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MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVELGTTAASYESVITRLTTESWMGPASMAMIAAAQ PYLAWLTYTSEAAMHAGAQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATEALY AEMWAQDAGAMYGYAAASSTSGSLQPLSTPQQTTNPGGLAAQSAAVSQAAASAAATDGITSLLSNLPNTI MGLASPITSAIDATGLGGIIQDIEDFLGIGFVANVINGGVNTAAWYTTATIPTAIFLANALDTGAPVVAA EGAIEAAEGAAAATAGLANTVTPTGVGAALGEATLVGKLAVPTSWSSALPETAATTGALGGSGWTVPEEA APVSGVAGVPGMAAAAKGAGAYAGPRYGFKPIVMPKQVVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4452 | - | - | 100% (390) | PPE family protein, PPE15 |
| M. marinum M | MMAR_1950 | - | e-136 | 63.41% (399) | PPE family protein, PPE15_1 |
| M. marinum M | MMAR_1947 | - | e-100 | 53.69% (393) | PPE family protein, PPE44 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1068c | PPE15 | 1e-169 | 78.12% (393) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-32 | 28.92% (408) | PPE protein |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | 1e-169 | 78.12% (393) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-42 | 32.51% (403) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 7e-30 | 40.36% (166) | PPE family protein |
| M. avium 104 | MAV_1347 | - | 1e-96 | 49.74% (392) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 8e-34 | 32.38% (383) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-36 | 32.52% (409) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4621 | - | 0.0 | 98.21% (390) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-37 | 33.09% (414) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4452|M.marinum_M -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
MUL_4621|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
Mb1068c|M.bovis_AF2122/97 -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
Rv1039c|M.tuberculosis_H37Rv -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MSMEG_0064|M.smegmatis_MC2_155 --------------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVL
* .** ::: : *.*...: *. : *.
MMAR_4452|M.marinum_M LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
MUL_4621|M.ulcerans_Agy99 LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
Mb1068c|M.bovis_AF2122/97 LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
Rv1039c|M.tuberculosis_H37Rv LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
MSMEG_0064|M.smegmatis_MC2_155 LETQAAELAAALTN-LTSVWTGAASERAVAATMPMITWLQTTAAQAQKRA
: * : : : * .: * *: : .
MMAR_4452|M.marinum_M AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
MUL_4621|M.ulcerans_Agy99 AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
Mb1068c|M.bovis_AF2122/97 SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
Rv1039c|M.tuberculosis_H37Rv SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MSMEG_0064|M.smegmatis_MC2_155 LQASAQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNE
* . * :: * : . : *: * :*.:* *: .* .*
MMAR_4452|M.marinum_M ALY-AEMWAQDAGAMYGYAAASSTSGSLQPLSTPQQTTNPGGLAAQSAAV
MUL_4621|M.ulcerans_Agy99 ALY-AEMWAQDAGAMYGYAAASSTSGSLQPLSTPQQTTNPGGLAAQSAAV
Mb1068c|M.bovis_AF2122/97 ALY-AEMWAQDALAMYGYAAASGAAGMLQPLSPPSQTTNPGGLAAQSAAV
Rv1039c|M.tuberculosis_H37Rv ALY-AEMWAQDALAMYGYAAASGAAGMLQPLSPPSQTTNPGGLAAQSAAV
MAV_1347|M.avium_104 AQY-GEMWAQDAAAMYGYAASSATAGKLSPLTSPAPTNQPGGLGAQAAAV
Mflv_0325|M.gilvum_PYR-GCK ADY-VRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADY-VRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAA
MAB_0809c|M.abscessus_ATCC_199 ADY-VRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD---------
TH_3113|M.thermoresistible__bu ADY-ARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAA
MLBr_01182|M.leprae_Br4923 AEY-TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVE
MSMEG_0064|M.smegmatis_MC2_155 MDYFVRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAA
* .** * * :* * :
MMAR_4452|M.marinum_M SQAAASAAATDG-ITSLLSNLPNTIMG-----------------------
MUL_4621|M.ulcerans_Agy99 SQAAASAAATDG-TTSLLSNLPNTIMG-----------------------
Mb1068c|M.bovis_AF2122/97 GSAAATAAVNQVSVADLISSLPNAVSG-----------------------
Rv1039c|M.tuberculosis_H37Rv GSAAATAAVNQVSVADLISSLPNAVSG-----------------------
MAV_1347|M.avium_104 SGATATSAQTSG-LQGTVANVPNVVRT-----------------------
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRL-----------YGEVLRFL
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRA-----------YGELLRFL
MAB_0809c|M.abscessus_ATCC_199 ---HDHGHDDHDHEHGHDDDHG--------------------HGDLDPTD
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTL
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEAEQAISQAALDQAVN-----------------------
MSMEG_0064|M.smegmatis_MC2_155 LAQTAPRVAEGVMRNAVIEGVSAIATIES---------------------
MMAR_4452|M.marinum_M -LASPITSAIDATGLGGIIQDIEDFLGIGFVANVINGGVNTAAWYTTATI
MUL_4621|M.ulcerans_Agy99 -LASPITSAIDATGLGGIIQDIEDFLGIPFVANVINGAVNTAAWYTTATI
Mb1068c|M.bovis_AF2122/97 -LASPVTSVLDSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAI
Rv1039c|M.tuberculosis_H37Rv -LASPVTSVLDSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAI
MAV_1347|M.avium_104 -LAAPA----DPPGLS----ALDNLLGNPVVNNVGNAGFNVVSWNVFNTI
Mflv_0325|M.gilvum_PYR-GCK FEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSW
Mvan_0415|M.vanbaalenii_PYR-1 FEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSW
MAB_0809c|M.abscessus_ATCC_199 PEWWVHVAG---EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQL
TH_3113|M.thermoresistible__bu LAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVA
MLBr_01182|M.leprae_Br4923 -------EGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQ
MSMEG_0064|M.smegmatis_MC2_155 -----------VGLAAGHAAAQANFAEQRGQGAAQKGENAGQEAGRESGK
MMAR_4452|M.marinum_M PTAIFLANALDTGAPVVAAEGAIEAAEGAA-AATAGLANT-VTPTGVGAA
MUL_4621|M.ulcerans_Agy99 PTAIFLANALNTGAPVIAAEGAIEAAEGAA-AATAGLANT-VTPTGVGAA
Mb1068c|M.bovis_AF2122/97 PTAIFLANALNSGAPVAIAEGAIEAAEGAASAAAAGLADS-VTPAGLGAS
Rv1039c|M.tuberculosis_H37Rv PTAIFLANALNSGAPVAIAEGAIEAAEGAASAAAAGLADS-VTPAGLGAS
MAV_1347|M.avium_104 VSNILYNHTLDTAAAAGVAGEVGGAVGGGALVGAAAPATAGVGAAPVLAS
Mflv_0325|M.gilvum_PYR-GCK VGASILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQ
Mvan_0415|M.vanbaalenii_PYR-1 VGASILYPSLLLLPLVATTLAIVLGVGAYLLENLPAPAEDAPAEEPAASS
MAB_0809c|M.abscessus_ATCC_199 ASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVE
TH_3113|M.thermoresistible__bu VSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADG
MLBr_01182|M.leprae_Br4923 HLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKA
MSMEG_0064|M.smegmatis_MC2_155 NMQQGMQMVMQMGSQAAQAPAQLASMFQSGVQTMTQPLQQATQMVSQFAS
:
MMAR_4452|M.marinum_M LGEATLVG----KLAVPTSWSSALPETAATTGALGGSGWTVP-EEAAPVS
MUL_4621|M.ulcerans_Agy99 LGEATLVG----KLAVPTSWSNALPKTAATTGALGGSGWTVP-EEAAPVS
Mb1068c|M.bovis_AF2122/97 LGEATLVG----RLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVT
Rv1039c|M.tuberculosis_H37Rv LGEATLVG----RLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVT
MAV_1347|M.avium_104 MGSAATVG----ELSTPATWSAPTPEPAATT--VGATEWASPAEEPHTAW
Mflv_0325|M.gilvum_PYR-GCK SAPSRPDQ-----QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAA
Mvan_0415|M.vanbaalenii_PYR-1 PAPTRADQ-----PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAA
MAB_0809c|M.abscessus_ATCC_199 DAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PPVGD
TH_3113|M.thermoresistible__bu GASAAPVPAG--GPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSP-PPAGH
MLBr_01182|M.leprae_Br4923 MGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAA
MSMEG_0064|M.smegmatis_MC2_155 MGGSERAMQVGLMGASPFSNHPMLGGSGPSTGAGLVRAMSLPGAGGTAPR
. : . .
MMAR_4452|M.marinum_M GVAGVPGMAAAAKGAGAYAGPRYGFKPIVMPKQVVV--------------
MUL_4621|M.ulcerans_Agy99 GVAGVPGMAAAAKGAGAYAGPRYGFKPIVMPKQVVV--------------
Mb1068c|M.bovis_AF2122/97 GMM--PGMASAAKGTGAYAGPRYGFKPTVMPKQVVV--------------
Rv1039c|M.tuberculosis_H37Rv GMM--PGMASAAKGTGAYAGPRYGFKPTVMPKQVVV--------------
MAV_1347|M.avium_104 ATG-MPAVASAGRG-GYGMGPRYGVKPKVMPTRLPV--------------
Mflv_0325|M.gilvum_PYR-GCK AATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAER
Mvan_0415|M.vanbaalenii_PYR-1 TASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAER
MAB_0809c|M.abscessus_ATCC_199 PGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAAR
TH_3113|M.thermoresistible__bu SVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAA
MLBr_01182|M.leprae_Br4923 TRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPR
MSMEG_0064|M.smegmatis_MC2_155 TPLLSNLLGISGEMKAAPAGAGSAAAGGLAPVGAGAGGGAGAPVAHAGQN
MMAR_4452|M.marinum_M --------------------------------------------------
MUL_4621|M.ulcerans_Agy99 --------------------------------------------------
Mb1068c|M.bovis_AF2122/97 --------------------------------------------------
Rv1039c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMG
Mvan_0415|M.vanbaalenii_PYR-1 RKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMG
MAB_0809c|M.abscessus_ATCC_199 QARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAGTMG
TH_3113|M.thermoresistible__bu AAAAARESAPIRRRR-GQKDGLHGHRHEHQQPASMSAATAPSAAGIRVLG
MLBr_01182|M.leprae_Br4923 AFVMPRNPAAG---------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 SKSGGKKDGLVAPTPLTYDLSEDEDDEW----------------------
MMAR_4452|M.marinum_M --------------------------------------------------
MUL_4621|M.ulcerans_Agy99 --------------------------------------------------
Mb1068c|M.bovis_AF2122/97 --------------------------------------------------
Rv1039c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK FAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGR
Mvan_0415|M.vanbaalenii_PYR-1 FAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD------
MAB_0809c|M.abscessus_ATCC_199 FAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP-----------
TH_3113|M.thermoresistible__bu GAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN----------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4452|M.marinum_M ------------
MUL_4621|M.ulcerans_Agy99 ------------
Mb1068c|M.bovis_AF2122/97 ------------
Rv1039c|M.tuberculosis_H37Rv ------------
MAV_1347|M.avium_104 ------------
Mflv_0325|M.gilvum_PYR-GCK DGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ERHNHHDGKDSQ
MAB_0809c|M.abscessus_ATCC_199 -EHGRQD-----
TH_3113|M.thermoresistible__bu ------------
MLBr_01182|M.leprae_Br4923 ------------
MSMEG_0064|M.smegmatis_MC2_155 ------------