVGGLLGAVAMLSIAGRGGLARMFTLARLSEALLLAAIGA-----
MUL_0501|M.ulcerans_Agy99 YLIPQGLGAMLTMPIASAFMDRRGPGKSVLLGIVLIAVGLAMFTFGVATR
. . .
Mflv_1033|M.gilvum_PYR-GCK GMQSWIAYTGFALAGFGFGCAMTGLSTVVQERAPEELRGRIMALWLVGFL
Mvan_5800|M.vanbaalenii_PYR-1 AMEPWVALTGFAVSGFGFGCAMTGLSTVVQERAPEELRGRIMALWLVGFL
MSMEG_1329|M.smegmatis_MC2_155 ATEAPVALIGFAIAGLGFGWSMTGLSTVVQERAPEELRGRIMALWLVGFL
TH_1753|M.thermoresistible__bu STVTAVALAGFVVAGVGFGWAMTGLSTVVQERAPDELRGRIMALWLVGFL
Mb1288c|M.bovis_AF2122/97 LPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAY
Rv1258c|M.tuberculosis_H37Rv LPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAY
MAB_0880|M.abscessus_ATCC_1997 MPTYLSVALALVPAGLLALTFTTSAMNIIQLSVDSQLRGRVMGIYMVAFL
MAV_0138|M.avium_104 LTP-ALGVPLFVVLGCASGLCLREGLIDLEAAAPQRLRGGLTGLFYVVTY
MMAR_0333|M.marinum_M ASLPALGLVLAAGVGGGSAASWAIAPTLVQRSVNRASMVTAAASLQSVSQ
MUL_0501|M.ulcerans_Agy99 AQYLPTLLVGLAIMGMGTGCTMMPLAGAAVLTLKPREIARGSTLISVTQQ
. *
Mflv_1033|M.gilvum_PYR-GCK GSRPIAAAVLG-GTADLTNVFVAFAVASGLALVVTVLCRPSKLVDLR---
Mvan_5800|M.vanbaalenii_PYR-1 GSRPIAAAVLG-GTADVLSVYAAFAVAAALSLAVTLLCRPAKLVGPIPD-
MSMEG_1329|M.smegmatis_MC2_155 GSRPFAAALLG-GAADVFNVRVAFLIAAAATFALALAARPATMSAPIPAS
TH_1753|M.thermoresistible__bu GSRPIAAAVLG-GTADTISVAAAFALAALSVAVIAVLCRPATLGRPAPFE
Mb1288c|M.bovis_AF2122/97 AAGPLGLLLAG-PLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLA
Rv1258c|M.tuberculosis_H37Rv AAGPLGLLLAG-PLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLA
MAB_0880|M.abscessus_ATCC_1997 GGTPLGSPLVG-WLADLHGGRMPLLVGGLVSAAAGLVCATYLHRHPCPVV
MAV_0138|M.avium_104 IGFGLPLILAS-VRPGVATAILSGMAVLAVTAAVGRAARLRRDDHRQN--
MMAR_0333|M.marinum_M LAIAAGAGIAA-VLVGSLGLTGALAIVSGAAALITVLAWPQVRRADKLSD
MUL_0501|M.ulcerans_Agy99 VGGSIGTALMATILTNQFNRSDNIWVANKVATLEQNAAARGVTVDPSGLP
. : . . .
Mflv_1033|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1329|M.smegmatis_MC2_155 V-------------------------------------------------
TH_1753|M.thermoresistible__bu PVPVGGGSTGADRARSNMVVTNPAEL------------------------
Mb1288c|M.bovis_AF2122/97 PQADIDRPVGSAQ-------------------------------------
Rv1258c|M.tuberculosis_H37Rv PQADIDRPVGSAQ-------------------------------------
MAB_0880|M.abscessus_ATCC_1997 AGEVPEADDMVPPAPAATPVCEPTPLARRS--------------------
MAV_0138|M.avium_104 --------------------------------------------------
MMAR_0333|M.marinum_M DDSAKLAVIRATPVLAPLPALALEQLARTATRMAVPAGSDVIRQGDRGDR
MUL_0501|M.ulcerans_Agy99 PQALTPDFADNVMHDLSHAYTVVFGVVVVLVVSTLIPAASLPKTPAAAPA
Mflv_1033|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1329|M.smegmatis_MC2_155 --------------------------------------------------
TH_1753|M.thermoresistible__bu --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0138|M.avium_104 --------------------------------------------------
MMAR_0333|M.marinum_M FYMIASGLADATVNGRRVATLGPGGSFGEIALLHDVARSATVTARKDLDL
MUL_0501|M.ulcerans_Agy99 SFEQHHCDTQYGVHRV----------------------------------
Mflv_1033|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1329|M.smegmatis_MC2_155 --------------------------------------------------
TH_1753|M.thermoresistible__bu --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0138|M.avium_104 --------------------------------------------------
MMAR_0333|M.marinum_M VAVDRAEFLAALSSNTAAGLRLGGLARTRLGTVPVEERLIELGPDPALNS
MUL_0501|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1033|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1329|M.smegmatis_MC2_155 --------------------------------------------------
TH_1753|M.thermoresistible__bu --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0138|M.avium_104 --------------------------------------------------
MMAR_0333|M.marinum_M QSLSELLAAQPALAGIGDGALRELADTAKVLAAPDGALITCEGDHGDTYY
MUL_0501|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1033|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5800|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1329|M.smegmatis_MC2_155 --------------------------------------------------
TH_1753|M.thermoresistible__bu --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0138|M.avium_104 --------------------------------------------------
MMAR_0333|M.marinum_M VILEGAAQVLDDGTAVHHLGPGEGFGEQAILRDVPRTATVRAVGDTTLVA
MUL_0501|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1033|M.gilvum_PYR-GCK -----------
Mvan_5800|M.vanbaalenii_PYR-1 -----------
MSMEG_1329|M.smegmatis_MC2_155 -----------
TH_1753|M.thermoresistible__bu -----------
Mb1288c|M.bovis_AF2122/97 -----------
Rv1258c|M.tuberculosis_H37Rv -----------
MAB_0880|M.abscessus_ATCC_1997 -----------
MAV_0138|M.avium_104 -----------
MMAR_0333|M.marinum_M VDREAFQRARR
MUL_0501|M.ulcerans_Agy99 -----------