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MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAELGTTAASYESVITRLTTESWMGPASMAMVAAAQ PYLAWLTYTAEAAAHAGSQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATEALY AEMWAQDALAMYGYAAASGAAGMLQPLSPPSQTTNPGGLAAQSAAVGSAAATAAVNQVSVADLISSLPNA VSGLASPVTSVLDSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSGAPVAI AEGAIEAAEGAASAAAAGLADSVTPAGLGASLGEATLVGRLSVPAAWSTAAPATTAGATALEGSGWTVAA EEAGPVTGMMPGMASAAKGTGAYAGPRYGFKPTVMPKQVVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1068c | PPE15 | - | 100% (391) | PPE family protein |
| M. bovis AF2122 / 97 | Mb2790c | PPE43 | e-147 | 69.85% (398) | PPE family protein |
| M. bovis AF2122 / 97 | Mb2792c | PPE44 | e-107 | 55.84% (394) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-34 | 32.93% (413) | PPE protein |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | 0.0 | 100.00% (391) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-48 | 33.67% (401) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-29 | 30.75% (387) | PPE family protein |
| M. marinum M | MMAR_4452 | - | 1e-169 | 78.12% (393) | PPE family protein, PPE15 |
| M. avium 104 | MAV_1347 | - | 4e-93 | 51.26% (396) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-37 | 32.37% (414) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-35 | 35.14% (313) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4621 | - | 1e-171 | 78.88% (393) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-39 | 33.09% (417) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1068c|M.bovis_AF2122/97 -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
Rv1039c|M.tuberculosis_H37Rv -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
MMAR_4452|M.marinum_M -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
MUL_4621|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: * .** :*: : *.*...:::*. : *. .
Mb1068c|M.bovis_AF2122/97 LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
Rv1039c|M.tuberculosis_H37Rv LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
MMAR_4452|M.marinum_M LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
MUL_4621|M.ulcerans_Agy99 LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : : : * :: ** *: : .
Mb1068c|M.bovis_AF2122/97 SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
Rv1039c|M.tuberculosis_H37Rv SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
MMAR_4452|M.marinum_M AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
MUL_4621|M.ulcerans_Agy99 AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .:* ** :* : . : *:: *: :*.:* *: .* .*
Mb1068c|M.bovis_AF2122/97 ALYAEMWAQDALAMYGYAAASGAAG-MLQPLSPPSQTTNPGGLAAQSAAV
Rv1039c|M.tuberculosis_H37Rv ALYAEMWAQDALAMYGYAAASGAAG-MLQPLSPPSQTTNPGGLAAQSAAV
MMAR_4452|M.marinum_M ALYAEMWAQDAGAMYGYAAASSTSG-SLQPLSTPQQTTNPGGLAAQSAAV
MUL_4621|M.ulcerans_Agy99 ALYAEMWAQDAGAMYGYAAASSTSG-SLQPLSTPQQTTNPGGLAAQSAAV
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAG-KLSPLTSPAPTNQPGGLGAQAAAV
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAV-MSAPASSPAPLLLAPGVSEAADAM
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVGEAGRAA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVAL-ASAPPSTPPPSILHD--HDHGHDD
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * .** * * :* * : : . :.*
Mb1068c|M.bovis_AF2122/97 GSAAATAAVNQVSVADLISSLPNAVSG-LASPVTSVL----------DST
Rv1039c|M.tuberculosis_H37Rv GSAAATAAVNQVSVADLISSLPNAVSG-LASPVTSVL----------DST
MMAR_4452|M.marinum_M SQAAASAAATDG-ITSLLSNLPNTIMG-LASPITSAI----------DAT
MUL_4621|M.ulcerans_Agy99 SQAAASAAATDG-TTSLLSNLPNTIMG-LASPITSAI----------DAT
MAV_1347|M.avium_104 SGATATSAQTSG-LQGTVANVPNVVRT-LAAPA--------------DPP
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISD-LLNQYLQGVPGGQ-AILDFLKD
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIAN-LLQYYQDYLDQLFGPIVDFLRD
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIAD-IIRLYGEVLRFLFEPIFNFLRD
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIAD-LIRAYGELLRFLFEPIFDFLRD
MAB_0809c|M.abscessus_ATCC_199 HDHEHGHDDDHGHGDLDPTDP-EWWVH-VAGEMVEHFELLLNNLLTDPAA
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
. :
Mb1068c|M.bovis_AF2122/97 GLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSG
Rv1039c|M.tuberculosis_H37Rv GLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSG
MMAR_4452|M.marinum_M GLGGIIQDIEDFLGIGFVANVINGGVNTAAWYTTATIPTAIFLANALDTG
MUL_4621|M.ulcerans_Agy99 GLGGIIQDIEDFLGIPFVANVINGAVNTAAWYTTATIPTAIFLANALNTG
MAV_1347|M.avium_104 GLS----ALDNLLGNPVVNNVGNAGFNVVSWNVFNTIVSNILYNHTLDTA
MSMEG_0619|M.smegmatis_MC2_155 PLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFAS
TH_3569|M.thermoresistible__bu PIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILAS
Mflv_0325|M.gilvum_PYR-GCK PIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLL
Mvan_0415|M.vanbaalenii_PYR-1 PLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLL
MAB_0809c|M.abscessus_ATCC_199 LLTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAG
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
:
Mb1068c|M.bovis_AF2122/97 APVAIAEGAIEAAEGAASAAAAGLADS-VTPAGLGASLGEATLVG-----
Rv1039c|M.tuberculosis_H37Rv APVAIAEGAIEAAEGAASAAAAGLADS-VTPAGLGASLGEATLVG-----
MMAR_4452|M.marinum_M APVVAAEGAIEAAEGAA-AATAGLANT-VTPTGVGAALGEATLVG-----
MUL_4621|M.ulcerans_Agy99 APVIAAEGAIEAAEGAA-AATAGLANT-VTPTGVGAALGEATLVG-----
MAV_1347|M.avium_104 AAAGVAGEVGGAVGGGALVGAAAPATAGVGAAPVLASMGSAATVG-----
MSMEG_0619|M.smegmatis_MC2_155 PFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLA
TH_3569|M.thermoresistible__bu PVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP-------
Mflv_0325|M.gilvum_PYR-GCK PLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFP
Mvan_0415|M.vanbaalenii_PYR-1 PLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPA
MAB_0809c|M.abscessus_ATCC_199 LAGIQPSPEILAVEPGSVEDAPMA-ASAGTALAPSPPASAAAP-------
MLBr_01182|M.leprae_Br4923 AMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLG-----
. . .:
Mb1068c|M.bovis_AF2122/97 ---------RLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVTGMM
Rv1039c|M.tuberculosis_H37Rv ---------RLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVTGMM
MMAR_4452|M.marinum_M ---------KLAVPTSWSSALPETAATTGALGGSGWTVP-EEAAPVSGVA
MUL_4621|M.ulcerans_Agy99 ---------KLAVPTSWSNALPKTAATTGALGGSGWTVP-EEAAPVSGVA
MAV_1347|M.avium_104 ---------ELSTPATWSAPTPEPAATT--VGATEWASPAEEPHTAWATG
MSMEG_0619|M.smegmatis_MC2_155 VGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEG
TH_3569|M.thermoresistible__bu ------------VRAEPQNPLPLTXXX-----------------------
Mflv_0325|M.gilvum_PYR-GCK ATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEG
Mvan_0415|M.vanbaalenii_PYR-1 IAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTG
MAB_0809c|M.abscessus_ATCC_199 ------AAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLGTG
MLBr_01182|M.leprae_Br4923 ---RAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGG
.
Mb1068c|M.bovis_AF2122/97 --------------------------------------------------
Rv1039c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4452|M.marinum_M G-------------------------------------------------
MUL_4621|M.ulcerans_Agy99 G-------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 FTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYAD
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK FSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYAD
Mvan_0415|M.vanbaalenii_PYR-1 FSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYAD
MAB_0809c|M.abscessus_ATCC_199 LALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG---
MLBr_01182|M.leprae_Br4923 G-------------------------------------------------
Mb1068c|M.bovis_AF2122/97 ------------------PGMASAAKGTGAYAGPRYGFKPTVMPKQVVV-
Rv1039c|M.tuberculosis_H37Rv ------------------PGMASAAKGTGAYAGPRYGFKPTVMPKQVVV-
MMAR_4452|M.marinum_M -----------------VPGMAAAAKGAGAYAGPRYGFKPIVMPKQVVV-
MUL_4621|M.ulcerans_Agy99 -----------------VPGMAAAAKGAGAYAGPRYGFKPIVMPKQVVV-
MAV_1347|M.avium_104 -----------------MPAVASAGRG-GYGMGPRYGVKPKVMPTRLPV-
MSMEG_0619|M.smegmatis_MC2_155 AYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTL
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTL
Mvan_0415|M.vanbaalenii_PYR-1 AYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTL
MAB_0809c|M.abscessus_ATCC_199 --IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLAML
MLBr_01182|M.leprae_Br4923 -----------------LPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRN
Mb1068c|M.bovis_AF2122/97 --------------------------------------------
Rv1039c|M.tuberculosis_H37Rv --------------------------------------------
MMAR_4452|M.marinum_M --------------------------------------------
MUL_4621|M.ulcerans_Agy99 --------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 T-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu --------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK A-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 P-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_0809c|M.abscessus_ATCC_199 SRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------
MLBr_01182|M.leprae_Br4923 PAAG----------------------------------------