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MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVELGTTAASYESVITRLTTESWMGPASMAMIAAAQ PYLAWLTYTSEAAMHAGAQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATEALY AEMWAQDAGAMYGYAAASSTSGSLQPLSTPQQTTNPGGLAAQSAAVSQAAASAAATDGTTSLLSNLPNTI MGLASPITSAIDATGLGGIIQDIEDFLGIPFVANVINGAVNTAAWYTTATIPTAIFLANALNTGAPVIAA EGAIEAAEGAAAATAGLANTVTPTGVGAALGEATLVGKLAVPTSWSNALPKTAATTGALGGSGWTVPEEA APVSGVAGVPGMAAAAKGAGAYAGPRYGFKPIVMPKQVVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4621 | - | - | 100% (390) | PPE family protein |
| M. ulcerans Agy99 | MUL_2167 | - | e-101 | 53.69% (393) | PPE family protein |
| M. ulcerans Agy99 | MUL_2428 | - | 2e-77 | 44.50% (400) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1068c | PPE15 | 1e-171 | 78.88% (393) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-33 | 28.92% (408) | PPE protein |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | 1e-171 | 78.88% (393) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-42 | 32.51% (403) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 2e-30 | 28.99% (407) | PPE family protein |
| M. marinum M | MMAR_4452 | - | 0.0 | 98.21% (390) | PPE family protein, PPE15 |
| M. avium 104 | MAV_1347 | - | 4e-95 | 49.23% (392) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-34 | 30.98% (410) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-35 | 34.29% (312) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-39 | 33.57% (414) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4621|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
MMAR_4452|M.marinum_M -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
Mb1068c|M.bovis_AF2122/97 -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
Rv1039c|M.tuberculosis_H37Rv -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_2254c|M.abscessus_ATCC_199 ----------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: *:.** :*: : *.*...:::*. : *: *
MUL_4621|M.ulcerans_Agy99 LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
MMAR_4452|M.marinum_M LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
Mb1068c|M.bovis_AF2122/97 LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
Rv1039c|M.tuberculosis_H37Rv LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_2254c|M.abscessus_ATCC_199 YSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:* . : : * :: ** *: : .
MUL_4621|M.ulcerans_Agy99 AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
MMAR_4452|M.marinum_M AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
Mb1068c|M.bovis_AF2122/97 SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
Rv1039c|M.tuberculosis_H37Rv SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_2254c|M.abscessus_ATCC_199 ALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.:* ** :* : . : *:: *: :*.:* *: .* .*
MUL_4621|M.ulcerans_Agy99 ALYAEMWAQDAGAMYGYAAASSTSG-SLQPLSTPQQTTNPGGLAAQSAAV
MMAR_4452|M.marinum_M ALYAEMWAQDAGAMYGYAAASSTSG-SLQPLSTPQQTTNPGGLAAQSAAV
Mb1068c|M.bovis_AF2122/97 ALYAEMWAQDALAMYGYAAASGAAG-MLQPLSPPSQTTNPGGLAAQSAAV
Rv1039c|M.tuberculosis_H37Rv ALYAEMWAQDALAMYGYAAASGAAG-MLQPLSPPSQTTNPGGLAAQSAAV
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAG-KLSPLTSPAPTNQPGGLGAQAAAV
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAV-MSAPASSPAPLLLAPGVSEAADAM
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVGEAGRAA
MAB_2254c|M.abscessus_ATCC_199 ADYVRMWVQAATTMGVYQGVSSTAV-AAAAPTTTSPLIMPPGS-ELSRMA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * .** * * :* * . : . :.. *
MUL_4621|M.ulcerans_Agy99 SQAAASAAATDG-TTSLLSNLPNTIMGLASPITS----------AIDATG
MMAR_4452|M.marinum_M SQAAASAAATDG-ITSLLSNLPNTIMGLASPITS----------AIDATG
Mb1068c|M.bovis_AF2122/97 GSAAATAAVNQVSVADLISSLPNAVSGLASPVTS----------VLDSTG
Rv1039c|M.tuberculosis_H37Rv GSAAATAAVNQVSVADLISSLPNAVSGLASPVTS----------VLDSTG
MAV_1347|M.avium_104 SGATATSAQTSG-LQGTVANVPNVVRTLAAPA--------------DPPG
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MAB_2254c|M.abscessus_ATCC_199 ADMSGFAAQAQATESGSALDSSNSVIDQL--------------LNFFRDP
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVP-----QVDQQVNVDV
. :
MUL_4621|M.ulcerans_Agy99 LGGIIQDIEDFLGIP------------FVANVINGAVNTAAWYTTATIPT
MMAR_4452|M.marinum_M LGGIIQDIEDFLGIG------------FVANVINGGVNTAAWYTTATIPT
Mb1068c|M.bovis_AF2122/97 LSGIIADIDALLATP------------FVANIINSAVNTAAWYVNAAIPT
Rv1039c|M.tuberculosis_H37Rv LSGIIADIDALLATP------------FVANIINSAVNTAAWYVNAAIPT
MAV_1347|M.avium_104 LS----ALDNLLGNP------------VVNNVGNAGFNVVSWNVFNTIVS
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQ--VFFNLVGWPTWGMIFA
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQ--VFTNLVGWPTWAMILA
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQ--AVSWVGASILYPSLFL
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQ--AVSWVGASILYPSLLL
MAB_2254c|M.abscessus_ATCC_199 LGTLRQIIEDFIRNPGAALATWLPFLLVLASMTYVLFAQVFWLFWAALLS
MLBr_01182|M.leprae_Br4923 ATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLV
:
MUL_4621|M.ulcerans_Agy99 AIFLANALNTGAPVIAAEGAIEAAEGAA-AATAGLANT-VTPTGVGAALG
MMAR_4452|M.marinum_M AIFLANALDTGAPVVAAEGAIEAAEGAA-AATAGLANT-VTPTGVGAALG
Mb1068c|M.bovis_AF2122/97 AIFLANALNSGAPVAIAEGAIEAAEGAASAAAAGLADS-VTPAGLGASLG
Rv1039c|M.tuberculosis_H37Rv AIFLANALNSGAPVAIAEGAIEAAEGAASAAAAGLADS-VTPAGLGASLG
MAV_1347|M.avium_104 NILYNHTLDTAAAAGVAGEVGGAVGGGALVGAAAPATAGVGAAPVLASMG
MSMEG_0619|M.smegmatis_MC2_155 SPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPL
TH_3569|M.thermoresistible__bu SPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP------
Mflv_0325|M.gilvum_PYR-GCK LPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSF
Mvan_0415|M.vanbaalenii_PYR-1 LPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSP
MAB_2254c|M.abscessus_ATCC_199 APLWLPLLILAAWQYLQPPAVDAAP--ADEIRPELGSTVNGQREHIEPLP
MLBr_01182|M.leprae_Br4923 NGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLG
.
MUL_4621|M.ulcerans_Agy99 EATLVGKLAVPTSWSNALPKTAATTGALGGSGWTVP-EEAAPVSGVAGVP
MMAR_4452|M.marinum_M EATLVGKLAVPTSWSSALPETAATTGALGGSGWTVP-EEAAPVSGVAGVP
Mb1068c|M.bovis_AF2122/97 EATLVGRLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVTGMM--P
Rv1039c|M.tuberculosis_H37Rv EATLVGRLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVTGMM--P
MAV_1347|M.avium_104 SAATVGELSTPATWSAPTPEPAATT--VGATEWASPAEEPHTAWATG-MP
MSMEG_0619|M.smegmatis_MC2_155 AVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu -------------VRAEPQNPLPLTXXX----------------------
Mflv_0325|M.gilvum_PYR-GCK PATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 AIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGT
MAB_2254c|M.abscessus_ATCC_199 AIALAPTATPVPTASASAPSAPAPAPAPTAAGAGFAPYLVGAIPDEPPAI
MLBr_01182|M.leprae_Br4923 RAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLP
MUL_4621|M.ulcerans_Agy99 GMAAAAKGAGAYAGPRYGFKPIVMPKQVVV--------------------
MMAR_4452|M.marinum_M GMAAAAKGAGAYAGPRYGFKPIVMPKQVVV--------------------
Mb1068c|M.bovis_AF2122/97 GMASAAKGTGAYAGPRYGFKPTVMPKQVVV--------------------
Rv1039c|M.tuberculosis_H37Rv GMASAAKGTGAYAGPRYGFKPTVMPKQVVV--------------------
MAV_1347|M.avium_104 AVASAGRG-GYGMGPRYGVKPKVMPTRLPV--------------------
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MAB_2254c|M.abscessus_ATCC_199 QFGPTLNEGNKAQAPASGISAAAA-AAASARSRARRKRGARVKDPAPQYM
MLBr_01182|M.leprae_Br4923 MAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG---------------
MUL_4621|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4452|M.marinum_M --------------------------------------------------
Mb1068c|M.bovis_AF2122/97 --------------------------------------------------
Rv1039c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTT
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTT
MAB_2254c|M.abscessus_ATCC_199 DMNVTVDADYGEPPGSAQR-QSTASARGAGHLGLAGTSPKTTATAAGLVA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MUL_4621|M.ulcerans_Agy99 -------------------------------------------------
MMAR_4452|M.marinum_M -------------------------------------------------
Mb1068c|M.bovis_AF2122/97 -------------------------------------------------
Rv1039c|M.tuberculosis_H37Rv -------------------------------------------------
MAV_1347|M.avium_104 -------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 -----LTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu -------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK -----LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -----LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_2254c|M.abscessus_ATCC_199 RGSAGSDTDVPETARIVPMIPTTWSTDSDEAID----------------
MLBr_01182|M.leprae_Br4923 -------------------------------------------------