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LTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKARGGSRSAARMANTKTNRKPRS ARALCARAVAAPLGGARPLGERAGGRHRPAREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAA AVGAVLAAFGVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAGVLVGMAEARSVAALLVGAMITGVVYDAP RPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGRAITGGVGGLLAAWSGVPVLFWINAVACALLALVAAR CIPATAHRPPVAPAVHVRAAHNSYRRAFSDGRLVLLFASSLATLTAVRGLYATVPMLMADSGLGAGEFGW AQVANAAAGIGLTPVITPWLGRKVAARINPRLDILAIAGGWTALTMAGAALAHTTFGFAIAVAASAAGEI AWFVIAVGTVHRIAPPASGGRYHGIWSMTLAIASVVAPIVSSCSLTHGGHRLVALVTVTVGLAGAALCLP LNRSGDVGVRDSQYTAVAAAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0354 | - | - | 100% (512) | integral membrane protein |
| M. ulcerans Agy99 | MUL_3679 | comEC | 1e-04 | 27.10% (155) | membrane metal-binding protein ComEC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0865 | - | 1e-134 | 59.25% (400) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1534 | - | 2e-11 | 27.20% (364) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0842 | - | 1e-134 | 59.25% (400) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4615 | - | 2e-12 | 26.98% (189) | major facilitator transporter |
| M. marinum M | MMAR_4785 | - | 0.0 | 97.25% (437) | integral membrane protein |
| M. avium 104 | MAV_4712 | - | 5e-08 | 25.31% (399) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_6245 | - | 6e-09 | 25.13% (398) | chloramphenicol resistance protein |
| M. thermoresistible (build 8) | TH_1753 | - | 1e-08 | 29.33% (208) | major facilitator superfamily protein MFS_1, putative |
| M. vanbaalenii PYR-1 | Mvan_5224 | - | 1e-12 | 27.02% (396) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
MMAR_4785|M.marinum_M --------------------------------------------------
Mb0865|M.bovis_AF2122/97 --------------------------------------------------
Rv0842|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1534|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6245|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4712|M.avium_104 --------------------------------------------------
TH_1753|M.thermoresistible__bu --------------------------------------------------
MAB_4615|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
MMAR_4785|M.marinum_M -----------------------------MAAPLGGARPLGERAGGRHRP
Mb0865|M.bovis_AF2122/97 ------------------------------MRYTGPERCSGD---GQVRA
Rv0842|M.tuberculosis_H37Rv ------------------------------MRYTGPERCSGD---GQVRA
Mflv_1534|M.gilvum_PYR-GCK --------------------------MDKVFTYSGGGAAPAGLDRPATIG
Mvan_5224|M.vanbaalenii_PYR-1 ------------------------------MTVVAVAAATT---RPS---
MSMEG_6245|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4712|M.avium_104 --------------------------------MTDSSPPAKGTFTVEMLS
TH_1753|M.thermoresistible__bu -------------------------VSTSPATTTTAATDPAPPRGALGLM
MAB_4615|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
MMAR_4785|M.marinum_M AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
Mb0865|M.bovis_AF2122/97 AGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVAAY
Rv0842|M.tuberculosis_H37Rv AGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVAAY
Mflv_1534|M.gilvum_PYR-GCK AGRGARGWVAVALATFAIAWGGNEFTPLLVMYRLDDGFSALTVDLLLFAY
Mvan_5224|M.vanbaalenii_PYR-1 -GRSARRWLAVAAATFAIAWGGNEFTPLLVMYRTQDGFSALTVDLLLFAY
MSMEG_6245|M.smegmatis_MC2_155 ---MPFSLYPLAVAVFAMGTSEFMLAGLVPDIAADLGVSIGSAGLLTSAF
MAV_4712|M.avium_104 RAKRGVTAVFVAHGLLFASWAAH-----IPQVKAGLGLDDAALGTALFGA
TH_1753|M.thermoresistible__bu FDPVFGGLFWGKILSVVAVWTHGIVAAITMFNATGSAVMVGLVG--VAQF
MAB_4615|M.abscessus_ATCC_1997 -MPQRLSAWRFVTTFGVISMLADIVYEGARSITGPLLASLGASALVVGVV
MUL_0354|M.ulcerans_Agy99 GVGWAVGQLVCGWLVDSLGPR-ATLAWTMTIAAGVLVGMAEARS----VA
MMAR_4785|M.marinum_M GVGWAVGQLVCGWLVDSLGPR-ATLAWTMTIAAGVLVGMAEARS----VA
Mb0865|M.bovis_AF2122/97 GLGWAVGQLLCGWLVDRVGAR-VTLVSTMLVAAAVLVLMAGLHT----VP
Rv0842|M.tuberculosis_H37Rv GLGWAVGQLLCGWLVDRVGAR-VTLVSTMLVAAAVLVLMAGLHT----VP
Mflv_1534|M.gilvum_PYR-GCK VLGIVPALLIGGPMSDRFGRRPLMLPAPLLAAIGSLILAVGADS----AW
Mvan_5224|M.vanbaalenii_PYR-1 VLGIVPALLIGGPLSDRFGRRPLMLPAPVLAAVGSAILALGAQS----AP
MSMEG_6245|M.smegmatis_MC2_155 AVGMVVGAPSMAALTRRWRAR-VSLSAFLLTFALVHVLGAVTTS----FG
MAV_4712|M.avium_104 PLGSVLATLAGHWALPRWGSH-RLIPVTVAGYAAAGTTVGLARS----GP
TH_1753|M.thermoresistible__bu GPQLILTPISGKWADVGNQARQILLGRLLCTAGSGLIAAWLFLSPHMQGV
MAB_4615|M.abscessus_ATCC_1997 TGIGEAAALALRLVSGPLTDRTRKFWAWTISGYALTVVTVPFLG----VS
: :
MUL_0354|M.ulcerans_Agy99 ALLVGAMITGVVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGR
MMAR_4785|M.marinum_M ALLVGAMITGMVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGR
Mb0865|M.bovis_AF2122/97 GLLVGAMIAGLVCDAPRPVLGAVIAELVADPQRRAQLDGWRYGWVLNIGA
Rv0842|M.tuberculosis_H37Rv GLLVGAMIAGLVCDAPRPVLGAVIAELVADPQRRAQLDGWRYGWVLNIGA
Mflv_1534|M.gilvum_PYR-GCK LLGVGRVFSGLALGLAMAVGGSWIKELSSPPWDVGDAGARRAAMSLTAGF
Mvan_5224|M.vanbaalenii_PYR-1 VLGVGRVFSGVALGLAMAVGGSWIKELSSPPWEDGDAGARRAAMSLTAGF
MSMEG_6245|M.smegmatis_MC2_155 VLLVTRLVAAVANAGFLAVALSTAATLVPAGRQGRGLAVLLAGTTLATIA
MAV_4712|M.avium_104 ALFAALALWGMFQGALDVAMNTQAGTVERRAGAPMMARFHGMWSLGTLAG
TH_1753|M.thermoresistible__bu AVAVPILIGTTLVGFGFVVGGPAMQSIVPSLIRPGELSTAMALNSLPMTV
MAB_4615|M.abscessus_ATCC_1997 SVLWIAATLVIAERVGKAVRSPAKDTLLSHATAVTGRGKGFAVHEAMDQI
: . . :
MUL_0354|M.ulcerans_Agy99 A-ITG-GVGGLLAAWSGVP-VLFWINAVACALLALVAARCIPATAHR-PP
MMAR_4785|M.marinum_M A-ITG-GVGGLLAAWSGVP-VLFWINAVACALLALVAARCIPATAHR-PP
Mb0865|M.bovis_AF2122/97 A-ITG-GVGGVVAGWLDTP-VLYWINGIGCAIFAGLAGRCIPADVCRRTE
Rv0842|M.tuberculosis_H37Rv A-ITG-GVGGVVAGWLDTP-VLYWINGIGCAIFAGLAGRCIPADVCRRTE
Mflv_1534|M.gilvum_PYR-GCK G-LGA-AVAGVLAQWGPAPTVLPYAINVAMAVAAAVLLLSAPETRARSVS
Mvan_5224|M.vanbaalenii_PYR-1 G-LGA-GTAGVLAEWGPAPTVLPYAVNIAMALAAAVFVSTAPETRTRHDS
MSMEG_6245|M.smegmatis_MC2_155 G-VPGGAVLGTMLGWRATF----WAIALLCLPAVVGIATALPAGAGR---
MAV_4712|M.avium_104 A-LIGAACVGAGIGLTAQL---TVLGAVVLLVVVMLTRRLLPDAADS---
TH_1753|M.thermoresistible__bu GRIAGPAVGAYIAASFGAPTAFAVSCVLHLLFALILVALPFPAQTPQPAG
MAB_4615|M.abscessus_ATCC_1997 GAITGPLLVAGMLALTHVN-YLPTFAILALPGGATLLLLFWLRRRVPHPE
. : . . :
MUL_0354|M.ulcerans_Agy99 VAPAVHVRAAHNSYRRAFSDGRLVLLFASSLATLTAVRGLYATVPMLMAD
MMAR_4785|M.marinum_M VAPAVHVRAARISYRRAFSDGRLVLLFASSLATLTAVRGLYATVPMLMAD
Mb0865|M.bovis_AF2122/97 SGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPMLMSA
Rv0842|M.tuberculosis_H37Rv SGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPMLMSA
Mflv_1534|M.gilvum_PYR-GCK VRPAANSWWSDLAIPGASHRRFLLVVVPLAPWVFGAGASAYAVLPALMTE
Mvan_5224|M.vanbaalenii_PYR-1 GRP----WWTDLAVPGASHRRFLLVVVPVAPWVFGAGATAYAVLPALMAG
MSMEG_6245|M.smegmatis_MC2_155 -AGWPVAGASLCDELAQLGRKRLALAMLLAALVNAGTFATFTFLAPIVTE
MAV_4712|M.avium_104 ------VAAPPEPAAGRRVTPAVAILAAVSFASFLCEGAATDWSATYLRD
TH_1753|M.thermoresistible__bu ------TDYRVRTALRHVWRDRPLLLALLAVTTVGFASDPSITLAPSLAD
MAB_4615|M.abscessus_ATCC_1997 RYEHDDYIRGAADRPHKLSLPLSFWLYSGFTAITMIGFATFGVLSFHMVQ
. :
MUL_0354|M.ulcerans_Agy99 SGLGAGEFGWAQVANAAAGIGLTPVITPWLGRKVAARINPRLDILAIAGG
MMAR_4785|M.marinum_M SGLGAGEFGWTQVANAAAGIGLTPVITPWLGRKVAARINPRLDILAIAGG
Mb0865|M.bovis_AF2122/97 SGLGVGAYGWVQLINALAVVAVTPLLTPWLSKQLA--LGPRPDILAGAGV
Rv0842|M.tuberculosis_H37Rv SGLGVGAYGWVQLINALAVVAVTPLLTPWLSKQLA--LGPRPDILAGAGV
Mflv_1534|M.gilvum_PYR-GCK HVAAAPIAFSALLCAVTLGVAFG---VQHLGRSLLS-GGALGVVVALGLV
Mvan_5224|M.vanbaalenii_PYR-1 RVSSAPIAFSALMCLVALGVGFT---VQQLGRHLGA-GGRRGVVTALALL
MSMEG_6245|M.smegmatis_MC2_155 SAG----LGRLWVSVVLLLFGFGSFIGVTVAGRLS---DTRPGIVIGAGG
MAV_4712|M.avium_104 VVGAGPSVAAASYAAYTLTMVVTRFAAGRLHARLPS------RRLLPALA
TH_1753|M.thermoresistible__bu NLGGGSELVGALSAAFGIGAAAGMATLALLRGRLAS------ARVSVIGL
MAB_4615|M.abscessus_ATCC_1997 RGVLPVPAVPIVYAAAMAADAVAALLSGWAYDRVGP----------KSLA
:
MUL_0354|M.ulcerans_Agy99 WTALTMAGAALAHTTFGFAIAVAASAAGEIAWFVIAVGTVHRIAPPASGG
MMAR_4785|M.marinum_M WTALTMAGAALAHTTFGFAIAVAASAPGEIAWFVIAAGIVHRIAPPASGG
Mb0865|M.bovis_AF2122/97 WVTLCMAAAGLARTTVGFSVAAAACSPGEIAWFVVAAGIVHRIAPPAHGG
Rv0842|M.tuberculosis_H37Rv WVTLCMAAAGLARTTVGFSVAAAACSPGEIAWFVVAAGIVHRIAPPAHGG
Mflv_1534|M.gilvum_PYR-GCK AAGMALAAWASASLTIWATVVAAAVLGAGYGMALVAG--LQEIQRIATPD
Mvan_5224|M.vanbaalenii_PYR-1 VVGMLLAGWAAAVLTVWSALVAAAVLGAGYGMALLAG--LQEIQRIAGPD
MSMEG_6245|M.smegmatis_MC2_155 PALLAGWAALALLSSQPVALLPLAFVQGALSFAVGSTLITRVLYEASAAP
MAV_4712|M.avium_104 VLAVAGMSVTLATADAAAGVLGFAALGVGVALLVPTAFSAAYGARGAG-S
TH_1753|M.thermoresistible__bu WLLGAGSLVLALSTVTAVALAGFVVAGVGFGWAMTGLS---TVVQERAPD
MAB_4615|M.abscessus_ATCC_1997 ALPIVGATVPMLAFTDSLPGIVLGALLWGAAVGIQESTLRAVVADLVPPP
. :
MUL_0354|M.ulcerans_Agy99 RYHGIWSMTLAIASVVAPIVSSCSLTHGGHRLVALVTVTVGLAGAALCLP
MMAR_4785|M.marinum_M RYHGIWSMTLAIASVVAPIVSSCSLTHGGHRLVALVTVTVGLAGAALCLP
Mb0865|M.bovis_AF2122/97 RYHGIWSMAVAASSVAAPILAAFNLANGGRLVLAATTVTVGFFGAALCLP
Rv0842|M.tuberculosis_H37Rv RYHGIWSMAVAASSVAAPILAAFNLANGGRLVLAATTVTVGFFGAALCLP
Mflv_1534|M.gilvum_PYR-GCK DLAGLTAVFYSLCYLGFGVPAAMVFLS--DYASYPSMFGFGAVAAVGCLA
Mvan_5224|M.vanbaalenii_PYR-1 DLAGLTAVFYSLSYLGFAVPAVLAFAV--RSFSYPAMFGFGAFAAAVCLL
MSMEG_6245|M.smegmatis_MC2_155 TMGGAYATAALNVGAAGGPVAAAAALGNHANVVAPVWVSSVMVALALLIA
MAV_4712|M.avium_104 AIAIVAATGWLGYLLGPPLIGHLSEWVGLSGALVTIPVMMTIVAVAIRYT
TH_1753|M.thermoresistible__bu ELRGRIMALWLVGFLGSRPIAAAVLGGTADTISVAAAFALAALSVAVIAV
MAB_4615|M.abscessus_ATCC_1997 RRATAYGVYAAVLGTATAIGGALTGYLYGVSIPMLIAVVGVIQLVALITA
. . .
MUL_0354|M.ulcerans_Agy99 ----LNRSGDVGVRDSQYTAVAAAA---------------
MMAR_4785|M.marinum_M LARALNRSGDVGVRDSQYTAVAGAA---------------
Mb0865|M.bovis_AF2122/97 LARVLAAAS-CGPLSSKEPSRDSYQ---------------
Rv0842|M.tuberculosis_H37Rv LARVLAAAS-CGPLSSKEPSRDSYQ---------------
Mflv_1534|M.gilvum_PYR-GCK ----------VAVTGLRRTPAIS-----------------
Mvan_5224|M.vanbaalenii_PYR-1 ----------VAVLGSRRTAAIS-----------------
MSMEG_6245|M.smegmatis_MC2_155 VPMLKIVAPRPNPATSTPPLGGNCG---------------
MAV_4712|M.avium_104 ----------PAFDTADEFHRAPAG---------------
TH_1753|M.thermoresistible__bu LCRPATLGRPAPFEPVPVGGGSTGADRARSNMVVTNPAEL
MAB_4615|M.abscessus_ATCC_1997 -----------APTLLRHAGQV------------------